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Search of human proteins with 188536002
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188536002 NLR family, pyrin domain containing 3 isoform d
[Homo sapiens]
(979 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 1990 0.0
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 1904 0.0
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 1904 0.0
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 1858 0.0
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 1764 0.0
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 857 0.0
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 573 e-163
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 481 e-135
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 459 e-129
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 447 e-125
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 443 e-124
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 443 e-124
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 443 e-124
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 441 e-123
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 440 e-123
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 440 e-123
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 410 e-114
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 409 e-114
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 405 e-113
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 400 e-111
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 400 e-111
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 394 e-109
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 356 5e-98
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 323 4e-88
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho... 201 2e-51
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 191 2e-48
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 191 2e-48
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 191 2e-48
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 191 2e-48
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 191 2e-48
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 1990 bits (5155), Expect = 0.0
Identities = 979/979 (100%), Positives = 979/979 (100%)
Query: 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
Sbjct: 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
Query: 61 FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
Sbjct: 61 FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
Query: 121 LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
Sbjct: 121 LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
Query: 181 QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
Sbjct: 181 QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
Query: 241 LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
Sbjct: 241 LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
Query: 301 MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
Sbjct: 301 MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
Query: 361 LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
Sbjct: 361 LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
Query: 421 GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
Sbjct: 421 GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
Query: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
Sbjct: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
Query: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
Sbjct: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
Query: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
Sbjct: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
Query: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
Sbjct: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
Query: 721 GRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSC 780
GRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSC
Sbjct: 721 GRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSC 780
Query: 781 CLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 840
CLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT
Sbjct: 781 CLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 840
Query: 841 SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC 900
SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC
Sbjct: 841 SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC 900
Query: 901 CWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA 960
CWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA
Sbjct: 901 CWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA 960
Query: 961 LETLQEEKPELTVVFEPSW 979
LETLQEEKPELTVVFEPSW
Sbjct: 961 LETLQEEKPELTVVFEPSW 979
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 1904 bits (4932), Expect = 0.0
Identities = 955/1036 (92%), Positives = 963/1036 (92%), Gaps = 57/1036 (5%)
Query: 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
Sbjct: 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
Query: 61 FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
Sbjct: 61 FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
Query: 121 LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
Sbjct: 121 LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
Query: 181 QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
Sbjct: 181 QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
Query: 241 LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
Sbjct: 241 LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
Query: 301 MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
Sbjct: 301 MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
Query: 361 LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
Sbjct: 361 LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
Query: 421 GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
Sbjct: 421 GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
Query: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
Sbjct: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
Query: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
Sbjct: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
Query: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
Sbjct: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
Query: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
Sbjct: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
Query: 721 GRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH------------- 767
L+ C + VLS++Q L ELDLSDN+LGD G+R+LC L+H
Sbjct: 721 VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC 780
Query: 768 ------------------------------------LLC--------NLKKLWLVSCCLT 783
LLC NLKKLWLVSCCLT
Sbjct: 781 GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT 840
Query: 784 SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC 843
SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC
Sbjct: 841 SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC 900
Query: 844 CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD 903
CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
Sbjct: 901 CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD 960
Query: 904 LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET 963
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET
Sbjct: 961 LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET 1020
Query: 964 LQEEKPELTVVFEPSW 979
LQEEKPELTVVFEPSW
Sbjct: 1021 LQEEKPELTVVFEPSW 1036
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 1904 bits (4932), Expect = 0.0
Identities = 955/1036 (92%), Positives = 963/1036 (92%), Gaps = 57/1036 (5%)
Query: 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
Sbjct: 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
Query: 61 FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
Sbjct: 61 FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
Query: 121 LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
Sbjct: 121 LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
Query: 181 QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
Sbjct: 181 QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
Query: 241 LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
Sbjct: 241 LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
Query: 301 MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
Sbjct: 301 MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
Query: 361 LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
Sbjct: 361 LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
Query: 421 GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
Sbjct: 421 GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
Query: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
Sbjct: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
Query: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
Sbjct: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
Query: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
Sbjct: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
Query: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
Sbjct: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
Query: 721 GRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH------------- 767
L+ C + VLS++Q L ELDLSDN+LGD G+R+LC L+H
Sbjct: 721 VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC 780
Query: 768 ------------------------------------LLC--------NLKKLWLVSCCLT 783
LLC NLKKLWLVSCCLT
Sbjct: 781 GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT 840
Query: 784 SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC 843
SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC
Sbjct: 841 SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC 900
Query: 844 CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD 903
CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
Sbjct: 901 CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD 960
Query: 904 LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET 963
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET
Sbjct: 961 LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET 1020
Query: 964 LQEEKPELTVVFEPSW 979
LQEEKPELTVVFEPSW
Sbjct: 1021 LQEEKPELTVVFEPSW 1036
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 1858 bits (4813), Expect = 0.0
Identities = 918/979 (93%), Positives = 940/979 (96%)
Query: 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
Sbjct: 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
Query: 61 FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
Sbjct: 61 FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
Query: 121 LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
Sbjct: 121 LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
Query: 181 QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
Sbjct: 181 QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
Query: 241 LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
Sbjct: 241 LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
Query: 301 MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
Sbjct: 301 MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
Query: 361 LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
Sbjct: 361 LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
Query: 421 GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
Sbjct: 421 GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
Query: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
Sbjct: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
Query: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
Sbjct: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
Query: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
Sbjct: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
Query: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
Sbjct: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
Query: 721 GRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSC 780
L+ C + VLS++Q L ELDLSDN+LGD G+R+LC L+H CN+++LWL C
Sbjct: 721 VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC 780
Query: 781 CLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 840
L+ CC D++ VLS++ L L + +NALGD G+ +LC K+ CNL+KL LVNSGLT
Sbjct: 781 GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLT 840
Query: 841 SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC 900
SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC
Sbjct: 841 SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC 900
Query: 901 CWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA 960
CWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA
Sbjct: 901 CWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA 960
Query: 961 LETLQEEKPELTVVFEPSW 979
LETLQEEKPELTVVFEPSW
Sbjct: 961 LETLQEEKPELTVVFEPSW 979
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 1764 bits (4568), Expect = 0.0
Identities = 886/979 (90%), Positives = 898/979 (91%), Gaps = 57/979 (5%)
Query: 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
Sbjct: 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
Query: 61 FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
Sbjct: 61 FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
Query: 121 LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
Sbjct: 121 LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
Query: 181 QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
Sbjct: 181 QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
Query: 241 LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
Sbjct: 241 LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
Query: 301 MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
Sbjct: 301 MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
Query: 361 LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
