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Search of human proteins with 188528616
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188528616 testis specific, 10 [Homo sapiens]
(698 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188528616 testis specific, 10 [Homo sapiens] 1349 0.0
gi|13376858 testis specific, 10 [Homo sapiens] 1349 0.0
gi|50083279 centrosome protein 4 [Homo sapiens] 500 e-141
gi|71061468 centromere protein E [Homo sapiens] 117 3e-26
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 117 4e-26
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 115 1e-25
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 113 7e-25
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 112 9e-25
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 112 1e-24
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 112 1e-24
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 112 1e-24
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 112 1e-24
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 107 5e-23
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 106 8e-23
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 105 2e-22
gi|58530840 desmoplakin isoform I [Homo sapiens] 103 4e-22
gi|55770834 centromere protein F [Homo sapiens] 103 4e-22
gi|31982906 cingulin-like 1 [Homo sapiens] 102 1e-21
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 101 2e-21
gi|38044112 restin isoform b [Homo sapiens] 100 3e-21
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 100 5e-21
gi|21735548 centrosomal protein 2 [Homo sapiens] 100 5e-21
gi|16262452 cingulin [Homo sapiens] 100 5e-21
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 99 1e-20
gi|4506751 restin isoform a [Homo sapiens] 99 2e-20
gi|110815815 centlein isoform 1 [Homo sapiens] 97 4e-20
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 97 5e-20
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 97 5e-20
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 97 5e-20
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 97 5e-20
>gi|188528616 testis specific, 10 [Homo sapiens]
Length = 698
Score = 1349 bits (3492), Expect = 0.0
Identities = 698/698 (100%), Positives = 698/698 (100%)
Query: 1 MMRSRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSE 60
MMRSRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSE
Sbjct: 1 MMRSRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSE 60
Query: 61 RDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERD 120
RDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERD
Sbjct: 61 RDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERD 120
Query: 121 SLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMK 180
SLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMK
Sbjct: 121 SLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMK 180
Query: 181 SLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDE 240
SLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDE
Sbjct: 181 SLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDE 240
Query: 241 KIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISG 300
KIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISG
Sbjct: 241 KIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISG 300
Query: 301 MKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQ 360
MKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQ
Sbjct: 301 MKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQ 360
Query: 361 FAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKA 420
FAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKA
Sbjct: 361 FAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKA 420
Query: 421 NEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQI 480
NEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQI
Sbjct: 421 NEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQI 480
Query: 481 STLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRE 540
STLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRE
Sbjct: 481 STLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRE 540
Query: 541 NELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLC 600
NELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLC
Sbjct: 541 NELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLC 600
Query: 601 LAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHM 660
LAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHM
Sbjct: 601 LAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHM 660
Query: 661 SSTMKPNTKCHSPERAHHRSPDRGLDRSLEENLCYRDF 698
SSTMKPNTKCHSPERAHHRSPDRGLDRSLEENLCYRDF
Sbjct: 661 SSTMKPNTKCHSPERAHHRSPDRGLDRSLEENLCYRDF 698
>gi|13376858 testis specific, 10 [Homo sapiens]
Length = 698
Score = 1349 bits (3492), Expect = 0.0
Identities = 698/698 (100%), Positives = 698/698 (100%)
Query: 1 MMRSRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSE 60
MMRSRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSE
Sbjct: 1 MMRSRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSE 60
Query: 61 RDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERD 120
RDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERD
Sbjct: 61 RDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERD 120
Query: 121 SLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMK 180
SLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMK
Sbjct: 121 SLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMK 180
Query: 181 SLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDE 240
SLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDE
Sbjct: 181 SLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDE 240
Query: 241 KIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISG 300
KIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISG
Sbjct: 241 KIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISG 300
Query: 301 MKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQ 360
MKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQ
Sbjct: 301 MKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQ 360
Query: 361 FAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKA 420
FAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKA
Sbjct: 361 FAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKA 420
Query: 421 NEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQI 480
NEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQI
Sbjct: 421 NEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQI 480
Query: 481 STLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRE 540
STLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRE
Sbjct: 481 STLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRE 540
Query: 541 NELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLC 600
NELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLC
Sbjct: 541 NELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLC 600
Query: 601 LAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHM 660
LAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHM
Sbjct: 601 LAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHM 660
Query: 661 SSTMKPNTKCHSPERAHHRSPDRGLDRSLEENLCYRDF 698
SSTMKPNTKCHSPERAHHRSPDRGLDRSLEENLCYRDF
Sbjct: 661 SSTMKPNTKCHSPERAHHRSPDRGLDRSLEENLCYRDF 698
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 500 bits (1288), Expect = e-141
Identities = 265/671 (39%), Positives = 441/671 (65%), Gaps = 13/671 (1%)
Query: 4 SRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDK 63
+R KS +P N ++ + TR+R+EL+ MLE++E+++ +IQ NVK+L +ERDK
Sbjct: 479 AREKSSIFRTPEKGDYNSEIHQI---TRERDELQRMLERFEKYMEDIQSNVKLLTAERDK 535
Query: 64 IFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLR 123
+ +LY +AQEE++ LR+E S ++T H I+ +E E+++A +DLRR+ E+++LR
Sbjct: 536 LSVLYNEAQEELSALRKE------STQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALR 589
Query: 124 ERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLA 183
E+L+ +E + K+ LE+ IE L C H L+ E+ E S + +MKETI ++E ++K A
Sbjct: 590 EKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQA 649
Query: 184 RKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKID 243
+K + QK E NSLR++ E ++ + D Q L+ K+ EL+ Q +I L+EKID
Sbjct: 650 QKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKID 709
Query: 244 NFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKN 303
+ +Q EE ++ T+ + KEK+ LQ +D+K+E IA+L E+LA KEK ++ MK
Sbjct: 710 ELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKI 769
Query: 304 IIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAK 363
+I+E E + Q E L+ +++++ +RRQLD + EL ++ R R+I +N LQ+ A
Sbjct: 770 MISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLAT 829
Query: 364 AKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANED 423
+ENQ +S +L E ++K +V EV++ ++++ ++E EN+ ++++ + +
Sbjct: 830 MARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNR 889
Query: 424 AENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTL 483
AE+WE KA Q+E ++++++LEL++ + E L+E+V+ L +E+++H+NA +Y+SQIS++
Sbjct: 890 AEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSM 949
Query: 484 HKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENEL 543
K++ ++EEEL+ + EK + L DLSS RELCIKLDS K+++ +QL +K+ E E EL
Sbjct: 950 AKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVEL 1009
Query: 544 DSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAE 603
++ SE +LL+ Q++NER +++NLE+LL NRDKE+ S + EK++EIQLLKE L L+E
Sbjct: 1010 ENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSE 1069
Query: 604 NKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHMSST 663
+K+ QSR+ R V QL+ D D KRQ+ TER+ERERA+QE+RR ++ +SST
Sbjct: 1070 SKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMRRHGLATPP--LSST 1127
Query: 664 MKPNTKCHSPE 674
++ + HSPE
Sbjct: 1128 LR--SPSHSPE 1136
Score = 81.6 bits (200), Expect = 2e-15
Identities = 123/573 (21%), Positives = 253/573 (44%), Gaps = 84/573 (14%)
Query: 98 LRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDE 157
+R + ++ +++ ++ + + L + L + A + H E+ +E + + E
Sbjct: 291 IRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKE 350
Query: 158 RMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDT 217
++S M ++ET++ ++ E+ +L +K + RL E K +T
Sbjct: 351 IKRKLSEMQDLEETMAKLQLEL-NLCQKEKE---------------RLSDELLVKSDLET 394
Query: 218 QRHLAKKKYELQLTQEKIMCLDEKIDNFT---RQNIAQREEISILGGTLNDLAKEKECLQ 274
H QL QEK L +K+++F RQ + E + + G K ++
Sbjct: 395 VVH--------QLEQEK-QRLSKKVESFAVTERQLTLEVERMRLEHG-----IKRRDRSP 440
Query: 275 ACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLD 334
+ LD + I E +K + +++II R C+ + E+ +
Sbjct: 441 SRLDTFLKGIE---EERDYYKKELERLQHIIQR-----RSCSTSYSAREKSSIFRTPEKG 492
Query: 335 ETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSK-------KLNDTHNELNDIKQ 387
+ N E+ QI RERD L + E+F K ++ Q+ K KL+ +NE +
Sbjct: 493 DYNSEIHQITRERDEL----QRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELS 548
Query: 388 KVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELIT 447
++ + + NI+ E E + LR+ + E K E + +
Sbjct: 549 ALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVS-------LF 601
Query: 448 AEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALAD 507
++E + E + +N ++E + + KS++ + +++ +E +L KVQ +K S +A
Sbjct: 602 GKSELEKTIEHLTCVNHQLE---SEKYELKSKVLIMKETIESLENKL-KVQAQKFSHVAG 657
Query: 508 LSSTRELCI-KLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQM--ANERISM 564
SS ++ + L E L R + + ++ EL+SA ++I++L ++ N +++
Sbjct: 658 DSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTS 717
Query: 565 QNLEA------LLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRN 618
Q+ EA + V +++K++ Q + EK +I L+E+L A + + VAQ +
Sbjct: 718 QDEEAHVMKKTIGVIDKEKDF-LQETVDEKTEKIANLQENL-------ANKEKAVAQMKI 769
Query: 619 VVTQLEADLDITKRQLGTERFERERAVQELRRQ 651
++++ E+ ++ K L R+R + LRRQ
Sbjct: 770 MISECESSVNQLKETL----VNRDREINSLRRQ 798
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 117 bits (294), Expect = 3e-26
Identities = 154/653 (23%), Positives = 299/653 (45%), Gaps = 84/653 (12%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQ---GNVKVLKSERDKIFLLYEQAQEEITRLRR 80
E LK ++ +E + L + ++E+Q ++ LK+E L E + E L +
Sbjct: 1127 EKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQ 1186
Query: 81 EMMKSCKSPKSTTAHA-----ILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFN 135
++ ++ + KS T + + ETERD +R + +E LKIA +
Sbjct: 1187 KLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAH---IH 1243
Query: 136 EKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSL--ARKAMDTESEL 193
K H ++ I+EL +V E+ Q+ N ++++ + +++E+ L ++ + E+
Sbjct: 1244 LKEH-QETIDELRRSV----SEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEV 1298
Query: 194 GRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQR 253
+ N L LL TE+ + LA+ + E EK E+I + T++ R
Sbjct: 1299 SETQETMNELELL---TEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE----R 1351
Query: 254 EEISILGGTLNDLAKE-KECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQAS 312
+ + + L + KE ++ L K E+ + +SL MKEK K I++EMEQ
Sbjct: 1352 DNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTK-IVSEMEQFK 1410
Query: 313 RQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALS 372
+ AL+ E ++ + ++L E++DE+ +A+E+D L + LQ + + K+ + +
Sbjct: 1411 PK-DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIV 1469
Query: 373 KKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKAR 432
K +T EL +++ +N+L+ L +E+E + +QL N+ +N +
Sbjct: 1470 AKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIY 1529
Query: 433 QSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAE----RSYKSQISTLHKSVV 488
+ E N ++ + ++EKV+ L ++ ++H A+ +S +S++ L +
Sbjct: 1530 EKEEQFNIKQI---------SEVQEKVNEL-KQFKEHRKAKDSALQSIESKMLELTNRLQ 1579
Query: 489 KMEEELQKVQFEKVSALADLSSTRE-LCIKLDSSKELLNRQLVAKDQEIEMRE------- 540
+ +EE+Q + EK ++ +E L I+ D KE +++VAK +E + +E
Sbjct: 1580 ESQEEIQIMIKEK----EEMKRVQEALQIERDQLKE-NTKEIVAKMKESQEKEYQFLKMT 1634
Query: 541 --NELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEH 598
NE EIE L+ Q ++++++N+E E Q+L E+
Sbjct: 1635 AVNETQEKMCEIEHLKEQFETQKLNLENIET-----------------ENIRLTQILHEN 1677
Query: 599 LCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQ 651
L E + + RD R+V L+ + D K L RE ++L +Q
Sbjct: 1678 --LEEMRSVTKERD--DLRSVEETLKVERDQLKENL------RETITRDLEKQ 1720
Score = 102 bits (253), Expect = 2e-21
Identities = 160/772 (20%), Positives = 318/772 (41%), Gaps = 128/772 (16%)
Query: 27 KTTTRDREE-LKCMLEKYERHLAEI----------QGNVKVLKSERD-KIFLLYEQAQEE 74
KT D E+ K +LE+ ER EI ++ LK+E K L E+ +E
Sbjct: 823 KTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREV 882
Query: 75 ITRLRR-EMMKSCKSPKSTTAHAILRR---VETERDVAFTDLRRMTTERDSLRERLKIAQ 130
RL E +K + +T + R + + +++ +T E+D L++ Q
Sbjct: 883 QERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQ----LQ 938
Query: 131 ETAFNEKAHLEQRIEELECTVHNLDDERMEQMSN----MTLMKETISTVEKEMKSLARKA 186
E+ E+ L+ I + TV N++ + EQ+ N + +ETI+T++ ++ +
Sbjct: 939 ESLQIERDQLKSDIHD---TV-NMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN 994
Query: 187 MDTESELGRQKAE----------------NNSLRLLYENTEKDLSDTQRH---LAKKKYE 227
+ E G K E N+ L + + ++ + QR L ++K E
Sbjct: 995 LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE 1054
Query: 228 LQLTQEKIMCLDEKIDNFTRQNIAQ----REEISILGGTLND------------LAKEKE 271
LQ E ++ E++ ++NI +EE+ +LG L + KE E
Sbjct: 1055 LQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGE 1114
Query: 272 CLQAC---------LDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVC 322
+ C L +KS+ + + L ++ +S M+ I E+E + +
Sbjct: 1115 LSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTL 1174
Query: 323 EQ---DVSRMRRQLDETNDELAQIARERDILAH-------DNDNLQEQFAKAKQENQALS 372
E + + ++L+E +E+ I +ER +L + D+L+ + +
Sbjct: 1175 EHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTK 1234
Query: 373 KKLNDTHNELNDIKQKVQDTNLEVN-KLKNILKSEESE--NRQMMEQLRKANEDAENWEN 429
++L H L + ++ + + V+ K I+ +++ E + ++ E++ +E+ E N
Sbjct: 1235 EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPN 1294
Query: 430 KARQSEADNNTLKLELITA-------------EAEGNRLKEKVDSLNREVEQHLNAERSY 476
SE +LEL+T E E RL EK E++ L ER
Sbjct: 1295 VKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKS-LTKERD- 1352
Query: 477 KSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNR------QLV 530
+ T+ +++ ++L++ E ++ + + S +E + + + Q
Sbjct: 1353 --NLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFK 1410
Query: 531 AKDQ-----EIEMR--ENELDSAHSEIELLRSQMANERISMQNLEALLVANRD--KEYQS 581
KD EIEM L +H E++ +A E+ +Q L+ +L + D KE
Sbjct: 1411 PKDSALLRIEIEMLGLSKRLQESHDEMK----SVAKEKDDLQRLQEVLQSESDQLKENIK 1466
Query: 582 QIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFER 641
+I + E+E +L H CL E Q + + R +++ E ++ ++QL +
Sbjct: 1467 EIVAKHLETEEELKVAHCCLKE-----QEETINELRVNLSEKETEISTIQKQLEAINDKL 1521
Query: 642 ERAVQELRRQNYSSNAYHMSSTMKPNTKCHSPERAHHRSPDRGLDRSLEENL 693
+ +QE+ + N +S + + + H ++ D L +S+E +
Sbjct: 1522 QNKIQEIYEKEEQFNIKQISEVQEKVNEL-KQFKEHRKAKDSAL-QSIESKM 1571
Score = 95.5 bits (236), Expect = 1e-19
Identities = 140/648 (21%), Positives = 267/648 (41%), Gaps = 103/648 (15%)
Query: 35 ELKCMLEKYERHLAEIQGN---VKVLKSERDKIF--LLYEQAQ-----EEITRLRREMMK 84
ELK + + ER EIQ + ++ SE+DK+F +++++++ EEI + + ++
Sbjct: 748 ELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLAT 807
Query: 85 SCKSPKSTTAH-----AILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAH 139
+ + KST + E + + + RM E +L + + + K
Sbjct: 808 TQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTE 867
Query: 140 LEQRIEELECTVHNLDDERMEQMSNMTLMKE----TISTVEKEMKSLARKAMDTESELGR 195
L + +EL+ + ER+ +M + E T+ TVE+E + K T E+
Sbjct: 868 LSYKTQELQEKTREVQ-ERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKT 926
Query: 196 QKAENNSLRLLYENTEKDLS--------------DTQRHLAKKKYELQLTQEKIMCLDEK 241
E + L+ L E+ + + DTQ L L+ QE I L K
Sbjct: 927 LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSK 986
Query: 242 IDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASL------GESLAMKE 295
I +N+ E G T ++ ++ + D +++N +L E + +
Sbjct: 987 ISEEVSRNLHMEENT---GETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQR 1043
Query: 296 KTIS----------GMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIAR 345
K S ++++IAE EQ E + + ++ +R DE + +A+
Sbjct: 1044 KIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQ 1103
Query: 346 ER--------------DILAHDNDNL----------QEQFAKAKQENQALSKKLNDTHNE 381
E+ D LA + L Q+Q ++E + KK+N+ N
Sbjct: 1104 EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENL 1163
Query: 382 LNDIKQK-VQDTNLEVNKLKNILKSEE--------SENRQMMEQLRKANE-DAENWENKA 431
N++K K + ++E +L+ K E ++ R+++++L+K+ E + ++
Sbjct: 1164 KNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYI 1223
Query: 432 RQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKME 491
R+ EA K EL A +E +D L R V + + + L KS K++
Sbjct: 1224 REIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE----KTAQIINTQDLEKSHTKLQ 1279
Query: 492 EELQKVQFEK--VSALADLSSTRELCIKLDSSKELLNRQLVAKDQ----EIEMRENELDS 545
EE+ + E+ + + ++S T+E +L ELL Q KD IEM L+
Sbjct: 1280 EEIPVLHEEQELLPNVKEVSETQETMNEL----ELLTEQSTTKDSTTLARIEMERLRLNE 1335
Query: 546 AHSEIELLRSQMANERISMQNLEALLVANRD--KEYQSQIALQEKESE 591
E + + ER +++ ++ L D KE+ + + +ES+
Sbjct: 1336 KFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQ 1383
Score = 88.6 bits (218), Expect = 2e-17
Identities = 117/608 (19%), Positives = 261/608 (42%), Gaps = 85/608 (13%)
Query: 45 RHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKST-----TAHAILR 99
+ L E +K + E+D + L E Q E +L+ + + T AH L+
Sbjct: 1428 KRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLK 1487
Query: 100 RVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERM 159
E + +L TE +++++L+ + N+ + ++ E+ + E++
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547
Query: 160 EQMSNMTLMKET----ISTVEKEMKSLARKAMDTESELGRQKAENNSLRL---------- 205
++ ++ + ++E +M L + +++ E+ E ++
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERD 1607
Query: 206 -LYENTEKDLSDTQRHLAKKKYE------LQLTQEKIMCLDEKIDNFTRQNIAQREEISI 258
L ENT K++ + +K+Y+ + TQEK+ ++ + F Q + E I
Sbjct: 1608 QLKENT-KEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKL-NLENIET 1665
Query: 259 LGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEA 318
L + E + K+ +++ S+ E+L ++ + +N+ + + + E
Sbjct: 1666 ENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLK--ENLRETITRDLEKQEEL 1723
Query: 319 LIVC------EQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALS 372
IV ++ + ++R + E +E++ + ++ L H ND L+ Q K ++E +
Sbjct: 1724 KIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKD---LEHSNDALKAQDLKIQEELRIAH 1780
Query: 373 KKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLR--KANE-------- 422
L + ++ ++ V + + +KL N+ K E+ N ++ E+++ KANE
Sbjct: 1781 MHLKEQQETIDKLRGIVSE---KTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK 1837
Query: 423 DAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQIST 482
D + K + E +K + +T K ++++LN + H N E
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLS------KLEIENLNLAQKLHENLEEM------- 1884
Query: 483 LHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMR--- 539
KSV+K + L++V+ L ++ D KE L ++ A+D EI+
Sbjct: 1885 --KSVMKERDNLRRVE-------------ETLKLERDQLKESL-QETKARDLEIQQELKT 1928
Query: 540 ENELDSAHSE-IELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEH 598
L H E ++ LR +++ + I + +++ L ++D+ + LQ+KE ++ +KE
Sbjct: 1929 ARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKED 1988
Query: 599 LCLAENKM 606
+ ++ K+
Sbjct: 1989 VNMSHKKI 1996
Score = 84.7 bits (208), Expect = 3e-16
Identities = 130/636 (20%), Positives = 278/636 (43%), Gaps = 77/636 (12%)
Query: 26 LKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSE-RDKIFLLYEQAQEEITRLRREMMK 84
LK EL+ L + E ++ IQ ++ + + ++KI +YE+ ++ + E+ +
Sbjct: 1486 LKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQE 1545
Query: 85 SCKSPKSTTAH-----AILRRVETERDVAFTDLRRMTTERDSL---RERLKIAQETAFNE 136
K H + L+ +E++ L+ E + +E +K QE E
Sbjct: 1546 KVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIE 1605
Query: 137 KAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQ 196
+ L++ +E+ + E+ Q MT + ET EK + K +L +
Sbjct: 1606 RDQLKENTKEIVAKMKE-SQEKEYQFLKMTAVNET---QEKMCEIEHLKEQFETQKLNLE 1661
Query: 197 KAENNSLRL---LYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQR 253
E ++RL L+EN E+ S T+ + E L E+ + + TR ++ ++
Sbjct: 1662 NIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITR-DLEKQ 1720
Query: 254 EEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASR 313
EE+ I+ L + + + L+ + +K+ I+++ + L E + +K ++++ R
Sbjct: 1721 EELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDL---EHSNDALKAQDLKIQEELR 1777
Query: 314 QCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAK-QENQ--A 370
L ++ + ++R + E D+L+ + ++ L + N LQE+ + K E+Q
Sbjct: 1778 IAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKD---LENSNAKLQEKIQELKANEHQLIT 1834
Query: 371 LSKKLNDTH---NELNDIKQKVQDTNLEVNKL------------------KNILKSEESE 409
L K +N+T +E+ +K++++D +L ++KL K+++K E +
Sbjct: 1835 LKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMK--ERD 1892
Query: 410 NRQMMEQLRKANEDAEN---WENKARQSEADNNTLKLELITAEAEG--NRLKEKV----- 459
N + +E+ K D E KAR E +++ E + ++L+EK+
Sbjct: 1893 NLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTI 1952
Query: 460 -------------DSLNREVEQHLNAERSY---KSQISTLHKSVVKMEEELQKVQFEKVS 503
D L +++++ E K ++ HK + +ME+ ++ + + +S
Sbjct: 1953 QISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLS 2012
Query: 504 ALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERIS 563
+ +L KL S E + +D+ ++E+ I LR +A +R +
Sbjct: 2013 MQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQN 2072
Query: 564 MQNLEALLVANRDKEYQSQIALQEKESEI-QLLKEH 598
Q + + +++ ++ +L+EK S I +LLK +
Sbjct: 2073 HQVKPEKRLLSDGQQHLTE-SLREKCSRIKELLKRY 2107
Score = 79.3 bits (194), Expect = 1e-14
Identities = 130/716 (18%), Positives = 296/716 (41%), Gaps = 81/716 (11%)
Query: 13 SPTARGANCDVELLKTTTRDREELKCMLEKYE---RHLAEIQGNVKVLKSERDKIFLLYE 69
+P + D LLK ++ +LK LE+ R A + + L E+D + +
Sbjct: 332 TPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQN 391
Query: 70 QAQEEITRL-----RREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRE 124
+ E +TR+ + + K+ + L ++ ++ + D + T +
Sbjct: 392 EKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTH 451
Query: 125 RLKI-----AQETAFNEKAHLEQRIEELECTVHN-----LDDERMEQ--------MSNMT 166
+L I E+ +E ++ L N L+ E +E N+
Sbjct: 452 KLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLV 511
Query: 167 LMKETISTVEKEM--KSLARKAMDTESELGRQKAENNSLRLLYE---------NTEKDLS 215
L E + T ++EM K + +D L R+ ++ ++L++E + E
Sbjct: 512 LDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQ 571
Query: 216 DTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECL-- 273
D + L+ K L+ +++I L E ID+ +NI + ++S ++ D + K+ L
Sbjct: 572 DLENELSSKVELLREKEDQIKKLQEYIDSQKLENI--KMDLSYSLESIEDPKQMKQTLFD 629
Query: 274 --QACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRR 331
LD K E+ E+L +KEK + + +ME + L ++ + +
Sbjct: 630 AETVALDAKRESAFLRSENLELKEK-MKELATTYKQMENDIQLYQSQLEAKKKMQVDLEK 688
Query: 332 QLDETNDELAQIAR------ERDILAHDN-----DNLQEQFAKAKQENQALSKK------ 374
+L +E+ ++ +D+L + +LQ++ K +EN+AL ++
Sbjct: 689 ELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSE 748
Query: 375 LNDTHNELNDIKQKVQDTNLEVN-------KLKNILKSEESENRQMMEQLRKANEDAENW 427
L +E+ +++++QD + E++ KL + + +ES + ++E++ K +D
Sbjct: 749 LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATT 808
Query: 428 ENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSV 487
++ + ++ + K + E + + E+ + +N+E+ + + S + L +
Sbjct: 809 QSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTEL 868
Query: 488 VKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAH 547
+ELQ+ E L ++ +E DS+ + + R+ ++++ E+ +
Sbjct: 869 SYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLT 928
Query: 548 SEIELLRSQMANERISMQNLEALL--VANRDKEYQSQI-----ALQEKESEIQLLKEHLC 600
E + L+ + +I L++ + N + + Q Q+ +L++ + I LK +
Sbjct: 929 QEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKIS 988
Query: 601 ------LAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRR 650
L + +++D Q + V + DL+ Q T + +++ R+
Sbjct: 989 EEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRK 1044
Score = 58.5 bits (140), Expect = 2e-08
Identities = 117/578 (20%), Positives = 237/578 (41%), Gaps = 65/578 (11%)
Query: 98 LRRVET----ERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHN 153
LRR++ ERD LR M RD ++K + + + HL + + E +
Sbjct: 2044 LRRIKESLKMERDQFIATLREMIA-RDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKE 2102
Query: 154 LDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKD 213
L E + + +EKE++ +M ++ L + + L+ ++
Sbjct: 2103 LLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRC 2162
Query: 214 LSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECL 273
+ R + K KY L + E I+ F I + E+ L + L ++ +
Sbjct: 2163 SMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVP 2222
Query: 274 QACL-DKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQ------DV 326
L D K L +K+ + S +I E +Q E E+ D+
Sbjct: 2223 SRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDI 2282
Query: 327 SRMRRQLDETNDELAQIAR--ERDILAHDNDNLQ------------EQFAKA-KQENQAL 371
+++ + + ND + Q+ I+A N++ + EQ K+ K++N+ L
Sbjct: 2283 EKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKL 2342
Query: 372 SKKLNDTHNEL---NDIKQKVQDT-NLEVNKLKNILKSEESENRQMMEQLRKANEDAENW 427
K L + QD N V L +E+ R++ L +A E A +
Sbjct: 2343 FKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKI--RELENSLHEAKESAMHK 2400
Query: 428 ENKARQSEAD---NNTLKLELITAEAEGNRLKEKVDSLNREVEQHLN-AERSYKSQISTL 483
E+K + + + N + +L E N+ EK + ++ + + YK +I L
Sbjct: 2401 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL 2460
Query: 484 HKSVVKMEEELQK--VQFEKVSALADLSSTRELCIKLDSSKELLN--RQLVAKDQEIEMR 539
+VK++ E K +FEK ++S+T+ ++ KE++ R+ + + Q+ +
Sbjct: 2461 KMKLVKIDLEKMKNAKEFEK-----EISATK---ATVEYQKEVIRLLRENLRRSQQAQ-- 2510
Query: 540 ENELDSAHSEIELLRSQMANERIS-------MQNLEALLVANRDKEYQSQIALQEKESEI 592
+ + S H++ Q +N+ ++ +QN +AL++ + + +I+ ++++E
Sbjct: 2511 DTSVISEHTD-----PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNE- 2564
Query: 593 QLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDIT 630
QL+K+ L N + S +V ++ + EA +T
Sbjct: 2565 QLIKQKNELLSNNQHL-SNEVKTWKERTLKREAHKQVT 2601
Score = 47.8 bits (112), Expect = 4e-05
Identities = 124/595 (20%), Positives = 235/595 (39%), Gaps = 148/595 (24%)
Query: 23 VELLKTTTRDREELKCMLE--KYERH---------LAEIQGNVKVLKSERDKIFLLYEQA 71
+E ++ ++R+EL+ + E K ER +A + N +V +R L
Sbjct: 2031 LEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKR-----LLSDG 2085
Query: 72 QEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQE 131
Q+ +T RE K +L+R +E D + L R++ + L + ++ +E
Sbjct: 2086 QQHLTESLREKCSRIKE--------LLKRY-SEMDDHYECLNRLSLD---LEKEIEFQKE 2133