Sbjct: 361 LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
Query: 421 GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
Sbjct: 421 GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
Query: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
Sbjct: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
Query: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
Sbjct: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
Query: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
Sbjct: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
Query: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSS
Sbjct: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSS-------- 712
Query: 721 GRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSC 780
H C + LG C
Sbjct: 713 ------HAAC-------------------SHGLG------------------------RC 723
Query: 781 CLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 840
L+ CC D++ VLS++ L L + +NALGD G+ +LC K+ CNL+KL LVNSGLT
Sbjct: 724 GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLT 783
Query: 841 SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC 900
SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC
Sbjct: 784 SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC 843
Query: 901 CWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA 960
CWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA
Sbjct: 844 CWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA 903
Query: 961 LETLQEEKPELTVVFEPSW 979
LETLQEEKPELTVVFEPSW
Sbjct: 904 LETLQEEKPELTVVFEPSW 922
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 857 bits (2215), Expect = 0.0
Identities = 456/946 (48%), Positives = 634/946 (67%), Gaps = 41/946 (4%)
Query: 8 CKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKA 67
C+L+ YLE+LE V+LKKFK++L + G +P G EKA +++A L+I G E+A
Sbjct: 11 CRLSTYLEELEAVELKKFKLYLGT-ATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69
Query: 68 WAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127
W +A+ F INR+DL+E+ +R+ D R + P S+ + LLE +
Sbjct: 70 WRLALSTFERINRKDLWERGQRE------DLVRDTPPG---GPSSLGNQSTCLLE----V 116
Query: 128 SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187
S+ +KD ++ YR YVR +F+ +EDRNARLGE V+L+ RYTRL L+KEH + + +Q+L
Sbjct: 117 SLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQL 176
Query: 188 LAIGK--TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWAS 245
L G+ +T SPIK+E LF+PD+E EP TVV QGAAGIGK++LA K+MLDWA
Sbjct: 177 LDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWAD 236
Query: 246 GTLYQDRFDYLFYIHCREVSL-VTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGF 304
G L+Q RFDYLFYI+CRE++ T+ S+ DLI SC P+P+ P+ +++R P R+LF++DGF
Sbjct: 237 GKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGF 296
Query: 305 DELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDH 364
DEL+ +F + GP C W++ ++LL+SLIRKKLLPE SLLITTRP ALEKL LL+H
Sbjct: 297 DELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEH 356
Query: 365 PRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQ 424
PRHVEILGFSEA+RKEYF+KYF + QA F+ +++NE LFTMCF+PLVCW+VCT L+Q
Sbjct: 357 PRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQ 416
Query: 425 QMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILF 484
Q+E G L QTS+TTTAVY+ +L SL+QP+ G+ + GLCSLAADG+WNQKILF
Sbjct: 417 QLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILF 476
Query: 485 EESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRT 544
EE DLR HGL DVSAFL MN+FQK+++CE++YSFIH++FQEFFAAMYY+L+E + G
Sbjct: 477 EEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAG 536
Query: 545 NVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQI 604
P +DVT LL Y E+ +L RFLFGL+N+E S+LEK L K+S I
Sbjct: 537 ---------PDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHI 587
Query: 605 RLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEI-NLSTRMDH 663
+++LL+WI+ KA++ +Q LE F CLYE+QEE+F+Q+A+ +F I + N++++M+H
Sbjct: 588 KMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEH 647
Query: 664 MVSSFCIENCHRVESLSL-GFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGR 722
MVSSFC++ C + L L G ++ E+ G H +VQ LP R
Sbjct: 648 MVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQ--LPE-----------R 694
Query: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782
L ++ L +N L+EL L NALG G++LLC GL+H C L+ L L C +
Sbjct: 695 TVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRI 754
Query: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842
+S+ C+DL++ L + +LTR+ + N +G G+ +LCE ++PQC LQ + L L S
Sbjct: 755 SSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESG 814
Query: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 902
C ++SVL TN +L L L GN L D G++LLC+GL HP C+L+ L L C LT+ C
Sbjct: 815 ACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACD 874
Query: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
+L++ L+ +QSLR+L L N+LGDLGV++ CE L+ +C LQ L L
Sbjct: 875 ELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 920
Score = 211 bits (537), Expect = 3e-54
Identities = 120/254 (47%), Positives = 149/254 (58%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L +C L C +++ VL +N LVELDL+ NAL D G+RLLC GL+H +C L+ LWL
Sbjct: 806 LRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKI 865
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
C LT+A C +LAS LS + SL L + N LGD GV +LCE ++P C LQ L L L
Sbjct: 866 CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRL 925
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
S C LS VL N NL L L N LGD G+ LL EGL HP C+LQ L LD+C LT+
Sbjct: 926 GSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAK 985
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
C +L L +Q+L L L NN LGD GV + C+ L C L+ L L M N T S
Sbjct: 986 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHS 1045
Query: 960 ALETLQEEKPELTV 973
L L+ KP L +
Sbjct: 1046 RLAALRVTKPYLDI 1059
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 573 bits (1478), Expect = e-163
Identities = 364/982 (37%), Positives = 529/982 (53%), Gaps = 103/982 (10%)
Query: 10 LARYLEDLEDVDLKKFKMHL-EDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
L YLE+L +L FK+ L E P+ G P + +KA DLA LM + EKAW
Sbjct: 15 LLLYLEELNKEELNTFKLFLKETMEPEHGLTPW--NEVKKARREDLANLMKKYYPGEKAW 72
Query: 69 AMAVWIFAAINRRDLYEKAKRDEPKW-----GSDNARVSNPTVICQEDSIEEEWMGLLEY 123
++++ IF +N +DL E+AK +E W G D+A+ QED +E +G
Sbjct: 73 SVSLKIFGKMNLKDLCERAK-EEINWSAQTIGPDDAKAGE----TQED--QEAVLG---- 121
Query: 124 LSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQER 183
+YR ++ +F D+ + G+ H E+
Sbjct: 122 ------------DGTEYRNRIKEKFCITWDKKSLAGKPEDF------------HHGIAEK 157
Query: 184 EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDW 243
+++LL E LFD D + VV QGAAG+GKT L RK MLDW
Sbjct: 158 DRKLL-----------------EHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDW 200
Query: 244 ASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDG 303
A G+LYQ RF Y+FY++ RE++ + +RS LI P PI +I+ +PS +LF++D
Sbjct: 201 AEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDS 260
Query: 304 FDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLD 363
FDEL AF+E LC DW + L+SSL+RK +LPEASLL+TTR ++L+ LL
Sbjct: 261 FDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLK 320
Query: 364 HPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLK 423
+ +VE+LG SE R+EY +++F D+ A FS ++ NE+LF+MC +PLVCW CT LK
Sbjct: 321 NHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLK 380
Query: 424 QQMESGKSLAQTSKTTTAVYVFFLSSLLQP-RGGSQEHGLCAHLWGLCSLAADGIWNQKI 482
QQME G + T +TTTA++ ++SSL P GGS A L LC +AA GIW
Sbjct: 381 QQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTY 440
Query: 483 LFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEG 542
+F +LR GL ++DVS+F+ N+ QK+ + E Y F H+ QEFFAAM+Y+L+ E
Sbjct: 441 VFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEA 500
Query: 543 RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
G+ P D+ LL++ ++ +L + FLFGL+N++R LE+ +CK+S
Sbjct: 501 -----GNPSCQPFEDLKSLLQS-TSYKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSL 554
Query: 603 QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
+I+ +LL+ +EV + Q LELF+CLYE Q++ F+ +AM FPK+ IN+ ++
Sbjct: 555 KIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIH 614
Query: 663 HMVSSFCIENCHRVESLSLG---------FLHNMPKEEEEEEK----------------E 697
+VSSFC+++C + ++ L ++P + ++
Sbjct: 615 LLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEH 674
Query: 698 GRHLDMVQCVLPSSSHAACSHGL--GRCGLSH---------ECCFDISLVLSSNQKLVEL 746
R LD+ L S+ H L C L + C DIS L N+ L+ L
Sbjct: 675 LRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHL 734
Query: 747 DLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVG 806
DL + +GD G++ LC LKH C L+ L L SC LT CC ++++ L S SL L +
Sbjct: 735 DLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLS 794
Query: 807 ENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNT 866
N L D GV +LCE ++P+C L++L L + GLT C LS L +N+ LTHL L N
Sbjct: 795 TNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNV 854
Query: 867 LGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGD 926
LGD G+KL+ + L H C L+ L L C+ TS LST L ++SL L LG+N L D
Sbjct: 855 LGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQD 914
Query: 927 LGVMMFCEVLKQQSCLLQNLGL 948
GV + C+V + SC LQ+L L
Sbjct: 915 NGVKLLCDVFRHPSCNLQDLEL 936
Score = 198 bits (504), Expect = 2e-50
Identities = 113/275 (41%), Positives = 158/275 (57%), Gaps = 3/275 (1%)
Query: 702 DMVQCVLPSSSHAAC---SHGLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGI 758
D VQ + + H C L CGL+ C +SL L SN++L L L+DN LGD G+
Sbjct: 801 DGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGV 860
Query: 759 RLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAIL 818
+L+ L+H C LK L L C TS + L++ L + SLT L +G N L D+GV +L
Sbjct: 861 KLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLL 920
Query: 819 CEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEG 878
C+ ++P CNLQ L L+ LT+ CC L+SV+ N NL L L N L D G+K+LC+
Sbjct: 921 CDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDA 980
Query: 879 LLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQ 938
L +P+C +Q L L+ C LTS CC DLS+ L ++ L K++L N LG G++ +VLK
Sbjct: 981 LRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKS 1040
Query: 939 QSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
C LQ LGL + F+ E + LE + P L +
Sbjct: 1041 PKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLII 1075
Score = 189 bits (481), Expect = 8e-48
Identities = 111/284 (39%), Positives = 160/284 (56%), Gaps = 21/284 (7%)
Query: 677 ESLSLGFLHNMPKEEEEEEKEGRHLDM---------VQCVLPSSSHAAC---SHGLGRCG 724
+ +S +HN K HLD+ V+ + + H C + L C
Sbjct: 719 QDISTSLIHN---------KNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCN 769
Query: 725 LSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTS 784
L+ CC +IS L +Q L+ L+LS N L D G++LLC L+H C L++L L SC LT
Sbjct: 770 LTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTE 829
Query: 785 ACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCC 844
A C+ L+ L ++ LT L + +N LGD GV ++ + ++ QC L+ L L TS+
Sbjct: 830 AGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSS 889
Query: 845 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDL 904
LS+ L N++LTHL L N L D G+KLLC+ HP C LQ LEL C LT+ CC DL
Sbjct: 890 EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949
Query: 905 STLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
++++ ++ +LR L LGNNDL D GV + C+ L+ +C +Q LGL
Sbjct: 950 ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGL 993
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 481 bits (1237), Expect = e-135
Identities = 334/1055 (31%), Positives = 514/1055 (48%), Gaps = 180/1055 (17%)
Query: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
YLE+L+ + +KFK HL+ Q +P + +KA +LA L+I E++AW + +
Sbjct: 14 YLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITL 73
Query: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
IF ++R+DL K R+
Sbjct: 74 RIFQKMDRKDLCMKVMRE------------------------------------------ 91
Query: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
+ Y K Y+ + + +F +RL S S+ T + L E +QE
Sbjct: 92 RTGYTKTYQAHAKQKF-------SRLWSSKSV----TEIHLYFEEEVKQEE--------- 131
Query: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
C+ ++ LF P + +P TV+ QG GIGKT L K+M+ W+ +++DR
Sbjct: 132 ---CDH------LDRLFAPKEAGKQP-RTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDR 181
Query: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
F Y FY CRE+ + SL DLI PDP PI +IV +P R+LF++D F+ELQG +
Sbjct: 182 FLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLN 241
Query: 313 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
E LC D + +LLSSL+RKK+LPEASLLI +PV ++L+ + + G
Sbjct: 242 EPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRG 301
Query: 373 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
F+E+ R YF +F D +A AF+L++E+E LF++C IPL+CWI+CT LKQ+M+ GK L
Sbjct: 302 FNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDL 361
Query: 433 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAH-LWGLCSLAADGIWNQKILFEESDLRN 491
A T ++TT+VY F+ +L P G H L LCSLAA+G+W F E DLR
Sbjct: 362 ALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRR 421
Query: 492 HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
+G+ AD+ A L + K + E Y F+H+ QEF AA++YLL+ S L
Sbjct: 422 NGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLK-----------SHL 470
Query: 552 KLPSRDV----TVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLE 607
P V +L+ N+ K + + IF+ FL GL+N++ L+ ++SQ+I+ +
Sbjct: 471 DHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQ 530
Query: 608 LLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSS 667
+ + ++ + Q Q L +FYCL+EMQ+ FV++A++ + ++ +D +VS+
Sbjct: 531 IHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSA 590
Query: 668 FCIENCHRVESLSLGFLHNMPKEEEEEEKEG-------------------RHLDMVQCVL 708