Query: 132 TAFNEKAHLE------QRIEEL-----ECTV--HNLDDERMEQMSNMTLMKET------- 171
+ KA+L + IE+L C++ H + + +S +T +KE
Sbjct: 2134 LSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINK 2193
Query: 172 -----ISTVEKEMKSLAR-----KAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHL 221
I VEK+ + L + + D S R N ++ L E KD S+++
Sbjct: 2194 FEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPS 2253
Query: 222 AKKKYELQLTQEKIMC------LDEKIDNFTRQNIAQREE--------------ISILGG 261
K +++ L+ K M L+ + D +N Q+E I+I+
Sbjct: 2254 IKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNE 2313
Query: 262 TLN------DLAKEKECLQACLDKKSE----NIASLGESLAMKEK---TISGMKNI---- 304
+ ++KE E L +K+E N +L SLA + T KN
Sbjct: 2314 STEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTS 2373
Query: 305 ---------IAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDND 355
I E+E + + E+ + E + +M+++L+ TND +A++ + H+++
Sbjct: 2374 RATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAK----VHESN 2429
Query: 356 NLQEQFAKAKQENQALSKKL----NDTHNELNDIKQKVQDTNLEVNKLKNILKSEESEN- 410
E K K+ Q L K+ E+ D+K K+ +LE K+KN + E+ +
Sbjct: 2430 KCLE---KTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLE--KMKNAKEFEKEISA 2484
Query: 411 ------------RQMMEQLRKANEDAENWENKARQSEADNN------------------T 440
R + E LR++ + + +N
Sbjct: 2485 TKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALI 2544
Query: 441 LKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQ 495
LK E I E E ++LK++ + L ++ + L+ + +++ T + +K E Q
Sbjct: 2545 LKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQ 2599
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
Length = 1116
Score = 117 bits (293), Expect = 4e-26
Identities = 140/643 (21%), Positives = 300/643 (46%), Gaps = 77/643 (11%)
Query: 22 DVELLKT----TTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITR 77
++++LK+ +T +REE +E Y H ++ V+ LK E +E+ +++
Sbjct: 404 EIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAG 463
Query: 78 LRREM--MKSCKSPKSTTAHAILRRVETERDVAFTDLRR------------------MTT 117
L+ E+ +K S K T A+ ++ET + F+D ++ + T
Sbjct: 464 LQAEIGQVKQELSRKDTELLALQTKLETLTN-QFSDSKQHIEVLKESLTAKEQRAAILQT 522
Query: 118 ERDSLRERLKIAQETAFNEKAHLEQRIEELECT----VHNLDDERMEQMSNMTLMKETIS 173
E D+LR RL+ +ET N+K Q + E + T +H+L D + + + ++
Sbjct: 523 EVDALRLRLE-EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDM-------LDVKERKVN 574
Query: 174 TVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQE 233
++K++++L + D E ++ K SL+ NT+ L+ + LA+K+ ++ +E
Sbjct: 575 VLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKE 634
Query: 234 KI----MCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGE 289
+ E+IDN+ + +E++S+L G L+ EKE + LD K E+ +SL
Sbjct: 635 QRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS----EKEA--SLLDLK-EHASSLAS 687
Query: 290 SLAMKEKTISGMKNIIAEMEQASRQCT--EALIVCEQDVSRMRRQLDETNDELAQIARER 347
S K+ S +K + +EQ +C E+ + + + R E +D + + RE
Sbjct: 688 SGLKKD---SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREI 744
Query: 348 DILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEE 407
++ Q + + + + + + ND ++ +++++V+D N +V LK+ + E+
Sbjct: 745 TRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEK 804
Query: 408 SENRQMMEQLRK----ANEDAENWENKARQS------------EADNNTLKLELITAEAE 451
++ QM+E+ R+ N+ ++ ++ R+ E+ T + E++ A+ E
Sbjct: 805 KKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEE 864
Query: 452 GNR--LKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLS 509
R +++V+ L +E+ S K+++S+ +S+ + E L ++ E+ L ++
Sbjct: 865 SARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVL 924
Query: 510 STRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEA 569
++ + S++ N L+ + + E+ + E + L Q+ + QN
Sbjct: 925 EMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQ---TQNRMK 981
Query: 570 LLVAN-RDKEYQSQIALQ--EKESEIQLLKEHLCLAENKMAIQ 609
L+ N D ++S + Q K S Q+++ L L +N+ ++
Sbjct: 982 LMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLK 1024
Score = 113 bits (283), Expect = 5e-25
Identities = 148/723 (20%), Positives = 302/723 (41%), Gaps = 90/723 (12%)
Query: 27 KTTTRDREELKCMLEKYERHLAEIQGNVKVLKSE----RDKIFLLYEQAQEEITRLRREM 82
K T D E + + E E H+ ++ ++ + E R+++ +E A + +
Sbjct: 324 KATEEDHERTRRLAEA-EMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQT 382
Query: 83 MKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQ 142
+ K K ++ LR +E E + ++ T ER+ +++++ + + K +EQ
Sbjct: 383 VIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQ 442
Query: 143 RIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENN- 201
+KE +S+ E + + L +KA ++E+G+ K E +
Sbjct: 443 -------------------------LKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSR 477
Query: 202 ------SLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNF---------- 245
+L+ E SD+++H+ K L +++ L ++D
Sbjct: 478 KDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETM 537
Query: 246 ----TRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGM 301
T+Q EE G ++DL + + ++ + I +L E L KEK +S +
Sbjct: 538 LNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSL 597
Query: 302 KNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQF 361
K + ++ + AL E+ ++ R ++ ++ + RE+ + DN ++
Sbjct: 598 KERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQ---EEIDNYKKDL 654
Query: 362 AKAKQENQALSKKLNDTHNELNDIKQKVQD-------TNLEVNKLKNILKSEESENRQMM 414
K++ L L++ L D+K+ + + L+ L+ ++ E +M
Sbjct: 655 KDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME 714
Query: 415 EQLRKANEDAENWENKARQSEADN-NTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAE 473
QL+KA+E A E +A +D L+ E+ + E ++ + +VD L +++ N +
Sbjct: 715 SQLKKAHEAA--LEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK 772
Query: 474 RSYKSQISTLHKSVVKMEEEL----QKVQFEKVSALADLSSTRELCIKLDSSKELLNRQL 529
+I+ L + V +++ K Q EK + L R L+ S + L L
Sbjct: 773 NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSL 832
Query: 530 VAKDQEIE-----MRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKE------ 578
KD IE +RE+ +A E+ L + + A Q E L+ + K+
Sbjct: 833 RKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMK 892
Query: 579 ---YQSQIALQEKESEIQLL----KEHL--CLAENKMAIQSRDVAQFRNV-VTQLEADLD 628
+Q +L EKE+ + L ++HL L + A+ + + N+ + +L +
Sbjct: 893 AKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKK 952
Query: 629 ITKRQLGTERFERERAVQELRRQNYSSNAYHMSSTMKPNTK-CHSPERAHHRSPDRGLDR 687
T+ ++ + E++R VQ+L++Q + + + K HS + H SPD+ +
Sbjct: 953 KTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQP 1012
Query: 688 SLE 690
LE
Sbjct: 1013 LLE 1015
Score = 102 bits (255), Expect = 9e-22
Identities = 122/599 (20%), Positives = 247/599 (41%), Gaps = 48/599 (8%)
Query: 69 EQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERD-SLRERLK 127
E +E RL E + K +LR+ E ++ ++ RD S+++ L+
Sbjct: 261 ELTEENFQRLHAEHERQAKEL------FLLRKTLEEMELRIETQKQTLNARDESIKKLLE 314
Query: 128 IAQETAFNEKAHLE-----QRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSL 182
+ Q + KA E +R+ E E VH+L+ + EKE S+
Sbjct: 315 MLQSKGLSAKATEEDHERTRRLAEAEMHVHHLES--------------LLEQKEKE-NSM 359
Query: 183 ARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKI 242
R+ M E A+ +L+ + E + +S +R L + E+Q+ + E+
Sbjct: 360 LREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEER 419
Query: 243 DNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMK 302
+ +Q R + + L +E +A ++ + A L + ++ +S
Sbjct: 420 EEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKD 479
Query: 303 NIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFA 362
+ ++ T +Q + ++ L A + E D L + +
Sbjct: 480 TELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLN 539
Query: 363 KAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANE 422
K ++ Q ++++ E++D+K + +VN L+ +++ + + R +Q+ E
Sbjct: 540 KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 599
Query: 423 DAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQIST 482
++ + ++ TL+ L E RLKE+ D RE ++ ++ +YK +
Sbjct: 600 RVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEID---NYKKDLKD 656
Query: 483 LHKSVVKMEEELQKVQFEKVSALADL----SSTRELCIKLDSSKELLNRQLVAKDQEIEM 538
L + V ++ +L EK ++L DL SS +K DS + L L K +E
Sbjct: 657 LKEKVSLLQGDLS----EKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLK 712
Query: 539 RENELDSAH-SEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKE 597
E++L AH + +E S ++RI Q+LE + +D+ ++Q +E+ L E
Sbjct: 713 MESQLKKAHEAALEARASPEMSDRI--QHLEREITRYKDESSKAQ-------AEVDRLLE 763
Query: 598 HLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSN 656
L EN+ + + +A+ V + K + E+ + + ++E RR+ + N
Sbjct: 764 ILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 822
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 115 bits (288), Expect = 1e-25
Identities = 150/694 (21%), Positives = 288/694 (41%), Gaps = 88/694 (12%)
Query: 45 RHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETE 104
R LAE + +V L+S L EQ ++E + LR EM + ++ + L+ V
Sbjct: 334 RRLAEAEMHVHHLES-------LLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEM 386
Query: 105 RDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSN 164
+D + + R LR+ LE+ I+ L+ +ER E+M
Sbjct: 387 KDSKISSMER------GLRD---------------LEEEIQMLKSNGALSTEEREEEMKQ 425
Query: 165 MTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKK 224
M + + K + K + EL R+ E +L+ E SD+++H+
Sbjct: 426 MEVYRS-------HSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVL 478
Query: 225 KYELQLTQEKIMCLDEKIDNF--------------TRQNIAQREEISILGGTLNDLAKEK 270
K L +++ L ++D T+Q EE G ++DL
Sbjct: 479 KESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDML 538
Query: 271 ECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMR 330
+ + ++ + I +L E L KEK +S +K + ++ + AL E+ ++
Sbjct: 539 DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKE 598
Query: 331 RQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQ 390
R ++ ++ + RE+ + DN ++ K++ L L++ L D+K+
Sbjct: 599 RTIERLKEQRDRDEREKQ---EEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHAS 655
Query: 391 D-------TNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADN-NTLK 442
+ + L+ L+ ++ E +M QL+KA+E A E +A +D L+
Sbjct: 656 SLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAA--LEARASPEMSDRIQHLE 713
Query: 443 LELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEEL----QKVQ 498
E+ + E ++ + +VD L +++ N + +I+ L + V +++ K Q
Sbjct: 714 REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQ 773
Query: 499 FEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIE-----MRENELDSAHSEIELL 553
EK + L R L+ S + L L KD IE +RE+ +A E+ L
Sbjct: 774 VEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLA 833
Query: 554 RSQMANERISMQNLEALLVANRDKE---------YQSQIALQEKESEIQLL----KEHL- 599
+ + A Q E L+ + K+ +Q +L EKE+ + L ++HL
Sbjct: 834 QEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE 893
Query: 600 -CLAENKMAIQSRDVAQFRNV-VTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNA 657
L + A+ + + N+ + +L + T+ ++ + E++R VQ+L++Q +
Sbjct: 894 EVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMK 953
Query: 658 YHMSSTMKPNTK-CHSPERAHHRSPDRGLDRSLE 690
+ + K HS + H SPD+ + LE
Sbjct: 954 LMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLE 987
Score = 73.6 bits (179), Expect = 6e-13
Identities = 94/436 (21%), Positives = 187/436 (42%), Gaps = 53/436 (12%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM 83
E +K+ D L E LAE + ++ LK +RD+ + QEEI +++ +
Sbjct: 571 ERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRD---EREKQEEIDNYKKD-L 626
Query: 84 KSCKSPKSTTAHAILRRVETERDVAFTDLRRMTT-------ERDSLRERLKIAQETAFNE 136
K K S +L+ +E++ + DL+ + ++DS + L+IA E E
Sbjct: 627 KDLKEKVS-----LLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE 681
Query: 137 KAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQ 196
+E ++++ L+ +MS+ ++ L R+ + E +
Sbjct: 682 CLKMESQLKKAHEAA--LEARASPEMSD-------------RIQHLEREITRYKDESSKA 726
Query: 197 KAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEI 256
+AE + L + + E + +D + +A+ + +++ +K+ L K +++ EE
Sbjct: 727 QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 786
Query: 257 SILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEME----QAS 312
LND +++ LQ L KK + I L E+L + + + ++A+ E A
Sbjct: 787 RRREDNLNDSSQQ---LQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAE 843
Query: 313 RQCTEALIVCE---QDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQ 369
+Q E L+ E Q++ M+ +L T LA+ L + E+ + KQE
Sbjct: 844 KQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEAL 903
Query: 370 ALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANED-----A 424
+ D + L ++ + T EV LK E ++++QL++ ++ A
Sbjct: 904 LAAISEKDANIALLELSSSKKKTQEEVAALKR-------EKDRLVQQLKQQTQNRMKLMA 956
Query: 425 ENWENKARQSEADNNT 440
+N+E+ +S N T
Sbjct: 957 DNYEDDHFKSSHSNQT 972
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 113 bits (282), Expect = 7e-25
Identities = 122/640 (19%), Positives = 274/640 (42%), Gaps = 95/640 (14%)
Query: 33 REELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRL------RREMMKSC 86
+E L +++ + HL Q V L++ +++ +++E++++L + E++ S
Sbjct: 595 QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 654
Query: 87 KSPKSTTAHAILRRVETERDVAFT---DLRRMTTERDSLRERLKIAQETAFNEKAHL--- 140
++ K+ + ++T ++ +L ++TT+ D + +L+ QE ++HL
Sbjct: 655 EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714
Query: 141 -------EQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESEL 193
EQ+ EELE + L+ + +E ++ + + + L +A + +L
Sbjct: 715 KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774
Query: 194 GRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQR 253
+K +S RL + + L ++ L K++ E Q+ L + + +++ Q
Sbjct: 775 EMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQI-------LKQDFETLSQETKIQH 827
Query: 254 EEISI-LGGTLNDLAK---EKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEME 309
EE++ + T+ +L K EKE L L + ++ + +SL KN +E E
Sbjct: 828 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSL----------KNSKSEFE 877
Query: 310 QASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQ 369
+ +++ A++ E+ ++ QL Q Q +E +
Sbjct: 878 KENQKGKAAILDLEKTCKELKHQL------------------------QVQMENTLKEQK 913
Query: 370 ALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWEN 429
L K L + +K ++ ++ + +N LK E E +Q+ + NE ++ E
Sbjct: 914 ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI---NELKQSSEQ 970
Query: 430 KARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVK 489
K +Q EA LK+ ++ N+L++++ + Q L AE K +IS L + K
Sbjct: 971 KKKQIEALQGELKIAVLQKTELENKLQQQLT----QAAQELAAE---KEKISVLQNNYEK 1023
Query: 490 MEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSE 549
+E +++Q + ++L +TR Q+++ E +L A +
Sbjct: 1024 SQETFKQLQSDFYGRESELLATR---------------------QDLKSVEEKLSLAQED 1062
Query: 550 IELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQ 609
+ R+Q+ N+ +Q L+ + + LQE+ +Q +++ L E ++ +
Sbjct: 1063 LISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122
Query: 610 SRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELR 649
+A+ + + E ++ +L + + E + + L+
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK 1162
Score = 110 bits (274), Expect = 6e-24
Identities = 139/669 (20%), Positives = 287/669 (42%), Gaps = 75/669 (11%)
Query: 26 LKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKS 85
L+ + +K M + +E+ A++ + +KS+ D+ L E A++++TRL E+ K
Sbjct: 144 LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKE 203
Query: 86 CKSPKSTTAHAILRRVETERDVAF---------TDLRRMTTERDSLRERLKIAQETAFNE 136
+ +L+R E DVA T + MT ER+ E+LK + ++
Sbjct: 204 ATVIQDLKTE-LLQRPGIE-DVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ 261
Query: 137 KAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQ 196
A E I +L + E + + +K +++ + ++ ++L + E + +
Sbjct: 262 YASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKL 321
Query: 197 KAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEI 256
+ ++N + +N + L + + L ++ + + ++ +EE+
Sbjct: 322 EEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEEL 381
Query: 257 SILGGTLNDLAKEKECLQACLDKKSEN-------IASLGESLAMKEKTISGMKNIIAEME 309
S + L E + LQ ++K ++ I L L E+ + + E
Sbjct: 382 SEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR 441
Query: 310 QASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQ 369
Q S +E L+ EQ V+ ++ +L ++L + L H D ++Q + + Q
Sbjct: 442 QLS---SEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQ 498
Query: 370 ALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWEN 429
+ + KL + N+L + +++ D + ++ L+ +L+ + EN ++E+ R E+
Sbjct: 499 STTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQ-KSKENISLLEKER------EDLYA 551
Query: 430 KARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREV----EQHLNAERSYKSQISTLHK 485
K + E + L N+L+EK +L +V E+ N S+K LH
Sbjct: 552 KIQAGEGETAVL-----------NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600
Query: 486 SVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDS 545
V + + L+ Q ++V +L +S EL +L+ SKE +++ D +I+ + L S
Sbjct: 601 QVQEQKAHLRAAQ-DRVLSLE--TSVNELNSQLNESKEKVSQ----LDIQIKAKTELLLS 653
Query: 546 AHSEIELLRSQMANERISMQNLEALLVANRDKEY----------QSQIALQEKESEIQLL 595
A + R+ + N + QN A +DK+ Q LQ+K+ L
Sbjct: 654 AEAAKTAQRADLQNHLDTAQN------ALQDKQQELNKITTQLDQVTAKLQDKQEHCSQL 707
Query: 596 KEHLCLAENKMAIQSRDVAQFRNVVTQLEAD-LDITKRQLGTERFERERAVQELRRQNYS 654
+ HL + K + + + +LEAD L++ + +E+A+Q+L++Q
Sbjct: 708 ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV--------KASKEQALQDLQQQRQL 759
Query: 655 SNAYHMSST 663
+ + +T
Sbjct: 760 NTDLELRAT 768
Score = 99.4 bits (246), Expect = 1e-20
Identities = 143/685 (20%), Positives = 297/685 (43%), Gaps = 74/685 (10%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM 83
EL K TT+ +++ L+ + H ++++ ++K K + +L EQ EE+ +++
Sbjct: 682 ELNKITTQ-LDQVTAKLQDKQEHCSQLESHLKEYKEK----YLSLEQKTEELEGQIKKLE 736
Query: 84 KSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQR 143
K++ A L+ ++ +R + TDL TE L ++L++ +E + + L+++
Sbjct: 737 ADSLEVKASKEQA-LQDLQQQRQLN-TDLELRATE---LSKQLEMEKEIVSSTRLDLQKK 791
Query: 144 IEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMK----SLARKAMDTESELGRQKAE 199
E LE L + E+ ++K+ T+ +E K L + T +EL + K E
Sbjct: 792 SEALESIKQKLTKQEEEKQ----ILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKME 847
Query: 200 NNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEK----IMCLDEKIDNFTRQNIAQREE 255
+L + LS L K E + +K I+ L++ Q Q E
Sbjct: 848 KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN 907
Query: 256 ISILGGTLN-DLAKEKEC---LQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQA 311
L L KEKE L+ L+ E + +L EK ++ I E++Q+
Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967
Query: 312 SRQCTEALIVCEQDV-----------SRMRRQLDETNDELAQIARERDILAHDNDNLQEQ 360
S Q + + + ++ +++++QL + ELA + +L ++ + QE
Sbjct: 968 SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027
Query: 361 FAK--------------AKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNI---L 403
F + +Q+ +++ +KL+ +L + ++ + N + +LK L
Sbjct: 1028 FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL 1087
Query: 404 KSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLN 463
+ + ++ Q +++ KA +D + E ++ E N KL I E R ++++ LN
Sbjct: 1088 EQDSAKKEQQLQERCKALQDIQK-EKSLKEKELVNEKSKLAEI--EEIKCRQEKEITKLN 1144
Query: 464 REVEQHLNAERSYKSQISTLHKSVVKMEEELQ-KVQFEKVSALADLSSTRELCIKLDSSK 522
E++ H + + + +++ + ELQ K K + + + + L ++ +
Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1204
Query: 523 ELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEAL--LVANRDKEYQ 580
E L ++ + K+ ++ E E+ + + + +++MQ + AL + KE+Q
Sbjct: 1205 EELKKEFIEKEAKLHSEIKE-----KEVGMKKHEENEAKLTMQ-ITALNENLGTVKKEWQ 1258
Query: 581 -SQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERF 639
SQ + E E + L+ + + E +Q+ + + L+ + +I K Q
Sbjct: 1259 SSQRRVSELEKQTDDLRGEIAVLE--ATVQNNQDERRALLERCLKGEGEIEKLQTKVLEL 1316
Query: 640 ERE-----RAVQELRRQNYSSNAYH 659
+R+ AVQEL R+N S H
Sbjct: 1317 QRKLDNTTAAVQELGRENQSLQIKH 1341
Score = 90.5 bits (223), Expect = 5e-18
Identities = 128/666 (19%), Positives = 284/666 (42%), Gaps = 115/666 (17%)
Query: 41 EKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRR 100
+K + L+E++ + LK+E ++ E+ ++ +L+ E+ + H+ L
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQ---------LHSKL-- 423
Query: 101 VETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERME 160
+ETER + R L+E+ +++ E ++ EQ++ +L+ + L+++ E
Sbjct: 424 LETERQLGEAHGR--------LKEQRQLSSEKLMDK----EQQVADLQLKLSRLEEQLKE 471
Query: 161 QMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRH 220
+++N T ++ + +++ + T ++L ++A+N+ ++L + + D +
Sbjct: 472 KVTNSTELQHQLDKTKQQHQEQQALQQSTTAKL--REAQNDLEQVL-----RQIGDKDQK 524
Query: 221 LAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKK 280
+ + LQ ++E I L+++ ++ + A E ++L N L ++ LQ + +
Sbjct: 525 IQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL----NQLQEKNHTLQEQVTQL 580
Query: 281 SENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDEL 340
+E + + ES ++ + + E + R + ++ E V+ + QL+E+ +++
Sbjct: 581 TEKLKNQSESHKQAQENLHDQ---VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV 637
Query: 341 AQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLK 400
+Q+ DI L AK +A D N L+ + +QD E+NK+
Sbjct: 638 SQL----DIQIKAKTELLLSAEAAKTAQRA------DLQNHLDTAQNALQDKQQELNKIT 687
Query: 401 NIL---------KSE-----ESENRQMMEQLRKANEDAENWENKARQSEAD--------- 437
L K E ES ++ E+ + E E + ++ EAD
Sbjct: 688 TQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKE 747
Query: 438 ------------NNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTL-- 483
N L+L + KE V S ++++ A S K +++
Sbjct: 748 QALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE 807
Query: 484 HKSVVKME-----------------------EELQKVQFEKVSALADLSSTRELCIKLDS 520
K ++K + ELQKV+ EK + + +LS+ ++ K+
Sbjct: 808 EKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSD 867
Query: 521 SKELLNRQLVAKDQEIEMRENELDSAHSEIE-LLRSQMANERISMQNLEALLVANRDKEY 579
S + + ++Q+ + +L+ E++ L+ QM N + L+ L ++KE
Sbjct: 868 SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL--EKEKEA 925
Query: 580 QSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERF 639
Q+ L E+ ++E L A+N + ++ Q + + +L+ + K+Q+ +
Sbjct: 926 SHQLKL-----ELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG 980
Query: 640 ERERAV 645
E + AV
Sbjct: 981 ELKIAV 986
Score = 71.6 bits (174), Expect = 2e-12
Identities = 106/489 (21%), Positives = 217/489 (44%), Gaps = 77/489 (15%)
Query: 163 SNMTLMKETISTVEKEMKSLA-------------RKAMDTESELGRQKAENNSL----RL 205
SN+ L ++ ++ + +E++ L +K ++ L +Q+A+ + L
Sbjct: 76 SNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSA 135
Query: 206 LYENTEKDLSDTQRHLAKKKYELQLTQEK-------IMCLDEKIDNFTRQNIAQREEISI 258
++ E+ L + Q K L ++K I + K D A ++++
Sbjct: 136 ELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTR 195
Query: 259 LGGTLNDLAKEKECLQACLDKKSENIASLG-ESLAMKEKTI----SGMKNIIAEMEQASR 313
L LN KE +Q D K+E + G E +A+ +K + + M N+ E E+ S
Sbjct: 196 LTEELN---KEATVIQ---DLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESE 249
Query: 314 QCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSK 373
+ + + + + + ELA+ +E + + L+ + Q+NQ L++
Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE 309
Query: 374 ----------KLNDTHNELNDIKQKVQDT----NLEVNKLKNILKSEES-------ENRQ 412
KL + HNE + K+ +Q T +L+ +L++ L + E+ E +
Sbjct: 310 NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSE 369
Query: 413 MMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNR---EVEQH 469
E +K E+ E K + +A+ L+ + E G +L+ +++ L+ E E+
Sbjct: 370 KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ 429
Query: 470 L-NAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALAD-----LSSTRELCIKLDSSKE 523
L A K Q + ++ E+++ +Q K+S L + ++++ EL +LD +K+
Sbjct: 430 LGEAHGRLKEQRQLSSEKLMDKEQQVADLQL-KLSRLEEQLKEKVTNSTELQHQLDKTKQ 488
Query: 524 L-LNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQ 582
+Q + + ++RE A +++E + Q+ ++ +QNLEALL +++
Sbjct: 489 QHQEQQALQQSTTAKLRE-----AQNDLEQVLRQIGDKDQKIQNLEALLQKSKE-----N 538
Query: 583 IALQEKESE 591
I+L EKE E
Sbjct: 539 ISLLEKERE 547
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 112 bits (281), Expect = 9e-25
Identities = 151/700 (21%), Positives = 295/700 (42%), Gaps = 96/700 (13%)
Query: 24 ELLKTTTRDREELKCM---LEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRR 80
E LK +EEL +E+ + LA+++ V E+D + QEE +L
Sbjct: 1494 EALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLIT 1553
Query: 81 EMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEK-AH 139
EM +S +S ++ ++ E D ++ E +SL+ KIA+ T + EK
Sbjct: 1554 EMDRSLLENQSLSSSCESLKLALEG--LTEDKEKLVKEIESLKSS-KIAESTEWQEKHKE 1610
Query: 140 LEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAE 199
L++ E L + N+ +E ++ + V +E + L K TE+ K E
Sbjct: 1611 LQKEYEILLQSYENVSNEAER-------IQHVVEAVRQEKQELYGKLRSTEAN----KKE 1659
Query: 200 NNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISIL 259
E +++ + R AK K Q+KI+ L+E+ D R E+
Sbjct: 1660 TEKQLQEAEQEMEEMKEKMRKFAKSK------QQKILELEEENDRL-------RAEVHPA 1706
Query: 260 GGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEAL 319
G T + + A + ++ E + E+L+ K +++ K+ ++E Q + E
Sbjct: 1707 GDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGN 1766
Query: 320 IVCEQDVSRMRRQLDETN------DELAQIARERDILAHDN-DNLQEQFAKAKQENQALS 372
+ + ++ + ++TN + E+D L+ E AK N A+S
Sbjct: 1767 VSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVS 1826
Query: 373 KKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKAR 432
K + +H+E+N+ Q++ Q+ E++ E+ + + ++
Sbjct: 1827 KDFS-SHDEINNYLQQID---------------------QLKERIAGLEEEKQKNKEFSQ 1864
Query: 433 QSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEE 492
E + NTL ++ T + E L+E+V +N +Q + ++S + K EE
Sbjct: 1865 TLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ-------IQEELSRVTKLKETAEE 1917
Query: 493 ELQKVQFEKVSALADLS-STRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIE 551
E ++ ++ LA+L+ S C +++ + Q+ K++ +E L SE+E
Sbjct: 1918 EKDDLEERLMNQLAELNGSIGNYC------QDVTDAQI--KNELLESEMKNLKKCVSELE 1969
Query: 552 LLRSQMANERISMQN------LEALLVANRDKEYQS-----QIALQEKESEIQLLKEHLC 600
+ Q+ E+ +++ LE + A ++ +S Q L+EK+ E++ L++
Sbjct: 1970 EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI 2029
Query: 601 LAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRR------QNYS 654
+ K++ R V V T+ + DL+ITK L R++A EL S
Sbjct: 2030 RYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQS 2089
Query: 655 SNAYHMSSTMKPNTKCHSPE---RAHHRSPDRGLDRSLEE 691
A ++ +K + S + ++ + D L+R LE+
Sbjct: 2090 EAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ 2129
Score = 94.0 bits (232), Expect = 4e-19
Identities = 125/635 (19%), Positives = 271/635 (42%), Gaps = 113/635 (17%)
Query: 26 LKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKI----------FLLYEQAQEEI 75
L ++ ++L+ L+ LA ++ L+ +RD++ F Q++EE
Sbjct: 2166 LNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEE 2225
Query: 76 TRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQ---ET 132
RL+ + +C K + E + +++ + + E + E +++ Q +T
Sbjct: 2226 IRLKED---NCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTE-VQLQQKVCDT 2281
Query: 133 AFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESE 192
E L ++EE H+ +E + S + +K+ ++ + ++ + + E
Sbjct: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGI 2341
Query: 193 LGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQ 252
+ +Q+A+ + + YE E DL ++ ++ E+ + ++KI
Sbjct: 2342 IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKI----------------- 2384
Query: 253 REEISILGGTLNDLAKEKECLQACL----DKKSENIASLGESLAMKEKTISGMKNIIAEM 308
IS+L G ++E +Q + + + I L L+ +E+ +NI+ E
Sbjct: 2385 ---ISLLSG-------KEEAIQVAIAELRQQHDKEIKELENLLSQEEE-----ENIVLEE 2429
Query: 309 E-----QASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQ--- 360
E + Q E L +++ + + QLD ++ + +RD + D L+E+
Sbjct: 2430 ENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLS 2489
Query: 361 --------FAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEV----NKLKNILKSEES 408
+A EN L +++ + ++D+ + + E+ L ++ ++S
Sbjct: 2490 IILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDS 2549
Query: 409 ENRQMMEQLRKANEDAEN----WENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNR 464
+ +Q++E + N++ EN E K ++SE N L+ N L+E+ L++
Sbjct: 2550 QQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSF-------NALQEEKQDLSK 2602
Query: 465 EVEQHLNAERSYKSQISTLHKSVVKMEEE--------LQKVQFEKVSALADL-SSTRELC 515
E+E S K IS L + V ++EE KV+ E+V L+ L SS+++
Sbjct: 2603 EIE-------SLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRI 2655
Query: 516 IKLDSSKELLNRQLVAKDQEIEMR-ENELDSAHSEIELLR----------SQMANERISM 564
+L+ + ++ K EIE + + EL H + ++R +++A + + M
Sbjct: 2656 AELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEM 2715
Query: 565 QNLEALLVANRDKEYQSQI-ALQEKESEIQLLKEH 598
+ + L+V +K +QI + S +Q ++H
Sbjct: 2716 EQ-KLLMVTKENKGLTAQIQSFGRSMSSLQNSRDH 2749
Score = 90.5 bits (223), Expect = 5e-18
Identities = 129/679 (18%), Positives = 284/679 (41%), Gaps = 90/679 (13%)
Query: 50 IQGNVKVLKSERDKIFLLYEQAQEEITRLRREM-------------MKSCKSPKSTTAHA 96
+QG K L S+ ++ LY +Q E+ +L E+ ++ CK K
Sbjct: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGI 2341
Query: 97 ILRRVETERDVAF------TDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECT 150
I ++ ++ F TDL+ L E + + ++ + + E+ I+
Sbjct: 2342 IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAE 2401
Query: 151 VHNLDDERMEQMSNMTLMKETISTV-EKEMKSLARKAMDTESELGRQKAENNSLRLLYEN 209
+ D+ ++++ N+ +E + V E+E K K L K EN + ++
Sbjct: 2402 LRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDS 2461
Query: 210 TEKDLSDTQRHLAKKKYELQLTQEKIMCL----DEKIDNFTRQNIAQREEISILGGTLND 265
K +S Q + + Q +E+ + + D+ I +N +EEI L ++D
Sbjct: 2462 FVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDD 2521
Query: 266 LAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQD 325
L E L A L + E+ L + + +K+ S K ++ Q +++ E
Sbjct: 2522 LNSENAKLDAELIQYRED---LNQVITIKD---SQQKQLLEVQLQQNKEL-------ENK 2568
Query: 326 VSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNE---- 381
+++ +L E+ + + R + L + +L ++ K L++++ E
Sbjct: 2569 YAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLG 2628
Query: 382 LNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQL--------RKANEDAENWENKARQ 433
L + KV++ EV++L + S + ++ E+L +K E + + + +
Sbjct: 2629 LYHAQLKVKEE--EVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKH 2686
Query: 434 SEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKME-- 491
D ++ E TAE L + + +++ + +QI + +S+ ++
Sbjct: 2687 LHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNS 2746
Query: 492 -----EELQKVQFEKVSALADLSSTRE--------------LCIKLDSSKE-------LL 525
EEL +++ + ++L +L+ +E ++S++E L
Sbjct: 2747 RDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKL 2806
Query: 526 NRQLVAKDQEIEMRENELDSAHSEIELLRSQMA---NERISMQNLEALLVANRDKEYQSQ 582
N+QL++KD+++ ++L+ ++++++ MA NER + N + + + +S
Sbjct: 2807 NQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSA 2866
Query: 583 IALQEKESEIQLLKEHLCLAEN---KMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERF 639
+E+Q LK+ + +N ++ + +++ Q + Q +L K QL E
Sbjct: 2867 AQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQL-QEYQ 2925
Query: 640 ERERAVQ----ELRRQNYS 654
++ +A Q ELR++N S
Sbjct: 2926 DKTKAFQIMQEELRQENLS 2944
Score = 89.0 bits (219), Expect = 1e-17
Identities = 144/657 (21%), Positives = 285/657 (43%), Gaps = 76/657 (11%)
Query: 44 ERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVET 103
E ++A +Q V L++E+ + L + E+ L+ E K S + T A R E
Sbjct: 467 EENIASLQKRVVELENEKGALLL----SSIELEELKAENEKL--SSQITLLEAQNRTGEA 520
Query: 104 ERDVAFTDLRRMTTERDSLRERL-KIAQETAFNEK--------AHLEQRIEELECTVHNL 154
+R+V+ + + +R S E + E F++K +++ EE+ L
Sbjct: 521 DREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL 580
Query: 155 DDERMEQMSNMTLMKETISTVEKE-MKSLARKAM--DTESELGRQKAENNSLRLLYENTE 211
+R E+ + L ++ + +E E + + K DT + E +SL + E
Sbjct: 581 QGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAV----E 636
Query: 212 KDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFT-----------RQNIAQREEISILG 260
K+ + T+ H ++ E+ L + K D Q+ +R + IL
Sbjct: 637 KEQASTE-HQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILE 695
Query: 261 GTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTI----SGMKNIIAEMEQASRQCT 316
LN K +E + LD+K++ I++L + + +K S + E +Q Q
Sbjct: 696 LELN-FHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVK 754
Query: 317 EALIVCEQDVSRMRRQLDETNDELAQIARERDI-----LAHDNDNLQEQFAKAKQENQAL 371
E +V E +R Q+ + LA+ R+R + AHDN L EQ E ++
Sbjct: 755 ELSMVTE-----LRAQVKQLEMNLAEAERQRRLDYESQTAHDN-LLTEQIHSLSIEAKSK 808
Query: 372 SKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKA 431
K+ NEL+D++ + + + + L++ L+++ESE + E++R + E
Sbjct: 809 DVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQAL 868
Query: 432 RQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQ----------HLNAER-SYKSQI 480
Q E + + L+ + + L++ ++ +++V + LN E+ S +I
Sbjct: 869 SQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEI 928
Query: 481 STLHK--SVVKMEEELQKVQFEKVSALAD--LSSTRELCIKLDSSKELLNRQLVAKDQEI 536
TL + +++ EE +K Q E+ + ++ + E+ SKE L + +E
Sbjct: 929 KTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN 988
Query: 537 EMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKE-SEIQLL 595
E R+ +L +A L+ + +R+S E +AN E + +I L E E E++
Sbjct: 989 EQRKRKLQAA-----LINRKELLQRVSRLEEE---LANLKDESKKEIPLSETERGEVEED 1040
Query: 596 KEHLCLAENKMAIQSRDVAQF-RNVVTQLEADLDITKRQLGTERFERERAVQELRRQ 651
KE+ +E + + +++ + + +++ E +L ++ L E+ E Q L +Q
Sbjct: 1041 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDL-EEKLAAEEQFQALVKQ 1096
Score = 85.1 bits (209), Expect = 2e-16
Identities = 143/700 (20%), Positives = 295/700 (42%), Gaps = 87/700 (12%)
Query: 21 CDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRR 80
C LL + +EEL+ + +YE + Q L SE+D L E+ Q+ ++
Sbjct: 1713 CMETLLSSNASMKEELERVKMEYETLSKKFQS----LMSEKDS---LSEEVQDLKHQIEG 1765
Query: 81 EMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLR--------ERLKIAQE- 131
+ K ++T H V E + T E+DSL E + A+
Sbjct: 1766 NVSKQANL-EATEKHDNQTNVTEE---GTQSIPGETEEQDSLSMSTRPTCSESVPSAKSA 1821
Query: 132 --------TAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLA 183
++ +E + Q+I++L+ + L++E+ + KE T+E E +L
Sbjct: 1822 NPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKN-------KEFSQTLENEKNTLL 1874
Query: 184 RKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMC----LD 239
+ + EL + E + LL + +++LS + + E +E++M L+
Sbjct: 1875 SQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELN 1934
Query: 240 EKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLG--ESLAMKE-- 295
I N+ + + + +L + +L K+C+ ++K + + ES KE
Sbjct: 1935 GSIGNYCQDVTDAQIKNELLESEMKNL---KKCVSELEEEKQQLVKEKTKVESEIRKEYL 1991
Query: 296 KTISG-------------MKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQ 342
+ I G ++ ++ E +Q +Q + I ++ +S + R + +
Sbjct: 1992 EKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTE 2051
Query: 343 IARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNK-LKN 401
++ +I + E KA+ E + L+DT +E +V NL++ K L++
Sbjct: 2052 SQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSE----AARVLADNLKLKKELQS 2107
Query: 402 ILKSEESENRQMMEQLRKANEDAENWENKARQSEADN-NTLKLELITAEAEGNRLKEKVD 460
+S +S+ +Q E L + E AE K +++ + + L+ E + E ++ ++
Sbjct: 2108 NKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167
Query: 461 SLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKV-----QFEKVSALADLSSTRELC 515
++EV+Q S +Q++ KS+ ++++ +V ++E+ + A S E+
Sbjct: 2168 KKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227
Query: 516 IKLDSSKELLN--RQLVAKDQEIEMRENELD------SAHSEIELLRSQMANERISMQNL 567
+K D+ L + RQ+ +E+++ + L+ + ++ E+ Q + + +N
Sbjct: 2228 LKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENK 2287
Query: 568 EAL--LVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEA 625
E L L R + SQ L + ESE++ LK+ L N + ++ Q EA
Sbjct: 2288 ELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEA 2347
Query: 626 DLDITKRQLGTERFERERAVQELRRQNYSSNAYHMSSTMK 665
D+ +K F E+ +L+ ++ H MK
Sbjct: 2348 DIQNSK-------FSYEQLETDLQASRELTSRLHEEINMK 2380
Score = 80.1 bits (196), Expect = 6e-15
Identities = 140/659 (21%), Positives = 273/659 (41%), Gaps = 62/659 (9%)
Query: 25 LLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRR---- 80
L T +REE K +LEK E +AE + + L+ E + +EQA + L
Sbjct: 306 LRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSA 365
Query: 81 -EMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTE--RDSLRERLKIAQETAFNEK 137
E + + T+ L++ E A L+ ++ +D + ++ AQ T +
Sbjct: 366 LEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQ-TIQQLE 424
Query: 138 AHLEQRIEELECTVHNLDDERMEQMSNMTL----MKETISTVEKEMKSLARKAMDTESEL 193
L+Q+ +E+ ++ L ++ E S + + T + E+ + SL ++ ++ E+E
Sbjct: 425 DQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEK 484
Query: 194 GRQKAENNSLRLLYENTEKDLSD-TQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQ 252
G + L L EK S T + E +I +D I N R + A+
Sbjct: 485 GALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVD--IAN-KRSSSAE 541
Query: 253 REEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQAS 312
+L T + KE L + + E IA L L ++ K + + + ++
Sbjct: 542 ESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFL--KLQLQGKRAEEADHEVLDQKEMK 599
Query: 313 RQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALS 372
+ E + +M+ L++T + + E L +EQ + Q +
Sbjct: 600 QMEGEGIAPI-----KMKVFLEDTGQDFPLMPNEESSLPAVE---KEQASTEHQSRTSEE 651
Query: 373 KKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQL-------RKANEDAE 425
LND EL K QD + ++ + +I + + E ++ Q+ KA E E
Sbjct: 652 ISLNDAGVELKSTK---QDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYE 708
Query: 426 -NWENKARQSEADNNTLKLELITAEAEGN-----RLKEKVDSLNREVEQHLNAERSYKSQ 479
N + KA+ E N +E A+ N L E+ D L +V++ L+ ++Q
Sbjct: 709 KNLDEKAK--EISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKE-LSMVTELRAQ 765
Query: 480 ISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMR 539
+ L ++ + E + +++ +E +A +L L L+ + +KD +IE+
Sbjct: 766 VKQLEMNLAEAERQ-RRLDYESQTAHDNL---------LTEQIHSLSIEAKSKDVKIEVL 815
Query: 540 ENELDSAHSEIELLRSQMANERISMQNLEALLV--ANRDKEYQSQI-----ALQEKESEI 592
+NELD + + + + + +QN E+ ++ A R + S++ AL +KE EI
Sbjct: 816 QNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEI 875
Query: 593 QLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQ 651
+ + L + + + + + VT++ + QL E+F ++ L+ Q
Sbjct: 876 TKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQ 934
Score = 77.0 bits (188), Expect = 5e-14
Identities = 117/665 (17%), Positives = 272/665 (40%), Gaps = 73/665 (10%)
Query: 36 LKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAH 95
L+ L+ E + E V+ + S+ +++ Q + EIT++ + +++ K T
Sbjct: 836 LQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEK-KRDVETLQQ 894
Query: 96 AILRRVETERDVAFTDLRRMT----------TERDSLRERLKIAQETAFNEKAHLEQRIE 145
I + + +++F+ +M E +L+E+L + +K +E+ E
Sbjct: 895 TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE 954
Query: 146 ELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKA----MDTESELGRQKAENN 201
N D+ + ++ ++KE + RK ++ + L R
Sbjct: 955 VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE 1014
Query: 202 SLRLLYENTEKD--LSDTQR-HLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQRE-EIS 257
L L + ++K+ LS+T+R + + K + +++ + ++I+ + +Q I+++E E+
Sbjct: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
Query: 258 ILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTE 317
+ L + +E QA + + ++ + + + + IS + II ++
Sbjct: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL--------- 1125
Query: 318 ALIVCEQDVSRMRRQLDETNDELAQIARERDILA--------HDNDNLQEQFAKAKQENQ 369
+ D ++ + + +E +++ H L+E+ ++E +
Sbjct: 1126 -----------ITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKE 1174
Query: 370 ALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWEN 429
L KKL + I +K Q+ + L+ LK ++ + ++ EQ + +++ EN +
Sbjct: 1175 QLQKKLQEALTSRKAILKKAQE---KERHLREELKQQKDDYNRLQEQFDEQSKENENIGD 1231
Query: 430 KARQSE---ADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAE----------RSY 476
+ RQ + ++ KL + + + L + EQH S+
Sbjct: 1232 QLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH 1291
Query: 477 KSQISTLH--KSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQ 534
S L SV +++ +L++++ EKV +SST K L Q+ +
Sbjct: 1292 SEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGL 1351
Query: 535 EIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQL 594
EIE + A E L+ ++ + ++ + LE L + K + Q + +KE ++
Sbjct: 1352 EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLREL-QPKLDELQKLISKKEEDVSY 1410
Query: 595 LKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITK-------RQLGTERFERERAVQE 647
L L E + ++ + +++ L L++ +QL E E ++ +E
Sbjct: 1411 LSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEE 1470
Query: 648 LRRQN 652
+ ++
Sbjct: 1471 IGEES 1475
Score = 74.7 bits (182), Expect = 3e-13
Identities = 116/556 (20%), Positives = 231/556 (41%), Gaps = 93/556 (16%)
Query: 110 TDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMK 169
+D+ T ++ ++ERL A++ K + Q+ +L+ L +ER + + +K
Sbjct: 38 SDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLK 97
Query: 170 -------ETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLA 222
+++ +EMK+ + TE + Q +++ +K ++ + +
Sbjct: 98 LHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKH----------DKSSTEEEMEIE 147
Query: 223 KKKYELQLTQEKIMCLDEKIDNFTRQNIAQR----EEISILGGTLNDLAKEKECLQACLD 278
K K++LQ +E I L ++ + AQ EE ++ L + + LQA L
Sbjct: 148 KIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQL- 206
Query: 279 KKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCE--QDVSRMRRQLDET 336
S+ A ++EK + ++ + T+A + E Q + ++R+L+E
Sbjct: 207 --SQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEH 264
Query: 337 NDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEV 396
+ L A+ D+L Q++ A+Q NQ LS Q++Q E
Sbjct: 265 EESLVGRAQVVDLL-------QQELTAAEQRNQILS--------------QQLQQMEAEH 303
Query: 397 NKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLK 456
N L+N +++E E++ ++E+ ++LE+ + + L+
Sbjct: 304 NTLRNTVETEREESKILLEK------------------------MELEVAERKLSFHNLQ 339
Query: 457 EKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSST----R 512
E++ L + EQ A+ +S+ S L + K + E++ EK S + L T +
Sbjct: 340 EEMHHLLEQFEQAGQAQAELESRYSALEQ---KHKAEME----EKTSHILSLQKTGQELQ 392
Query: 513 ELCIKL-DSSKELL---NRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLE 568
C L D + +LL N Q V Q I+ E++L EI SQ N R+ +Q E
Sbjct: 393 SACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEI----SQFLN-RLPLQQHE 447
Query: 569 ALLVANRDKEYQ--SQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEAD 626
+ Y +Q +E + +Q L + + + S ++ + + +L +
Sbjct: 448 TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQ 507
Query: 627 LDITKRQLGTERFERE 642
+ + + Q T +RE
Sbjct: 508 ITLLEAQNRTGEADRE 523
Score = 72.0 bits (175), Expect = 2e-12
Identities = 119/644 (18%), Positives = 245/644 (38%), Gaps = 85/644 (13%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAE-------IQGNVKVLKSERDKIFLLYEQAQEEIT 76
+LL+ + +EL+ K E L E ++ + L+ E+ + E + I+
Sbjct: 2553 QLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSIS 2612
Query: 77 RLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNE 136
+L R++ + HA L+ E E + R++ S ++R+ +E
Sbjct: 2613 QLTRQVTALQEEGTLGLYHAQLKVKEEE-------VHRLSALFSSSQKRIAELEEELVCV 2665
Query: 137 KAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQ 196
+ +++ E+E L E + +M+ T E+ + LAR ++ E +L
Sbjct: 2666 QKEAAKKVGEIE---DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMV 2722
Query: 197 KAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEI 256
EN L ++ + +S Q EL + K +++ Q + RE
Sbjct: 2723 TKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERD 2782
Query: 257 SILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCT 316
++L T + +E + L+K ++ + S E L + N + +A
Sbjct: 2783 ALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQ 2842
Query: 317 EALIVCEQDVSRMRR-----------------QLDETNDELAQIARERDILAHDNDNLQE 359
++ + R+ ++ ++ + +RD L + NLQ+
Sbjct: 2843 NERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQ 2902
Query: 360 QFAKAKQE------NQALSKKLNDTHNELNDIKQKVQDTNL----EVNKLKNILKSEESE 409
Q+ + QE +A ++ D ++++++ NL E+++L+ S E
Sbjct: 2903 QYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIH 2962
Query: 410 NRQMMEQLRKANED-------AENWENKARQSEADNNTLKLEL-------ITAEAEGNR- 454
R+M EQ A D +N + R S + LK++ +A +G++
Sbjct: 2963 ERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQN 3022
Query: 455 LKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTREL 514
L + + L ++ L + +I L+ + ++ EE + + L ++
Sbjct: 3023 LVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQH 3082
Query: 515 CIKLDSSKELLNRQLVAKDQEIEMRENELDSA------------HSEIELLR-------- 554
L + +L +Q+ QE++ +D A S+ E LR
Sbjct: 3083 YGDLLNHCAVLEKQV----QELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSE 3138
Query: 555 --SQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLK 596
Q+ N R + L LL RD+ ++ AL E +I+ L+
Sbjct: 3139 AQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLE 3182
Score = 71.2 bits (173), Expect = 3e-12
Identities = 129/632 (20%), Positives = 254/632 (40%), Gaps = 103/632 (16%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM 83
+L + T + LK EK ERHL E LK ++D Y + QE+ +E
Sbjct: 1179 KLQEALTSRKAILKKAQEK-ERHLRE------ELKQQKDD----YNRLQEQFDEQSKENE 1227
Query: 84 KSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQR 143
+ R + + TD + + L E L A E+ H +
Sbjct: 1228 NIGDQLRQLQIQV---RESIDGKLPSTDQQESCSSTPGLEEPLFKA-----TEQHHTQPV 1279
Query: 144 IEELECT---VHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAEN 200
+E C H+ D ++ +++ +K + +E E L K T SEL ++ E
Sbjct: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEV 1339
Query: 201 NSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILG 260
L Q + K+ E++ K + + ++ + Q + ++ I G
Sbjct: 1340 FQL--------------QEQINKQGLEIESL--KTVSHEAEVHAESLQQKLESSQLQIAG 1383
Query: 261 -GTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAE-----------M 308
L +L + + LQ + KK E+++ L L+ KE ++ ++ I E +
Sbjct: 1384 LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQL 1443
Query: 309 EQASRQCTEALIVCEQDVSRMRRQLDETNDE---LAQIARE-------RDILAHDNDNLQ 358
E +++ E + + ++ M+++ +E +E QI R+ R +N +LQ
Sbjct: 1444 EMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQ 1503
Query: 359 EQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLR 418
E+ + A+ + L+K L D ++++ + K +DT L + +E ++ + E
Sbjct: 1504 EELSLARGTIERLTKSLADVESQVS-AQNKEKDT-----VLGRLALLQEERDKLITEM-- 1555
Query: 419 KANEDAENWENKARQSEADNNTLKLELITAE----------------AEGNRLKEKVDSL 462
D EN++ S ++ L LE +T + AE +EK L
Sbjct: 1556 ----DRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKEL 1611
Query: 463 NREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSST----RELCIKL 518
+E E L + + ++ + V + +E Q++ + S A+ T +E ++
Sbjct: 1612 QKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEM 1671
Query: 519 DSSKELLNRQLVAKDQEIEMRENELDSAHSEI--------ELLRSQMANERISMQNLEAL 570
+ KE + + +K Q+I E E D +E+ E + + +++ + LE +
Sbjct: 1672 EEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERV 1731
Query: 571 LVANRDKEYQSQIALQEKES---EIQLLKEHL 599
+ + Q + EK+S E+Q LK +
Sbjct: 1732 KMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 112 bits (280), Expect = 1e-24
Identities = 151/720 (20%), Positives = 295/720 (40%), Gaps = 123/720 (17%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM 83
EL KT R ++ + E ++H +++ +L+ + LY +A+E RL +
Sbjct: 860 ELQKTKERQQKAENELKELEQKH-SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK-- 916
Query: 84 KSCKSPKSTTAHAILRRVETERDVA-------------FTDLRRMTTERDSLRERLKIAQ 130
K H + R+E E D DL E ++ R++L++ +
Sbjct: 917 ---KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 973
Query: 131 ETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTV-------EKEMKSLA 183
TA E +I++LE + +DD+ + L++E IS + E++ K+L
Sbjct: 974 VTA-------EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 184 R-----KAMDTESELGRQKAENN--SLRLLYENTEKDLSD-------TQRHLAKKKYELQ 229
+ ++M +E E+ +K E + L L E D SD Q +A+ K +L
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086
Query: 230 LTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGE 289
+E++ ++D+ Q ++I L G ++DL ++ + +A +K + LGE
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 290 SL---------------------AMKEKTISGMKNI-----------IAEMEQASRQCTE 317
L A +E+ ++ +K + EM Q Q E
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206
Query: 318 ALIVCEQDVSRMRRQLDETNDEL----AQIARERDILAHDNDNLQEQFAKAKQENQALSK 373
L + R + LD+ L A +A E +L ++ + K + + Q L
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266
Query: 374 KLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEE--------------SENRQMMEQLRK 419
K +D ++ KV EV + +L E S+ + E L++
Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE 1326
Query: 420 ANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQ 479
N K RQ E + N+L+ +L L+ + +LN ++ + + S
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386
Query: 480 ISTLHKSVVKMEEELQKV--QFEKVSALAD-LSSTR--------ELCIKLDSSKELLNRQ 528
+ L + + ++E++ + Q+E+ +A D L T+ +L + LD+ ++L++
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS-- 1444
Query: 529 LVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEK 588
+E ++ + D +E + + S+ A+ER EA R+KE ++ ++L
Sbjct: 1445 ------NLEKKQRKFDQLLAEEKNISSKYADER-DRAEAEA-----REKETKA-LSLARA 1491
Query: 589 ESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQEL 648
E KE L + + D+ ++ V + +L+ +KR L T+ E + ++EL
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Score = 100 bits (249), Expect = 5e-21
Identities = 140/664 (21%), Positives = 286/664 (43%), Gaps = 49/664 (7%)
Query: 34 EELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTT 93
+EL+ ER AE+ V L++E + + + +A+ + +L +++ S S T
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA-SLSSQLQDT 1320
Query: 94 AHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHN 153
+ + +V+ T LR++ ER+SL+++L E K +LE+ I L + +
Sbjct: 1321 QELLQEETRQKLNVS-TKLRQLEEERNSLQDQLDEEMEA----KQNLERHISTLNIQLSD 1375
Query: 154 LDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKD 213
+ + S + ++E +KE+++L ++ + + + + N L+ ++ D
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 214 LSDTQRHLA------KKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILG------- 260
L D QR L ++K++ L +EK + + + A+ +E L
Sbjct: 1436 L-DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 261 ---------GTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQA 311
T L E E L + D +N+ L +S E + MK + E+E
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 312 SRQCTEALIVCEQDVSRMRRQL-------DETNDELA-QIARERDILAHDNDNLQEQFAK 363
+ +A + E ++ ++ Q DE N+E Q+ R+ + ++ ++Q A
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 364 AKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANED 423
A + L L D + + + ++ ++ KL+ +K + E +
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 424 AENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTL 483
A+ E KA+ EAD L+ +L AE + + + L E+ L+ + + + L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 484 HKSVVKMEEELQKVQFEKVSALAD-----LSSTRELCIKLDSSKELLNRQLVAKDQEIEM 538
+ ++EEEL++ Q + A++D +L +L + + + A+ Q++E
Sbjct: 1735 EARIAQLEEELEEEQ-GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR-QQLER 1792
Query: 539 RENELDSAHSEIE-LLRSQMANERISMQNLEALLVANRDKE-YQSQIALQEKESEIQLLK 596
+ EL S E+E ++S+ + +++ A L ++E + Q A + + + + LK
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852
Query: 597 EHLCLAEN--KMAIQSRDVAQFRNV-VTQLEADLDITKRQLGTERFERERAVQELRRQNY 653
E L E+ KMA Q ++ A+ N V QL+ L+ + + R + +EL
Sbjct: 1853 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1912
Query: 654 SSNA 657
S+ A
Sbjct: 1913 SNEA 1916
Score = 72.0 bits (175), Expect = 2e-12
Identities = 80/360 (22%), Positives = 162/360 (45%), Gaps = 39/360 (10%)
Query: 305 IAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKA 364
+ E+ + + L ++ + +L E + +Q+ E+++L E +A+A
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 365 KQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDA 424
++ L+ K + L++++ + L+ EE +Q+ + +K +
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEAR--------------LEEEEDRGQQLQAERKKMAQQM 952
Query: 425 ENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLH 484
+ E + + EA L+LE +TAEA+ +L++++ ++ + + + + +IS L
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1012
Query: 485 KSVVKMEEE---LQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMREN 541
++ + EE+ L K++ + S +++L + K E L R+L E
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL----------EG 1062
Query: 542 ELDSAHSEIELLRSQMANERISM----QNLEALLVANRDKEYQSQIAL---QEKESEIQL 594
+ H +I L++Q+A ++ + + L+A L D+ Q AL +E E I
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 595 LKEHL---CLAENKMAIQSRDVA-QFRNVVTQLEADLDITKRQLGTERFERERAVQELRR 650
L+E L A NK Q RD+ + + T+LE LD T Q R +RE+ V L++
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL-RAKREQEVTVLKK 1181
Score = 70.5 bits (171), Expect = 5e-12
Identities = 100/463 (21%), Positives = 202/463 (43%), Gaps = 61/463 (13%)
Query: 219 RHLAKKKYELQLT--QEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQAC 276
R K K LQ+T +E++ ++++ + E+ L + L +EK LQ
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 277 LDKKSENIASLGESLAMKEKTISGMKNIIAEME-------------QASRQCTEALIVC- 322
L ++E A E ++ I+ EME QA R+ ++
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 323 -----EQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLND 377
E++ +R + QL++ E E +IL D+ N K +E + L ++++D
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN-----NKLSKERKLLEERISD 1010
Query: 378 THNELNDIKQKVQD-TNLE------VNKLKNILKSEESENRQMMEQLRKANEDAENWENK 430
L + ++K ++ T L+ +++L+ LK EE +++ + RK DA ++ +
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 431 ARQSEADNNTLKLELITAEAEGN----RLKEKVDSLN------REVEQH-------LNAE 473
+A LK++L E E RL +++ N RE+E H L++E
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 474 RSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKD 533
R+ +++ K + EEL+ ++ E L ++ +EL K + +L + L +
Sbjct: 1131 RAARNK---AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 534 QEIEMRENELDSAHSE-IELLRSQMANERISMQNL----EALLVANRDKEYQSQI---AL 585
+ E + E+ H++ +E L Q+ + + NL + L N D + ++ A
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 586 QEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLD 628
QE E + + L+ + ++K + R A+ + V +L+ +++
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Score = 67.8 bits (164), Expect = 3e-11
Identities = 107/556 (19%), Positives = 225/556 (40%), Gaps = 62/556 (11%)
Query: 31 RDREELKCMLEKYERHLA---EIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCK 87
R ++E++ + ++YE A +++ L+ E D + + + ++ ++ L ++ K
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF-- 1453
Query: 88 SPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEEL 147
I + ERD A + R T+ SL L E A K LE+ + L
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL----EEALEAKEELERTNKML 1509
Query: 148 ECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRL-- 205
+ + +L + + N+ ++++ +E +M+ + + + E EL Q E+ LRL
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL--QATEDAKLRLEV 1567
Query: 206 ----LYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGG 261
L E+DL +K+ +LQ ++ + ++++ +Q L G
Sbjct: 1568 NMQALKGQFERDLQARDEQNEEKRRQLQ---RQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 262 TLNDLAKEKECLQACLDKKSENIASLGESLAMK-------EKTISGMKNIIA---EMEQA 311
L DL + + + + + E I L + A E + I A E E+
Sbjct: 1625 DLKDLELQAD---SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681
Query: 312 SRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQAL 371
++ L+ ++D++ R + + E ++A E + LQ++ + + L
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 372 SKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEES---ENRQMMEQLRKANEDAENWE 428
++L + + + +V+ + +L N L +E S +N +QL + N++ +
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-- 1799
Query: 429 NKARQSE-ADNNTLKLELITAEAEGNRLKEKVDSLNRE---------------------V 466
K + E A + K + EA+ +L+E+V+ RE V
Sbjct: 1800 -KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1858
Query: 467 EQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLN 526
E YK Q + V +++ +L++ + E A+ + + S E +
Sbjct: 1859 EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1918
Query: 527 RQLVAKDQEIEMRENE 542
R++ A ++ R NE
Sbjct: 1919 REVNALKSKLR-RGNE 1933
Score = 64.7 bits (156), Expect = 3e-10
Identities = 87/426 (20%), Positives = 166/426 (38%), Gaps = 38/426 (8%)
Query: 252 QREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQA 311
Q EE+ L + ++ + L + + + L E + ++ + + AE E+
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 312 SRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQAL 371
+ E+ + M +L+E D Q+ ER +A +L+EQ + + Q L
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 372 SKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKA 431
+ ++ ++ ++ + + NKL K E + L + E A+N
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 432 RQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKME 491
+ E+ + L++ L E L++ L + ++QI+ L + K E
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 492 EELQKV-------------QFEKVSAL--------ADLSSTRELCIKLDSSKELLNRQLV 530
EELQ +K+ L DL S R K + K L +L
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 531 AKDQEIEMRENELDSAHSEIELLRSQMANERISMQNL-------EALLVANRDKEYQSQI 583
A E+ E+ LDS ++ EL + + + L EA + R K Q+
Sbjct: 1150 ALKTEL---EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206
Query: 584 ALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERER 643
L E+ + + K +L + + ++ D+A V+ Q + +++ K++L E
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL-------EA 1259
Query: 644 AVQELR 649
VQEL+
Sbjct: 1260 QVQELQ 1265
Score = 61.6 bits (148), Expect = 2e-09