+C++ C + L + KE+E R L + L
Sbjct: 591 YCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTL 650
Query: 709 PSSS---------HAACSHGLGRCGLSHECCFDISL----VLSSNQKLVELDLSDNALGD 755
S+ H +C L + G+++ S+ VL L L + L
Sbjct: 651 SESTFVTWCNQLRHPSCR--LQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSR 708
Query: 756 FGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGV 815
IR LC L + N+K+L LV+C L+ C+ LA +L+ + LT L V N L D+GV
Sbjct: 709 DDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGV 767
Query: 816 AILCEKAKNPQ----------CNLQK---------------------------------- 831
+LCE +P C+L +
Sbjct: 768 PLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTL 827
Query: 832 -------------LGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEG 878
L LV +T+ C L+S L +NQNL L + N +GD G++LLC
Sbjct: 828 CEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRA 887
Query: 879 LLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQ 938
L H DC+L++L L+ C LTS CC DL+++LT S++L++L+L N L GV++ CE L+
Sbjct: 888 LTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRH 947
Query: 939 QSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
C LQ LGL + F+ ET++ L +E P LT+
Sbjct: 948 PECALQVLGLRKTDFDEETQALLTAEEERNPNLTI 982
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 459 bits (1180), Expect = e-129
Identities = 320/1019 (31%), Positives = 500/1019 (49%), Gaps = 124/1019 (12%)
Query: 10 LARYLEDLEDVDLKKFKMHLEDYP-------PQKGCIPLPRGQTEKADHVDLATLMIDFN 62
L YL L+ L++FK+ LE PQ +P AD ++L+ L+ +
Sbjct: 17 LLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHF 76
Query: 63 GEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVI--------------- 107
+ +AW + + IF +N L EK R E K + +PT
Sbjct: 77 PKGQAWKVVLGIFQTMNLTSLCEKV-RAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQ 135
Query: 108 -CQE------DSIEEEW-----MGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRN 155
CQ+ D +EEE G + + D+R+KYR+ +++
Sbjct: 136 GCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAEL------- 188
Query: 156 ARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEH 215
+++S K + +R + S+ E E+ ++ L DP+
Sbjct: 189 LETWDNISWPKDHVYIR----NTSKDEHEE-------------------LQRLLDPNRTR 225
Query: 216 SEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDL 275
++ T+V G AG+GKT LA + ML WA+G L+Q RF Y+FY+ C ++ + + + +L
Sbjct: 226 AQ-AQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAEL 284
Query: 276 IMSCCPDPNPPIHKIVRKPSRILFLMDGFDEL------QGAFDEHIGPLCTDWQKAERGD 329
I PD + PI + + +P ++LF++DGF+E+ + D+ G CTDW +
Sbjct: 285 ISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDD--GSPCTDWYQELPVT 342
Query: 330 ILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDE 389
+L SL++K+L+P A+LLIT + + L+ L +P V+I GF+ + YF ++F D
Sbjct: 343 KILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDS 402
Query: 390 AQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSS 449
++ +++NE LF C P+VCW VC+ LKQ L ++TTT++Y +F S+
Sbjct: 403 SEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSN 462
Query: 450 LLQPRGGSQEHGLCAHLW-----GLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLR 504
L + E L W LCSLA +G+W+ F + D GL+ + +
Sbjct: 463 LF----STAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYE 518
Query: 505 MNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLEN 564
N+ QK DC +F H++FQEFFAAM ++LEE +E P K +++ +LL++
Sbjct: 519 FNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEPRE----FPPHSTK--PQEMKMLLQH 572
Query: 565 YGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQ 624
++ Y VV F FGL+N+ LE L CKIS ++ ELLKW E KA+ +Q
Sbjct: 573 VLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQ 632
Query: 625 PSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFL 684
L LF+CL+E QEEDF ++ + ++++N+ + SSFC+++C R+ L L
Sbjct: 633 FHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVS 692
Query: 685 HNMPKEEEE---------------------EEKEGRH-LDMVQCVLPSSSHAACSHGL-- 720
++ + + E E H LD+ L +SS L
Sbjct: 693 SHILERDLEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKN 752
Query: 721 GRCGLSHECC---------FDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCN 771
RC + C D+ + L N KL L+ S N LG + L+ L+H CN
Sbjct: 753 PRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACN 811
Query: 772 LKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQK 831
LK L L C L++A CQDLA L++ +TRL +G N L D G+ +LC +P+C L++
Sbjct: 812 LKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALER 871
Query: 832 LGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLEL 891
L L L + C LS L N++LTHL L N+L D+G+K LCE L PD LQ L L
Sbjct: 872 LELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNL 931
Query: 892 DNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
C+ T C +L+ L+ + +++ L LG NDL D GV + CE LK L LGL++
Sbjct: 932 SGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRA-LHTLGLAK 989
Score = 171 bits (433), Expect = 3e-42
Identities = 104/247 (42%), Positives = 137/247 (55%), Gaps = 4/247 (1%)
Query: 704 VQCVLPSSSHAACSHG---LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760
V +L + H+AC+ L +C LS C D++L L+S Q + L L N L D GI+L
Sbjct: 798 VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKL 857
Query: 761 LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 820
LC L H C L++L L C L + C+ L+ L + SLT L + +N+L D GV LCE
Sbjct: 858 LCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCE 917
Query: 821 KAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 880
P NLQ L L T C L++ LS N N+ L L N L D G+KLLCE L
Sbjct: 918 ALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEA-L 976
Query: 881 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 940
P L L L CNLT+ CC L ++L+SS+SL L+L N+L GV M C+ LK+ +
Sbjct: 977 KPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKST 1036
Query: 941 CLLQNLG 947
C LQ LG
Sbjct: 1037 CRLQKLG 1043
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 447 bits (1151), Expect = e-125
Identities = 297/971 (30%), Positives = 492/971 (50%), Gaps = 127/971 (13%)
Query: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
YL++L + KFK L+ + P+P + +KA D+A L+ ++AW + +
Sbjct: 14 YLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73
Query: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
+F INR+DL+ KA+ +
Sbjct: 74 NLFLQINRKDLWTKAQEE------------------------------------------ 91
Query: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
++ YRK+++ FQ I ++ L + EH ++ + E +
Sbjct: 92 MRNKLNPYRKHMKETFQLIWEKETCLH--------------VPEHFYKETMKNEYKELND 137
Query: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
T + HTVV +G GIGKT L RK+MLDWA G L++DR
Sbjct: 138 AYTAAARR-------------------HTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDR 178
Query: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
F ++F+++ E++ + + SL +L+ P+ + I I +P RILF+MDGF++L+ F+
Sbjct: 179 FTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLK--FN 236
Query: 313 EHI-GPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEIL 371
+ L DW++ + I+LSSL++KK+LPE+SLLI +A++K +L HP+ +++L
Sbjct: 237 LQLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLL 296
Query: 372 GFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKS 431
GFSE+++K YF +F ++++A F+ +++N LF +C P CW+VCT +KQ++E G+
Sbjct: 297 GFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGED 356
Query: 432 LAQTSKTTTAVYVFFLSSLLQPRGGSQEHG---LCAHLWGLCSLAADGIWNQKILFEESD 488
L S+ TT +Y FL+++ + GSQ A L LC+LAA+GIW +F D
Sbjct: 357 LEINSQNTTYLYASFLTTVF--KAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGD 414
Query: 489 LRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPG 548
LR +GL +++ ++ M L Q+ DC ++F+H+ QEF AAM+YLL+ K+ G
Sbjct: 415 LRRNGLSESEGVMWVGMRLLQRRGDC---FAFMHLCIQEFCAAMFYLLKRPKDDPNPAIG 471
Query: 549 SRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLEL 608
S +T L+ + L V F+FG+ +E S LE +S+ ++ E+
Sbjct: 472 S--------ITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEI 523
Query: 609 LKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSF 668
+ +E ++ + + + ELF L+E QE++FV + M++F ++ I + +++SF
Sbjct: 524 TQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASF 583
Query: 669 CIENCHRVESLSLGFLHNMPKEE------EEE-------------EKEGRHLDMVQCVLP 709
C+++C + +L + + P + E+ K + LDM L
Sbjct: 584 CLKHCQHLTTLRMCVENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLD 643
Query: 710 SSSHAACSHGLGR--CGL----------SHECCFDISLVLSSNQKLVELDLSDNALGDFG 757
S A L + C L H+ ++ + N L L L +L
Sbjct: 644 DPSLAILCKALAQPVCKLRKLIFTSVYFGHDS--ELFKAVLHNPHLKLLSLYGTSLSQSD 701
Query: 758 IRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAI 817
IR LC LKH +C +++L L C ++S C+D+ASVL+ + L L + EN L D G+ +
Sbjct: 702 IRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTL 761
Query: 818 LCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 877
LCE K+ C L++L L+ LTSV C ++S VL +++L+ L L N L D G+ LC
Sbjct: 762 LCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCA 821
Query: 878 GLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLK 937
L HP C ++ L L C LTS C D++ +L + L+ L LG+N++GD GV C L+
Sbjct: 822 ALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQ 881
Query: 938 QQSCLLQNLGL 948
C L+ LGL
Sbjct: 882 HPHCKLECLGL 892
Score = 204 bits (518), Expect = 4e-52
Identities = 110/258 (42%), Positives = 154/258 (59%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
LG+C +S E C DI+ VL+ N KL L L +N L D G+ LLC LKH C L++L L+
Sbjct: 721 LGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMY 780
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
CCLTS C ++ VL S SL+ L +G NAL D+GVA LC K+P C++++L L+ L
Sbjct: 781 CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL 840
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
TS C +++VL N L L L N +GD G++ LC L HP CKL+ L L C +T
Sbjct: 841 TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA 900
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
CC D++ L + ++LR L+L L V++ CE L C LQ LGL + F+ ET+
Sbjct: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960
Query: 960 ALETLQEEKPELTVVFEP 977
L +++E+ P LT+ P
Sbjct: 961 ILMSVEEKIPHLTISHGP 978
Score = 44.7 bits (104), Expect = 4e-04
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 2/104 (1%)
Query: 847 LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLST 906
L S+ TN+N L + +L D + +LC+ L P CKL+ L + +L
Sbjct: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDS--ELFK 679
Query: 907 LLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
+ + L+ LSL L + CE LK C ++ L L +
Sbjct: 680 AVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGK 723
Score = 35.4 bits (80), Expect = 0.26
Identities = 21/59 (35%), Positives = 30/59 (50%)
Query: 719 GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL 777
GL C ++ CC DI+ L + + L L+L AL + +LC L H C L+ L L
Sbjct: 891 GLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGL 949
Score = 33.1 bits (74), Expect = 1.3
Identities = 13/56 (23%), Positives = 32/56 (57%)
Query: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 958
+L ++ ++++ + L + N L D + + C+ L Q C L+ L + +YF ++++
Sbjct: 621 ELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSE 676
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 443 bits (1140), Expect = e-124
Identities = 280/706 (39%), Positives = 389/706 (55%), Gaps = 44/706 (6%)
Query: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
Query: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
Query: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
Query: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
Query: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
Query: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
Query: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
Query: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI+ V+ L L
Sbjct: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL- 769
Query: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL-VLSSNQ 741
EGR S+ + L R + + I VL +
Sbjct: 770 -------------IEGRQ--------HRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTR 808
Query: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 801
L ELDLS N+L ++ LC L+ C L+ L L C LT+ C+DLA L + +LT
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 802 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 861
L + N L D+G LC++ + P C LQ+L LV+ GLTS CC L+SVLS + +L L
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 907
L+ N L D G++LLCEGL HP CKL L LD L+ +L L
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
Score = 148 bits (374), Expect = 2e-35
Identities = 81/192 (42%), Positives = 114/192 (59%)
Query: 782 LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 841
+T A Q L SVL + +L L + N+L S V LC+ + P+C L+ L L GLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 842 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 901
C L+ L NQ LT L L N L D G K LC+ L P CKLQ L+L +C LTS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 902 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 961
DL+++L++S SL++L L N+L D+GV + CE L+ +C L LGL + + E + L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 962 ETLQEEKPELTV 973
L++EKP+L +
Sbjct: 972 RALEQEKPQLLI 983
Score = 39.3 bits (90), Expect = 0.018
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
Query: 69 AMAVWIFAAINRRDLYEKAK 88
+A+ + + R L +A+
Sbjct: 68 DLALHTWEQMGLRSLCAQAQ 87
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 443 bits (1140), Expect = e-124
Identities = 280/706 (39%), Positives = 389/706 (55%), Gaps = 44/706 (6%)
Query: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
Query: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
Query: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
Query: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
Query: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
Query: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
Query: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
Query: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI+ V+ L L
Sbjct: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL- 769
Query: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL-VLSSNQ 741
EGR S+ + L R + + I VL +
Sbjct: 770 -------------IEGRQ--------HRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTR 808
Query: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 801
L ELDLS N+L ++ LC L+ C L+ L L C LT+ C+DLA L + +LT
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 802 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 861
L + N L D+G LC++ + P C LQ+L LV+ GLTS CC L+SVLS + +L L
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 907
L+ N L D G++LLCEGL HP CKL L LD L+ +L L
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
Score = 148 bits (374), Expect = 2e-35
Identities = 81/192 (42%), Positives = 114/192 (59%)
Query: 782 LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 841
+T A Q L SVL + +L L + N+L S V LC+ + P+C L+ L L GLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 842 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 901
C L+ L NQ LT L L N L D G K LC+ L P CKLQ L+L +C LTS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 902 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 961
DL+++L++S SL++L L N+L D+GV + CE L+ +C L LGL + + E + L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 962 ETLQEEKPELTV 973
L++EKP+L +
Sbjct: 972 RALEQEKPQLLI 983
Score = 39.3 bits (90), Expect = 0.018
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
Query: 69 AMAVWIFAAINRRDLYEKAK 88
+A+ + + R L +A+
Sbjct: 68 DLALHTWEQMGLRSLCAQAQ 87
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 443 bits (1140), Expect = e-124
Identities = 280/706 (39%), Positives = 389/706 (55%), Gaps = 44/706 (6%)
Query: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
Query: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
Query: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
Query: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
Query: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
Query: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
Query: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
Query: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI+ V+ L L
Sbjct: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL- 769
Query: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL-VLSSNQ 741
EGR S+ + L R + + I VL +
Sbjct: 770 -------------IEGRQ--------HRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTR 808
Query: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 801
L ELDLS N+L ++ LC L+ C L+ L L C LT+ C+DLA L + +LT
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 802 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 861
L + N L D+G LC++ + P C LQ+L LV+ GLTS CC L+SVLS + +L L
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 907
L+ N L D G++LLCEGL HP CKL L LD L+ +L L
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
Score = 148 bits (374), Expect = 2e-35
Identities = 81/192 (42%), Positives = 114/192 (59%)
Query: 782 LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 841
+T A Q L SVL + +L L + N+L S V LC+ + P+C L+ L L GLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 842 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 901
C L+ L NQ LT L L N L D G K LC+ L P CKLQ L+L +C LTS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 902 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 961
DL+++L++S SL++L L N+L D+GV + CE L+ +C L LGL + + E + L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 962 ETLQEEKPELTV 973
L++EKP+L +
Sbjct: 972 RALEQEKPQLLI 983
Score = 39.3 bits (90), Expect = 0.018
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
Query: 69 AMAVWIFAAINRRDLYEKAK 88
+A+ + + R L +A+
Sbjct: 68 DLALHTWEQMGLRSLCAQAQ 87
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 441 bits (1134), Expect = e-123
Identities = 319/986 (32%), Positives = 487/986 (49%), Gaps = 82/986 (8%)
Query: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
L LE L +L KFK + + +P + +KAD L ++
Sbjct: 11 LQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEM 70
Query: 70 MAVWIFAAINRRDLYEKAKRD--EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127
++ +F ++R DL E+AK + E S N R I +++ +
Sbjct: 71 ASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKER------------PPL 118
Query: 128 SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187
+ +M + ++ + + + ++ I LG+ V K+ + + + RE
Sbjct: 119 DVDEMLERFKTEAQAFTETKGNVI-----CLGKEVFKGKKPDKDNRCRYILKTKFREMWK 173
Query: 188 LAIGKTKTCESPVSPIKMELLFDPDDEHSEPV-HTVVFQGAAGIGKTILARKMMLDWASG 246
G +K + KM + F P +TVV G AG+GKT LA+K+MLDWA
Sbjct: 174 SWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAED 233
Query: 247 TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
L +F Y FY+ CRE+S + S +L+ P+ I I+ + +ILF++DGFDE
Sbjct: 234 NLIH-KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDE 292
Query: 307 LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
L A I +C DW+K + +LL SL+ + +LP+A+LL+TTRP AL L+ L + P
Sbjct: 293 LGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPI 352
Query: 367 HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
++ + GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QM
Sbjct: 353 YIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQM 412
Query: 427 ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
E G+ T T T +++ FL S P+G L L L LAA G+W Q +
Sbjct: 413 EKGEDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQTSVLHR 467
Query: 487 SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKE----G 542
DL G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E+E G
Sbjct: 468 EDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDG 527
Query: 543 RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
T G DV LL + LI + FGL N++R LE C++S
Sbjct: 528 HTWDIG--------DVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSP 579
Query: 603 QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
I+ ELL+ ++ K + Q EL CLYE QEE+ V+ M F +I ++L+ +D
Sbjct: 580 DIKQELLR-CDISCKGGHSTVTDLQ-ELLGCLYESQEEELVKEVMAQFKEISLHLNA-VD 636
Query: 663 HMVSSFCIENCHRVESLSLGFL-HNMPKE--------EEEEEKEGRHL------------ 701
+ SSFC+++C ++ +SL + N+P+ E E ++ +H+
Sbjct: 637 VVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFG 696
Query: 702 ---DMVQCVLPSSSHAA------CSH-GLGRCGLSHECCFDIS---------LVLSSNQK 742
D++ + S +A C C L +IS L L ++
Sbjct: 697 SNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKT 756
Query: 743 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 802
+ L L N D LC L+H CNL+ L LVSC T+ DL+ L + SLT
Sbjct: 757 VTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTC 815
Query: 803 LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 862
+ + +N L D G +L ++P+C LQ+L L N LT C L++VL ++ LTHL L
Sbjct: 816 VNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCL 875
Query: 863 RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 922
N +G+ G+K LCEGL +P+CKLQ L L NC++TS C DL+ LL SL L LG N
Sbjct: 876 AKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLN 935
Query: 923 DLGDLGVMMFCEVLKQQSCLLQNLGL 948
+G G+ CE L++ C L+ L L
Sbjct: 936 HIGVKGMKFLCEALRKPLCNLRCLWL 961
Score = 176 bits (445), Expect = 1e-43
Identities = 110/275 (40%), Positives = 149/275 (54%), Gaps = 3/275 (1%)
Query: 702 DMVQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGI 758
DM + H C+ GL C + + D+SL L NQ L ++LSDN L D G
Sbjct: 769 DMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGA 828
Query: 759 RLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAIL 818
+LL L+H C L++L L +C LT A C+DLA+VL S LT L + +N +G++GV L
Sbjct: 829 KLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFL 888
Query: 819 CEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEG 878
CE + P+C LQ L L N +TS C L+ +L +L L L N +G KG+K LCE
Sbjct: 889 CEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEA 948
Query: 879 LLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQ 938
L P C L+ L L C++ C DL + L+ +QSL L LG N LG GV M E L
Sbjct: 949 LRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTC 1008
Query: 939 QSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
S L+ L L FN E LE ++E+ P+L +
Sbjct: 1009 SSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLII 1043
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 847 LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLST 906
L S+ +N++L L + + L +++LCE + C LQ + N + + +L
Sbjct: 691 LCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PADAHRNLCL 749
Query: 907 LLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQE 966
L +++ L+L ND D+ + CEVL+ C L+ LGL + + L E
Sbjct: 750 ALRGHKTVTYLTLQGNDQDDMFPAL-CEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808
Query: 967 EKPELTVV 974
LT V
Sbjct: 809 VNQSLTCV 816
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 440 bits (1132), Expect = e-123
Identities = 282/720 (39%), Positives = 396/720 (55%), Gaps = 45/720 (6%)
Query: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
Query: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
Query: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
Query: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
Query: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
Query: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
Query: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
Query: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI+ V+ L L
Sbjct: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL- 769
Query: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL-VLSSNQ 741
EGR S+ + L R + + I VL +
Sbjct: 770 -------------IEGRQ--------HRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTR 808
Query: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 801
L ELDLS N+L ++ LC L+ C L+ L L C LT+ C+DLA L + +LT
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 802 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 861
L + N L D+G LC++ + P C LQ+L LV+ GLTS CC L+SVLS + +L L
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGN 921
L+ N L D G++LLCEGL HP CKL L + +T D + S+ SL++ LG+
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDTGEMSNSTSSLKRQRLGS 987
Score = 132 bits (331), Expect = 2e-30
Identities = 73/166 (43%), Positives = 99/166 (59%)
Query: 782 LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 841
+T A Q L SVL + +L L + N+L S V LC+ + P+C L+ L L GLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 842 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 901
C L+ L NQ LT L L N L D G K LC+ L P CKLQ L+L +C LTS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 902 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
DL+++L++S SL++L L N+L D+GV + CE L+ +C L LG
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 79.3 bits (194), Expect = 2e-14
Identities = 48/133 (36%), Positives = 65/133 (48%)
Query: 839 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 898
+T L SVL +NL L L GN+L +K LC+ L P C L+ L L C LT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 899 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 958
C DL+ L ++Q+L +L L N L D G C+ L+Q SC LQ L L +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 959 SALETLQEEKPEL 971
L ++ P L
Sbjct: 912 QDLASVLSASPSL 924
Score = 39.3 bits (90), Expect = 0.018
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
Query: 69 AMAVWIFAAINRRDLYEKAK 88
+A+ + + R L +A+
Sbjct: 68 DLALHTWEQMGLRSLCAQAQ 87
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 440 bits (1132), Expect = e-123
Identities = 282/720 (39%), Positives = 396/720 (55%), Gaps = 45/720 (6%)
Query: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
Query: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
Query: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
Query: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
Query: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
Query: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
Query: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
Query: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI+ V+ L L
Sbjct: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL- 769
Query: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL-VLSSNQ 741
EGR S+ + L R + + I VL +
Sbjct: 770 -------------IEGRQ--------HRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTR 808
Query: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 801
L ELDLS N+L ++ LC L+ C L+ L L C LT+ C+DLA L + +LT
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 802 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 861
L + N L D+G LC++ + P C LQ+L LV+ GLTS CC L+SVLS + +L L
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGN 921
L+ N L D G++LLCEGL HP CKL L + +T D + S+ SL++ LG+
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDTGEMSNSTSSLKRQRLGS 987
Score = 132 bits (331), Expect = 2e-30
Identities = 73/166 (43%), Positives = 99/166 (59%)
Query: 782 LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 841
+T A Q L SVL + +L L + N+L S V LC+ + P+C L+ L L GLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 842 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 901
C L+ L NQ LT L L N L D G K LC+ L P CKLQ L+L +C LTS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 902 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
DL+++L++S SL++L L N+L D+GV + CE L+ +C L LG
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 79.3 bits (194), Expect = 2e-14
Identities = 48/133 (36%), Positives = 65/133 (48%)
Query: 839 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 898
+T L SVL +NL L L GN+L +K LC+ L P C L+ L L C LT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 899 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 958
C DL+ L ++Q+L +L L N L D G C+ L+Q SC LQ L L +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 959 SALETLQEEKPEL 971