Identities = 80/405 (19%), Positives = 162/405 (40%), Gaps = 74/405 (18%)
Query: 22 DVEL-LKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRR 80
D+EL + + REE L K + + + Q ++ ++ RD+IF ++ +++ L
Sbjct: 1628 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1687
Query: 81 EMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHL 140
++M+ + A ++ + E++ +L + R++L++ EK L
Sbjct: 1688 DLMQLQED--LAAAERARKQADLEKEELAEELASSLSGRNALQD-----------EKRRL 1734
Query: 141 EQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAEN 200
E RI +LE +E E+ NM M + + RKA +L + A
Sbjct: 1735 EARIAQLE-------EELEEEQGNMEAMSDRV-----------RKATQQAEQLSNELATE 1776
Query: 201 NSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILG 260
S E+ + L + L K +E++ + F A +I+ L
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKS---------KFKSTIAALEAKIAQLE 1827
Query: 261 GTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALI 320
+ A+EK+ +SL K+K + + + + + + Q E
Sbjct: 1828 EQVEQEAREKQAAT--------------KSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1873
Query: 321 VCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHN 380
V +++RQL+E +E +I R LQ + +A + N+A+ +
Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINANR-------RKLQRELDEATESNEAMGR------- 1919
Query: 381 ELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAE 425
E+N +K K++ N + + S S R+++E + E+ +
Sbjct: 1920 EVNALKSKLRRGN-----ETSFVPSRRSGGRRVIENADGSEEETD 1959
Score = 38.5 bits (88), Expect = 0.021
Identities = 43/194 (22%), Positives = 82/194 (42%), Gaps = 15/194 (7%)
Query: 479 QISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQ---E 535
Q++ + + E+ELQK + + A +L + +L K LL QL A+ + E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 536 IEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLL 595
E L + E+E + +M ++ L A R K Q + L+E+ E +
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 596 KEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSS 655
++ L L K+ +++ + +LE ++ + Q + +ER + E R + ++
Sbjct: 966 RQKLQL--EKVTAEAK--------IKKLEDEILVMDDQ--NNKLSKERKLLEERISDLTT 1013
Query: 656 NAYHMSSTMKPNTK 669
N K TK
Sbjct: 1014 NLAEEEEKAKNLTK 1027
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 112 bits (280), Expect = 1e-24
Identities = 151/720 (20%), Positives = 295/720 (40%), Gaps = 123/720 (17%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM 83
EL KT R ++ + E ++H +++ +L+ + LY +A+E RL +
Sbjct: 867 ELQKTKERQQKAENELKELEQKH-SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK-- 923
Query: 84 KSCKSPKSTTAHAILRRVETERDVA-------------FTDLRRMTTERDSLRERLKIAQ 130
K H + R+E E D DL E ++ R++L++ +
Sbjct: 924 ---KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 980
Query: 131 ETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTV-------EKEMKSLA 183
TA E +I++LE + +DD+ + L++E IS + E++ K+L
Sbjct: 981 VTA-------EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 184 R-----KAMDTESELGRQKAENN--SLRLLYENTEKDLSD-------TQRHLAKKKYELQ 229
+ ++M +E E+ +K E + L L E D SD Q +A+ K +L
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093
Query: 230 LTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGE 289
+E++ ++D+ Q ++I L G ++DL ++ + +A +K + LGE
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 290 SL---------------------AMKEKTISGMKNI-----------IAEMEQASRQCTE 317
L A +E+ ++ +K + EM Q Q E
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213
Query: 318 ALIVCEQDVSRMRRQLDETNDEL----AQIARERDILAHDNDNLQEQFAKAKQENQALSK 373
L + R + LD+ L A +A E +L ++ + K + + Q L
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273
Query: 374 KLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEE--------------SENRQMMEQLRK 419
K +D ++ KV EV + +L E S+ + E L++
Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE 1333
Query: 420 ANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQ 479
N K RQ E + N+L+ +L L+ + +LN ++ + + S
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393
Query: 480 ISTLHKSVVKMEEELQKV--QFEKVSALAD-LSSTR--------ELCIKLDSSKELLNRQ 528
+ L + + ++E++ + Q+E+ +A D L T+ +L + LD+ ++L++
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS-- 1451
Query: 529 LVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEK 588
+E ++ + D +E + + S+ A+ER EA R+KE ++ ++L
Sbjct: 1452 ------NLEKKQRKFDQLLAEEKNISSKYADER-DRAEAEA-----REKETKA-LSLARA 1498
Query: 589 ESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQEL 648
E KE L + + D+ ++ V + +L+ +KR L T+ E + ++EL
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Score = 100 bits (249), Expect = 5e-21
Identities = 140/664 (21%), Positives = 286/664 (43%), Gaps = 49/664 (7%)
Query: 34 EELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTT 93
+EL+ ER AE+ V L++E + + + +A+ + +L +++ S S T
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA-SLSSQLQDT 1327
Query: 94 AHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHN 153
+ + +V+ T LR++ ER+SL+++L E K +LE+ I L + +
Sbjct: 1328 QELLQEETRQKLNVS-TKLRQLEEERNSLQDQLDEEMEA----KQNLERHISTLNIQLSD 1382
Query: 154 LDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKD 213
+ + S + ++E +KE+++L ++ + + + + N L+ ++ D
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 214 LSDTQRHLA------KKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILG------- 260
L D QR L ++K++ L +EK + + + A+ +E L
Sbjct: 1443 L-DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 261 ---------GTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQA 311
T L E E L + D +N+ L +S E + MK + E+E
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 312 SRQCTEALIVCEQDVSRMRRQL-------DETNDELA-QIARERDILAHDNDNLQEQFAK 363
+ +A + E ++ ++ Q DE N+E Q+ R+ + ++ ++Q A
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 364 AKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANED 423
A + L L D + + + ++ ++ KL+ +K + E +
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 424 AENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTL 483
A+ E KA+ EAD L+ +L AE + + + L E+ L+ + + + L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 484 HKSVVKMEEELQKVQFEKVSALAD-----LSSTRELCIKLDSSKELLNRQLVAKDQEIEM 538
+ ++EEEL++ Q + A++D +L +L + + + A+ Q++E
Sbjct: 1742 EARIAQLEEELEEEQ-GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR-QQLER 1799
Query: 539 RENELDSAHSEIE-LLRSQMANERISMQNLEALLVANRDKE-YQSQIALQEKESEIQLLK 596
+ EL S E+E ++S+ + +++ A L ++E + Q A + + + + LK
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859
Query: 597 EHLCLAEN--KMAIQSRDVAQFRNV-VTQLEADLDITKRQLGTERFERERAVQELRRQNY 653
E L E+ KMA Q ++ A+ N V QL+ L+ + + R + +EL
Sbjct: 1860 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1919
Query: 654 SSNA 657
S+ A
Sbjct: 1920 SNEA 1923
Score = 72.0 bits (175), Expect = 2e-12
Identities = 80/360 (22%), Positives = 162/360 (45%), Gaps = 39/360 (10%)
Query: 305 IAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKA 364
+ E+ + + L ++ + +L E + +Q+ E+++L E +A+A
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 365 KQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDA 424
++ L+ K + L++++ + L+ EE +Q+ + +K +
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEAR--------------LEEEEDRGQQLQAERKKMAQQM 959
Query: 425 ENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLH 484
+ E + + EA L+LE +TAEA+ +L++++ ++ + + + + +IS L
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1019
Query: 485 KSVVKMEEE---LQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMREN 541
++ + EE+ L K++ + S +++L + K E L R+L E
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL----------EG 1069
Query: 542 ELDSAHSEIELLRSQMANERISM----QNLEALLVANRDKEYQSQIAL---QEKESEIQL 594
+ H +I L++Q+A ++ + + L+A L D+ Q AL +E E I
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 595 LKEHL---CLAENKMAIQSRDVA-QFRNVVTQLEADLDITKRQLGTERFERERAVQELRR 650
L+E L A NK Q RD+ + + T+LE LD T Q R +RE+ V L++
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL-RAKREQEVTVLKK 1188
Score = 70.5 bits (171), Expect = 5e-12
Identities = 100/463 (21%), Positives = 202/463 (43%), Gaps = 61/463 (13%)
Query: 219 RHLAKKKYELQLT--QEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQAC 276
R K K LQ+T +E++ ++++ + E+ L + L +EK LQ
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 277 LDKKSENIASLGESLAMKEKTISGMKNIIAEME-------------QASRQCTEALIVC- 322
L ++E A E ++ I+ EME QA R+ ++
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 323 -----EQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLND 377
E++ +R + QL++ E E +IL D+ N K +E + L ++++D
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN-----NKLSKERKLLEERISD 1017
Query: 378 THNELNDIKQKVQD-TNLE------VNKLKNILKSEESENRQMMEQLRKANEDAENWENK 430
L + ++K ++ T L+ +++L+ LK EE +++ + RK DA ++ +
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 431 ARQSEADNNTLKLELITAEAEGN----RLKEKVDSLN------REVEQH-------LNAE 473
+A LK++L E E RL +++ N RE+E H L++E
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 474 RSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKD 533
R+ +++ K + EEL+ ++ E L ++ +EL K + +L + L +
Sbjct: 1138 RAARNK---AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 534 QEIEMRENELDSAHSE-IELLRSQMANERISMQNL----EALLVANRDKEYQSQI---AL 585
+ E + E+ H++ +E L Q+ + + NL + L N D + ++ A
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 586 QEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLD 628
QE E + + L+ + ++K + R A+ + V +L+ +++
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Score = 67.8 bits (164), Expect = 3e-11
Identities = 107/556 (19%), Positives = 225/556 (40%), Gaps = 62/556 (11%)
Query: 31 RDREELKCMLEKYERHLA---EIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCK 87
R ++E++ + ++YE A +++ L+ E D + + + ++ ++ L ++ K
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF-- 1460
Query: 88 SPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEEL 147
I + ERD A + R T+ SL L E A K LE+ + L
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL----EEALEAKEELERTNKML 1516
Query: 148 ECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRL-- 205
+ + +L + + N+ ++++ +E +M+ + + + E EL Q E+ LRL
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL--QATEDAKLRLEV 1574
Query: 206 ----LYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGG 261
L E+DL +K+ +LQ ++ + ++++ +Q L G
Sbjct: 1575 NMQALKGQFERDLQARDEQNEEKRRQLQ---RQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 262 TLNDLAKEKECLQACLDKKSENIASLGESLAMK-------EKTISGMKNIIA---EMEQA 311
L DL + + + + + E I L + A E + I A E E+
Sbjct: 1632 DLKDLELQAD---SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688
Query: 312 SRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQAL 371
++ L+ ++D++ R + + E ++A E + LQ++ + + L
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 372 SKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEES---ENRQMMEQLRKANEDAENWE 428
++L + + + +V+ + +L N L +E S +N +QL + N++ +
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-- 1806
Query: 429 NKARQSE-ADNNTLKLELITAEAEGNRLKEKVDSLNRE---------------------V 466
K + E A + K + EA+ +L+E+V+ RE V
Sbjct: 1807 -KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1865
Query: 467 EQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLN 526
E YK Q + V +++ +L++ + E A+ + + S E +
Sbjct: 1866 EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1925
Query: 527 RQLVAKDQEIEMRENE 542
R++ A ++ R NE
Sbjct: 1926 REVNALKSKLR-RGNE 1940
Score = 64.7 bits (156), Expect = 3e-10
Identities = 87/426 (20%), Positives = 166/426 (38%), Gaps = 38/426 (8%)
Query: 252 QREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQA 311
Q EE+ L + ++ + L + + + L E + ++ + + AE E+
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 312 SRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQAL 371
+ E+ + M +L+E D Q+ ER +A +L+EQ + + Q L
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 372 SKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKA 431
+ ++ ++ ++ + + NKL K E + L + E A+N
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 432 RQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKME 491
+ E+ + L++ L E L++ L + ++QI+ L + K E
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 492 EELQKV-------------QFEKVSAL--------ADLSSTRELCIKLDSSKELLNRQLV 530
EELQ +K+ L DL S R K + K L +L
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 531 AKDQEIEMRENELDSAHSEIELLRSQMANERISMQNL-------EALLVANRDKEYQSQI 583
A E+ E+ LDS ++ EL + + + L EA + R K Q+
Sbjct: 1157 ALKTEL---EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213
Query: 584 ALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERER 643
L E+ + + K +L + + ++ D+A V+ Q + +++ K++L E
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL-------EA 1266
Query: 644 AVQELR 649
VQEL+
Sbjct: 1267 QVQELQ 1272
Score = 61.6 bits (148), Expect = 2e-09
Identities = 80/405 (19%), Positives = 162/405 (40%), Gaps = 74/405 (18%)
Query: 22 DVEL-LKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRR 80
D+EL + + REE L K + + + Q ++ ++ RD+IF ++ +++ L
Sbjct: 1635 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1694
Query: 81 EMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHL 140
++M+ + A ++ + E++ +L + R++L++ EK L
Sbjct: 1695 DLMQLQED--LAAAERARKQADLEKEELAEELASSLSGRNALQD-----------EKRRL 1741
Query: 141 EQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAEN 200
E RI +LE +E E+ NM M + + RKA +L + A
Sbjct: 1742 EARIAQLE-------EELEEEQGNMEAMSDRV-----------RKATQQAEQLSNELATE 1783
Query: 201 NSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILG 260
S E+ + L + L K +E++ + F A +I+ L
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKS---------KFKSTIAALEAKIAQLE 1834
Query: 261 GTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALI 320
+ A+EK+ +SL K+K + + + + + + Q E
Sbjct: 1835 EQVEQEAREKQAAT--------------KSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880
Query: 321 VCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHN 380
V +++RQL+E +E +I R LQ + +A + N+A+ +
Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINANR-------RKLQRELDEATESNEAMGR------- 1926
Query: 381 ELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAE 425
E+N +K K++ N + + S S R+++E + E+ +
Sbjct: 1927 EVNALKSKLRRGN-----ETSFVPSRRSGGRRVIENADGSEEETD 1966
Score = 38.5 bits (88), Expect = 0.021
Identities = 43/194 (22%), Positives = 82/194 (42%), Gaps = 15/194 (7%)
Query: 479 QISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQ---E 535
Q++ + + E+ELQK + + A +L + +L K LL QL A+ + E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 536 IEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLL 595
E L + E+E + +M ++ L A R K Q + L+E+ E +
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 596 KEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSS 655
++ L L K+ +++ + +LE ++ + Q + +ER + E R + ++
Sbjct: 973 RQKLQL--EKVTAEAK--------IKKLEDEILVMDDQ--NNKLSKERKLLEERISDLTT 1020
Query: 656 NAYHMSSTMKPNTK 669
N K TK
Sbjct: 1021 NLAEEEEKAKNLTK 1034
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 112 bits (280), Expect = 1e-24
Identities = 151/720 (20%), Positives = 295/720 (40%), Gaps = 123/720 (17%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM 83
EL KT R ++ + E ++H +++ +L+ + LY +A+E RL +
Sbjct: 867 ELQKTKERQQKAENELKELEQKH-SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK-- 923
Query: 84 KSCKSPKSTTAHAILRRVETERDVA-------------FTDLRRMTTERDSLRERLKIAQ 130
K H + R+E E D DL E ++ R++L++ +
Sbjct: 924 ---KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 980
Query: 131 ETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTV-------EKEMKSLA 183
TA E +I++LE + +DD+ + L++E IS + E++ K+L
Sbjct: 981 VTA-------EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 184 R-----KAMDTESELGRQKAENN--SLRLLYENTEKDLSD-------TQRHLAKKKYELQ 229
+ ++M +E E+ +K E + L L E D SD Q +A+ K +L
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093
Query: 230 LTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGE 289
+E++ ++D+ Q ++I L G ++DL ++ + +A +K + LGE
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 290 SL---------------------AMKEKTISGMKNI-----------IAEMEQASRQCTE 317
L A +E+ ++ +K + EM Q Q E
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213
Query: 318 ALIVCEQDVSRMRRQLDETNDEL----AQIARERDILAHDNDNLQEQFAKAKQENQALSK 373
L + R + LD+ L A +A E +L ++ + K + + Q L
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273
Query: 374 KLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEE--------------SENRQMMEQLRK 419
K +D ++ KV EV + +L E S+ + E L++
Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE 1333
Query: 420 ANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQ 479
N K RQ E + N+L+ +L L+ + +LN ++ + + S
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393
Query: 480 ISTLHKSVVKMEEELQKV--QFEKVSALAD-LSSTR--------ELCIKLDSSKELLNRQ 528
+ L + + ++E++ + Q+E+ +A D L T+ +L + LD+ ++L++
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS-- 1451
Query: 529 LVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEK 588
+E ++ + D +E + + S+ A+ER EA R+KE ++ ++L
Sbjct: 1452 ------NLEKKQRKFDQLLAEEKNISSKYADER-DRAEAEA-----REKETKA-LSLARA 1498
Query: 589 ESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQEL 648
E KE L + + D+ ++ V + +L+ +KR L T+ E + ++EL
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Score = 100 bits (249), Expect = 5e-21
Identities = 140/664 (21%), Positives = 286/664 (43%), Gaps = 49/664 (7%)
Query: 34 EELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTT 93
+EL+ ER AE+ V L++E + + + +A+ + +L +++ S S T
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA-SLSSQLQDT 1327
Query: 94 AHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHN 153
+ + +V+ T LR++ ER+SL+++L E K +LE+ I L + +
Sbjct: 1328 QELLQEETRQKLNVS-TKLRQLEEERNSLQDQLDEEMEA----KQNLERHISTLNIQLSD 1382
Query: 154 LDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKD 213
+ + S + ++E +KE+++L ++ + + + + N L+ ++ D
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 214 LSDTQRHLA------KKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILG------- 260
L D QR L ++K++ L +EK + + + A+ +E L
Sbjct: 1443 L-DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 261 ---------GTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQA 311
T L E E L + D +N+ L +S E + MK + E+E
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 312 SRQCTEALIVCEQDVSRMRRQL-------DETNDELA-QIARERDILAHDNDNLQEQFAK 363
+ +A + E ++ ++ Q DE N+E Q+ R+ + ++ ++Q A
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 364 AKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANED 423
A + L L D + + + ++ ++ KL+ +K + E +
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 424 AENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTL 483
A+ E KA+ EAD L+ +L AE + + + L E+ L+ + + + L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 484 HKSVVKMEEELQKVQFEKVSALAD-----LSSTRELCIKLDSSKELLNRQLVAKDQEIEM 538
+ ++EEEL++ Q + A++D +L +L + + + A+ Q++E
Sbjct: 1742 EARIAQLEEELEEEQ-GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR-QQLER 1799
Query: 539 RENELDSAHSEIE-LLRSQMANERISMQNLEALLVANRDKE-YQSQIALQEKESEIQLLK 596
+ EL S E+E ++S+ + +++ A L ++E + Q A + + + + LK
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859
Query: 597 EHLCLAEN--KMAIQSRDVAQFRNV-VTQLEADLDITKRQLGTERFERERAVQELRRQNY 653
E L E+ KMA Q ++ A+ N V QL+ L+ + + R + +EL
Sbjct: 1860 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1919
Query: 654 SSNA 657
S+ A
Sbjct: 1920 SNEA 1923
Score = 72.0 bits (175), Expect = 2e-12
Identities = 80/360 (22%), Positives = 162/360 (45%), Gaps = 39/360 (10%)
Query: 305 IAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKA 364
+ E+ + + L ++ + +L E + +Q+ E+++L E +A+A
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 365 KQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDA 424
++ L+ K + L++++ + L+ EE +Q+ + +K +
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEAR--------------LEEEEDRGQQLQAERKKMAQQM 959
Query: 425 ENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLH 484
+ E + + EA L+LE +TAEA+ +L++++ ++ + + + + +IS L
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1019
Query: 485 KSVVKMEEE---LQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMREN 541
++ + EE+ L K++ + S +++L + K E L R+L E
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL----------EG 1069
Query: 542 ELDSAHSEIELLRSQMANERISM----QNLEALLVANRDKEYQSQIAL---QEKESEIQL 594
+ H +I L++Q+A ++ + + L+A L D+ Q AL +E E I
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 595 LKEHL---CLAENKMAIQSRDVA-QFRNVVTQLEADLDITKRQLGTERFERERAVQELRR 650
L+E L A NK Q RD+ + + T+LE LD T Q R +RE+ V L++
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL-RAKREQEVTVLKK 1188
Score = 70.5 bits (171), Expect = 5e-12
Identities = 100/463 (21%), Positives = 202/463 (43%), Gaps = 61/463 (13%)
Query: 219 RHLAKKKYELQLT--QEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQAC 276
R K K LQ+T +E++ ++++ + E+ L + L +EK LQ
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 277 LDKKSENIASLGESLAMKEKTISGMKNIIAEME-------------QASRQCTEALIVC- 322
L ++E A E ++ I+ EME QA R+ ++
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 323 -----EQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLND 377
E++ +R + QL++ E E +IL D+ N K +E + L ++++D
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN-----NKLSKERKLLEERISD 1017
Query: 378 THNELNDIKQKVQD-TNLE------VNKLKNILKSEESENRQMMEQLRKANEDAENWENK 430
L + ++K ++ T L+ +++L+ LK EE +++ + RK DA ++ +
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 431 ARQSEADNNTLKLELITAEAEGN----RLKEKVDSLN------REVEQH-------LNAE 473
+A LK++L E E RL +++ N RE+E H L++E
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 474 RSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKD 533
R+ +++ K + EEL+ ++ E L ++ +EL K + +L + L +
Sbjct: 1138 RAARNK---AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 534 QEIEMRENELDSAHSE-IELLRSQMANERISMQNL----EALLVANRDKEYQSQI---AL 585
+ E + E+ H++ +E L Q+ + + NL + L N D + ++ A
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 586 QEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLD 628
QE E + + L+ + ++K + R A+ + V +L+ +++
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Score = 67.0 bits (162), Expect = 6e-11
Identities = 104/545 (19%), Positives = 220/545 (40%), Gaps = 61/545 (11%)
Query: 31 RDREELKCMLEKYERHLA---EIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCK 87
R ++E++ + ++YE A +++ L+ E D + + + ++ ++ L ++ K
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF-- 1460
Query: 88 SPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEEL 147
I + ERD A + R T+ SL L E A K LE+ + L
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL----EEALEAKEELERTNKML 1516
Query: 148 ECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRL-- 205
+ + +L + + N+ ++++ +E +M+ + + + E EL Q E+ LRL
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL--QATEDAKLRLEV 1574
Query: 206 ----LYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGG 261
L E+DL +K+ +LQ ++ + ++++ +Q L G
Sbjct: 1575 NMQALKGQFERDLQARDEQNEEKRRQLQ---RQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 262 TLNDLAKEKECLQACLDKKSENIASLGESLAMK-------EKTISGMKNIIA---EMEQA 311
L DL + + + + + E I L + A E + I A E E+
Sbjct: 1632 DLKDLELQAD---SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688
Query: 312 SRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQAL 371
++ L+ ++D++ R + + E ++A E + LQ++ + + L
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 372 SKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEES---ENRQMMEQLRKANEDAENWE 428
++L + + + +V+ + +L N L +E S +N +QL + N++ +
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-- 1806
Query: 429 NKARQSE-ADNNTLKLELITAEAEGNRLKEKVDSLNRE---------------------V 466
K + E A + K + EA+ +L+E+V+ RE V
Sbjct: 1807 -KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1865
Query: 467 EQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLN 526
E YK Q + V +++ +L++ + E A+ + + S E +
Sbjct: 1866 EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1925
Query: 527 RQLVA 531
R++ A
Sbjct: 1926 REVNA 1930
Score = 64.7 bits (156), Expect = 3e-10
Identities = 87/426 (20%), Positives = 166/426 (38%), Gaps = 38/426 (8%)
Query: 252 QREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQA 311
Q EE+ L + ++ + L + + + L E + ++ + + AE E+
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 312 SRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQAL 371
+ E+ + M +L+E D Q+ ER +A +L+EQ + + Q L
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 372 SKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKA 431
+ ++ ++ ++ + + NKL K E + L + E A+N
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 432 RQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKME 491
+ E+ + L++ L E L++ L + ++QI+ L + K E
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 492 EELQKV-------------QFEKVSAL--------ADLSSTRELCIKLDSSKELLNRQLV 530
EELQ +K+ L DL S R K + K L +L
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 531 AKDQEIEMRENELDSAHSEIELLRSQMANERISMQNL-------EALLVANRDKEYQSQI 583
A E+ E+ LDS ++ EL + + + L EA + R K Q+
Sbjct: 1157 ALKTEL---EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213
Query: 584 ALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERER 643
L E+ + + K +L + + ++ D+A V+ Q + +++ K++L E
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL-------EA 1266
Query: 644 AVQELR 649
VQEL+
Sbjct: 1267 QVQELQ 1272
Score = 60.5 bits (145), Expect = 5e-09
Identities = 72/362 (19%), Positives = 146/362 (40%), Gaps = 62/362 (17%)
Query: 22 DVEL-LKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRR 80
D+EL + + REE L K + + + Q ++ ++ RD+IF ++ +++ L
Sbjct: 1635 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1694
Query: 81 EMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHL 140
++M+ + A ++ + E++ +L + R++L++ EK L
Sbjct: 1695 DLMQLQED--LAAAERARKQADLEKEELAEELASSLSGRNALQD-----------EKRRL 1741
Query: 141 EQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAEN 200
E RI +LE +E E+ NM M + + RKA +L + A
Sbjct: 1742 EARIAQLE-------EELEEEQGNMEAMSDRV-----------RKATQQAEQLSNELATE 1783
Query: 201 NSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILG 260
S E+ + L + L K +E++ + F A +I+ L
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKS---------KFKSTIAALEAKIAQLE 1834
Query: 261 GTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALI 320
+ A+EK+ +SL K+K + + + + + + Q E
Sbjct: 1835 EQVEQEAREKQAAT--------------KSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880
Query: 321 VCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHN 380
V +++RQL+E +E +I R LQ + +A + N+A+ +++N +
Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINANR-------RKLQRELDEATESNEAMGREVNALKS 1933
Query: 381 EL 382
+L
Sbjct: 1934 KL 1935
Score = 57.4 bits (137), Expect = 4e-08
Identities = 84/404 (20%), Positives = 173/404 (42%), Gaps = 49/404 (12%)
Query: 34 EELKCMLEKYERHLA-------EIQGNVKVLKSERDKIFLLYEQAQEEITR-LRREMMK- 84
EE+K LE+ E L ++ N++ LK + ++ ++ EE R L+R++ +
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 85 --SCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQ 142
+ + A A + + E D L+ + + DS + +E A + L+
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGD-----LKDLELQADSAIK----GREEAIKQLRKLQA 1659
Query: 143 RIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNS 202
++++ + L+D R + KE EK+ KSL M + +L +
Sbjct: 1660 QMKDFQ---RELEDARASRDEIFATAKEN----EKKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 203 LRLLYENTEKDLS----------DTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQ 252
L E ++L+ D +R L + +L+ E+ E + + R+ Q
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 253 REEISILGGTLNDLAKEKECLQACLDKKSENIASLGESL--AMKEK---TISGMKNIIAE 307
E++S T A++ E + L+++++ + S + A+K K TI+ ++ IA+
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 308 ME----QASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDN---DNLQEQ 360
+E Q +R+ A +Q +++ L + DE + ++ N L+ Q
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 361 FAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILK 404
+A++E+Q ++ EL++ + + EVN LK+ L+
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 38.5 bits (88), Expect = 0.021
Identities = 43/194 (22%), Positives = 82/194 (42%), Gaps = 15/194 (7%)
Query: 479 QISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQ---E 535
Q++ + + E+ELQK + + A +L + +L K LL QL A+ + E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 536 IEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLL 595
E L + E+E + +M ++ L A R K Q + L+E+ E +
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 596 KEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSS 655
++ L L K+ +++ + +LE ++ + Q + +ER + E R + ++
Sbjct: 973 RQKLQL--EKVTAEAK--------IKKLEDEILVMDDQ--NNKLSKERKLLEERISDLTT 1020
Query: 656 NAYHMSSTMKPNTK 669
N K TK
Sbjct: 1021 NLAEEEEKAKNLTK 1034