L ++ P L
Sbjct: 912 QDLASVLSASPSL 924
Score = 39.3 bits (90), Expect = 0.018
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
Query: 69 AMAVWIFAAINRRDLYEKAK 88
+A+ + + R L +A+
Sbjct: 68 DLALHTWEQMGLRSLCAQAQ 87
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 410 bits (1055), Expect = e-114
Identities = 321/1014 (31%), Positives = 471/1014 (46%), Gaps = 110/1014 (10%)
Query: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
Query: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
Query: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
K+ +R K +S+ + + + H R Q +
Sbjct: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
Query: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
Query: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Query: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
Query: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
Query: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
Query: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
Query: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 494 AWDI--GDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
Query: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
+ + A K E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 552 Q-CKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
Query: 670 IENCHRVESLSLG-----FLHNMPKEEEEEEKEG-------------------------- 698
+++C ++ LSL FL N E + E E
Sbjct: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSL 670
Query: 699 -------RHLDMVQCVLPSSS-HAACSH-GLGRCGLS---------HECCFDISLVLSSN 740
+ L++ Q L SS C H C L D L
Sbjct: 671 FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGK 730
Query: 741 QKLVELDLSDNALGDFGIRL-LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHS 799
+ L L L+ + + + L LC L++ CNL+ L L C T + VL + S
Sbjct: 731 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQS 790
Query: 800 LTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTH 859
L L + N L D G +L + P+ LQ L L N LT C L++VL ++ LTH
Sbjct: 791 LKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTH 850
Query: 860 LYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 919
L L N +GD G+K LCEGL +PDCKLQ L L C++T C LS L + SL L L
Sbjct: 851 LCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDL 910
Query: 920 GNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
N + G+ + C+ L+ +C L++L L N E K LE ++E+ P+LT+
Sbjct: 911 SINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI 963
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 409 bits (1051), Expect = e-114
Identities = 289/987 (29%), Positives = 482/987 (48%), Gaps = 63/987 (6%)
Query: 14 LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
L +L+ + + FK L+ + +P+ + E A+ LA L+ ++ G AWA ++
Sbjct: 69 LYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSIS 128
Query: 74 IFAAINRRDLYEKAKRD-------EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSR 126
IF +N R L EKA+ D +P+ + S V +++++ E +
Sbjct: 129 IFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKEQ 188
Query: 127 ISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQE 186
M+++ + Q +E A E+ K H + E+E
Sbjct: 189 EISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDY-KSHVMTKFAEEE 247
Query: 187 LLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASG 246
+ T + FD D P TVV G +GIGK+ LAR+++L WA G
Sbjct: 248 DVRRSFENTAADWPEMQTLAGAFDSDRWGFRP-RTVVLHGKSGIGKSALARRIVLCWAQG 306
Query: 247 TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
LYQ F Y+F++ RE+ + S+ + I PD P+ +I+ +P R+LF++DGFD+
Sbjct: 307 GLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDD 366
Query: 307 LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
L G+ + LC DW + + L+ SL+RK LLPE+ L++T R V EKL+ + PR
Sbjct: 367 L-GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPR 425
Query: 367 HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
++ + G S +R + E Q I N L C +P V ++C L+ Q
Sbjct: 426 YLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQD 485
Query: 427 ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAH------LWGLCSLAADGIWNQ 480
G+S+A ++T T ++ F+ L PRG + C + L C +A +G+WN+
Sbjct: 486 VVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRR---CLNLEERVVLKRFCRMAVEGVWNR 542
Query: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
K +F+ DL GL ++++ A MN+ + CE++Y+F H++ Q+F AA+YY+LE +
Sbjct: 543 KSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLE 602
Query: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
P L + ++ L+ G + +++ RFLFGLV+++ LE L C +
Sbjct: 603 IEPALCP---LYVEKTKRSMELKQAGFHI--HSLWMKRFLFGLVSEDVRRPLEVLLGCPV 657
Query: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
++ +LL W+ + + L+ F+CL+E Q+++FV+ A++ F ++ + ++
Sbjct: 658 PLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQN 717
Query: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEE-----------------EEEKE------ 697
+D + SSFC+++C + + + P++E EE+ E
Sbjct: 718 LDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSML 777
Query: 698 GRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL----------------VLSSNQ 741
G H + Q L SS + L H C +L ++ +N+
Sbjct: 778 GTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHLWRIVMANR 837
Query: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 801
L L+L L + +R+ C LKH C L+ L L C LT AC ++ +L+TS SL
Sbjct: 838 NLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLK 897
Query: 802 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 861
L + N + D GV L + + QC LQKL L + G+T+ C +L+S L +N++LTHL
Sbjct: 898 SLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLC 957
Query: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGN 921
L N+LG++G+ LLC + P C LQ L L+ C+L + C L+ L + L LSL
Sbjct: 958 LSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSM 1017
Query: 922 NDLGDLGVMMFCEVLKQQSCLLQNLGL 948
N + D GV + CEV+++ SC LQ+L L
Sbjct: 1018 NPVEDNGVKLLCEVMREPSCHLQDLEL 1044
Score = 179 bits (455), Expect = 9e-45
Identities = 109/273 (39%), Positives = 152/273 (55%), Gaps = 10/273 (3%)
Query: 676 VESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL 735
+ SL+LG H +EE+ L +C+L S L CGL+H C IS
Sbjct: 839 LRSLNLGGTH---LKEEDVRMACEALKHPKCLLESLR-------LDCCGLTHACYLKISQ 888
Query: 736 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 795
+L+++ L L L+ N + D G+ L L+ C L+KL L C +T+ CQ LAS L
Sbjct: 889 ILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALV 948
Query: 796 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 855
++ SLT L + N+LG+ GV +LC + P C+LQ+L L L + C L+ L N
Sbjct: 949 SNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNS 1008
Query: 856 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 915
LTHL L N + D G+KLLCE + P C LQ LEL C+LT+ CC LS +++ S+ L+
Sbjct: 1009 WLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLK 1068
Query: 916 KLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
L L +N LGD GV CE LKQ++ +L LGL
Sbjct: 1069 SLDLTDNALGDGGVAALCEGLKQKNSVLARLGL 1101
Score = 167 bits (422), Expect = 6e-41
Identities = 98/257 (38%), Positives = 142/257 (55%), Gaps = 2/257 (0%)
Query: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782
CG++ C ++ L SN+ L L LS+N+LG+ G+ LLC ++ C+L++L L C L
Sbjct: 933 CGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHL 992
Query: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842
+A C LA L + LT L + N + D+GV +LCE + P C+LQ L LV LT+
Sbjct: 993 DTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAA 1052
Query: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 902
CC +LS V+S +++L L L N LGD G+ LCEGL + L L L C LTS CC
Sbjct: 1053 CCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCE 1112
Query: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALE 962
LS L+ ++ L L+L N+ G+M C + LQ +GL + + + + LE
Sbjct: 1113 ALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLE 1172
Query: 963 TLQEEKPELTVVFEPSW 979
+Q KP VV + SW
Sbjct: 1173 EVQLLKPR--VVIDGSW 1187
Score = 132 bits (331), Expect = 2e-30
Identities = 75/172 (43%), Positives = 97/172 (56%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L +C L C ++L L N L L LS N + D G++LLC ++ C+L+ L LV
Sbjct: 987 LNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVK 1046
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
C LT+ACC+ L+ V+S S L L + +NALGD GVA LCE K L +LGL GL
Sbjct: 1047 CHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGL 1106
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLEL 891
TS CC ALS LS N++LT L L N KG+ LC P LQ++ L
Sbjct: 1107 TSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
Score = 109 bits (273), Expect = 1e-23
Identities = 63/181 (34%), Positives = 94/181 (51%), Gaps = 1/181 (0%)
Query: 770 CNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNL 829
C + LW+ L +D S+L T L +L +G + L + + LC K ++P C +
Sbjct: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
Query: 830 QKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVL 889
Q L N+ +T L ++ N+NL L L G L ++ +++ CE L HP C L+ L
Sbjct: 813 QTLMFRNAQITP-GVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
Query: 890 ELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLS 949
LD C LT C +S +LT+S SL+ LSL N + D GVM + L+ C LQ L L
Sbjct: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931
Query: 950 E 950
+
Sbjct: 932 D 932
Score = 40.4 bits (93), Expect = 0.008
Identities = 22/59 (37%), Positives = 30/59 (50%)
Query: 719 GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL 777
GL CGL+ +CC +SL LS N+ L L+L N G+ LC NL+ + L
Sbjct: 1100 GLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 405 bits (1042), Expect = e-113
Identities = 311/961 (32%), Positives = 456/961 (47%), Gaps = 82/961 (8%)
Query: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
Query: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
Query: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
K+ +R K +S+ + + + H R Q +
Sbjct: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
Query: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
Query: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Query: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
Query: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
Query: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
Query: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
Query: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 494 AWDI--GDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
Query: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
+ + A K E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 552 Q-CKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
Query: 670 IENCHRVESLSLG-----FLHN-----MPKEEEEEEKEGRHLDMVQCVLPSSS-HAACSH 718
+++C ++ LSL FL N + E E + L++ Q L SS C H
Sbjct: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDH 670
Query: 719 -GLGRCGLS---------HECCFDISLVLSSNQKLVELDLSDNALGDFGIRL-LCVGLKH 767
C L D L + L L L+ + + + L LC L++
Sbjct: 671 VTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRN 730
Query: 768 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 827
CNL+ L L C T + VL + SL L + N L D G +L + P+
Sbjct: 731 HKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKH 790
Query: 828 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 887
LQ L L N LT C L++VL ++ LTHL L N +GD G+K LCEGL +PDCKLQ
Sbjct: 791 FLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQ 850
Query: 888 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
L L C++T C LS L + SL L L N + G+ + C+ L+ +C L++L
Sbjct: 851 TLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLR 909
Query: 948 L 948
L
Sbjct: 910 L 910
Score = 147 bits (370), Expect = 6e-35
Identities = 93/238 (39%), Positives = 130/238 (54%), Gaps = 1/238 (0%)
Query: 736 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 795
VL +NQ L L LS N L D G LL + L+ L L +C LT A C+DLA+VL
Sbjct: 756 VLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLV 815
Query: 796 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 855
S LT L + +N +GD+GV LCE P C LQ L L +T + C LS L
Sbjct: 816 VSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEAC 875
Query: 856 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 915
+LT+L L N + +G+ +LC+ L +P+C L+ L L +C+L C L + L S+Q L
Sbjct: 876 SLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLE 934
Query: 916 KLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
L LG N L G++ VL+Q++ L+ L L N E K LE ++E+ P+LT+
Sbjct: 935 TLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 400 bits (1028), Expect = e-111
Identities = 299/919 (32%), Positives = 450/919 (48%), Gaps = 106/919 (11%)
Query: 2 KMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDF 61
++A R L LE+L LK+F+ L D P IP G+ E+AD VDLA + F
Sbjct: 14 RLAVARELLLAALEELSQEQLKRFRHKLRDVGPDGRSIPW--GRLERADAVDLAEQLAQF 71
Query: 62 NGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLL 121
G E A +A + RD+ + QE ++ +G
Sbjct: 72 YGPEPALEVARKTLKRADARDVAAQ---------------------LQERRLQRLGLGSG 110
Query: 122 EYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQ 181
LS +Y+KKYR++V +++RNAR SV + KR+T+L + E + +
Sbjct: 111 TLLS-------VSEYKKKYREHVLQLHARVKERNAR---SVKITKRFTKLLIAPESAAPE 160
Query: 182 ER--EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKM 239
E E G+ + ++ LF D+E P+ TVV QG AGIGKT+ A+K+
Sbjct: 161 EALGPAEEPEPGRARRSDTHT----FNRLFRRDEEGRRPL-TVVLQGPAGIGKTMAAKKI 215
Query: 240 MLDWASGTLYQDRFDYLFYIHCRE-VSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRIL 298
+ DWA+G LYQ + D+ F++ C E + RSL DLI+ CPD P+ +++ +P R+L
Sbjct: 216 LYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLL 275
Query: 299 FLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKL 358
F++DG DEL P CTD +A G +L L+ K LLP A LL+TTR A +L
Sbjct: 276 FILDGADELPALGGPEAAP-CTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRL 334
Query: 359 QHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIV 418