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 112 bits (280), Expect = 1e-24
Identities = 151/720 (20%), Positives = 295/720 (40%), Gaps = 123/720 (17%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM 83
EL KT R ++ + E ++H +++ +L+ + LY +A+E RL +
Sbjct: 860 ELQKTKERQQKAENELKELEQKH-SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK-- 916
Query: 84 KSCKSPKSTTAHAILRRVETERDVA-------------FTDLRRMTTERDSLRERLKIAQ 130
K H + R+E E D DL E ++ R++L++ +
Sbjct: 917 ---KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 973
Query: 131 ETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTV-------EKEMKSLA 183
TA E +I++LE + +DD+ + L++E IS + E++ K+L
Sbjct: 974 VTA-------EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 184 R-----KAMDTESELGRQKAENN--SLRLLYENTEKDLSD-------TQRHLAKKKYELQ 229
+ ++M +E E+ +K E + L L E D SD Q +A+ K +L
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086
Query: 230 LTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGE 289
+E++ ++D+ Q ++I L G ++DL ++ + +A +K + LGE
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 290 SL---------------------AMKEKTISGMKNI-----------IAEMEQASRQCTE 317
L A +E+ ++ +K + EM Q Q E
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206
Query: 318 ALIVCEQDVSRMRRQLDETNDEL----AQIARERDILAHDNDNLQEQFAKAKQENQALSK 373
L + R + LD+ L A +A E +L ++ + K + + Q L
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266
Query: 374 KLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEE--------------SENRQMMEQLRK 419
K +D ++ KV EV + +L E S+ + E L++
Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE 1326
Query: 420 ANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQ 479
N K RQ E + N+L+ +L L+ + +LN ++ + + S
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386
Query: 480 ISTLHKSVVKMEEELQKV--QFEKVSALAD-LSSTR--------ELCIKLDSSKELLNRQ 528
+ L + + ++E++ + Q+E+ +A D L T+ +L + LD+ ++L++
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS-- 1444
Query: 529 LVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEK 588
+E ++ + D +E + + S+ A+ER EA R+KE ++ ++L
Sbjct: 1445 ------NLEKKQRKFDQLLAEEKNISSKYADER-DRAEAEA-----REKETKA-LSLARA 1491
Query: 589 ESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQEL 648
E KE L + + D+ ++ V + +L+ +KR L T+ E + ++EL
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Score = 100 bits (249), Expect = 5e-21
Identities = 140/664 (21%), Positives = 286/664 (43%), Gaps = 49/664 (7%)
Query: 34 EELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTT 93
+EL+ ER AE+ V L++E + + + +A+ + +L +++ S S T
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA-SLSSQLQDT 1320
Query: 94 AHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHN 153
+ + +V+ T LR++ ER+SL+++L E K +LE+ I L + +
Sbjct: 1321 QELLQEETRQKLNVS-TKLRQLEEERNSLQDQLDEEMEA----KQNLERHISTLNIQLSD 1375
Query: 154 LDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKD 213
+ + S + ++E +KE+++L ++ + + + + N L+ ++ D
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 214 LSDTQRHLA------KKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILG------- 260
L D QR L ++K++ L +EK + + + A+ +E L
Sbjct: 1436 L-DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 261 ---------GTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQA 311
T L E E L + D +N+ L +S E + MK + E+E
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 312 SRQCTEALIVCEQDVSRMRRQL-------DETNDELA-QIARERDILAHDNDNLQEQFAK 363
+ +A + E ++ ++ Q DE N+E Q+ R+ + ++ ++Q A
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 364 AKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANED 423
A + L L D + + + ++ ++ KL+ +K + E +
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 424 AENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTL 483
A+ E KA+ EAD L+ +L AE + + + L E+ L+ + + + L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 484 HKSVVKMEEELQKVQFEKVSALAD-----LSSTRELCIKLDSSKELLNRQLVAKDQEIEM 538
+ ++EEEL++ Q + A++D +L +L + + + A+ Q++E
Sbjct: 1735 EARIAQLEEELEEEQ-GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR-QQLER 1792
Query: 539 RENELDSAHSEIE-LLRSQMANERISMQNLEALLVANRDKE-YQSQIALQEKESEIQLLK 596
+ EL S E+E ++S+ + +++ A L ++E + Q A + + + + LK
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852
Query: 597 EHLCLAEN--KMAIQSRDVAQFRNV-VTQLEADLDITKRQLGTERFERERAVQELRRQNY 653
E L E+ KMA Q ++ A+ N V QL+ L+ + + R + +EL
Sbjct: 1853 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1912
Query: 654 SSNA 657
S+ A
Sbjct: 1913 SNEA 1916
Score = 72.0 bits (175), Expect = 2e-12
Identities = 80/360 (22%), Positives = 162/360 (45%), Gaps = 39/360 (10%)
Query: 305 IAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKA 364
+ E+ + + L ++ + +L E + +Q+ E+++L E +A+A
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 365 KQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDA 424
++ L+ K + L++++ + L+ EE +Q+ + +K +
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEAR--------------LEEEEDRGQQLQAERKKMAQQM 952
Query: 425 ENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLH 484
+ E + + EA L+LE +TAEA+ +L++++ ++ + + + + +IS L
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1012
Query: 485 KSVVKMEEE---LQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMREN 541
++ + EE+ L K++ + S +++L + K E L R+L E
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL----------EG 1062
Query: 542 ELDSAHSEIELLRSQMANERISM----QNLEALLVANRDKEYQSQIAL---QEKESEIQL 594
+ H +I L++Q+A ++ + + L+A L D+ Q AL +E E I
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 595 LKEHL---CLAENKMAIQSRDVA-QFRNVVTQLEADLDITKRQLGTERFERERAVQELRR 650
L+E L A NK Q RD+ + + T+LE LD T Q R +RE+ V L++
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL-RAKREQEVTVLKK 1181
Score = 70.5 bits (171), Expect = 5e-12
Identities = 100/463 (21%), Positives = 202/463 (43%), Gaps = 61/463 (13%)
Query: 219 RHLAKKKYELQLT--QEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQAC 276
R K K LQ+T +E++ ++++ + E+ L + L +EK LQ
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 277 LDKKSENIASLGESLAMKEKTISGMKNIIAEME-------------QASRQCTEALIVC- 322
L ++E A E ++ I+ EME QA R+ ++
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 323 -----EQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLND 377
E++ +R + QL++ E E +IL D+ N K +E + L ++++D
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN-----NKLSKERKLLEERISD 1010
Query: 378 THNELNDIKQKVQD-TNLE------VNKLKNILKSEESENRQMMEQLRKANEDAENWENK 430
L + ++K ++ T L+ +++L+ LK EE +++ + RK DA ++ +
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 431 ARQSEADNNTLKLELITAEAEGN----RLKEKVDSLN------REVEQH-------LNAE 473
+A LK++L E E RL +++ N RE+E H L++E
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 474 RSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKD 533
R+ +++ K + EEL+ ++ E L ++ +EL K + +L + L +
Sbjct: 1131 RAARNK---AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 534 QEIEMRENELDSAHSE-IELLRSQMANERISMQNL----EALLVANRDKEYQSQI---AL 585
+ E + E+ H++ +E L Q+ + + NL + L N D + ++ A
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 586 QEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLD 628
QE E + + L+ + ++K + R A+ + V +L+ +++
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Score = 67.0 bits (162), Expect = 6e-11
Identities = 104/545 (19%), Positives = 220/545 (40%), Gaps = 61/545 (11%)
Query: 31 RDREELKCMLEKYERHLA---EIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCK 87
R ++E++ + ++YE A +++ L+ E D + + + ++ ++ L ++ K
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF-- 1453
Query: 88 SPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEEL 147
I + ERD A + R T+ SL L E A K LE+ + L
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL----EEALEAKEELERTNKML 1509
Query: 148 ECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRL-- 205
+ + +L + + N+ ++++ +E +M+ + + + E EL Q E+ LRL
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL--QATEDAKLRLEV 1567
Query: 206 ----LYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGG 261
L E+DL +K+ +LQ ++ + ++++ +Q L G
Sbjct: 1568 NMQALKGQFERDLQARDEQNEEKRRQLQ---RQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 262 TLNDLAKEKECLQACLDKKSENIASLGESLAMK-------EKTISGMKNIIA---EMEQA 311
L DL + + + + + E I L + A E + I A E E+
Sbjct: 1625 DLKDLELQAD---SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681
Query: 312 SRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQAL 371
++ L+ ++D++ R + + E ++A E + LQ++ + + L
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 372 SKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEES---ENRQMMEQLRKANEDAENWE 428
++L + + + +V+ + +L N L +E S +N +QL + N++ +
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-- 1799
Query: 429 NKARQSE-ADNNTLKLELITAEAEGNRLKEKVDSLNRE---------------------V 466
K + E A + K + EA+ +L+E+V+ RE V
Sbjct: 1800 -KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1858
Query: 467 EQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLN 526
E YK Q + V +++ +L++ + E A+ + + S E +
Sbjct: 1859 EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1918
Query: 527 RQLVA 531
R++ A
Sbjct: 1919 REVNA 1923
Score = 64.7 bits (156), Expect = 3e-10
Identities = 87/426 (20%), Positives = 166/426 (38%), Gaps = 38/426 (8%)
Query: 252 QREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQA 311
Q EE+ L + ++ + L + + + L E + ++ + + AE E+
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 312 SRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQAL 371
+ E+ + M +L+E D Q+ ER +A +L+EQ + + Q L
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 372 SKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKA 431
+ ++ ++ ++ + + NKL K E + L + E A+N
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 432 RQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKME 491
+ E+ + L++ L E L++ L + ++QI+ L + K E
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 492 EELQKV-------------QFEKVSAL--------ADLSSTRELCIKLDSSKELLNRQLV 530
EELQ +K+ L DL S R K + K L +L
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 531 AKDQEIEMRENELDSAHSEIELLRSQMANERISMQNL-------EALLVANRDKEYQSQI 583
A E+ E+ LDS ++ EL + + + L EA + R K Q+
Sbjct: 1150 ALKTEL---EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206
Query: 584 ALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERER 643
L E+ + + K +L + + ++ D+A V+ Q + +++ K++L E
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL-------EA 1259
Query: 644 AVQELR 649
VQEL+
Sbjct: 1260 QVQELQ 1265
Score = 60.5 bits (145), Expect = 5e-09
Identities = 72/362 (19%), Positives = 146/362 (40%), Gaps = 62/362 (17%)
Query: 22 DVEL-LKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRR 80
D+EL + + REE L K + + + Q ++ ++ RD+IF ++ +++ L
Sbjct: 1628 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1687
Query: 81 EMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHL 140
++M+ + A ++ + E++ +L + R++L++ EK L
Sbjct: 1688 DLMQLQED--LAAAERARKQADLEKEELAEELASSLSGRNALQD-----------EKRRL 1734
Query: 141 EQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAEN 200
E RI +LE +E E+ NM M + + RKA +L + A
Sbjct: 1735 EARIAQLE-------EELEEEQGNMEAMSDRV-----------RKATQQAEQLSNELATE 1776
Query: 201 NSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILG 260
S E+ + L + L K +E++ + F A +I+ L
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKS---------KFKSTIAALEAKIAQLE 1827
Query: 261 GTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALI 320
+ A+EK+ +SL K+K + + + + + + Q E
Sbjct: 1828 EQVEQEAREKQAAT--------------KSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1873
Query: 321 VCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHN 380
V +++RQL+E +E +I R LQ + +A + N+A+ +++N +
Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINANR-------RKLQRELDEATESNEAMGREVNALKS 1926
Query: 381 EL 382
+L
Sbjct: 1927 KL 1928
Score = 57.4 bits (137), Expect = 4e-08
Identities = 84/404 (20%), Positives = 173/404 (42%), Gaps = 49/404 (12%)
Query: 34 EELKCMLEKYERHLA-------EIQGNVKVLKSERDKIFLLYEQAQEEITR-LRREMMK- 84
EE+K LE+ E L ++ N++ LK + ++ ++ EE R L+R++ +
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 85 --SCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQ 142
+ + A A + + E D L+ + + DS + +E A + L+
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGD-----LKDLELQADSAIK----GREEAIKQLRKLQA 1652
Query: 143 RIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNS 202
++++ + L+D R + KE EK+ KSL M + +L +
Sbjct: 1653 QMKDFQ---RELEDARASRDEIFATAKEN----EKKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 203 LRLLYENTEKDLS----------DTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQ 252
L E ++L+ D +R L + +L+ E+ E + + R+ Q
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 253 REEISILGGTLNDLAKEKECLQACLDKKSENIASLGESL--AMKEK---TISGMKNIIAE 307
E++S T A++ E + L+++++ + S + A+K K TI+ ++ IA+
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 308 ME----QASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDN---DNLQEQ 360
+E Q +R+ A +Q +++ L + DE + ++ N L+ Q
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 361 FAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILK 404
+A++E+Q ++ EL++ + + EVN LK+ L+
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 38.5 bits (88), Expect = 0.021
Identities = 43/194 (22%), Positives = 82/194 (42%), Gaps = 15/194 (7%)
Query: 479 QISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQ---E 535
Q++ + + E+ELQK + + A +L + +L K LL QL A+ + E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 536 IEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLL 595
E L + E+E + +M ++ L A R K Q + L+E+ E +
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 596 KEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSS 655
++ L L K+ +++ + +LE ++ + Q + +ER + E R + ++
Sbjct: 966 RQKLQL--EKVTAEAK--------IKKLEDEILVMDDQ--NNKLSKERKLLEERISDLTT 1013
Query: 656 NAYHMSSTMKPNTK 669
N K TK
Sbjct: 1014 NLAEEEEKAKNLTK 1027
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 107 bits (266), Expect = 5e-23
Identities = 161/714 (22%), Positives = 295/714 (41%), Gaps = 121/714 (16%)
Query: 5 RSKSPRRPSPTARGANCDVELLKTTTRDRE------------------ELKCMLEKYERH 46
R +SPRR A + + L+ + R+ L+ L E
Sbjct: 503 RGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESE 562
Query: 47 LAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAI--------- 97
++ ++ L+ + D +E AQ E+ RLR + KS AH++
Sbjct: 563 RRALEEQLQRLRDKTDGAMQAHEDAQREVQRLR-SANELLSREKSNLAHSLQVAQQQAEE 621
Query: 98 LRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDE 157
LR+ + A +LRR R+RL+ QE A + A + + +E + L+ +
Sbjct: 622 LRQEREKLQAAQEELRRQ-------RDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGK 674
Query: 158 RMEQMSNMTLMKETIS--TVEKEM----KSLARKAMDTESELGRQKAENNSLRLLYENTE 211
R + ++E +S T++++M K+ +A+ T++E GR + E + +L E
Sbjct: 675 RSVLAKELVEVREALSRATLQRDMLQAEKAEVAEAL-TKAEAGRVELELSMTKLRAEEAS 733
Query: 212 -----KDLSDTQRHLAKKKYEL-----QLTQEKIMCLDEKIDNFTRQNIAQREEISILGG 261
LS LA+ K +L QL +EK + +A+ E+
Sbjct: 734 LQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQ-----E 788
Query: 262 TLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIV 321
L +L E+E + L+ E+L E+ + +++ +++++ Q + L
Sbjct: 789 RLEELRLEQEVARQGLEGSLRVAEQAQEAL---EQQLPTLRHERSQLQEQLAQLSRQLSG 845
Query: 322 CEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNE 381
EQ++ + RR+ + L + ARE++ LA ++ L Q A++E + LS++ E
Sbjct: 846 REQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLE 905
Query: 382 LNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTL 441
K L+ E ++ + QL E + Q EA+ L
Sbjct: 906 ------------------KEALEGSLFEVQRQLAQL----------EARREQLEAEGQAL 937
Query: 442 KL--ELITAEAEGNRLK----EKVDSLNREV--EQHLNAERSYKSQISTLHKSVVKMEEE 493
L E +T E G R + ++ SL++E+ ++ + AER + ++L + EE+
Sbjct: 938 LLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQ---ASLREQRAAHEED 994
Query: 494 LQKVQFEKVSALADLSSTR------------ELCIKLDSSKELLNRQLVAKDQEIEMREN 541
LQ++Q EK +A +L + R EL +L++ KE L+ ++ A QE R+
Sbjct: 995 LQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQE---RDE 1051
Query: 542 ELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCL 601
L A SE + S +E+ + L L+ R + ++ ++ + Q +E
Sbjct: 1052 GLLLAESEKQQALSLKESEKTA---LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRS 1108
Query: 602 AENKMAIQSRDVAQFRNVVTQLEAD----LDITKRQLGTERFERERAVQELRRQ 651
N + + RD+ R A L R LG +R R +ELR Q
Sbjct: 1109 TVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQ 1162
Score = 88.2 bits (217), Expect = 2e-17
Identities = 143/674 (21%), Positives = 290/674 (43%), Gaps = 90/674 (13%)
Query: 31 RDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITR--LRREMMKSCKS 88
+D ++ LE+ R L +++G VL E ++ +E ++R L+R+M+++
Sbjct: 652 QDGARVRRELERSHRQLEQLEGKRSVLAKELVEV-------REALSRATLQRDMLQA--- 701
Query: 89 PKSTTAHAILR----RVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRI 144
K+ A A+ + RVE E ++ T LR +L E+ +K L + +
Sbjct: 702 EKAEVAEALTKAEAGRVELE--LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLV 759
Query: 145 EELECTVHNLDDERMEQMSNMTLMKETISTVEKEM--KSLARKAMDTESELGRQKAEN-- 200
+LE L + + T+ +E +E+ + +AR+ ++ + Q E
Sbjct: 760 AQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALE 819
Query: 201 ---NSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEIS 257
+LR ++ L+ R L+ ++ EL+ + + E ++ R+ A +E +
Sbjct: 820 QQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHA 879
Query: 258 IL----------GGTLND----LAKEKECLQ----------ACLDKKSENIASLGESLAM 293
L G TL++ L EKE L+ A L+ + E + + G++L +
Sbjct: 880 GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLL 939
Query: 294 KEKTISG-----MKNIIAEMEQASRQ---CTEALIVCEQDV-SRMRRQLDETNDELAQIA 344
++T++G + IIA E+AS + L+ E++ + +R Q ++L ++
Sbjct: 940 AKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQ 999
Query: 345 RERDI----LAHDNDNLQEQFAKAKQENQA-LSKKLNDTHNELNDIKQKVQDTNLEVNKL 399
RE++ L + LQ Q + ++E A L + + E+ ++Q+ + L
Sbjct: 1000 REKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESE 1059
Query: 400 KN-ILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEK 458
K L +ESE + E+L R S A T+ LE+ + + +E+
Sbjct: 1060 KQQALSLKESEKTALSEKLMGT-----------RHSLA---TISLEMERQKRDAQSRQEQ 1105
Query: 459 VDSLNREVEQHLNAERSYKSQISTLH-KSVVKMEEELQKVQFEKVSALADLSSTRELCIK 517
S + L R+ + + + H + V +++E+ + + ++ S L + R
Sbjct: 1106 DRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRL 1165
Query: 518 LDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDK 577
L+ +++ L R+L+ +++ + + E LR + + EAL +N +
Sbjct: 1166 LEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGE---GAKEREALRRSNEEL 1222
Query: 578 EYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTE 637
+ A+++ ESE LK E K+A+ + + R V + +L +++
Sbjct: 1223 ----RSAVKKAESERISLKLANEDKEQKLAL----LEEARTAVGKEAGELRTGLQEVERS 1274
Query: 638 RFERERAVQELRRQ 651
R E R +QELRRQ
Sbjct: 1275 RLEARRELQELRRQ 1288
Score = 87.4 bits (215), Expect = 4e-17
Identities = 116/551 (21%), Positives = 227/551 (41%), Gaps = 79/551 (14%)
Query: 98 LRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDE 157
LR + ERD +LR T+ + ++ +++A + L++ + E E ++D
Sbjct: 1518 LRSAQRERD----ELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGR 1573
Query: 158 RMEQMSNMTLMKETISTVEKEMKS-------LARKAMDTESELGRQKAENNSLRLLYENT 210
+ + L +E++ E+E ++ L R TESEL +A + + N
Sbjct: 1574 LSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESEL---RASQEKISKMKANE 1630
Query: 211 EKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEK 270
K D +R K L ++ + + L+ R+++ + S LG L+D +
Sbjct: 1631 TKLEGDKRR----LKEVLDASESRTVKLE-----LQRRSLEGELQRSRLG--LSDREAQA 1679
Query: 271 ECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMR 330
+ LQ +D +A + T+ + +A++E++ + + + +++
Sbjct: 1680 QALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSS 1739
Query: 331 RQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQ 390
L+ T D+ + + HD LQE+ A+Q L++ + + + ++VQ
Sbjct: 1740 ASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQ-------ALSEARKQSSSLGEQVQ 1792
Query: 391 DTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEA 450
EV L+ E + +Q+ E LR+ E ++ A N KL +
Sbjct: 1793 TLRGEVADLELQRVEAEGQLQQLREVLRQRQEG---------EAAALNTVQKL-----QD 1838
Query: 451 EGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSS 510
E L+E++ SL R + Q +R + L K V + L KV+ EK+ + D
Sbjct: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHED--- 1895
Query: 511 TRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEAL 570
++L + K L+R L +E+EL +Q +Q LEA
Sbjct: 1896 ----TVRLSAEKGRLDRTLTG----------------AELELAEAQR-----QIQQLEAQ 1930
Query: 571 LVANRDKEYQSQIALQEKESEIQLLKE----HLCLAENKMAIQSRDVAQFRNVVTQLEAD 626
+V +Q+ + ++ +++L +E A+ + +++R+ A R V LE
Sbjct: 1931 VVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAH-RQRVRGLEEQ 1989
Query: 627 LDITKRQLGTE 637
+ K QL E
Sbjct: 1990 VSTLKGQLQQE 2000
Score = 84.0 bits (206), Expect = 4e-16
Identities = 139/684 (20%), Positives = 266/684 (38%), Gaps = 96/684 (14%)
Query: 26 LKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKS 85
LK D+E+ +LE+ + + G ++ E ++ L +A+ E+ LRR+M
Sbjct: 1236 LKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRL---EARRELQELRRQM--- 1289
Query: 86 CKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIE 145
K S E + +A + E++S RE L + Q E A LE +
Sbjct: 1290 -KMLDSENTRLGRELAELQGRLALGE----RAEKESRRETLGLRQRLLKGE-ASLEVMRQ 1343
Query: 146 ELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRL 205
EL+ L ++ E + + ++ K A E +L +AE L L
Sbjct: 1344 ELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGL 1403
Query: 206 LYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEIS-----ILG 260
E + LA+ + + + + ++ L + R+ + S + G
Sbjct: 1404 RLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSAL----RRGLGLGRAPSPAPRPVPG 1459
Query: 261 GTLNDLAKEK-----------ECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEME 309
D E EC S E ++ + E+
Sbjct: 1460 SPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELR 1519
Query: 310 QASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQ 369
A R+ E +R Q N +LA++ ERD LQ+ A++++ +
Sbjct: 1520 SAQRERDE-----------LRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARR 1568
Query: 370 ALSKKLNDTHNELNDIKQKVQDTNLE-------VNKLKNILKSEESENRQMMEQLRKANE 422
++ +L+ EL ++ V+ + E V L+ L++ ESE R E++ K
Sbjct: 1569 SVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKA 1628
Query: 423 DAENWENKARQ-----SEADNNTLKLE----------------LITAEAEGNRLKEKVDS 461
+ E R+ +++ T+KLE L EA+ L+++VDS
Sbjct: 1629 NETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDS 1688
Query: 462 LNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSAL--------ADLSSTRE 513
L R+V + + + L+ ++ K+EE ++ +KV L A L+STR+
Sbjct: 1689 LQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR-DKVRGLTEALAQSSASLNSTRD 1747
Query: 514 LCIKL-------DSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERI---- 562
+ L + +++L +L A Q + + S +++ LR ++A+ +
Sbjct: 1748 KNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVE 1807
Query: 563 ---SMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNV 619
+Q L +L ++ E + +Q+ + E +LL+E L + +A + +
Sbjct: 1808 AEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERS 1867
Query: 620 VTQLEADLDITKRQLGTERFERER 643
+LE D +R L ++ ERE+
Sbjct: 1868 ALRLEKDRVALRRTL--DKVEREK 1889
Score = 80.5 bits (197), Expect = 5e-15
Identities = 148/688 (21%), Positives = 270/688 (39%), Gaps = 125/688 (18%)
Query: 25 LLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMK 84
L ++ +D+ +L ++ + E + +QG + ++E++ EQ + E RL +E+ +
Sbjct: 744 LNESLAQDKLDLNRLVAQLEEEKSALQGRQR--QAEQEATVAREEQERLEELRLEQEVAR 801
Query: 85 SCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRI 144
LR E ++ L + ER L+E+L + LEQ
Sbjct: 802 Q-------GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR 854
Query: 145 EELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLR 204
E + V L+ E KE ++ KE LA + + E E E LR
Sbjct: 855 REAQRQVEALERAARE--------KEALA---KEHAGLAVQLVAAEREGRTLSEEATRLR 903
Query: 205 LLYENTEKDLSDTQRHLAK---KKYELQLTQEKIMCLDE----KIDNFTRQNIAQREEIS 257
L E E L + QR LA+ ++ +L+ + ++ E ++ +Q IA +E+ S
Sbjct: 904 LEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKAS 963
Query: 258 ILGGTLNDLAKEKECL-QACLDKKSENIASLGESLAMKEKTISGM---KNIIAEMEQASR 313
+ +KE + Q + + E ASL E A E+ + + K +A R
Sbjct: 964 L----------DKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Query: 314 QCTEALIVCEQD--VSRMRRQLDETNDELAQIARERD--ILAHDNDNLQEQFAKAKQENQ 369
++ + EQ+ ++R+ + +E ++E+A + +ERD +L +++ Q+ + + E
Sbjct: 1014 AQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEK-QQALSLKESEKT 1072
Query: 370 ALSKKLNDTHNEL-----------NDIKQKVQDTNLEVNKLKNILKS-----EES----- 408
ALS+KL T + L D + + + VN L + L+ EE+
Sbjct: 1073 ALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA 1132
Query: 409 -ENRQMMEQLRKANE-------DAENWENKARQSEADNNTLKLELITAEA------EGNR 454
E R++ EQ R + +AE + R E + L+ EL+ A+ EG
Sbjct: 1133 QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGRE 1192
Query: 455 L-KEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEE-------------------- 493
+ +++ L R + + + + L +V K E E
Sbjct: 1193 VQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEE 1252
Query: 494 ---------------LQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEM 538
LQ+V+ ++ A +L R LDS L R+L + +
Sbjct: 1253 ARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLAL 1312
Query: 539 RENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEH 598
E + E LR ++ EA L R + +Q LQE+E E + +
Sbjct: 1313 GERAEKESRRETLGLRQRLLKG-------EASLEVMRQELQVAQRKLQEQEGEFRTRERR 1365
Query: 599 LC-LAENKMAIQSRDVAQFRNVVTQLEA 625
L E + + + R + +LEA
Sbjct: 1366 LLGSLEEARGTEKQQLDHARGLELKLEA 1393
Score = 68.6 bits (166), Expect = 2e-11
Identities = 114/562 (20%), Positives = 227/562 (40%), Gaps = 69/562 (12%)
Query: 8 SPRRPSPTARGANCD-VELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFL 66
SP RGA + ++ L++ R+R+EL+ R LAE +++ERD
Sbjct: 1499 SPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAE-------MEAERD---- 1547
Query: 67 LYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERL 126
A +L++ + +S ++ +S L V+ E + +RR ER
Sbjct: 1548 ---SATSRARQLQKAVAESEEARRSVDGR--LSGVQAELALQEESVRRSERER------- 1595
Query: 127 KIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKA 186
+A L+Q + LE ++ + E ++ MK + +E + + L
Sbjct: 1596 ----------RATLDQ-VATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVL 1644
Query: 187 MDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFT 246
+ES + + + SL E +L ++ L+ ++ + Q Q+++ L ++ +
Sbjct: 1645 DASESRTVKLELQRRSL-------EGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSE 1697
Query: 247 RQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIA 306
+ + + L G LAK +E A DK + L E+LA +++ ++
Sbjct: 1698 VKAGTLQLTVERLNGA---LAKVEESEGALRDK----VRGLTEALAQSSASLNSTRDKNL 1750
Query: 307 EMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQ 366
+++A C V ++ + R+ L E + + + + L + +L+ Q +A+
Sbjct: 1751 HLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEG 1810
Query: 367 ENQALSKKLNDTHN----ELNDIKQKVQDTNL----EVNKLKNILKSEESENRQMMEQLR 418
+ Q L + L LN + QK+QD + L+ L E+E R++
Sbjct: 1811 QLQQLREVLRQRQEGEAAALNTV-QKLQDERRLLQERLGSLQRALAQLEAEKREVERSAL 1869
Query: 419 KANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKS 478
+ +D + E + + + AE RL + E+ + A+R
Sbjct: 1870 RLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAE---AQR---- 1922
Query: 479 QISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEM 538
QI L VV +E+ Q E + L +E+ +L S++ R L A+++
Sbjct: 1923 QIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV-ERLRSAQAQTERTLEARERAHRQ 1981
Query: 539 RENELDSAHSEIELLRSQMANE 560
R L+ ++ L+ Q+ E
Sbjct: 1982 RVRGLE---EQVSTLKGQLQQE 2000
Score = 63.9 bits (154), Expect = 5e-10
Identities = 150/717 (20%), Positives = 262/717 (36%), Gaps = 117/717 (16%)
Query: 31 RDREELKCMLEKYE-------RHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM 83
R+ EEL+ L E R L E Q ++ + R E ++E LRR +
Sbjct: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR-------EVQRQEAGELRRSLG 1206
Query: 84 KSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQR 143
+ K ++ LRR E LR + +S R LK+A E EQ+
Sbjct: 1207 EGAKEREA------LRRSNEE-------LRSAVKKAESERISLKLANEDK-------EQK 1246
Query: 144 IEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLAR--KAMDTES-ELGRQKAEN 200
+ LE + E E + + ++ + +E++ L R K +D+E+ LGR+ AE
Sbjct: 1247 LALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAEL 1306
Query: 201 NSLRLLYENTEKD-----------LSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQN 249
L E EK+ L + L + ELQ+ Q K+ + + R+
Sbjct: 1307 QGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRL 1366
Query: 250 IAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEME 309
+ EE GT L+ L+ A LG L+ E G++ +A +E
Sbjct: 1367 LGSLEEAR---GTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVE 1423
Query: 310 QASRQCTEALIVCEQDVSRMRRQLDETNDELAQI---ARERDILAHDN-DNLQEQF---- 361
R+ EA + + R L + + RD A + + L
Sbjct: 1424 -VQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLEC 1482
Query: 362 ---AKAKQENQALSKKLNDTHNE-----LNDIKQKVQDTNLEVNKLKNILKSEESENRQM 413
++ A S D E L + Q+++ E ++L+ + + +M
Sbjct: 1483 SPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEM 1542
Query: 414 MEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNRE----VEQH 469
+ A A + +SE ++ L +AE +E V RE ++Q
Sbjct: 1543 EAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQV 1602
Query: 470 LNAERSYKSQISTLHKS---VVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLN 526
ERS ++ S L S + KM+ K++ +K L ++ +KL+ + L
Sbjct: 1603 ATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLE 1662
Query: 527 RQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLE------------------ 568
+L + RE + + ++ L+ Q+A+ + L+
Sbjct: 1663 GELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEG 1722
Query: 569 -----------------ALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSR 611
A L + RDK Q AL E + Q+L+E L A ++ +
Sbjct: 1723 ALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARK 1782
Query: 612 DVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELR---RQNYSSNAYHMSSTMK 665
+ V L ++ L +R E E +Q+LR RQ A +++ K
Sbjct: 1783 QSSSLGEQVQTLRGEV----ADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQK 1835
Score = 61.2 bits (147), Expect = 3e-09
Identities = 94/461 (20%), Positives = 185/461 (40%), Gaps = 46/461 (9%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM 83
+L R++EEL LE + L+E + L+ ERD+ LL E +++ L+ E
Sbjct: 1015 QLQSQLQREQEELLARLEAEKEELSE---EIAALQQERDEGLLLAESEKQQALSLK-ESE 1070
Query: 84 KSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQR 143
K+ S K L + E + R + S +E+ + +E L +
Sbjct: 1071 KTALSEKLMGTRHSLATISLE-------MERQKRDAQSRQEQDRSTVNALTSELRDLRAQ 1123
Query: 144 IEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSL 203
EE H + R+++ + + K+ S R+A + ++L + + L
Sbjct: 1124 REEA-AAAHAQEVRRLQEQAR---------DLGKQRDSCLREAEELRTQLRLLEDARDGL 1173
Query: 204 RLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTL 263
R ++L + QR L + + ++ +++ L + ++ A R L +
Sbjct: 1174 R-------RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAV 1226
Query: 264 NDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCE 323
E+ L+ + K + +A L E+ K ++ + E+E++ + L
Sbjct: 1227 KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARREL---- 1282
Query: 324 QDVSRMRRQLDETNDELA-QIARERDILAHDNDNLQEQFAK-AKQENQALSKKLNDTHNE 381
Q++ R + LD N L ++A + LA L E+ K +++E L ++L
Sbjct: 1283 QELRRQMKMLDSENTRLGRELAELQGRLA-----LGERAEKESRRETLGLRQRLLKGEAS 1337
Query: 382 LNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKAN----EDAENWENKARQSEAD 437
L ++Q++Q ++ + + ++ E +E+ R + A E K + A+
Sbjct: 1338 LEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAE 1397
Query: 438 NNTLKLELITAEAEGNRLK---EKVDSLNREVEQHLNAERS 475
L L L AE L+ +V+ R E L RS
Sbjct: 1398 AAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRS 1438
Score = 42.4 bits (98), Expect = 0.001
Identities = 83/413 (20%), Positives = 160/413 (38%), Gaps = 63/413 (15%)
Query: 234 KIMCLDEKIDNFTRQNIAQREEISILGGT----LNDLAKEKECLQACLDKKSENIASLG- 288
+I L I +N++Q E +L T L L +E + LQ L + + +A
Sbjct: 43 QITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRA 102
Query: 289 --ESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARE 346
+ LA+K +S +E + E + Q V +RRQL E Q +
Sbjct: 103 ERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVE-LRRQLQEE-----QASYR 156
Query: 347 RDILAHDN---------DNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVN 397
R + A+ LQ + + K+ L ++L + EL +Q+++DT +
Sbjct: 157 RKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELE--QQRLRDTEHSQD 214
Query: 398 KLKNILKSEESENRQ---------MMEQLRKANEDAENWENKARQSEADNNTLKLELITA 448
+++ EE + R + EQL +A + R+ D + EL
Sbjct: 215 LESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHR 274
Query: 449 EAEGNRLKEKVDS-LNREVEQHLNAERS---YKSQISTL----HKSVVKMEEELQKVQ-- 498
EA R +E ++ + E + L R ++ +S + + ++++ EL +
Sbjct: 275 EAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRA 334
Query: 499 -----------FEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAH 547
+ A+ + ++ ++ ++L ++ L KD + +++LD A
Sbjct: 335 VQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKAD 394
Query: 548 SEIELLRSQMANERISMQNLE---------ALLVANRDKEYQSQIALQEKESE 591
+ +A +R+ QNLE L A Q Q AL+ ++ E
Sbjct: 395 LSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGE 447
Score = 38.9 bits (89), Expect = 0.016
Identities = 58/308 (18%), Positives = 121/308 (39%), Gaps = 46/308 (14%)
Query: 340 LAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKL 399
L + E +L + +++ A+++ E L+ K N L +++ LE +
Sbjct: 76 LLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQAL-RLEPGELETQEP 134
Query: 400 KNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKV 459
+ ++ RQ +E R+ E+ ++ K Q+ + + +L+ RL+ K+
Sbjct: 135 RGLV-------RQSVELRRQLQEEQASYRRKL-QAYQEGQQRQAQLV------QRLQGKI 180
Query: 460 DSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLD 519
YK + S L + +++ EL++ + DL S I+L+
Sbjct: 181 --------------LQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESA---LIRLE 223
Query: 520 SSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEY 579
++ + + Q M +LD A S + L + ++ E+
Sbjct: 224 EEQQ----RSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTR------CRKELEH 273
Query: 580 QSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERF 639
+ +E+ES + +++ + R V FR +V++++ + QLG E
Sbjct: 274 REAAWRREEES----FNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELA 329
Query: 640 ERERAVQE 647
RAVQE
Sbjct: 330 RTSRAVQE 337
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 106 bits (264), Expect = 8e-23
Identities = 147/652 (22%), Positives = 272/652 (41%), Gaps = 55/652 (8%)
Query: 23 VELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREM 82
VE L+TT E + K E+ + V++L++E + +Q+ + L +++
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE----IVQEKQSLQNCQNLSKDL 531
Query: 83 MKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQ 142
MK K+ T + E + + + + SLR+R +I+ E +
Sbjct: 532 MKE-KAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD------ 584
Query: 143 RIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNS 202
IE+ +H E ++S + K I + K +A + E+EL + EN
Sbjct: 585 -IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENEL 643
Query: 203 LRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGT 262
L+ N K + L ++ EL+ K+ + N T Q + +E S L
Sbjct: 644 LQKKITNL-KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702
Query: 263 LNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVC 322
+L + E L+ K ++ E + KE+ G+ E+ +AS + TE L V
Sbjct: 703 NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL-----ELLKASFKKTERLEVS 757
Query: 323 EQDVS----RMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDT 378
Q + R+++ L+ +N ++ Q+ E L +N LQ+ +E + SK+L
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL----EELKISSKRLEQL 813
Query: 379 HNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADN 438
E ++Q E ++L+ K E EN+++ +Q + E K E +N
Sbjct: 814 EKENKSLEQ-------ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866
Query: 439 NTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAE-----------RSYKSQISTLHKSV 487
TL E+ + RLKE ++ N+E+ + + S K + ++ +
Sbjct: 867 KTLSKEIGIYKESCVRLKE-LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 488 VKMEEELQKVQFEKVSALADLSSTRELCIKLDSSK--ELLNRQLVAKDQEIEMRENELDS 545
K+ EL+K+ K L D ST + KL SK L + L K+++I E L+
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 985
Query: 546 AHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENK 605
+ + + LR ++ + +N EA L +D+E Q + + + +E
Sbjct: 986 STNYNQQLRQELKTVK---KNYEA-LKQRQDEERMVQSSPPISGEDNKWERESQETTREL 1041
Query: 606 MAIQSRDVAQFRNVVTQLEADLDITK---RQLGTERFERERAVQELRRQNYS 654
+ ++ R + RN T L+A+ K +QL T+ + + L+RQ S
Sbjct: 1042 LKVKDRLIEVERNNAT-LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1092
Score = 101 bits (252), Expect = 2e-21
Identities = 147/637 (23%), Positives = 272/637 (42%), Gaps = 89/637 (13%)
Query: 22 DVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRRE 81
D++ ++ T +E+++ +L+ HL K L ERD+ + EE L
Sbjct: 172 DLQWMEVTDMSQEDIEPLLKNMALHL-------KRLIDERDEHSETIIELSEERDGLHF- 223
Query: 82 MMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLE 141
+ + S +S ++R E+ + ++ +L + LR+ L+ E + K LE
Sbjct: 224 LPHASSSAQSPCGSPGMKRTESRQHLS-VELADAKAKIRRLRQELEEKTEQLLDCKQELE 282
Query: 142 QRIEELECTVHNLDDERMEQMSNMTLMKETIST--VEKEMKSLARKAMDT---ESELGRQ 196
Q EL+ R++Q NM L+ + S E+ +L KA+ ESE+ R
Sbjct: 283 QMEIELK---------RLQQ-ENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRY 332
Query: 197 KAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEI 256
K + + Y+ ++L + + L + K L+ E +K+ ++N+
Sbjct: 333 KERLHDIEF-YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ----- 386
Query: 257 SILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEK-TISGMKNIIAEMEQASR-- 313
L L+D+ E++ + KK E + +L M +K ++ ++ E+EQ SR
Sbjct: 387 --LKAKLHDMEMERDMDR----KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTS 440
Query: 314 ------QCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQE 367
Q + V E SR+ + L+ N L + E + + K ++E
Sbjct: 441 ELSEAPQKSLGHEVNELTSSRLLK-LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKE 499
Query: 368 NQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENW 427
NQ LSKK+ NE+ KQ +Q+ N K+++K E+++ + +E LR
Sbjct: 500 NQRLSKKVEILENEIVQEKQSLQNCQ---NLSKDLMK-EKAQLEKTIETLR--------- 546
Query: 428 ENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAE-RSYKSQISTLHKS 486
EN RQ + E E L + V SL + + A + + + LH+S
Sbjct: 547 ENSERQIKI-----------LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHES 595
Query: 487 VVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSA 546
+ + +L K++FEK R++ +L+ KE K + E ENEL
Sbjct: 596 IKETSSKLSKIEFEK----------RQIKKELEHYKE--------KGERAEELENELHHL 637
Query: 547 HSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKM 606
E ELL+ ++ N +I+ + +EAL N + E +++ + +S L + L +
Sbjct: 638 EKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS 697
Query: 607 AIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERER 643
+ ++ RNV + A + + + QL + E E+
Sbjct: 698 QLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Score = 58.5 bits (140), Expect = 2e-08
Identities = 116/560 (20%), Positives = 218/560 (38%), Gaps = 48/560 (8%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQ---GNVKVLKSERDKIFLLYEQAQEEITRLRR 80
EL+K T D + L + E + Q +++ L E +KI L E+ +
Sbjct: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951
Query: 81 EMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQET--AFNEKA 138
K +S +T L E + L T LR+ LK ++ A ++
Sbjct: 952 SRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011
Query: 139 HLEQRIEE---LECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGR 195
E+ ++ + + + E E + +K+ + VE+ +L + +++L +
Sbjct: 1012 DEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ 1071
Query: 196 QKAENNSLR---LLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQ 252
+ +NN+L+ L + L + L + +LQ+ + + N Q + Q
Sbjct: 1072 LETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ 1131
Query: 253 REEISILGGTLNDLAKEKECLQACLDKK----------SENIASLGESLAMKEKTI-SGM 301
+ S L + KE+E L++ D E AS ESL K T+ S
Sbjct: 1132 Q---SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAH 1188
Query: 302 KNIIAEMEQASRQCTEALIVCEQ--DVSRMRRQLDET----NDELAQIARERDILAHDND 355
KN+ E + + L Q D+ +M + E N +A E L +ND
Sbjct: 1189 KNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND 1248
Query: 356 NLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMME 415
L +++ +E + L + + LN+ K + E +KLK + +Q+
Sbjct: 1249 RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK-------EQYQQLDI 1301
Query: 416 QLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAE-R 474
K N E E +N L ++ T + L E+ N E + + E R
Sbjct: 1302 TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQ----NMESKDLFHVEQR 1357
Query: 475 SYKSQISTLHKSVVKMEEE-LQKVQFEKVSALADLSSTRELCI-KLDSSKELLNRQLVAK 532
Y +++ L + K+EE+ + + +F S + L + KL SK+ +NR+ +
Sbjct: 1358 QYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRE---R 1414
Query: 533 DQEIEMRENELDSAHSEIEL 552
+ + + DS+ ++L
Sbjct: 1415 QKSLTLTPTRSDSSEGFLQL 1434
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 105 bits (261), Expect = 2e-22
Identities = 146/651 (22%), Positives = 272/651 (41%), Gaps = 54/651 (8%)
Query: 23 VELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREM 82
VE L+TT E + K E+ + V++L++E + +Q+ + L +++
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE----IVQEKQSLQNCQNLSKDL 531
Query: 83 MKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQ 142
MK K+ T + E + + + + SLR+R +I+ E +
Sbjct: 532 MKE-KAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD------ 584
Query: 143 RIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNS 202
IE+ +H E ++S + K I + K +A + E+EL + EN
Sbjct: 585 -IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENEL 643
Query: 203 LRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGT 262
L+ N K + L ++ EL+ K+ + N T Q + +E S L
Sbjct: 644 LQKKITNL-KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702
Query: 263 LNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVC 322
+L + E L+ K ++ E + KE+ G+ E+ +AS + TE L V
Sbjct: 703 NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL-----ELLKASFKKTERLEVS 757
Query: 323 EQDVS----RMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDT 378
Q + R+++ L+ +N ++ Q+ E L +N LQ+ +E + SK+L
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL----EELKISSKRLEQL 813
Query: 379 HNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADN 438
E ++Q E ++L+ K E EN+++ +Q + E K E +N
Sbjct: 814 EKENKSLEQ-------ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866
Query: 439 NTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAE-----------RSYKSQISTLHKSV 487
TL E+ + RLKE ++ N+E+ + + S K + ++ +
Sbjct: 867 KTLSKEIGIYKESCVRLKE-LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 488 VKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKE-LLNRQLVAKDQEIEMRENELDSA 546
K+ EL+K+ K L D ST + L+S E L + L K+++I E L+ +
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985
Query: 547 HSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKM 606
+ + LR ++ + +N EA L +D+E Q + + + +E +
Sbjct: 986 TNYNQQLRQELKTVK---KNYEA-LKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1041
Query: 607 AIQSRDVAQFRNVVTQLEADLDITK---RQLGTERFERERAVQELRRQNYS 654
++ R + RN T L+A+ K +QL T+ + + L+RQ S
Sbjct: 1042 KVKDRLIEVERNNAT-LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1091
Score = 101 bits (252), Expect = 2e-21
Identities = 147/637 (23%), Positives = 272/637 (42%), Gaps = 89/637 (13%)
Query: 22 DVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRRE 81
D++ ++ T +E+++ +L+ HL K L ERD+ + EE L
Sbjct: 172 DLQWMEVTDMSQEDIEPLLKNMALHL-------KRLIDERDEHSETIIELSEERDGLHF- 223
Query: 82 MMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLE 141
+ + S +S ++R E+ + ++ +L + LR+ L+ E + K LE
Sbjct: 224 LPHASSSAQSPCGSPGMKRTESRQHLS-VELADAKAKIRRLRQELEEKTEQLLDCKQELE 282
Query: 142 QRIEELECTVHNLDDERMEQMSNMTLMKETIST--VEKEMKSLARKAMDT---ESELGRQ 196
Q EL+ R++Q NM L+ + S E+ +L KA+ ESE+ R
Sbjct: 283 QMEIELK---------RLQQ-ENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRY 332
Query: 197 KAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEI 256
K + + Y+ ++L + + L + K L+ E +K+ ++N+
Sbjct: 333 KERLHDIEF-YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ----- 386
Query: 257 SILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEK-TISGMKNIIAEMEQASR-- 313
L L+D+ E++ + KK E + +L M +K ++ ++ E+EQ SR
Sbjct: 387 --LKAKLHDMEMERDMDR----KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTS 440
Query: 314 ------QCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQE 367
Q + V E SR+ + L+ N L + E + + K ++E
Sbjct: 441 ELSEAPQKSLGHEVNELTSSRLLK-LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKE 499
Query: 368 NQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENW 427
NQ LSKK+ NE+ KQ +Q+ N K+++K E+++ + +E LR
Sbjct: 500 NQRLSKKVEILENEIVQEKQSLQNCQ---NLSKDLMK-EKAQLEKTIETLR--------- 546
Query: 428 ENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAE-RSYKSQISTLHKS 486
EN RQ + E E L + V SL + + A + + + LH+S
Sbjct: 547 ENSERQIKI-----------LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHES 595
Query: 487 VVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSA 546
+ + +L K++FEK R++ +L+ KE K + E ENEL
Sbjct: 596 IKETSSKLSKIEFEK----------RQIKKELEHYKE--------KGERAEELENELHHL 637
Query: 547 HSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKM 606
E ELL+ ++ N +I+ + +EAL N + E +++ + +S L + L +
Sbjct: 638 EKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS 697
Query: 607 AIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERER 643
+ ++ RNV + A + + + QL + E E+
Sbjct: 698 QLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Score = 57.0 bits (136), Expect = 6e-08
Identities = 119/563 (21%), Positives = 228/563 (40%), Gaps = 55/563 (9%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQ---GNVKVLKSERDKIFLLYEQA--QEEITRL 78
EL+K T D + L + E + Q +++ L E +KI L E+ E+ T
Sbjct: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951
Query: 79 RREMMKSCKSPKSTTAHAILRRVETERDVAF-TDLRRMTTERDSLRERLKIAQET--AFN 135
R ++++S +ST ++ ++ E+ A L T LR+ LK ++ A
Sbjct: 952 RYKLLES--KLESTLKKSL--EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALK 1007
Query: 136 EKAHLEQRIEE---LECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESE 192
++ E+ ++ + + + E E + +K+ + VE+ +L + +++
Sbjct: 1008 QRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1067
Query: 193 LGRQKAENNSLR---LLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQN 249
L + + +NN+L+ L + L + L + +LQ+ + + N Q
Sbjct: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
Query: 250 IAQREEISILGGTLNDLAKEKECLQACLDKK----------SENIASLGESLAMKEKTI- 298
+ Q+ S L + KE+E L++ D E AS ESL K T+
Sbjct: 1128 LIQQ---SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLK 1184
Query: 299 SGMKNIIAEMEQASRQCTEALIVCEQ--DVSRMRRQLDET----NDELAQIARERDILAH 352
S KN+ E + + L Q D+ +M + E N +A E L
Sbjct: 1185 SAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCG 1244
Query: 353 DNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQ 412
+ND L +++ +E + L + + LN+ K + E +KLK + +Q
Sbjct: 1245 ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK-------EQYQQ 1297
Query: 413 MMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNA 472
+ K N E E +N L ++ T + L E+ N E + +
Sbjct: 1298 LDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQ----NMESKDLFHV 1353
Query: 473 E-RSYKSQISTLHKSVVKMEEE-LQKVQFEKVSALADLSSTRELCI-KLDSSKELLNRQL 529
E R Y +++ L + K+EE+ + + +F S + L + KL SK+ +NR+
Sbjct: 1354 EQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRE- 1412
Query: 530 VAKDQEIEMRENELDSAHSEIEL 552
+ + + + DS+ ++L
Sbjct: 1413 --RQKSLTLTPTRSDSSEGFLQL 1433
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 103 bits (258), Expect = 4e-22
Identities = 135/670 (20%), Positives = 282/670 (42%), Gaps = 103/670 (15%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM 83
EL K EE+ + ++E + + + L ++++ Y + +TR R +
Sbjct: 1347 ELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLS 1406
Query: 84 KSCKSPKSTTAHAI--LRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLE 141
+ K K+T LRRVE + ++ + L L+ + E +
Sbjct: 1407 EEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYK 1466
Query: 142 QRIEELECTVH--NLDDERMEQMSNMTLMKET------------ISTVEKEMKSLARKAM 187
Q +++ T+ N + ER++Q+ + KET + V+ +++ A
Sbjct: 1467 QSLDDAAKTIQDKNKEIERLKQLID----KETNDRKCLEDENARLQRVQYDLQKANSSAT 1522
Query: 188 DTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKY---ELQLTQEKIMCLDEKIDN 244
+T ++L Q+ E LR+ YE ++ + + + + + ELQL ++K+
Sbjct: 1523 ETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKV--------- 1573
Query: 245 FTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNI 304
EE++ L T A E C + L+++ E G ++KE+ I + N+
Sbjct: 1574 --------EEELNRLKRT----ASEDSCKRKKLEEELE-----GMRRSLKEQAIK-ITNL 1615
Query: 305 IAEMEQAS--RQCTEALIVCEQDV-SRMRRQLDETNDELAQIARERDILAHDNDNLQEQF 361
++EQAS ++ +E + ++DV R+ T +EL +++ E + L QE
Sbjct: 1616 TQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESV 1675
Query: 362 AKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKAN 421
+A N+ K + D LN+ K +E+ +L+++ ++ E+ + E+LR
Sbjct: 1676 KQAHLRNEHFQKAIEDKSRSLNESK-------IEIERLQSLTENLTKEHLMLEEELRNLR 1728
Query: 422 EDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQIS 481
+ ++ ++++D N LEL + N NR +E + I+
Sbjct: 1729 LEYDDLRRGRSEADSDKNATILELRSQLQISN---------NRTLE--------LQGLIN 1771
Query: 482 TLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMREN 541
L + + +E++K Q + + A + ++ C ++ +E L+ K + +E +
Sbjct: 1772 DLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERE----SLLVKIKVLEQDKA 1827
Query: 542 ELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCL 601
L E+ +S + E Q LE ++ Q Q L + +++ +E +
Sbjct: 1828 RLQRLEDELNRAKSTLEAETRVKQRLEC-------EKQQIQNDLNQWKTQYSRKEEAIRK 1880
Query: 602 AENKMAIQSRDVAQFRNVVTQLEADLD---------------ITKRQLGTERFERERAVQ 646
E++ R+ R+ + +L+A++ T+ QL TER +R +
Sbjct: 1881 IESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREID 1940
Query: 647 ELRRQNYSSN 656
+LR++ Y S+
Sbjct: 1941 KLRQRPYGSH 1950
Score = 93.2 bits (230), Expect = 7e-19
Identities = 114/519 (21%), Positives = 220/519 (42%), Gaps = 77/519 (14%)
Query: 15 TARGANCDVELLKTTT-RDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQE 73
T + N ++E LK ++ + KC LE L +Q +++ S + + ++
Sbjct: 1475 TIQDKNKEIERLKQLIDKETNDRKC-LEDENARLQRVQYDLQKANSSATETINKLKVQEQ 1533
Query: 74 EITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTD-------LRRMTTERDSLRERL 126
E+TRLR + RV ER V D L+ + ++ + E L
Sbjct: 1534 ELTRLRID----------------YERVSQERTVKDQDITRFQNSLKELQLQKQKVEEEL 1577
Query: 127 KIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKA 186
+ TA + ++ EELE +L ++ + +++N+T E S V+K + R+
Sbjct: 1578 NRLKRTASEDSCKRKKLEEELEGMRRSLKEQAI-KITNLTQQLEQASIVKKRSEDDLRQQ 1636
Query: 187 MD-----------TESELGRQKAENNSLR--------------LLYENTEKDLSDTQRHL 221
D T+ EL R +E +LR L E+ +K + D R L
Sbjct: 1637 RDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSL 1696
Query: 222 AKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKS 281
+ K E+ E++ L E N T++++ EE+ L +DL + + +A DK +
Sbjct: 1697 NESKIEI----ERLQSLTE---NLTKEHLMLEEELRNLRLEYDDLRRGRS--EADSDKNA 1747
Query: 282 ENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELA 341
I L L + ++ +I ++++ + + ++ ++ E+ ++
Sbjct: 1748 -TILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCT 1806
Query: 342 QIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKN 401
Q+ +ER+ L L++ A+ Q L +LN + L + Q E +++N
Sbjct: 1807 QVVQERESLLVKIKVLEQDKARL----QRLEDELNRAKSTLEAETRVKQRLECEKQQIQN 1862
Query: 402 ILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKE---- 457
L +++ + E +RK E++ +SE + N+L+ E+ +AE R++E
Sbjct: 1863 DLNQWKTQYSRKEEAIRKI-------ESEREKSEREKNSLRSEIERLQAEIKRIEERCRR 1915
Query: 458 KVDSLNREVEQHLNAERS-YKSQISTLHKSVVKMEEELQ 495
K++ RE + L ERS Y+ +I L + E Q
Sbjct: 1916 KLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1954
Score = 91.7 bits (226), Expect = 2e-18
Identities = 149/739 (20%), Positives = 305/739 (41%), Gaps = 119/739 (16%)
Query: 24 ELLKTTTRDREELKCMLEKYERHL-----------AEIQGNVKVLKSERDKIFLLYEQAQ 72
EL K EE+ + KYE + + + + K L+++ D++ +
Sbjct: 1191 ELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLK 1250
Query: 73 EEITRLRREMMKSCKSPKSTTAHAILRR-----VETERDVAFTDLRRMTTER-------- 119
+EI RL ++++ + + +A+ ++ + ++ +L+++ +R
Sbjct: 1251 DEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHK 1310
Query: 120 DSLRERLKIAQE---------TAFNEKAHLEQRIEELECTVHNLDDERMEQMSN-----M 165
SL E K Q+ F E+A E V N DE + + N +
Sbjct: 1311 QSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEI 1370
Query: 166 TLMKETIS--TVEKE---------MKSLARKAMDTESELGRQKAENNSLRLLYENTEKDL 214
+ K TI T++KE + +L R+ E+ R K N+L EN +
Sbjct: 1371 NITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLK---NTLTQTTENLRRVE 1427
Query: 215 SDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQ 274
D Q+ A Q Q+ + L + T +++ ++ + T+ D KE E L+
Sbjct: 1428 EDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLK 1487
Query: 275 ACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEA---LIVCEQDVSRMRR 331
+DK++ + L + A ++ + ++++A+ TE L V EQ+++R+R
Sbjct: 1488 QLIDKETNDRKCLEDENAR-------LQRVQYDLQKANSSATETINKLKVQEQELTRLRI 1540
Query: 332 QLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQD 391
+ + E + +++DI N + Q K K E + +L T +E + ++K+++
Sbjct: 1541 DYERVSQE--RTVKDQDITRFQNSLKELQLQKQKVEEEL--NRLKRTASEDSCKRKKLEE 1596
Query: 392 TNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAE 451
E+ ++ LK + + + +QL +A+ + E+ RQ + E + E
Sbjct: 1597 ---ELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEE 1653
Query: 452 GNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEEL--QKVQFEKVSALADLS 509
RL +V++L R++ Q + + + K++ L K++ E++ +L +
Sbjct: 1654 LRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENL 1713
Query: 510 STRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMA---NERISMQN 566
+ L ++ +EL N +L D E + D + +E LRSQ+ N + +Q
Sbjct: 1714 TKEHLMLE----EELRNLRLEYDDLRRGRSEADSDKNATILE-LRSQLQISNNRTLELQG 1768
Query: 567 L--------------------EALLVANRDKEYQSQI--ALQEKES-------------E 591
L +AL +NR +E ++Q +QE+ES
Sbjct: 1769 LINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR 1828
Query: 592 IQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTE-----RFERERAVQ 646
+Q L++ L A++ + ++R + Q++ DL+ K Q + + E ER
Sbjct: 1829 LQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKS 1888
Query: 647 ELRRQNYSSNAYHMSSTMK 665
E + + S + + +K
Sbjct: 1889 EREKNSLRSEIERLQAEIK 1907
Score = 71.6 bits (174), Expect = 2e-12
Identities = 116/589 (19%), Positives = 239/589 (40%), Gaps = 106/589 (17%)
Query: 157 ERMEQMSNMTLMKETISTVEKEMKSLARKAMDT---------------ESELGRQKAENN 201
E ++ + ++ L I +E+E++ LAR A ++E + KA+
Sbjct: 1019 EMLKSLEDLKLKNTKIEVLEEELR-LARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
Query: 202 SLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGG 261
SL L E D +++L K +++ EKI L +I++ R+ + +
Sbjct: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
Query: 262 TLNDLAKEKECLQACLDKKSENIASLGESLAMKEK--TISGMKNIIAEMEQASRQCTEAL 319
+ L K ++C +K++ L A+KEK I ++ ++ E R+ L
Sbjct: 1138 DYDQLQKARQC-----EKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENEL 1192
Query: 320 IVC----EQDVSRMRR----QLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQAL 371
+++S +R +++ T + +I+ +++ D+ NL+ Q + +EN+ L
Sbjct: 1193 AKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKE---DDSKNLRNQLDRLSRENRDL 1249
Query: 372 SK---KLNDT------------HNEL------NDIKQKVQDTNLEVNKLKNILKSEESEN 410
+LND+ N L ++I QK Q +E+ ++ + + +
Sbjct: 1250 KDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARH 1309
Query: 411 RQMMEQLRKANED---------AENWENKARQSEADNNTLKL------ELITA----EAE 451
+Q +E+ K +D AE E R+ E +N K+ E+I+ E E
Sbjct: 1310 KQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETE 1369
Query: 452 GNRLKEKVDSLNREVEQHLNA-----------ERSYKSQISTLHKSVVKMEEELQKV--- 497
N K + L + E+ + RS +I L ++ + E L++V
Sbjct: 1370 INITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEED 1429
Query: 498 -QFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQ 556
Q +K + ++L ++L ++ + V Q ++ + + EIE L+
Sbjct: 1430 IQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQL 1489
Query: 557 MANERISMQNLEALLVANRDKEYQSQIA----------LQEKESEIQLLKEHLCLAENKM 606
+ E + LE + +Y Q A L+ +E E+ L+ +
Sbjct: 1490 IDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQER 1549
Query: 607 AIQSRDVAQFRNVVTQL-------EADLDITKRQLGTERFERERAVQEL 648
++ +D+ +F+N + +L E +L+ KR + +R++ +EL
Sbjct: 1550 TVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEEL 1598
Score = 54.7 bits (130), Expect = 3e-07
Identities = 100/493 (20%), Positives = 196/493 (39%), Gaps = 104/493 (21%)
Query: 224 KKYELQLTQEKIMCLD-EKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSE 282
K YE +LT+E+ +CLD +K++ + C KK +
Sbjct: 785 KVYEARLTEEETVCLDLDKVEAY-----------------------------RCGLKKIK 815
Query: 283 NIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQ 342
N L +K+ ++ MK + + +Q Q ++ + + D+ + ++ + D +
Sbjct: 816 N------DLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQR 869
Query: 343 IARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIK-QKVQDTNLE---VNK 398
I ++ D D + +Q + QA K L D + ++ K D+N +N+
Sbjct: 870 IDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNE 929
Query: 399 LKNILKSEESENRQMMEQLRKANEDAENW------------------------------- 427
KN L SE S R E+++K E N