Q L P+ E+ GFS+ +K+YF+K+F DE +A A+ ++ENE LF +CF+P VCWIV
Sbjct: 335 QGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLFALCFVPFVCWIV 394
Query: 419 CTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIW 478
CT L+QQ+E G+ L++TSKTTT+VY+ F++S+L + L L LC LA +G+
Sbjct: 395 CTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDLRNLCRLAREGVL 454
Query: 479 NQKILFEESDLRNHGLQKADV-SAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLE 537
++ F E +L L+ + V + FL ++ E Y FI +FQEF AA+ YLLE
Sbjct: 455 GRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLE 514
Query: 538 EEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLS 597
+ RT G V LL + +L+ RFLFGL++ ER +E+
Sbjct: 515 DGGVPRTAAGG---------VGTLLRGDAQ-PHSHLVLTTRFLFGLLSAERMRDIERHFG 564
Query: 598 CKISQQIRLELLKWI------------EVKAKAKKLQ--IQPSQ----------LELFYC 633
C +S++++ E L+W+ EV AK L+ +P + LEL YC
Sbjct: 565 CMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYC 624
Query: 634 LYEMQEEDFVQRAMDYFPKIEIN--LSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEE 691
LYE QE+ FV++A+ FP++ + RMD V S+C+ C ++L L + +E
Sbjct: 625 LYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQE 684
Query: 692 EEEEKEGRHLD-----------------------MVQCVLPSSSHAACSHGLGRCGLSHE 728
++++ G+ L + Q + H + S L C L
Sbjct: 685 KKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPLCHLS-SLTLSHCKLPDA 743
Query: 729 CCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQ 788
C D+S L + L EL L N L + G+R+L GL C ++ + V Q
Sbjct: 744 VCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTV-RVQLPDPQRGLQ 802
Query: 789 DLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALS 848
L +L S +LT L + L V LC ++ C LQ L L + L+ L
Sbjct: 803 YLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQ 862
Query: 849 SVLSTNQNL--THLYLRGN 865
+V +L TH L G+
Sbjct: 863 AVKRAKPDLVITHPALDGH 881
Score = 70.5 bits (171), Expect = 7e-12
Identities = 75/292 (25%), Positives = 119/292 (40%), Gaps = 30/292 (10%)
Query: 688 PKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISLVLSSNQKLVELD 747
P+EEEE E+ L+++ C+ + A L C L L V
Sbjct: 606 PEEEEEGEEPNYPLELLYCLYETQEDAFVRQAL---------CRFPELALQR----VRFC 652
Query: 748 LSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGE 807
D A+ + +R G + L L+SC L +A Q+ L G
Sbjct: 653 RMDVAVLSYCVRCCPAG--------QALRLISCRLVAA--QEKKKKSLGKRLQASLGGGS 702
Query: 808 NALGD------SGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 861
++ G S + L + +P C+L L L + L C LS L LT L
Sbjct: 703 SSQGTTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELG 762
Query: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGN 921
L N L + G+++L EGL P C++Q + + + + L +L S +L L L
Sbjct: 763 LLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPDPQRGLQY-LVGMLRQSPALTTLDLSG 821
Query: 922 NDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
L V C VL+ Q C LQ L L+ + + ++ L+ ++ KP+L +
Sbjct: 822 CQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 400 bits (1027), Expect = e-111
Identities = 300/1019 (29%), Positives = 476/1019 (46%), Gaps = 139/1019 (13%)
Query: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Y+ ++ +L++FK L G +P+ Q E A ++ L+I+ +AW +
Sbjct: 44 YMRNVSHEELQRFKQLLLT-ELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTS 102
Query: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
IFA +N + +R+ NA + PT+ ++ ++ E +++++ +
Sbjct: 103 NIFAIMNCDKMCVVVRREI------NAIL--PTLEPEDLNVGE---------TQVNLEEG 145
Query: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
+ ++Y+ V +F I D G N+R + + H
Sbjct: 146 ESGKIRRYKSNVMEKFFPIWDITTWPG-----NQRDFFYQGVHRHEEY------------ 188
Query: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
+ L P TV QGA GIGKTILA+K+M +WA Y +
Sbjct: 189 ------------LPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHK 236
Query: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
FY HC+EV+ T +S +LI P + KI+ KP ++L L+DGF+EL
Sbjct: 237 RWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLI 296
Query: 313 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
+ + L DW++ G +LLSSL+ K +LPEA+LLI R + + + LL P V + G
Sbjct: 297 DRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPG 356
Query: 373 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
F+ ++ +YF YF + S EN +LF+MC +P+VCW+VC+GLKQQME G +L
Sbjct: 357 FNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNL 416
Query: 433 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGL-CAHLWGLCSLAADGIWNQKILFEESDLRN 491
Q+ T+V+V ++SSL R + + A L GLC LAAD +W++K + + DL
Sbjct: 417 TQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEE 476
Query: 492 HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
L + V+AFL M++ ++ E Y F +TFQEFFAA++Y+L RL
Sbjct: 477 AKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVL---------CFPQRL 527
Query: 552 K----LPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLE 607
K L ++ L+ + + K YL + FLFG +N+ S +E+ CK+S + +
Sbjct: 528 KNFHVLSHVNIQRLIAS-PRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRK 586
Query: 608 LLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSS 667
LLK I + K +LFYCL+E++EE FV +A++ + K+ + + + VS+
Sbjct: 587 LLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSA 646
Query: 668 FCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSH----AACSHGLGRC 723
FC++ C + + L N M L SSSH A S+GL
Sbjct: 647 FCLKRCQYLHEVELTVTLNF---------------MNVWKLSSSSHPGSEAPESNGL--- 688
Query: 724 GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT 783
H D+ V ++N KL L ++++ LG ++ L L+H C L+KL L+ +
Sbjct: 689 ---HRWWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKL-LLRRVNS 744
Query: 784 SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQ------------- 830
+ QDL VL+ + L L + + V +LC ++P+C LQ
Sbjct: 745 TMLNQDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRI 804
Query: 831 --------------------------------------KLGLVNSGLTSVCCSALSSVLS 852
+L + N LT + C +L+S L
Sbjct: 805 WTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLR 864
Query: 853 TNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQ 912
++ LTHL L N L D+G K + L H C LQ L L C+LT +CC D+ + L ++
Sbjct: 865 QSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNK 924
Query: 913 SLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPEL 971
+L+ L L N L D GV++ CE LK C LQ L L F A+ ++ + L
Sbjct: 925 TLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHL 983
Score = 135 bits (340), Expect = 2e-31
Identities = 81/208 (38%), Positives = 109/208 (52%), Gaps = 6/208 (2%)
Query: 732 DISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLA 791
D+ L N L L L N+L + G L V L++L + +C LT C+ LA
Sbjct: 807 DLGNNLQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLA 860
Query: 792 SVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVL 851
S L S LT L + ENAL D G + + +C LQ+L L LT CC + S L
Sbjct: 861 SCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISAL 920
Query: 852 STNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSS 911
N+ L L L N+L D G+ LLCE L +PDC LQ+LEL+NC TS CC ++++L +
Sbjct: 921 CKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKN 980
Query: 912 QSLRKLSLGNNDLGDLGVMMFCEVLKQQ 939
Q LR L L N +G G++ CE Q
Sbjct: 981 QHLRHLDLSKNAIGVYGILTLCEAFSSQ 1008
Score = 124 bits (312), Expect = 3e-28
Identities = 67/155 (43%), Positives = 90/155 (58%)
Query: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782
C L+ C ++ L ++ L L L++NAL D G + + L HL C L++L L C L
Sbjct: 849 CNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDL 908
Query: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842
T CCQD+ S L + +L L + N+L D GV +LCE KNP C LQ L L N TS+
Sbjct: 909 TFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSI 968
Query: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 877
CC A++S+L NQ+L HL L N +G GI LCE
Sbjct: 969 CCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
Score = 83.6 bits (205), Expect = 8e-16
Identities = 44/101 (43%), Positives = 60/101 (59%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L +C L+ CC D+ L N+ L LDLS N+L D G+ LLC LK+ C L+ L L +
Sbjct: 903 LRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELEN 962
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 820
C TS CCQ +AS+L + L L + +NA+G G+ LCE
Sbjct: 963 CLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 394 bits (1012), Expect = e-109
Identities = 312/989 (31%), Positives = 457/989 (46%), Gaps = 110/989 (11%)
Query: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
Query: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
Query: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
K+ +R K +S+ + + + H R Q +
Sbjct: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
Query: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
Query: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Query: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
Query: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
Query: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
Query: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
Query: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 494 AWDI--GDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
Query: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
+ + A K E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 552 Q-CKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
Query: 670 IENCHRVESLSLG-----FLHNMPKEEEEEEKEG-------------------------- 698
+++C ++ LSL FL N E + E E
Sbjct: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSL 670
Query: 699 -------RHLDMVQCVLPSSS-HAACSH-GLGRCGLS---------HECCFDISLVLSSN 740
+ L++ Q L SS C H C L D L
Sbjct: 671 FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGK 730
Query: 741 QKLVELDLSDNALGDFGIRL-LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHS 799
+ L L L+ + + + L LC L++ CNL+ L L C T + VL + S
Sbjct: 731 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQS 790
Query: 800 LTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTH 859
L L + N L D G +L + P+ LQ L L N LT C L++VL ++ LTH
Sbjct: 791 LKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTH 850
Query: 860 LYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 919
L L N +GD G+K LCEGL +PDCKLQ L L C++T C LS L + SL L L
Sbjct: 851 LCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDL 910
Query: 920 GNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
N + G+ + C+ L+ +C L++L L
Sbjct: 911 SINQIA-RGLWILCQALENPNCNLKHLRL 938
Score = 147 bits (370), Expect = 6e-35
Identities = 93/238 (39%), Positives = 130/238 (54%), Gaps = 1/238 (0%)
Query: 736 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 795
VL +NQ L L LS N L D G LL + L+ L L +C LT A C+DLA+VL
Sbjct: 784 VLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLV 843
Query: 796 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 855
S LT L + +N +GD+GV LCE P C LQ L L +T + C LS L
Sbjct: 844 VSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEAC 903
Query: 856 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 915
+LT+L L N + +G+ +LC+ L +P+C L+ L L +C+L C L + L S+Q L
Sbjct: 904 SLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLE 962
Query: 916 KLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
L LG N L G++ VL+Q++ L+ L L N E K LE ++E+ P+LT+
Sbjct: 963 TLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
Score = 97.8 bits (242), Expect = 4e-20
Identities = 63/172 (36%), Positives = 88/172 (51%), Gaps = 1/172 (0%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L C L+ C D++ VL ++KL L L+ N +GD G++ LC GL + C L+ L L
Sbjct: 825 LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQ 884
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
C +T C+ L+ L + SLT L + N + G+ ILC+ +NP CNL+ L L + L
Sbjct: 885 CSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSL 943
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLEL 891
C L S L +NQ L L L N L GI L L L++L L
Sbjct: 944 MPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 995
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 356 bits (914), Expect = 5e-98
Identities = 236/639 (36%), Positives = 347/639 (54%), Gaps = 86/639 (13%)
Query: 14 LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
L DLE+ D KK K +L D +G PL RG+ E VDLA L+I GE++A + +
Sbjct: 17 LSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLK 76
Query: 74 IFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRIS-ICKM 132
+N LLE + ++S IC
Sbjct: 77 GLKVMN----------------------------------------LLELVDQLSHICL- 95
Query: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
DYR+ YR++VR C+E+ + +N RY ++ L+ + S+ E LA
Sbjct: 96 -HDYREVYREHVR----CLEE-----WQEAGVNGRYNQVLLVAKPSSESP---ESLACPF 142
Query: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
E + + +E LFD ++ S VV QG+AG GKT LARKM+LDWA+GTLY R
Sbjct: 143 P---EQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGR 199
Query: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
FDY+FY+ C+EV L+ + L L+ CC D P+ +I+R+P R+LF++DGFDELQ F+
Sbjct: 200 FDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFE 259
Query: 313 EHIGPLCTDWQKAERG----DILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHV 368
E + +RG + LL LIR+ LP SLLITTRP+AL L+ LL RHV
Sbjct: 260 EKL---------KKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHV 310
Query: 369 EILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMES 428
ILGFSE +R YF YF+DE QA AF ++Q+N++L+ C +P +CW+VC+ L+ QME
Sbjct: 311 HILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMER 370
Query: 429 GKSLAQTSKTTTAVYVFFLSSLLQP--RGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
GK + +T + +T +++ ++S+ L P GG E L LCSLAA+GI +Q+ LFEE
Sbjct: 371 GKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEE 430
Query: 487 SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNV 546
++LR H L ++AFL N +Q + +KFYSF H++FQ+FF AM YL++E++
Sbjct: 431 AELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQ------ 484
Query: 547 PGSRL-KLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIR 605