Sbjct: 930 QKN-LHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSP 988
Query: 428 ENKARQSEADNNTLKLELITAEAEGNR-LKEKVDSLN---------REVEQHLNAERSYK 477
Q AD + +EL+T + R L E + SL +E+ L R
Sbjct: 989 SGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDAN 1048
Query: 478 SQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLD----SSKELLNR---QLV 530
S+ +K +++ LQK Q E A L+S EL + + S+K+ L++ Q+
Sbjct: 1049 SENCNKNKF---LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
Query: 531 AKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRD----KEYQSQIALQ 586
+++I E++ + + + ++ L+ ++ ++ +S+ A++
Sbjct: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK 1165
Query: 587 EKESEIQLLKEHLCLA-------ENKMA-IQSRDVAQFRNVVTQLEADLDITKRQLGTER 638
EKE EI+ L+ L EN++A +++ + N+ + E +++ITK +
Sbjct: 1166 EKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEIS 1225
Query: 639 FERERAVQELRRQ 651
++E + LR Q
Sbjct: 1226 MQKEDDSKNLRNQ 1238
Score = 38.1 bits (87), Expect = 0.028
Identities = 78/410 (19%), Positives = 163/410 (39%), Gaps = 46/410 (11%)
Query: 264 NDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCE 323
N LA + C +++ E I +L L + K++ + ++E+ L
Sbjct: 516 NPLAVDLSCK---IEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMR 572
Query: 324 Q-DVSRMRRQLDETNDELAQIARERDILAHDNDN-LQEQFAKAKQENQALSKKLND--TH 379
Q D + L+ E + ++ ++ D+ +Q QF A++ Q L +L H
Sbjct: 573 QEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQH 632
Query: 380 NELNDIKQKVQDTNLEVNKLKNILKSEESENRQ--MMEQLRKANEDAENWENK------- 430
+ + T +VN K I + E++ ++ M+ +L+K E+ E +
Sbjct: 633 QTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLP 692
Query: 431 -ARQSEADNNTLKL-ELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVV 488
A Q + + T+K+ EL + + + + E ++ L + +E+ L V
Sbjct: 693 LADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEK-----YCYLQNEVF 747
Query: 489 KMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAH- 547
+ ++L+ + L L + R L + ++++L K E + E E
Sbjct: 748 GLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDML------KVYEARLTEEETVCLDL 801
Query: 548 SEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMA 607
++E R + + + NL+ L+A E Q + + S+ +
Sbjct: 802 DKVEAYRCGLKKIKNDL-NLKKSLLATMKTELQKAQQIHSQTSQ-------------QYP 847
Query: 608 IQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELR--RQNYSS 655
+ D+ +F VTQL +Q+ ++ E+ +++LR R NY +
Sbjct: 848 LYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQA 897
Score = 30.4 bits (67), Expect = 5.8
Identities = 31/138 (22%), Positives = 61/138 (44%), Gaps = 32/138 (23%)
Query: 466 VEQHLNAER-------SYKSQISTL------HKSVVKMEEE---LQKVQFEKVSALADL- 508
VEQH+N+ R Y+ Q+ + ++ ++EEE L K FE++ L L
Sbjct: 214 VEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQ 273
Query: 509 ----SSTRELCIKLDSSKELL-------NRQLVAKDQEIEMRENELDSAHSEIELLRSQ- 556
+++RE+ D +E L N + K + +R ++L+ E+ L+ +
Sbjct: 274 NIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQES 333
Query: 557 ---MANERISMQNLEALL 571
+ N+ + +EA +
Sbjct: 334 DQLVLNQHPASDKIEAYM 351
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 103 bits (258), Expect = 4e-22
Identities = 134/657 (20%), Positives = 289/657 (43%), Gaps = 80/657 (12%)
Query: 27 KTTTRDR--EELKCMLEKYERHLAEIQGNVKVLKSE-RDKIFLLYEQAQE--EITRLRRE 81
KTT D+ E++K ++ E H +E ++V ++E ++K LL + + E+ + +
Sbjct: 1973 KTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTH 2032
Query: 82 MMKSCKSPKSTTAHAILRRVETERDVAFTDLRR--MTTERDSLRERLKIAQETAFNEKAH 139
+ + +S + + L + E E +A + + + E +SL+ RL + N
Sbjct: 2033 LQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKA 2092
Query: 140 LEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAE 199
LE + E L + E + ++ I + +++ +K + +L ++ E
Sbjct: 2093 LEAALVEKGEFALRLSSTQEE----VHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERE 2148
Query: 200 NNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISIL 259
N+SL+ EN E++L ++ + + + ++ ++ L +I+ R + +
Sbjct: 2149 NDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARS-------LKVF 2201
Query: 260 GGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEAL 319
L L EKE L + +K ++ L +K +S K+++ E EQA Q E
Sbjct: 2202 ELDLVTLRSEKENLTKQIQEKQGQLSEL-------DKLLSSFKSLLEEKEQAEIQIKEE- 2253
Query: 320 IVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTH 379
+ V ++ QL E N+ +A + +++I+ K Q+L + + H
Sbjct: 2254 --SKTAVEMLQNQLKELNEAVAALCGDQEIM--------------KATEQSLDPPIEEEH 2297
Query: 380 NELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNN 439
N I+ KL+ L+++E + +++QL+++ A+ + + E +
Sbjct: 2298 QLRNSIE-----------KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELE 2346
Query: 440 TLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQF 499
+ A E K +V++L ++E + R + + T+ + ELQK Q
Sbjct: 2347 IARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQ- 2405
Query: 500 EKVSALADLSSTRELCI------------KLDSSKELLNRQLVAKDQEIEMRENELDSAH 547
E++S L ++S+ E + K ++ E+L QL ++ + N+ ++
Sbjct: 2406 ERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACK 2465
Query: 548 SEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKES----EIQLLKEHLCLAE 603
++ + L SQ+ E + ++ +A L+ D+ + I LQ + E++ K+ L +
Sbjct: 2466 AKEQNLSSQV--ECLELE--KAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKD 2521
Query: 604 ---NKMAIQSRDVAQFRNVVTQLEADLDITKRQ---LGTERFERERAVQELRRQNYS 654
+++ Q +D Q + ++Q+E + + K Q L E E+ +Q L+ +N S
Sbjct: 2522 EEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNAS 2578
Score = 100 bits (248), Expect = 6e-21
Identities = 136/681 (19%), Positives = 288/681 (42%), Gaps = 76/681 (11%)
Query: 25 LLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMK 84
LL +EL+ + + E L QG+ K +K + +K +++ Q ++ + + E+++
Sbjct: 279 LLDQLKAQNQELRNKINELELRL---QGHEKEMKGQVNK----FQELQLQLEKAKVELIE 331
Query: 85 SCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRI 144
K L R + D A T + + L E L ++ A + + LEQ+I
Sbjct: 332 --KEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKI 389
Query: 145 EELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKS-LARKAMDTESELGRQKAENNSL 203
+E E E E++S +T+ +MK+ L ++ ++ +AE + L
Sbjct: 390 KEKE-------KEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKL 442
Query: 204 RLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTL 263
+ + E +L + ++ L + + Q +Q K L ++ ++N + +
Sbjct: 443 TSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREV 502
Query: 264 NDLAKEKECLQACLDKKSENIAS---------------LGESLAMKEK--TISGMKNIIA 306
L E + ++ CL++ S+N A L E + +E T+ +K +A
Sbjct: 503 CHLEAELKNIKQCLNQ-SQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVA 561
Query: 307 EMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQ 366
++E+ R C++ L+ + +++ ND+L++ +E L + ++++ + K+
Sbjct: 562 DLEK-QRDCSQDLL------KKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKE 614
Query: 367 ENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAEN 426
E S ++ L ++ + ++ ++N L+ LK+++ ++ + E++R D EN
Sbjct: 615 EKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDREN 674
Query: 427 WENKARQSEADNNTLKLELITAEAEGNRLKEKVD----SLNREVEQHLNAERSYKSQIST 482
+ R ++ +E+ T + L++K + +E+E Q+
Sbjct: 675 LSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVED 734
Query: 483 LHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSS---KELLNRQLVAKDQEIEM- 538
L + + E+ A+ S R+L D+S E R L+A DQ+ M
Sbjct: 735 LEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMH 794
Query: 539 --------RENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKES 590
+ + S SE L Q +QN L + + + Q LQ++
Sbjct: 795 HSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCE 854
Query: 591 EIQLLK----EHLCLAE-----------NKMAIQSRDVAQFRNVVTQLEADLDITKR--Q 633
E+ +K E+L AE +++ D + +NVV + + L+ ++ Q
Sbjct: 855 ELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQ 914
Query: 634 LGTERFERERA-VQELRRQNY 653
L ++ E E+A +QEL++ N+
Sbjct: 915 LLNDKVETEQAEIQELKKSNH 935
Score = 96.7 bits (239), Expect = 7e-20
Identities = 123/638 (19%), Positives = 277/638 (43%), Gaps = 70/638 (10%)
Query: 44 ERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVET 103
+ + +Q VK +E ++ + E ++ L EM K S ++ ++E
Sbjct: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEM-KELDSKLHLQEVQLMTKIE- 1823
Query: 104 ERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMS 163
A +L ++ E L E + L QR+E T L+ + +E +
Sbjct: 1824 ----ACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVE----TSEGLNSD-LEMHA 1874
Query: 164 NMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAK 223
+ + ++ V K S + +D E+EL R ++E S+ +
Sbjct: 1875 DKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASI--------------EHEALY 1920
Query: 224 KKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQ---ACLDKK 280
+ +L++ Q + +CL++ +N + + EE+S++ N L E + + LD+
Sbjct: 1921 LEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQL 1980
Query: 281 SENIASLGESL----------------AMKEKT--ISGMKNIIAEMEQASRQCTEALIVC 322
SE + + L +KEKT + + + ++E+ + E L
Sbjct: 1981 SEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSL 2040
Query: 323 EQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNEL 382
E+D + E +++AQ+ +E+++L ++++LQ + +++ E +SK L E
Sbjct: 2041 EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100
Query: 383 NDIKQKVQDTNLEVN-------KLKNILKSEESENRQMMEQLRKANEDAENWENKAR--Q 433
+ ++ T EV+ KL+ ++++E + + E+L++ + ++ ++K +
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2160
Query: 434 SEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEE 493
E + EL+ +AE + K +V++L ++E+ + + ++ + TL + ++
Sbjct: 2161 RELQMSEENQELVILDAENS--KAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQ 2218
Query: 494 LQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQ-EIEMRENELDSAHSEIEL 552
+Q EK L++L L KE Q+ + + +EM +N+L + +
Sbjct: 2219 IQ----EKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAA 2274
Query: 553 LRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQL-LKEHLC-LAENKMAIQS 610
L + + Q+L+ + ++E+Q + ++++ + ++ K+ LC L + K +
Sbjct: 2275 LCGDQEIMKATEQSLDPPI----EEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHH 2330
Query: 611 RDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQEL 648
D+ + R V LE +L+I + E E + E+
Sbjct: 2331 ADLLKGR--VENLERELEIARTNQEHAALEAENSKGEV 2366
Score = 83.6 bits (205), Expect = 6e-16
Identities = 144/701 (20%), Positives = 301/701 (42%), Gaps = 95/701 (13%)
Query: 34 EELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREM--MKSCKSPKS 91
E LK +E+ R L + ++ L+SE++ + ++ Q +++ L + + KS K
Sbjct: 2185 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244
Query: 92 TTAHAILRRVETERDVAFTDLRRMTTERDSL---RERLKIAQETA---FNEKAHLEQRIE 145
I +T ++ L+ + +L +E +K +++ E+ L IE
Sbjct: 2245 QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 2304
Query: 146 ELECTVHNLDDERM-------EQMSNMTLMKETISTVEKEMK-------SLARKAMDTES 191
+L + + +++ E + L+K + +E+E++ A +A +++
Sbjct: 2305 KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKG 2364
Query: 192 ELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIA 251
E+ KA+ + E D+ + ELQ QE+I L+ I N + +NI
Sbjct: 2365 EVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE--IINSSFENIL 2422
Query: 252 QREEISILGGTLNDLAKEK-----ECLQACLDKKSENIASLG---ESLAMKEKTISGMKN 303
Q +E + KEK E LQ L + +E +A+L E+ KE+ +S
Sbjct: 2423 QEKEQEKVQ------MKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE 2476
Query: 304 II----AEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAH---DNDN 356
+ A++ Q + IV + V+ + +++++ +L + E L + D +
Sbjct: 2477 CLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ 2536
Query: 357 LQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQ 416
L + ++ + E+Q ++ + N +++QK+Q + L++ L+ +S + + +
Sbjct: 2537 LVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENE 2596
Query: 417 LRKANEDAENWENKARQSEADNNTLKLEL-----ITAE------AEGNRLKEKVDSLNRE 465
L D ++ K + A L+ E+ TAE E NRL ++ L E
Sbjct: 2597 LELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEE 2656
Query: 466 VE------QHLNAERS-YKSQISTLHKSVV----KMEEELQKVQF-----EKVSALADLS 509
++ + L E S K + +HK V K+ EE+ + Q EK L
Sbjct: 2657 IKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLD 2716
Query: 510 STRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEA 569
+ ++ +++ + +E +L +K++ + ++ E+D S E L + + + + Q LE
Sbjct: 2717 TNKQYEVEIQTYRE----KLTSKEECLSSQKLEIDLLKSSKEELNNSL---KATTQILEE 2769
Query: 570 LLVANRDK-EYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLD 628
L D +Y +Q+ +KE+E K L + K + +++ Q ++QL+A +
Sbjct: 2770 LKKTKMDNLKYVNQL---KKENERAQGKMKLLIKSCKQLEEEKEILQ--KELSQLQAAQE 2824
Query: 629 ITKRQLGTERFERERAVQELRRQNYSSNAYHMSSTMKPNTK 669
K++ GT V + + ++ + T++ TK
Sbjct: 2825 --KQKTGT--------VMDTKVDELTTEIKELKETLEEKTK 2855
Score = 78.6 bits (192), Expect = 2e-14
Identities = 154/766 (20%), Positives = 310/766 (40%), Gaps = 150/766 (19%)
Query: 20 NCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKI--------------- 64
+C +LLK E+L L K E+ + +++ K E +++
Sbjct: 568 DCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENE 627
Query: 65 -FLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVET---ERDVAFTDLRRMTTERD 120
L ++++E + + +++C + +H RV T +R+ ++R + D
Sbjct: 628 KLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLD 687
Query: 121 SLRER--------LKIAQETAFNEKAH-------------LEQRIEELECTVHNLDDERM 159
S +++ Q+ F+++ H L ++E+LE + L +E M
Sbjct: 688 SKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIM 747
Query: 160 -----------EQMSNMTLMK-ETISTVEKEMKSLARKAMDTE-----------SELGRQ 196
E S L+K + S V E + A D + E G
Sbjct: 748 DKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSM 807
Query: 197 KAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTR------QNI 250
+E + RL + + K+ + Q + ++ L+ ++ L ++ + + +N+
Sbjct: 808 PSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENL 867
Query: 251 AQREEI--SILGGTLNDLAKEKECLQA----------CLDKKSENIASLGESLAMKEKTI 298
+ E++ S + T ++K +E A L+ K + + L + + ++ I
Sbjct: 868 MKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEI 927
Query: 299 SGMKNIIAEMEQASRQ---CTEALIVCEQDVSRM----RRQLDETNDELAQIARERDILA 351
+K +E + ++ +E L + ++++S + +R+++E E + L
Sbjct: 928 QELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLN 987
Query: 352 HDNDNL---QEQFA---------------KAKQENQALSKKLNDTHNELNDIKQKVQDTN 393
+ NL E FA + KQE L ++ +T N D+ QK +
Sbjct: 988 QEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQ 1047
Query: 394 LEVNKLKNILKSEES--ENRQ-MMEQLRKA-NEDAENWENKARQSEADNNTLKLELITAE 449
+ +KL+ +L S ENR+ +EQL++A ++ + + K +E N L LEL T +
Sbjct: 1048 EKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQ 1107
Query: 450 AEGNRLKEKVDSLNREVEQHLNAERS----YKSQISTLHKSVVKMEEELQKVQFEKVSAL 505
+L E+ + N +S K +I TL + KM++E+ + ++ L
Sbjct: 1108 ----------QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL-LQENEQL 1156
Query: 506 ADLSSTRELCIKLDS--------SKELLNRQLVAKDQ-EIEMRENELDSAHSEIELLRSQ 556
+ T+ C L+S +E Q K Q ++E++E LDS ++++ L +
Sbjct: 1157 MKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAM 1216
Query: 557 MANERISMQNLE--------ALLVANRDKEYQSQIALQEKES-EIQLLKEHLCLAENKMA 607
+ N+ + +Q E L D E + LQ+ +S EI LK+ AE K
Sbjct: 1217 LRNKELKLQESEKEKECLQHELQTIRGDLETSN---LQDMQSQEISGLKDCEIDAEEKYI 1273
Query: 608 IQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNY 653
+++ +N L+ L T +L E E+ + L+ + Y
Sbjct: 1274 SGPHELSTSQNDNAHLQCSLQTTMNKLN----ELEKICEILQAEKY 1315
Score = 77.4 bits (189), Expect = 4e-14
Identities = 121/559 (21%), Positives = 235/559 (42%), Gaps = 79/559 (14%)
Query: 124 ERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERME-QMSNMTLMKETISTVEKEMKSL 182
+ L+ + E+ + L+++ EEL +++ M+ + + + + ET + K +
Sbjct: 833 DSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDT 892
Query: 183 ARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQR-----HLAKKKY-ELQLTQEKIM 236
+ L + + L+LL + E + ++ Q HL + ELQL E +
Sbjct: 893 SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLS 952
Query: 237 CLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEK 296
+++ + N + EE++ GTL ++ + L +KSE+ A+ + +EK
Sbjct: 953 LEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDE---REK 1009
Query: 297 TISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDN 356
+IS + + + + Q E +D+S+ + E N +L + E L + N
Sbjct: 1010 SISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKN 1069
Query: 357 ----LQEQFAKAKQE----------------------NQALSKKLNDTHN----ELNDIK 386
L+E FAK QE QAL ++ D N E +K
Sbjct: 1070 ELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLK 1129
Query: 387 QKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELI 446
Q++ E NK++ + EN Q+M ++ K + +N E SE N++K
Sbjct: 1130 QEIMTLKEEQNKMQKEVNDLLQENEQLM-KVMKTKHECQNLE-----SEPIRNSVK---- 1179
Query: 447 TAEAEGNR--LKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSA 504
E+E N+ K ++D +E+ SY +Q+ L + E +LQ+ + EK
Sbjct: 1180 ERESERNQCNFKPQMDLEVKEISLD-----SYNAQLVQLEAMLRNKELKLQESEKEKECL 1234
Query: 505 LADLSSTRELCIKLDSSKELLNRQLVA-KDQEIEMRENELDSAHSEIELLRSQMANERIS 563
+L + R ++ + +++ ++++ KD EI+ E + H E+ ++ A+ + S
Sbjct: 1235 QHELQTIRG-DLETSNLQDMQSQEISGLKDCEIDAEEKYISGPH-ELSTSQNDNAHLQCS 1292
Query: 564 MQ-------NLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCL-AENKMAIQSRDVAQ 615
+Q LE + + ++Y+ L + SE C+ A KMA +V +
Sbjct: 1293 LQTTMNKLNELEKICEILQAEKYELVTELNDSRSE--------CITATRKMA---EEVGK 1341
Query: 616 FRNVVTQLEADLDITKRQL 634
N V L D + +L
Sbjct: 1342 LLNEVKILNDDSGLLHGEL 1360
Score = 71.2 bits (173), Expect = 3e-12
Identities = 138/646 (21%), Positives = 252/646 (39%), Gaps = 100/646 (15%)
Query: 23 VELLKTTTRDREELK-C---MLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRL 78
+E LK D E+ + C +L+K E H+ ++ + + E + E ++E L
Sbjct: 553 LEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEEL 612
Query: 79 RREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKA 138
+ E K+ S + +L ++E+E++ + ++ + L LK Q K+
Sbjct: 613 KEE--KTLFSCWKSENEKLLTQMESEKE-------NLQSKINHLETCLKTQQI-----KS 658
Query: 139 H-LEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQK 197
H +R+ LE NL E + + N+ K +VE E + LA + ++E QK
Sbjct: 659 HEYNERVRTLEMDRENLSVE-IRNLHNVLDSK----SVEVETQKLAYMELQQKAEFSDQK 713
Query: 198 AENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEIS 257
+ EN S + +++LQL +IM D Q++ E
Sbjct: 714 HQKE-----IENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDR-----CYQDLHAEYE-- 761
Query: 258 ILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTE 317
+L DL K K+ + ++ + + AM NII E + +E
Sbjct: 762 ----SLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHS----FANIIGEQGSMPSERSE 813
Query: 318 ALIVCEQD----------VSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQE 367
+ +Q V + L+ + + ++ + L ++E KA+Q
Sbjct: 814 CRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873
Query: 368 NQA--------LSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRK 419
+Q+ +SK DT N + + + + +L+ + E+E ++ E L+K
Sbjct: 874 HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQE-LKK 932
Query: 420 ANEDAEN-------------WENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREV 466
+N E+ E K S N ++E +T E LKE SLN+E
Sbjct: 933 SNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQE--NGTLKEINASLNQEK 990
Query: 467 EQHLNAERSYKSQISTLHKSVVKMEEELQKVQF-------EKVSALADLSSTRELCIKLD 519
+ S+ + I KS+ ++ ++ ++ + E +A DLS + + +
Sbjct: 991 MNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN 1050
Query: 520 SSKELLNRQLVA----KDQEIEMRENELDSAHSEIELLRSQMANERIS--MQNLEALLVA 573
S E L + + + E+E + H E L + A ER M LE + A
Sbjct: 1051 SKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF-LTKLAFAEERNQNLMLELETVQQA 1109
Query: 574 NR----DKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQ 615
R D + S+ + EI LKE +NKM + D+ Q
Sbjct: 1110 LRSEMTDNQNNSKSEAGGLKQEIMTLKEE----QNKMQKEVNDLLQ 1151
Score = 55.5 bits (132), Expect = 2e-07
Identities = 118/595 (19%), Positives = 236/595 (39%), Gaps = 94/595 (15%)
Query: 142 QRIEELECTVHNLDDERMEQM-----------------------------SNMTLMKETI 172
Q+I+ELE + L E+ ++ N LM E
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLM-EIC 76
Query: 173 STVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQL-- 230
++EK + ++ + ES++ Q+ + NS + E E++L + L + + Q
Sbjct: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
Query: 231 -------TQEKIMCLD------------EKIDNFTRQNIAQREEISILGGTLNDLAKEKE 271
T +KI E + + + +R+ + L +
Sbjct: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQT 196
Query: 272 CLQACLDKK--SENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRM 329
QA ++ + + + AS +EKT S + + ++ R + + EQ+V+
Sbjct: 197 LPQATMNHRDIARHQASSSVFSWQQEKTPSHLSS-NSQRTPIRRDFSASYFSGEQEVTPS 255
Query: 330 RRQLDETNDELAQIA-RERDILAHDNDNLQEQFAKAKQENQALSKKLNDT-------HNE 381
R L QI R+ + DN + + K +NQ L K+N+ E
Sbjct: 256 RSTL--------QIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKE 307
Query: 382 LNDIKQKVQDTNLEVNKLK-NILKSEESENRQMMEQLR-KANEDAENWENKARQSEADNN 439
+ K Q+ L++ K K +++ E+ N+ E +R A D + + A + +
Sbjct: 308 MKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKL 367
Query: 440 TLKLELITAEAEGNR--LKEKVDSLNREVEQHLN-AERSYKSQISTLHKSVVKMEEELQK 496
T L AE R L++K+ +E ++ L+ +RS+++ + ++ +ELQ+
Sbjct: 368 TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQ 427
Query: 497 VQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEI---EMRENELDSAHSEIE-- 551
+ A+L + +L+++ E ++L +Q +++ENEL + E++
Sbjct: 428 AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487
Query: 552 --LLRSQMANERISMQNLEALLVANRDKEYQSQIALQE-------KESEIQLLKEHLCLA 602
LL+S + + +LEA L + QSQ +E +E+ ++ L+E +
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQ 547
Query: 603 ENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNA 657
EN + ++ +A V LE D ++ L E+ +L + S A
Sbjct: 548 ENSLTLEKLKLA-----VADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597
Score = 48.1 bits (113), Expect = 3e-05
Identities = 103/533 (19%), Positives = 217/533 (40%), Gaps = 68/533 (12%)
Query: 32 DREELKCMLEKYERHLAEIQG-----NVKVLKSERDKIFLLYEQAQEEITRLRREMMKSC 86
D E + L+ Y L +++ +K+ +SE++K E Q E+ +R ++ S
Sbjct: 1195 DLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEK-----ECLQHELQTIRGDLETSN 1249
Query: 87 KSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEE 146
+ + L+ E + + + + + L+ + +T N+ LE+ E
Sbjct: 1250 LQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEI 1309
Query: 147 LECT----VHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESEL--------- 193
L+ V L+D R E ++ M E + + E+K L + EL
Sbjct: 1310 LQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEF 1369
Query: 194 GRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQL----TQEKIMCLDEKIDNFTRQN 249
G Q E + + L D S++ HL E+Q+ QEK + L + Q+
Sbjct: 1370 GEQPNEQHPVSL----APLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQH 1425
Query: 250 IAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEME 309
++S L ++ L E L S N+ + L +KE + + ++ +
Sbjct: 1426 CQMSSKMSELQTYVDSLKAENLVL-------STNLRNFQGDL-VKEMQLGLEEGLVPSLS 1477
Query: 310 QASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQ 369
+ + +L D S R L++T D ++ ++ ++ + ++ E F + QE
Sbjct: 1478 SSCVPDSSSLSSLG-DSSFYRALLEQTGD-MSLLSNLEGAVSANQCSVDEVFCSSLQEEN 1535
Query: 370 ALSKKLNDTHNE-LNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWE 428
K+ + + +++ + + KL+ E+ E++ +M+ N++ + E
Sbjct: 1536 LTRKETPSAPAKGVEELESLCEVYRQSLEKLE-----EKMESQGIMK-----NKEIQELE 1585
Query: 429 NKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVV 488
+ + L+ + ++ E + ++K+ S+ E+E L AE+ Q+S
Sbjct: 1586 QLLSSERQELDCLRKQYLS---ENEQWQQKLTSVTLEMESKLAAEKKQTEQLS------- 1635
Query: 489 KMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQL-VAKDQEIEMRE 540
+E E+ ++Q + + DLSS L I + + + N ++K+ E E
Sbjct: 1636 -LELEVARLQLQGL----DLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTE 1683
Score = 45.4 bits (106), Expect = 2e-04
Identities = 19/104 (18%), Positives = 56/104 (53%)
Query: 454 RLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRE 513
R +K+ L ++++ ++ + Q+ +L ++ K +++++ + E + + E
Sbjct: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLME 74
Query: 514 LCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQM 557
+C L+ +K+ ++ +L K+ ++ +E +L+S +IE L ++
Sbjct: 75 ICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQEL 118
Score = 44.3 bits (103), Expect = 4e-04
Identities = 71/401 (17%), Positives = 160/401 (39%), Gaps = 43/401 (10%)
Query: 324 QDVSRMRRQLDETNDELAQIARERDILA-------HDNDNLQEQFAKAKQENQALSKKLN 376
Q + + QLD+ E Q + D L +N + + K+ENQ L +
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 377 DTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEA 436
I ++Q +VN + L S + + ++ ++L++ + E + A+ ++
Sbjct: 78 SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137
Query: 437 DNNTLKL--ELITAEA------EGNRLKEKVDSLNREVEQHLNAERSYKS---------- 478
N ++ T G++ ++ + N+EVE+ E K+
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTL 197
Query: 479 -QISTLHKSVVKMEEELQKVQFEKVSALADLSS-TRELCIKLDSSKELLN--RQLVAKDQ 534
Q + H+ + + + +++ + LSS ++ I+ D S + +++
Sbjct: 198 PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRS 257
Query: 535 EIEMRENELDSAHSE-------IELLRSQMANERISMQNLEALLVANRDKEYQSQI-ALQ 586
+++ + + +S+ + ++ L++Q R + LE L + +KE + Q+ Q
Sbjct: 258 TLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE-LRLQGHEKEMKGQVNKFQ 316
Query: 587 EKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQ 646
E + +++ K L + + K+ + RD V T + D TK ++ ++
Sbjct: 317 ELQLQLEKAKVEL-IEKEKVLNKCRD----ELVRTTAQYDQASTKYTALEQKLKKLTEDL 371
Query: 647 ELRRQNYSSNAYHMSSTMKPNTKCHSPERAHHRSPDRGLDR 687
+RQN S + +K K E + + + LD+
Sbjct: 372 SCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQ 412
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 102 bits (254), Expect = 1e-21
Identities = 119/570 (20%), Positives = 244/570 (42%), Gaps = 41/570 (7%)
Query: 102 ETERDVAFTDLRRMTTERDSLRER---LKIAQETAFNEKAHLEQRIEELECTVHNLDDER 158
ET + + + L+ +T+ D +R L + +A + C + +
Sbjct: 553 ETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDL 612
Query: 159 MEQMSNMTLMKETIS-----------TVEKEMKSLARKAMDTESELGRQKAENNSLRLLY 207
+EQ S +T+ + +++E + + + S+ + EN++L+
Sbjct: 613 LEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRL 672
Query: 208 ENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQ-NIAQREEISILGGTLNDL 266
E +E +L L + K E + Q +I L +++ + + A+R E G + +L
Sbjct: 673 EESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEEL 732
Query: 267 AKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIV-CEQD 325
+ K+ LQ L K E + L +E+ ++ +K + E + Q + L + +
Sbjct: 733 LQAKQDLQDLLIAKEEQ----EDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAE 788
Query: 326 VSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDI 385
+ +R ++E + +A + D + + ++EN+ L + + + +
Sbjct: 789 LQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQL 848
Query: 386 KQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLEL 445
+++++D + K K LK E E RQ+ E L A ++ + + R E + + L
Sbjct: 849 QRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNL 908
Query: 446 ITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSAL 505
E +L EK+ + + EQ + +++ L K++ K+++E+ +
Sbjct: 909 SQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI------VE 962
Query: 506 ADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQ 565
A +ST EL +LD KE R+L + + +++E L++ S + ++ Q M+
Sbjct: 963 ASRTSTLELQNQLDEYKEKNRRELA--EMQRQLKEKTLEAEKSRLTAMKMQ-----DEMR 1015
Query: 566 NLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAI---QSRDVAQFRNVVTQ 622
+E L RD + AL +++ Q LK+ E K + +SR V Q + V+Q
Sbjct: 1016 LMEEEL---RDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQ 1072
Query: 623 LEADLDITKR--QLGTERFERERAVQELRR 650
LE +L+ + L +ER R R E R
Sbjct: 1073 LEMELEEERNNSDLLSERISRSREQMEQLR 1102
Score = 92.0 bits (227), Expect = 2e-18
Identities = 133/552 (24%), Positives = 231/552 (41%), Gaps = 70/552 (12%)
Query: 33 REELKCMLEKYERHLAEIQGNVKVLKSERDK-IFLLYEQAQEEITRLRREMMKSCKSPKS 91
+EE + +L K ER L ++G +K S D+ + L EQ E+ LR + ++ K+ +
Sbjct: 746 KEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEV 805
Query: 92 TTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTV 151
+ R +E+D A T++R +K+ QE NEK L+ R EELE V
Sbjct: 806 LAS----RSNTSEQDQAGTEMR------------VKLLQEE--NEK--LQGRSEELERRV 845
Query: 152 HNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTE 211
L + + + KET+ E E++ L + E + E S R EN
Sbjct: 846 AQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKE----EKEAVSARRALEN-- 899
Query: 212 KDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEK- 270
+L Q +L++ E + EK+ E+ + R E LG T+ L KE
Sbjct: 900 -ELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMA 958
Query: 271 ECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMR 330
+ ++A E L E KEK + +AEM++ ++ T +M+
Sbjct: 959 DIVEASRTSTLELQNQLDE---YKEKN----RRELAEMQRQLKEKTLEAEKSRLTAMKMQ 1011
Query: 331 RQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQ 390
++ +EL R +D L++ + E +A S +D + ++ KV
Sbjct: 1012 DEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVS 1071
Query: 391 DTNLEVNKLKN---ILKSEESENRQMMEQLRKANEDAENWENKARQS--------EADNN 439