SRL K R+V LLE + + ++FL + ++ S LE K +IS +
Sbjct: 485 --SRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLA 542
Query: 606 LELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQ 644
+L + E K +L + LYE + ++ V+
Sbjct: 543 QDLKHFKEQMESMK----HNRTWDLEFSLYEAKIKNLVK 577
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 323 bits (829), Expect = 4e-88
Identities = 227/787 (28%), Positives = 366/787 (46%), Gaps = 61/787 (7%)
Query: 205 MELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREV 264
++L +D +S V G GKTI+ +L W G ++Q+ Y+ ++ E+
Sbjct: 132 LQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEI 191
Query: 265 SLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQK 324
+ +T SL +LI PD PI I+ P ++LF+++ D ++ + + LC++ +
Sbjct: 192 NQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQ 251
Query: 325 AERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFK 384
+LL SL+++K+ P LI++RP ++ L L S KR+ YF
Sbjct: 252 KVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNS 311
Query: 385 YFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYV 444
+F D +A AA L+ E+E+L +C + ++CWI CT LK+QM+ G+ +T T ++
Sbjct: 312 FFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHA 371
Query: 445 FFLSSLLQPRGG---SQEH-GLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVS 500
FL+ L G +Q H GL L LC LAA G++ + F DLR G +ADVS
Sbjct: 372 HFLADALTSEAGLTANQYHLGL---LKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVS 428
Query: 501 AFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTV 560
N+ + Y FIH+ QEF A+ +L+ VP + SR+
Sbjct: 429 VLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMA--------VPNYLIPSGSREYKE 480
Query: 561 LLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKK 620
E Y F + V F+FGL+N R LE ++ ++ KW V K
Sbjct: 481 KREQYSDFNQ-----VFTFIFGLLNANRRKILETSFGYQLPM---VDSFKWYSV-GYMKH 531
Query: 621 LQIQPSQL----ELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRV 676
L P +L LFYCLYE +EE+FV+ +D ++ + L + D MVS +C++ C +
Sbjct: 532 LDRDPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHL 591
Query: 677 ESLSLGFLHNMPKEEEEEEKEGRHLDMVQ-----CVLPSSSHA------------ACSHG 719
+L L +E + + C L + + S
Sbjct: 592 RTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISER 651
Query: 720 LGRCGLSHECC----------------FDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 763
+ L H C D+ L+ N+ L L ++ ++ LL
Sbjct: 652 ILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHD 711
Query: 764 GLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 823
L C + L L+ C L ++ C+++AS+L + SL +L + N L G+ ILC+
Sbjct: 712 ILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALL 771
Query: 824 NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 883
+P C L L LV LT CCSAL VL + L L L N L + G+ + LL P
Sbjct: 772 HPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPT 831
Query: 884 CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLL 943
C+L+ L L C +S C ++ ++ +++ LR L +G+N + D G+ + C L+ +C+L
Sbjct: 832 CQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCML 891
Query: 944 QNLGLSE 950
N+GL E
Sbjct: 892 VNIGLEE 898
Score = 160 bits (404), Expect = 7e-39
Identities = 96/257 (37%), Positives = 141/257 (54%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L +C L C +I+ +L S L +L LS N L G+ +LC L H C L L LV
Sbjct: 725 LMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVF 784
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
CCLT CC L VL S +L +L + N L + GV + P C L++L L
Sbjct: 785 CCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFF 844
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
+S C ++ V++TN+ L L + N + D G++LLC GL HP+C L + L+ C LTS
Sbjct: 845 SSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSA 904
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
CC L+++LT++++L +L+L N LG+ GV E L C+L+ +GL N +T+
Sbjct: 905 CCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQ 964
Query: 960 ALETLQEEKPELTVVFE 976
L T++E KP L + E
Sbjct: 965 LLMTVKERKPSLIFLSE 981
Score = 39.3 bits (90), Expect = 0.018
Identities = 28/82 (34%), Positives = 40/82 (48%)
Query: 719 GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLV 778
GL C L+ CC ++ VL++N+ L L+L N LG+ G+ L L C LK + L
Sbjct: 895 GLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLP 954
Query: 779 SCCLTSACCQDLASVLSTSHSL 800
L + Q L +V SL
Sbjct: 955 LTGLNTQTQQLLMTVKERKPSL 976
>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
sapiens]
Length = 287
Score = 201 bits (512), Expect = 2e-51
Identities = 113/254 (44%), Positives = 147/254 (57%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L RC +S C D+S L +N+ L +DLS N +G G+ LLC GL+H C L+ + L
Sbjct: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
C L S CQ++ASVL T+ L L + NAL D G+ +LC+ ++P C L+ L L L
Sbjct: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
T+ C L+S LS NQ+L L L N LGD G+ LLCEGL HP CKLQ L LD+C LT+
Sbjct: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
C +L L +Q+L L L NN LGD GV + C+ L C L+ L L M N T S
Sbjct: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHS 271
Query: 960 ALETLQEEKPELTV 973
L L+ KP L +
Sbjct: 272 RLAALRVTKPYLDI 285
Score = 159 bits (401), Expect = 2e-38
Identities = 78/176 (44%), Positives = 116/176 (65%)
Query: 773 KKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKL 832
++LWL C ++S+ C+DL++ L + +LTR+ + N +G G+ +LCE ++PQC LQ +
Sbjct: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Query: 833 GLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELD 892
L L S C ++SVL TN +L L L GN L D G++LLC+GL HP C+L+ L L
Sbjct: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
Query: 893 NCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
C LT+ C +L++ L+ +QSLR+L L N+LGDLGV++ CE L+ +C LQ L L
Sbjct: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 203
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 191 bits (486), Expect = 2e-48
Identities = 99/255 (38%), Positives = 147/255 (57%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L CG++ + C D+ +++S L EL L N LGD G+ LC GL H L+ LW+
Sbjct: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
C +T+ C DL VL SL L + N LGD G +LCE P C L+ L + +
Sbjct: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
T+ CCS SSVL+ N+ L L + N L D G++ LC+GL P L+VL L +C+++
Sbjct: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
C L+ L ++ SLR+L L NN LGD G++ E ++Q CLL+ L L ++Y++ E +
Sbjct: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
Query: 960 ALETLQEEKPELTVV 974
L+ L+++KP L V+
Sbjct: 446 RLQALEKDKPSLRVI 460
Score = 177 bits (449), Expect = 4e-44
Identities = 93/231 (40%), Positives = 137/231 (59%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L CGL+ C DIS L N L EL+L N LGD G+ + GL+ C ++KL L +
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
CCLT A C L+S L T +L L++ +N LGD+G+ +LCE +PQC L+KL L L
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
++ C L+SVL + L + N + + G+++LC+GL C+L+ L+L++C +TS
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
C DL ++ S SLR+L+LG+N LGD+G+ C L S L+ L + E
Sbjct: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Score = 173 bits (438), Expect = 8e-43
Identities = 98/253 (38%), Positives = 139/253 (54%), Gaps = 3/253 (1%)
Query: 704 VQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760
V CVL +C L C L+ C +S L + L EL LSDN LGD G++L
Sbjct: 73 VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
Query: 761 LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 820
LC GL C L+KL L C L++A C+ LASVL L V N + ++GV +LC+
Sbjct: 133 LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
Query: 821 KAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 880
K+ C L+ L L + G+TS C L ++++ +L L L N LGD G+ LC GLL
Sbjct: 193 GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
Query: 881 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 940
HP +L+ L + C +T+ C DL +L + +SL++LSL N+LGD G + CE L +
Sbjct: 253 HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312
Query: 941 CLLQNLGLSEMYF 953
C L++L + F
Sbjct: 313 CQLESLWVKSCSF 325
Score = 162 bits (411), Expect = 1e-39
Identities = 88/228 (38%), Positives = 132/228 (57%)
Query: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782
C LS C ++ VL + EL +S+N + + G+R+LC GLK C L+ L L SC +
Sbjct: 152 CSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGV 211
Query: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842
TS C+DL ++++ SL L +G N LGD G+A LC +P L+ L + G+T+
Sbjct: 212 TSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAK 271
Query: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 902
C L VL ++L L L GN LGD+G +LLCE LL P C+L+ L + +C+ T+ CC
Sbjct: 272 GCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
Query: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
S++L ++ L +L + NN L D GV C+ L Q +L+ L L++
Sbjct: 332 HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLAD 379
Score = 139 bits (350), Expect = 1e-32
Identities = 72/181 (39%), Positives = 107/181 (59%)
Query: 768 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 827
LL + + L C LT A C+D++S L + +L L + N LGD GV + + + P C
Sbjct: 26 LLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
Query: 828 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 887
+QKL L N LT C LSS L T L L+L N LGD G++LLCEGLL P C+L+
Sbjct: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
Query: 888 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
L+L+ C+L++ C L+++L + ++L++ NND+ + GV + C+ LK C L+ L
Sbjct: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
Query: 948 L 948
L
Sbjct: 206 L 206
Score = 94.0 bits (232), Expect = 6e-19
Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)
Query: 826 QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 885
QC + +L + GLT C +SS L N L L LR N LGD G+ + +GL P CK
Sbjct: 29 QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
Query: 886 LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 945
+Q L L NC LT C LS+ L + +L++L L +N LGD G+ + CE L C L+
Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
Query: 946 LGLSEMYFNYETKSALETLQEEKP---ELTV 973
L L + + L ++ KP ELTV
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 191 bits (486), Expect = 2e-48
Identities = 99/255 (38%), Positives = 147/255 (57%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L CG++ + C D+ +++S L EL L N LGD G+ LC GL H L+ LW+
Sbjct: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
C +T+ C DL VL SL L + N LGD G +LCE P C L+ L + +
Sbjct: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
T+ CCS SSVL+ N+ L L + N L D G++ LC+GL P L+VL L +C+++
Sbjct: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
C L+ L ++ SLR+L L NN LGD G++ E ++Q CLL+ L L ++Y++ E +
Sbjct: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
Query: 960 ALETLQEEKPELTVV 974
L+ L+++KP L V+
Sbjct: 446 RLQALEKDKPSLRVI 460
Score = 177 bits (449), Expect = 4e-44
Identities = 93/231 (40%), Positives = 137/231 (59%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L CGL+ C DIS L N L EL+L N LGD G+ + GL+ C ++KL L +
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
CCLT A C L+S L T +L L++ +N LGD+G+ +LCE +PQC L+KL L L
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
++ C L+SVL + L + N + + G+++LC+GL C+L+ L+L++C +TS
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
C DL ++ S SLR+L+LG+N LGD+G+ C L S L+ L + E
Sbjct: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Score = 173 bits (438), Expect = 8e-43
Identities = 98/253 (38%), Positives = 139/253 (54%), Gaps = 3/253 (1%)
Query: 704 VQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760
V CVL +C L C L+ C +S L + L EL LSDN LGD G++L
Sbjct: 73 VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
Query: 761 LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 820
LC GL C L+KL L C L++A C+ LASVL L V N + ++GV +LC+
Sbjct: 133 LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
Query: 821 KAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 880
K+ C L+ L L + G+TS C L ++++ +L L L N LGD G+ LC GLL
Sbjct: 193 GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
Query: 881 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 940
HP +L+ L + C +T+ C DL +L + +SL++LSL N+LGD G + CE L +
Sbjct: 253 HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312
Query: 941 CLLQNLGLSEMYF 953
C L++L + F
Sbjct: 313 CQLESLWVKSCSF 325
Score = 162 bits (411), Expect = 1e-39
Identities = 88/228 (38%), Positives = 132/228 (57%)
Query: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782
C LS C ++ VL + EL +S+N + + G+R+LC GLK C L+ L L SC +
Sbjct: 152 CSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGV 211
Query: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842
TS C+DL ++++ SL L +G N LGD G+A LC +P L+ L + G+T+
Sbjct: 212 TSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAK 271
Query: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 902
C L VL ++L L L GN LGD+G +LLCE LL P C+L+ L + +C+ T+ CC
Sbjct: 272 GCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
Query: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
S++L ++ L +L + NN L D GV C+ L Q +L+ L L++
Sbjct: 332 HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLAD 379
Score = 139 bits (350), Expect = 1e-32
Identities = 72/181 (39%), Positives = 107/181 (59%)
Query: 768 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 827
LL + + L C LT A C+D++S L + +L L + N LGD GV + + + P C
Sbjct: 26 LLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
Query: 828 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 887
+QKL L N LT C LSS L T L L+L N LGD G++LLCEGLL P C+L+
Sbjct: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
Query: 888 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
L+L+ C+L++ C L+++L + ++L++ NND+ + GV + C+ LK C L+ L
Sbjct: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
Query: 948 L 948
L
Sbjct: 206 L 206
Score = 94.0 bits (232), Expect = 6e-19
Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)
Query: 826 QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 885
QC + +L + GLT C +SS L N L L LR N LGD G+ + +GL P CK
Sbjct: 29 QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
Query: 886 LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 945
+Q L L NC LT C LS+ L + +L++L L +N LGD G+ + CE L C L+
Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
Query: 946 LGLSEMYFNYETKSALETLQEEKP---ELTV 973
L L + + L ++ KP ELTV
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 191 bits (486), Expect = 2e-48
Identities = 99/255 (38%), Positives = 147/255 (57%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L CG++ + C D+ +++S L EL L N LGD G+ LC GL H L+ LW+
Sbjct: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
C +T+ C DL VL SL L + N LGD G +LCE P C L+ L + +
Sbjct: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
T+ CCS SSVL+ N+ L L + N L D G++ LC+GL P L+VL L +C+++
Sbjct: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
C L+ L ++ SLR+L L NN LGD G++ E ++Q CLL+ L L ++Y++ E +
Sbjct: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
Query: 960 ALETLQEEKPELTVV 974
L+ L+++KP L V+
Sbjct: 446 RLQALEKDKPSLRVI 460
Score = 177 bits (449), Expect = 4e-44
Identities = 93/231 (40%), Positives = 137/231 (59%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L CGL+ C DIS L N L EL+L N LGD G+ + GL+ C ++KL L +
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
CCLT A C L+S L T +L L++ +N LGD+G+ +LCE +PQC L+KL L L
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
++ C L+SVL + L + N + + G+++LC+GL C+L+ L+L++C +TS
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
C DL ++ S SLR+L+LG+N LGD+G+ C L S L+ L + E
Sbjct: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Score = 173 bits (438), Expect = 8e-43
Identities = 98/253 (38%), Positives = 139/253 (54%), Gaps = 3/253 (1%)
Query: 704 VQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760
V CVL +C L C L+ C +S L + L EL LSDN LGD G++L
Sbjct: 73 VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
Query: 761 LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 820
LC GL C L+KL L C L++A C+ LASVL L V N + ++GV +LC+
Sbjct: 133 LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
Query: 821 KAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 880
K+ C L+ L L + G+TS C L ++++ +L L L N LGD G+ LC GLL
Sbjct: 193 GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
Query: 881 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 940
HP +L+ L + C +T+ C DL +L + +SL++LSL N+LGD G + CE L +
Sbjct: 253 HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312
Query: 941 CLLQNLGLSEMYF 953
C L++L + F
Sbjct: 313 CQLESLWVKSCSF 325
Score = 162 bits (411), Expect = 1e-39
Identities = 88/228 (38%), Positives = 132/228 (57%)
Query: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782
C LS C ++ VL + EL +S+N + + G+R+LC GLK C L+ L L SC +
Sbjct: 152 CSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGV 211
Query: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842
TS C+DL ++++ SL L +G N LGD G+A LC +P L+ L + G+T+
Sbjct: 212 TSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAK 271
Query: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 902
C L VL ++L L L GN LGD+G +LLCE LL P C+L+ L + +C+ T+ CC
Sbjct: 272 GCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
Query: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
S++L ++ L +L + NN L D GV C+ L Q +L+ L L++
Sbjct: 332 HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLAD 379
Score = 139 bits (350), Expect = 1e-32
Identities = 72/181 (39%), Positives = 107/181 (59%)
Query: 768 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 827
LL + + L C LT A C+D++S L + +L L + N LGD GV + + + P C
Sbjct: 26 LLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
Query: 828 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 887
+QKL L N LT C LSS L T L L+L N LGD G++LLCEGLL P C+L+
Sbjct: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
Query: 888 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
L+L+ C+L++ C L+++L + ++L++ NND+ + GV + C+ LK C L+ L
Sbjct: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
Query: 948 L 948
L
Sbjct: 206 L 206
Score = 94.0 bits (232), Expect = 6e-19
Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)
Query: 826 QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 885
QC + +L + GLT C +SS L N L L LR N LGD G+ + +GL P CK
Sbjct: 29 QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
Query: 886 LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 945
+Q L L NC LT C LS+ L + +L++L L +N LGD G+ + CE L C L+
Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
Query: 946 LGLSEMYFNYETKSALETLQEEKP---ELTV 973
L L + + L ++ KP ELTV
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 191 bits (486), Expect = 2e-48
Identities = 99/255 (38%), Positives = 147/255 (57%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L CG++ + C D+ +++S L EL L N LGD G+ LC GL H L+ LW+
Sbjct: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
C +T+ C DL VL SL L + N LGD G +LCE P C L+ L + +
Sbjct: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
T+ CCS SSVL+ N+ L L + N L D G++ LC+GL P L+VL L +C+++
Sbjct: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
C L+ L ++ SLR+L L NN LGD G++ E ++Q CLL+ L L ++Y++ E +
Sbjct: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
Query: 960 ALETLQEEKPELTVV 974
L+ L+++KP L V+
Sbjct: 446 RLQALEKDKPSLRVI 460
Score = 177 bits (449), Expect = 4e-44
Identities = 93/231 (40%), Positives = 137/231 (59%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L CGL+ C DIS L N L EL+L N LGD G+ + GL+ C ++KL L +
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
CCLT A C L+S L T +L L++ +N LGD+G+ +LCE +PQC L+KL L L
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
++ C L+SVL + L + N + + G+++LC+GL C+L+ L+L++C +TS
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
C DL ++ S SLR+L+LG+N LGD+G+ C L S L+ L + E
Sbjct: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Score = 173 bits (438), Expect = 8e-43
Identities = 98/253 (38%), Positives = 139/253 (54%), Gaps = 3/253 (1%)
Query: 704 VQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760
V CVL +C L C L+ C +S L + L EL LSDN LGD G++L
Sbjct: 73 VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
Query: 761 LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 820
LC GL C L+KL L C L++A C+ LASVL L V N + ++GV +LC+
Sbjct: 133 LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
Query: 821 KAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 880
K+ C L+ L L + G+TS C L ++++ +L L L N LGD G+ LC GLL
Sbjct: 193 GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
Query: 881 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 940
HP +L+ L + C +T+ C DL +L + +SL++LSL N+LGD G + CE L +
Sbjct: 253 HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312
Query: 941 CLLQNLGLSEMYF 953
C L++L + F
Sbjct: 313 CQLESLWVKSCSF 325
Score = 162 bits (411), Expect = 1e-39
Identities = 88/228 (38%), Positives = 132/228 (57%)
Query: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782
C LS C ++ VL + EL +S+N + + G+R+LC GLK C L+ L L SC +
Sbjct: 152 CSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGV 211
Query: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842
TS C+DL ++++ SL L +G N LGD G+A LC +P L+ L + G+T+
Sbjct: 212 TSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAK 271
Query: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 902
C L VL ++L L L GN LGD+G +LLCE LL P C+L+ L + +C+ T+ CC
Sbjct: 272 GCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
Query: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
S++L ++ L +L + NN L D GV C+ L Q +L+ L L++
Sbjct: 332 HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLAD 379
Score = 139 bits (350), Expect = 1e-32
Identities = 72/181 (39%), Positives = 107/181 (59%)
Query: 768 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 827
LL + + L C LT A C+D++S L + +L L + N LGD GV + + + P C
Sbjct: 26 LLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
Query: 828 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 887
+QKL L N LT C LSS L T L L+L N LGD G++LLCEGLL P C+L+
Sbjct: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
Query: 888 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
L+L+ C+L++ C L+++L + ++L++ NND+ + GV + C+ LK C L+ L
Sbjct: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
Query: 948 L 948
L
Sbjct: 206 L 206
Score = 94.0 bits (232), Expect = 6e-19
Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)
Query: 826 QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 885
QC + +L + GLT C +SS L N L L LR N LGD G+ + +GL P CK
Sbjct: 29 QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
Query: 886 LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 945
+Q L L NC LT C LS+ L + +L++L L +N LGD G+ + CE L C L+
Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
Query: 946 LGLSEMYFNYETKSALETLQEEKP---ELTV 973
L L + + L ++ KP ELTV
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 191 bits (486), Expect = 2e-48
Identities = 99/255 (38%), Positives = 147/255 (57%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L CG++ + C D+ +++S L EL L N LGD G+ LC GL H L+ LW+
Sbjct: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
C +T+ C DL VL SL L + N LGD G +LCE P C L+ L + +
Sbjct: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
T+ CCS SSVL+ N+ L L + N L D G++ LC+GL P L+VL L +C+++
Sbjct: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
C L+ L ++ SLR+L L NN LGD G++ E ++Q CLL+ L L ++Y++ E +
Sbjct: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
Query: 960 ALETLQEEKPELTVV 974
L+ L+++KP L V+
Sbjct: 446 RLQALEKDKPSLRVI 460
Score = 177 bits (449), Expect = 4e-44
Identities = 93/231 (40%), Positives = 137/231 (59%)
Query: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
L CGL+ C DIS L N L EL+L N LGD G+ + GL+ C ++KL L +
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
CCLT A C L+S L T +L L++ +N LGD+G+ +LCE +PQC L+KL L L
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
++ C L+SVL + L + N + + G+++LC+GL C+L+ L+L++C +TS
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
C DL ++ S SLR+L+LG+N LGD+G+ C L S L+ L + E
Sbjct: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
Score = 173 bits (438), Expect = 8e-43
Identities = 98/253 (38%), Positives = 139/253 (54%), Gaps = 3/253 (1%)
Query: 704 VQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760
V CVL +C L C L+ C +S L + L EL LSDN LGD G++L
Sbjct: 73 VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
Query: 761 LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 820
LC GL C L+KL L C L++A C+ LASVL L V N + ++GV +LC+
Sbjct: 133 LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
Query: 821 KAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 880
K+ C L+ L L + G+TS C L ++++ +L L L N LGD G+ LC GLL
Sbjct: 193 GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
Query: 881 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 940
HP +L+ L + C +T+ C DL +L + +SL++LSL N+LGD G + CE L +
Sbjct: 253 HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312
Query: 941 CLLQNLGLSEMYF 953
C L++L + F
Sbjct: 313 CQLESLWVKSCSF 325
Score = 162 bits (411), Expect = 1e-39
Identities = 88/228 (38%), Positives = 132/228 (57%)
Query: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782
C LS C ++ VL + EL +S+N + + G+R+LC GLK C L+ L L SC +
Sbjct: 152 CSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGV 211
Query: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842
TS C+DL ++++ SL L +G N LGD G+A LC +P L+ L + G+T+
Sbjct: 212 TSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAK 271
Query: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 902
C L VL ++L L L GN LGD+G +LLCE LL P C+L+ L + +C+ T+ CC
Sbjct: 272 GCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
Query: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
S++L ++ L +L + NN L D GV C+ L Q +L+ L L++
Sbjct: 332 HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLAD 379
Score = 139 bits (350), Expect = 1e-32
Identities = 72/181 (39%), Positives = 107/181 (59%)
Query: 768 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 827
LL + + L C LT A C+D++S L + +L L + N LGD GV + + + P C
Sbjct: 26 LLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
Query: 828 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 887
+QKL L N LT C LSS L T L L+L N LGD G++LLCEGLL P C+L+
Sbjct: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
Query: 888 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
L+L+ C+L++ C L+++L + ++L++ NND+ + GV + C+ LK C L+ L
Sbjct: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
Query: 948 L 948
L
Sbjct: 206 L 206
Score = 94.0 bits (232), Expect = 6e-19
Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)
Query: 826 QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 885
QC + +L + GLT C +SS L N L L LR N LGD G+ + +GL P CK
Sbjct: 29 QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
Query: 886 LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 945
+Q L L NC LT C LS+ L + +L++L L +N LGD G+ + CE L C L+
Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
Query: 946 LGLSEMYFNYETKSALETLQEEKP---ELTV 973
L L + + L ++ KP ELTV
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,541,007
Number of Sequences: 37866
Number of extensions: 1704985
Number of successful extensions: 5510
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 4882
Number of HSP's gapped (non-prelim): 314
length of query: 979
length of database: 18,247,518
effective HSP length: 112
effective length of query: 867
effective length of database: 14,006,526
effective search space: 12143658042
effective search space used: 12143658042
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.