+E+ + +N +L S +R+ MEQLR NE + E ARQ E N
Sbjct: 1072 QLEMELEEERNNSDLLSERISRSREQMEQLR--NELLQ--ERAARQDLECDKISLERQNK 1127
Query: 440 TLKLELITAEAEGNRLKE----KVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQ 495
LK +I E KE ++++ E+E L +E ++ + ++ + + +EL
Sbjct: 1128 DLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELV 1187
Query: 496 KVQFEKVSALADLSSTRELCIK---------------LDSSKELLNRQLVAKDQEIEMRE 540
++ +L D L +K L+SSK+ L R+L + E +
Sbjct: 1188 MQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQ 1247
Query: 541 NELDSAHSEIEL 552
+L+S ++ L
Sbjct: 1248 GQLNSMKKDLRL 1259
Score = 56.6 bits (135), Expect = 8e-08
Identities = 88/473 (18%), Positives = 182/473 (38%), Gaps = 92/473 (19%)
Query: 26 LKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKS 85
+K + E+L+ E+ ER +A++Q ++ LK + K ++ + EI +L ++ +
Sbjct: 824 VKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHA 883
Query: 86 CKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERL------------------- 126
K K A + R +E E + A +L + T E+ L E+L
Sbjct: 884 RKEEKE--AVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMEN 941
Query: 127 ----------KIAQETA-------------------FNEK-----AHLEQRIEELECTVH 152
K+ +E A + EK A ++++++E
Sbjct: 942 ERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAE 1001
Query: 153 NLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEK 212
M+ M LM+E + ++ K E L + E + L ++ +
Sbjct: 1002 KSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSR 1061
Query: 213 DLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKEC 272
+ + +++ + EL+ + L E+I Q R E+ DL EC
Sbjct: 1062 LVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDL----EC 1117
Query: 273 LQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQ 332
+ L++++++ +K+ I +E + R E L+V +M +
Sbjct: 1118 DKISLERQNKD-----------------LKSRIIHLEGSYRSSKEGLVV------QMEAR 1154
Query: 333 LDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDT 392
+ E D L R+R NLQ + +++ + L +++D H L D K ++
Sbjct: 1155 IAELEDRLESEERDR-------ANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQL--- 1204
Query: 393 NLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLEL 445
+L + +K ++ E E ++ +K + E + + N++K +L
Sbjct: 1205 SLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL 1257
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 101 bits (252), Expect = 2e-21
Identities = 143/713 (20%), Positives = 293/713 (41%), Gaps = 143/713 (20%)
Query: 27 KTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEI-------TRLR 79
K ++R+ L +E+ L +I+ LK ++ QEE+ ++L
Sbjct: 630 KQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLE 689
Query: 80 REMMKSCKS--------PKSTTAHAIL--RRVETERDVAFTD--LRRMTTERDSLRERLK 127
EM K C + A++ + + E E+++ + +R + T ++ E++
Sbjct: 690 SEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKIC 749
Query: 128 IAQETAFNEKAHLEQ------RIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKS 181
+A E A +K HLEQ +IE LE + D + EQ M+++++ I + ++S
Sbjct: 750 LAFEKA--KKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLES 807
Query: 182 LARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLA------------------- 222
L R +++ E+ ++ + + +N + + R L
Sbjct: 808 LDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEG 867
Query: 223 -KKKYELQLTQ--EKIMCLDE--KIDNFTRQNIAQREEI---------------SILGGT 262
K+K+E QL + E++ CL + KI N + Q +++ I +I G
Sbjct: 868 NKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGE 927
Query: 263 LND---------------LAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAE 307
L D L K++E L K E S +K + + + +
Sbjct: 928 LEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQ 987
Query: 308 MEQASRQCTEALIVCEQDVSRMRRQ--------------LDETNDELAQ---IARERDIL 350
++ Q E L E+++ ++R LD+T EL + +E + L
Sbjct: 988 VKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKL 1047
Query: 351 AHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESEN 410
H + + +A Q+ + L +L + H EL +++Q+ + K + L+ + +
Sbjct: 1048 QHSTET---ELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTI 1104
Query: 411 RQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHL 470
+ + +LR+ + E+ K EL+ + LKE+ L + Q
Sbjct: 1105 KDLTAELRECKMEIED--------------KKQELLEMD---QALKERNWELKQRAAQVT 1147
Query: 471 NAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLV 530
+ + + + + + ++K+E L+K + E + S + KL ++KE L
Sbjct: 1148 HLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLND---KLQNAKEQL----- 1199
Query: 531 AKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKES 590
+++E M +NE EI L+ ++ + M+ +E+++ KE + IA Q KE+
Sbjct: 1200 -REKEFIMLQNE-----QEISQLKKEIERTQQRMKEMESVM-----KEQEQYIATQYKEA 1248
Query: 591 -----EIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTER 638
E++L +E + + ++A Q + + +L ++L+ K QL E+
Sbjct: 1249 IDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMK-QLSKEK 1300
Score = 90.9 bits (224), Expect = 4e-18
Identities = 145/656 (22%), Positives = 280/656 (42%), Gaps = 91/656 (13%)
Query: 35 ELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKS-----CKSP 89
EL+ L E + ++ N+ + + I Q +++ L E +K +S
Sbjct: 561 ELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESV 620
Query: 90 KSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELEC 149
K H + ++ E ER +R+ T + LR +L + + K ++ R + +
Sbjct: 621 KDQNQHTMNKQYEKER-------QRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQL 673
Query: 150 TVHNLDDERMEQMSN-------MTLMKETISTVEKEMK-------SLARKAMDTESELGR 195
+ +E +E+ SN MT + T+EK+++ S+A K + E EL
Sbjct: 674 ----IQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELME 729
Query: 196 QKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREE 255
+ + SL NTE + AKK + L Q K M +++I+ Q + ++
Sbjct: 730 KNEKIRSLETNI-NTEHEKICLAFEKAKK---IHLEQHKEM--EKQIERLEAQLEKKDQQ 783
Query: 256 ISILGGTLNDLAKEKECLQACLDK----KSENIASLGESLAMKEKTISGMKNIIAEMEQA 311
T++ L ++ C Q L+ +E+ + + K++ + ++N ++E
Sbjct: 784 FKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIK 843
Query: 312 SRQCTEALIVCEQDV-----------SRMRRQLDETNDELAQIARERDILAHDNDNLQEQ 360
RQ AL +C++++ + +QL + ++E+ + +E I H EQ
Sbjct: 844 VRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQ 903
Query: 361 ---FAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQL 417
Q+ Q + ++ + EL D + K++ +V+KL+ L+ + + E+L
Sbjct: 904 NVILQHTLQQQQQMLQQETIRNGELEDTQTKLEK---QVSKLEQELQKQRESS---AEKL 957
Query: 418 RKANEDAENWENKARQSEADNNTLKLELITAEA-----EGNRLKEKVDSLNREVEQHLNA 472
RK E E + EAD K+ +T A E ++ KE++ + +E+ HL
Sbjct: 958 RKMEEKCE-----SAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEI-MHLKR 1011
Query: 473 ERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAK 532
+ K+ +H S + M + K + EK + ++ +EL KL S E +L
Sbjct: 1012 DGENKA----MHLSQLDMILDQTKTELEKKT-----NAVKEL-EKLQHSTE---TELTEA 1058
Query: 533 DQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEI 592
Q+ E+ E EL +AH E++ Q+ R +Q + L L+E + EI
Sbjct: 1059 LQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEI 1118
Query: 593 QLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQEL 648
+ K+ L + + ++ ++ Q VT LD+T R+ R E E+ + +L
Sbjct: 1119 EDKKQELLEMDQALKERNWELKQRAAQVTH----LDMTIRE---HRGEMEQKIIKL 1167
Score = 83.2 bits (204), Expect = 8e-16
Identities = 123/569 (21%), Positives = 247/569 (43%), Gaps = 65/569 (11%)
Query: 41 EKYERHLAEIQGNVKVLKSE-RDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILR 99
EK+E+ L + V L+ E + K L E +++ + + + T + L
Sbjct: 870 EKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELE 929
Query: 100 RVETERDVAFTDLRR-MTTERDSLRERLKIAQE---TAFNEKAHLEQRIEELECTVHNLD 155
+T+ + + L + + +R+S E+L+ +E +A +E Q++ EL T +
Sbjct: 930 DTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVK 989
Query: 156 DERMEQMSNMTLMKETISTVEKEMKSLAR----KAM----------DTESELGRQKAENN 201
E M KE +S +EKE+ L R KAM T++EL ++
Sbjct: 990 IE-------MDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVK 1042
Query: 202 SLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGG 261
L L +TE +L++ + + ELQ ++ ++ +++ Q+ ++S+
Sbjct: 1043 ELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQEL--RDVLQKAQLSLEEK 1100
Query: 262 --TLNDLAKE-KECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEA 318
T+ DL E +EC DKK E L A+KE+ +K A++ E
Sbjct: 1101 YTTIKDLTAELRECKMEIEDKKQE---LLEMDQALKERNWE-LKQRAAQVTHLDMTIREH 1156
Query: 319 LIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDT 378
EQ + ++ L+++ EL + ++ + L ND LQ AK++ + +
Sbjct: 1157 RGEMEQKIIKLEGTLEKSELELKECNKQIESL---NDKLQN----AKEQLREKEFIMLQN 1209
Query: 379 HNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADN 438
E++ +K++++ T + ++++++K +E ++ ++ + + S +
Sbjct: 1210 EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTEL 1269
Query: 439 NTLKLELITAEAEGNRLKEKVDS---LNREVEQHLN--AERSYKSQISTLHKSVVKMEEE 493
+ + + A+ E RL +++ L++E + H N AE S++ H +M+ E
Sbjct: 1270 AEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEA-RMQAE 1328
Query: 494 LQKVQFEKVSA--------LADLSSTRELCIKLDSSK---ELLNRQLVAKDQEIEMRENE 542
++K+ E S ++ + + I DS K + LN QL E+E ++
Sbjct: 1329 IKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDT 1388
Query: 543 LDSAHSEIELLRSQMANERISMQNLEALL 571
+ + H ++ Q NE I N EALL
Sbjct: 1389 VSNLHQQV-----QDRNEVIEAAN-EALL 1411
Score = 78.2 bits (191), Expect = 2e-14
Identities = 137/691 (19%), Positives = 284/691 (41%), Gaps = 135/691 (19%)
Query: 58 KSERDKIFLLYEQAQEEITRLRREM--MKSCKSPKSTTAHAILRRVETERDVAFTDLRRM 115
K RDK+F +EI LR ++ ++ + T H+++ + F +
Sbjct: 214 KKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTK--------FESIHFE 265
Query: 116 TTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLD------DERMEQMSNMTLMK 169
T+ + L+ AQ+ A + LE++I LE V D + ++EQ M + K
Sbjct: 266 LTQSRAKVSMLESAQQQAASVPI-LEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEK 324
Query: 170 ETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQ 229
E S E + + + K E ++AE LY N E+ Q++ K +L+
Sbjct: 325 EQ-SLQESKEECIKLKVDLLEQTKQGKRAERQRNEALY-NAEELSKAFQQYKKKVAEKLE 382
Query: 230 LTQEKIMCLDEKIDNFTRQNIAQRE-------EISILGGTLNDLAKE----KECLQACLD 278
Q + L+ + N ++N +E E+ IL L L +E KE L+
Sbjct: 383 KVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAV 442
Query: 279 KKSENIASLGES----------LAMKEKTIS---GMKNIIAEMEQASRQCTEALIVCEQD 325
K SE +A L ES L K++ + + N E++ E L +C+Q+
Sbjct: 443 KNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQE 502
Query: 326 VSRMRRQLDETNDELAQIARERDILAHDN----------DNLQEQFAKAKQENQALSKKL 375
+ R +L ++Q+ +R++ + N +++ + N+ + +L
Sbjct: 503 IESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISEL 562
Query: 376 ----------------NDTHNEL-------NDIKQKVQDTNLEVNKLK----NILKSEES 408
N T N+L ND ++ + ++LE +K + +S +
Sbjct: 563 RIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKD 622
Query: 409 ENRQMM-EQLRKANE----DAENWENKARQSEADNNTLKLELITAEAEGNRLKEKV---- 459
+N+ M +Q K + E K Q EA+N+ LK+ + ++ ++E++
Sbjct: 623 QNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKA 682
Query: 460 -------DSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSST- 511
+ ++ Q L E+ + +I + S+ EL++ EK + L +
Sbjct: 683 SNSSKLESEMTKKCSQLLTLEKQLEEKI-VAYSSIAAKNAELEQELMEKNEKIRSLETNI 741
Query: 512 ----RELCIKLDSSKEL-------LNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANE 560
++C+ + +K++ + +Q+ + ++E ++ + + +L+ + +
Sbjct: 742 NTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICK 801
Query: 561 RISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVV 620
+ +++L+ LL ES+ ++ KE++ E A+Q++ V++ V
Sbjct: 802 QHHLESLDRLLT----------------ESKGEMKKENMKKDEALKALQNQ-VSEETIKV 844
Query: 621 TQLEADLDITKRQL---------GTERFERE 642
QL++ L+I K +L E+FE++
Sbjct: 845 RQLDSALEICKEELVLHLNQLEGNKEKFEKQ 875
Score = 64.3 bits (155), Expect = 4e-10
Identities = 104/510 (20%), Positives = 207/510 (40%), Gaps = 46/510 (9%)
Query: 168 MKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYE 227
M + + V++E+KSL K + +N+SL +E+ +L+ ++ ++ +
Sbjct: 220 MFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLE-S 278
Query: 228 LQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASL 287
Q + L+E+I N E+S L + + E Q + +K + SL
Sbjct: 279 AQQQAASVPILEEQIINL-------EAEVSAQDKVLREAENKLEQSQKMVIEKEQ---SL 328
Query: 288 GESLAMKEKTISGMKNIIAEMEQ---ASRQCTEALIVCEQDVSRMRRQLDETNDELAQIA 344
ES KE+ I +++ + +Q A RQ EAL E+ ++ + ++L ++
Sbjct: 329 QES---KEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQ 385
Query: 345 RERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILK 404
E +IL + N ++ EN+ L ++ +EL +K+K++ E N K L+
Sbjct: 386 AEEEILERNLTNCEK-------ENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLR 438
Query: 405 SEESENRQMMEQLRKANEDAENWENKARQSE---ADNNTLKLELITAEAEGNRLKEKVDS 461
+N ++M QL ++ + E++ + D +L E + E++D
Sbjct: 439 IMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDL 498
Query: 462 LNREVEQHLNAERSYKSQIS--TLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLD 519
+E+E RS + IS L + + + L K Q ++ S+ + CI
Sbjct: 499 CQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQ------MSSFSNKEDRCIGCC 552
Query: 520 SSKEL----LNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANR 575
+ +L L +L K+ EI+ L + L+ + E + +LE V
Sbjct: 553 EANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPV--- 609
Query: 576 DKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLG 635
K Q+A K+ + + E + + + R + Q+EA+ K +
Sbjct: 610 -KLGGHQVAESVKDQNQHTMNKQY---EKERQRLVTGIEELRTKLIQIEAENSDLKVNMA 665
Query: 636 TERFERERAVQELRRQNYSSNAYHMSSTMK 665
+ + +EL + +S+ T K
Sbjct: 666 HRTSQFQLIQEELLEKASNSSKLESEMTKK 695
Score = 60.5 bits (145), Expect = 5e-09
Identities = 85/419 (20%), Positives = 183/419 (43%), Gaps = 55/419 (13%)
Query: 192 ELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIA 251
+LG ++ ++ Y N + + ++A ++EL++T+ + L E++ + + +
Sbjct: 115 DLGEMESSSSD----YYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENS 170
Query: 252 ------QREEISILG------GTLNDLAKEKEC--LQACLDKKSENIASLGESLAMKEKT 297
R E IL G LN E C + D + + + S A ++
Sbjct: 171 DYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQE 230
Query: 298 ISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDN- 356
I ++ + ++ Q + A +V + + + + + EL Q + +L
Sbjct: 231 IKSLREKLNKLRQQN-----ACLVTQN--HSLMTKFESIHFELTQSRAKVSMLESAQQQA 283
Query: 357 -----LQEQFAKAKQENQALSKKLNDTHNELN-------DIKQKVQDTNLEVNKLKNILK 404
L+EQ + E A K L + N+L + +Q +Q++ E KLK L
Sbjct: 284 ASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLL 343
Query: 405 SEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNR 464
+ + ++ Q +A +AE +KA Q KLE + AE E L+ + + +
Sbjct: 344 EQTKQGKRAERQRNEALYNAEEL-SKAFQQYKKKVAEKLEKVQAEEE--ILERNLTNCEK 400
Query: 465 EVEQHLNAERSYKSQISTLHKSVVKMEEE-------LQKVQFEKVSALADLSSTRELCIK 517
E ++ YKS++ L + + +++EE L+ + + +A L+ +R+ +K
Sbjct: 401 ENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILK 460
Query: 518 LDSSKELLNRQLVAKDQEIEMREN-----ELDSAHSEIELLRSQMANERISMQNLEALL 571
L+S EL N+ + +D+ M EN + + + ++L + ++ + R+ +++LE ++
Sbjct: 461 LES--ELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKII 517
Score = 58.2 bits (139), Expect = 3e-08
Identities = 74/371 (19%), Positives = 151/371 (40%), Gaps = 42/371 (11%)
Query: 26 LKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKS 85
LK+T R +EL+ +L+K + L E +K L +E + + E ++E+ + + + +
Sbjct: 1076 LKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKER 1135
Query: 86 CKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIE 145
K A T D+ +R E + +L+ E + E ++IE
Sbjct: 1136 NWELKQRAAQV------THLDMT---IREHRGEMEQKIIKLEGTLEKSELELKECNKQIE 1186
Query: 146 ELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRL 205
L + N ++ E+ M ++ IS ++KE++ ++ + ES + Q
Sbjct: 1187 SLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQ--------- 1237
Query: 206 LYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLND 265
E+ ++ + EL+LT+E++ ++ Q + + EI L L D
Sbjct: 1238 -----EQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELED 1292
Query: 266 ---LAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVC 322
L+KEK+ L E AS ++ + + +K + AE+E +I
Sbjct: 1293 MKQLSKEKDAHGNHL--AEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISH 1350
Query: 323 EQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNEL 382
+++ ++ + D + Q L EQ KAK E + +++ H ++
Sbjct: 1351 QENHAKWKISADSQKSSVQQ--------------LNEQLEKAKLELEEAQDTVSNLHQQV 1396
Query: 383 NDIKQKVQDTN 393
D + ++ N
Sbjct: 1397 QDRNEVIEAAN 1407
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 100 bits (250), Expect = 3e-21
Identities = 154/737 (20%), Positives = 319/737 (43%), Gaps = 121/737 (16%)
Query: 25 LLKTTTRDREELKCMLEKYERHLAEIQ----------GNVKVLK-SERDKIFLLYEQAQ- 72
+++ R++ EL LE+ +R + ++Q G+++V SE+ +I L +
Sbjct: 416 MVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLAL 475
Query: 73 --EEITRLRREMMKSCKSPKSTTAHAILRRVET---ERDVAFTDLRRMTTERDSLRERLK 127
+E+ LRR + + + + ++L+ + + + +V TD +R T SL+E
Sbjct: 476 RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT---SLKEHFG 532
Query: 128 IAQETAFNEKAHLEQRIEEL----ECTVHNLDDERMEQMSNMTLMKETISTV-------E 176
+ET E L E+L E L+ E + L K + T
Sbjct: 533 AREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAM 592
Query: 177 KEMKSLARKAMDTES-ELGRQKAENNSLRLLYENTEKDLS---DTQRHLAKKKYE----- 227
+E+K K + TE+ E K + +RL Y++ ++L D++R K+ E
Sbjct: 593 EELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAK 652
Query: 228 -LQLTQEKIMCLD---EKIDNFTRQNIAQREEISILGGTLNDL------AKEKECLQACL 277
+++ +EK L+ K+D Q++ + E+ TLN L KE E LQA
Sbjct: 653 LMKVIKEKENSLEAIRSKLDKAEDQHLVEMED------TLNKLQEAEIKVKELEVLQAKC 706
Query: 278 DKKSENIASLGESLAMKEKTI--------------SGMKNIIAEMEQASRQCTEALIVCE 323
+++++ I + L E+ + S MK + ++E A +Q I
Sbjct: 707 NEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKN 766
Query: 324 QDVSRMR--------RQLDETN--DELAQIARERDILAHDNDNLQEQFAKAKQENQALSK 373
+ S+ R+L TN + L+++++ ++ L + L+E+FA+A +E ++ +
Sbjct: 767 AESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQR 826
Query: 374 KLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEES---ENRQMMEQLRKANEDAEN---- 426
+ +T N+L+ +++ + ++ KL+ L E+ E + EQL KA E EN
Sbjct: 827 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 886
Query: 427 --------------WENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQ-HLN 471
++ R E D L+L+L A + L++ ++ + + EQ
Sbjct: 887 IMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQE 946
Query: 472 AERSYKSQISTLHKSVVKMEEELQKV--QFEKVSALADLSSTRELCIKLDSSKELLNRQL 529
A + ++ + L + + +E++++ Q +++ A + +T E K + + L + L
Sbjct: 947 AAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE-RATSETKTKHEEILQNLQKTL 1005
Query: 530 VAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEAL-LVANRDKEYQSQIALQEK 588
+ + +++ E E+E LR Q + + +A+ ++ KE +A E
Sbjct: 1006 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1065
Query: 589 --------ESEIQLLKEH-------LCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQ 633
++E+ LKE+ L ++ + ++++ + +FR + L+ +Q
Sbjct: 1066 TKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQ 1125
Query: 634 LGTERFERERAVQELRR 650
L + E + +EL R
Sbjct: 1126 LSALQEENVKLAEELGR 1142
Score = 98.6 bits (244), Expect = 2e-20
Identities = 131/549 (23%), Positives = 241/549 (43%), Gaps = 68/549 (12%)
Query: 58 KSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTT 117
KSE K+ E A+++I L E K+ +S+ A +I R ++ R++ T+L+ +
Sbjct: 741 KSEMKKLRQQLEAAEKQIKHLEIE-----KNAESSKASSITRELQG-RELKLTNLQENLS 794
Query: 118 E----RDSLRERLKIAQET---AFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKE 170
E +++L + L+I +E A E +++ ++E +H +++ S++ ++E
Sbjct: 795 EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE 854
Query: 171 TISTVEKEMKSLARKAMDTESEL--GRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYEL 228
++ +E + R+ + E +L ++K EN+ ++ K D L K EL
Sbjct: 855 NLADMEAKF----REKDEREEQLIKAKEKLENDIAEIM-----KMSGDNSSQLTKMNDEL 905
Query: 229 QLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLA-KEKECLQACLDKKSENIASL 287
+L + + L K+ T+ N E S L ++ D+ K ++ Q K E L
Sbjct: 906 RLKERDVEELQLKL---TKAN----ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL 958
Query: 288 GESLAMKEKTISGMKNIIAEME-QASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARE 346
L+ EK + N E++ + R +E E+ + +++ L +T D+L E
Sbjct: 959 ERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREE 1018
Query: 347 RDILAHDNDNLQEQFAKAKQENQA---------LSKKLNDTHNELNDIKQ---KVQDT-- 392
L + + L++Q KAK A ++K+ +T L D KQ K+Q+
Sbjct: 1019 NSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELD 1078
Query: 393 NLEVNKLKNILKSEESEN-----RQMMEQLRKANEDAENWENKARQSEADNNTLKLELIT 447
L+ N LKN+ + +S+ Q ME+ RK + E + A Q + L+ E +
Sbjct: 1079 TLKENNLKNVEELNKSKELLTVENQKMEEFRK---EIETLKQAAAQKSQQLSALQEENVK 1135
Query: 448 AEAEGNRLKEKVDSLNREVEQHLNAERSY-KSQISTLHKSVVKMEEELQKVQFEKVSALA 506
E R +++V S Q L ERS +Q+ + K K ++ + EK S
Sbjct: 1136 LAEELGRSRDEVTS-----HQKLEEERSVLNNQLLEMKKRESKFIKDADE---EKASLQK 1187
Query: 507 DLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQN 566
+S T L + D+ E L ++ E S HS ++ L S + ++N
Sbjct: 1188 SISITSALLTEKDAELEKLRNEVTVLRGE----NASAKSLHSVVQTLESDKVKLELKVKN 1243
Query: 567 LEALLVANR 575
LE L N+
Sbjct: 1244 LELQLKENK 1252
Score = 79.3 bits (194), Expect = 1e-14
Identities = 103/538 (19%), Positives = 225/538 (41%), Gaps = 66/538 (12%)
Query: 20 NCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLR 79
N + + TR+ + + L + +L+E+ + L+ E + + +A EE ++
Sbjct: 766 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 825
Query: 80 REMMKSCKS--PKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEK 137
R M ++ K + + +E R+ D+ E+D E+L A+E N+
Sbjct: 826 RSMQETVNKLHQKEEQFNMLSSDLEKLRE-NLADMEAKFREKDEREEQLIKAKEKLENDI 884
Query: 138 AHLEQRIEELECTVHNLDDERM-------EQMSNMTLMKETISTVEKEMKSLARKAMDTE 190
A + + + + ++DE E +T E S ++K ++ + KA ++
Sbjct: 885 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 944
Query: 191 SELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNI 250
E ++ E + E+ LSD ++ +++ + + L + + T +
Sbjct: 945 QEAAKKHEEEK------KELERKLSDLEK-------KMETSHNQCQELKARYERATSETK 991
Query: 251 AQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGE--SLAMKEKTISGMKNIIAEM 308
+ EEI L L ++ L+ ++ S + L E A K K ++ + M
Sbjct: 992 TKHEEI--LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM 1049
Query: 309 EQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQEN 368
EQ +++ TE L L++T A++ E D L +N E+ K+K+
Sbjct: 1050 EQMTKEKTETLA-----------SLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELL 1098
Query: 369 QALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWE 428
++K+ + E+ +KQ + +++ L + EN ++ E+L ++ ++ + +
Sbjct: 1099 TVENQKMEEFRKEIETLKQAAAQKSQQLSAL-------QEENVKLAEELGRSRDEVTSHQ 1151
Query: 429 NKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVV 488
+ NN L +K++ ++ ++ + S + IS +
Sbjct: 1152 KLEEERSVLNNQLL-----------EMKKRESKFIKDADEE---KASLQKSISITSALLT 1197
Query: 489 KMEEELQKVQFEKVSAL----ADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENE 542
+ + EL+K++ E V+ L A S + L+S K L +L K+ E++++EN+
Sbjct: 1198 EKDAELEKLRNE-VTVLRGENASAKSLHSVVQTLESDKVKL--ELKVKNLELQLKENK 1252
Score = 36.6 bits (83), Expect = 0.081
Identities = 39/197 (19%), Positives = 90/197 (45%), Gaps = 23/197 (11%)
Query: 455 LKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTREL 514
L+E + + +EQ L +++++ V ++E+EL ALA + +
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQEL---------ALARDGHDQHV 403
Query: 515 CIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVAN 574
++L++ + L + A D+E N+L+ ++E L+ ++ E I+ +LE V+
Sbjct: 404 -LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSE 462
Query: 575 RDK--EYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKR 632
+ + E + +AL+ +E +AE + ++S A ++ L ++ +
Sbjct: 463 KSRIMELEKDLALRVQE-----------VAELRRRLESNKPAGDVDMSLSLLQEISSLQE 511
Query: 633 QLGTERFERERAVQELR 649
+L R + +R + L+
Sbjct: 512 KLEVTRTDHQREITSLK 528
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 100 bits (249), Expect = 5e-21
Identities = 143/674 (21%), Positives = 279/674 (41%), Gaps = 104/674 (15%)
Query: 23 VELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREM 82
++L K TT E K + E+ + E Q N K+ K ++ LL ++ E T L E
Sbjct: 962 LQLEKVTT----EAKLKKLEEEQIILEDQ-NCKLAKEKK----LLEDRIAEFTTNLTEEE 1012
Query: 83 MKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQ 142
KS KS L +++ + + TDL + R+ L+ + + L
Sbjct: 1013 EKS----KS------LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSD 1062
Query: 143 RIEELECTVHNLDDERMEQMSNMTLMKETISTVEKE--MKSLA-RKAMDTESELGRQKAE 199
+I EL+ + L +M+ ++ ++ VE+E K++A +K + ES++ + +
Sbjct: 1063 QIAELQAQIAEL---KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQED 1119
Query: 200 NNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISIL 259
S R EK D L K EL+ T + E + +E++IL
Sbjct: 1120 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE-------LRSKREQEVNIL 1172
Query: 260 GGTLNDLAKEKEC-LQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEA 318
TL + AK E +Q K S+ + L E L E+T K + A +E+A +
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQL---EQT----KRVKANLEKAKQ----- 1220
Query: 319 LIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDT 378
+E ++A E +L + + + K + + Q L K N+
Sbjct: 1221 ----------------TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG 1264
Query: 379 HNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADN 438
++ KV +E++ + +L +S++ ++ + ++ + ++
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 439 NTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQ 498
+L +L E E N +E ++E+ A+ + + QI+TLH V M+++++
Sbjct: 1325 LSLSTKLKQVEDEKNSFRE-------QLEEEEEAKHNLEKQIATLHAQVADMKKKME--- 1374
Query: 499 FEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMA 558
++ L + E+ KL E L++ R E +A+ ++E ++++
Sbjct: 1375 ----DSVGCLETAEEVKRKLQKDLEGLSQ-----------RHEEKVAAYDKLEKTKTRL- 1418
Query: 559 NERISMQNLEALLVANRDKEYQSQIALQEKESEI-QLLKEHLCLAENKMAIQSRDVAQFR 617
Q L+ LLV + D + QS L++K+ + QLL E ++ + R A+ R
Sbjct: 1419 -----QQELDDLLV-DLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR 1472
Query: 618 NVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHMSSTMKPNTKCHSPERAH 677
T+ ++ + E E++ ++ L +Q + MSS H E++
Sbjct: 1473 EKETKA-----LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKS- 1526
Query: 678 HRSPDRGLDRSLEE 691
R L++ +EE
Sbjct: 1527 ----KRALEQQVEE 1536
Score = 98.2 bits (243), Expect = 2e-20
Identities = 118/623 (18%), Positives = 264/623 (42%), Gaps = 44/623 (7%)
Query: 34 EELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTT 93
+EL+ + ER E+ V L+ E D + L Q+ + ++L ++ S +
Sbjct: 1255 QELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDF--SALESQLQD 1312
Query: 94 AHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHN 153
+L+ ++ T L+++ E++S RE+L+ +E N LE++I L V +
Sbjct: 1313 TQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHN----LEKQIATLHAQVAD 1368
Query: 154 LDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKD 213
+ + + + + +E ++K+++ L+++ + + + + L+ ++ D
Sbjct: 1369 MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVD 1428
Query: 214 LSDTQRHLA------KKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLA 267
L D QR A +KK++ L +EK + + + A+ +E L LA
Sbjct: 1429 L-DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS-----LA 1482
Query: 268 KEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVS 327
+ L+ +++K+E + L + + + + K+ + + + AL EQ V
Sbjct: 1483 R---ALEEAMEQKAE-LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRAL---EQQVE 1535
Query: 328 RMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQ 387
M+ QL+E DEL D NLQ A+ +++ Q ++ + +L ++Q
Sbjct: 1536 EMKTQLEELEDELQAT---EDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQL--VRQ 1590
Query: 388 KVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELIT 447
V +++ L+ E + + +K D ++ E + + + +L
Sbjct: 1591 --------VREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK 1642
Query: 448 AEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALAD 507
+A+ ++D E+ L + + ++ ++ +++++EEL + K A +
Sbjct: 1643 LQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQE 1702
Query: 508 LSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNL 567
+ L + + I E EL+ EL+ ++ + + +
Sbjct: 1703 RDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQI 1762
Query: 568 EALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADL 627
L R +++ A Q+ E + + LK + L E + ++S+ ++ +T LEA +
Sbjct: 1763 NTDLNLERSHAQKNENARQQLERQNKELK--VKLQEMEGTVKSK----YKASITALEAKI 1816
Query: 628 DITKRQLGTERFERERAVQELRR 650
+ QL E ER+ A +++RR
Sbjct: 1817 AQLEEQLDNETKERQAACKQVRR 1839
Score = 85.9 bits (211), Expect = 1e-16
Identities = 116/651 (17%), Positives = 273/651 (41%), Gaps = 74/651 (11%)
Query: 35 ELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTA 94
+L+ L + E+ E++ + L+ + + + Q +I L+ ++ K K
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAK-----KEEEL 1085
Query: 95 HAILRRVETE---RDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRI--EELEC 149
A L RVE E +++A +R + ++ L+E L+ E A KA ++R EELE
Sbjct: 1086 QAALARVEEEAAQKNMALKKIRELESQISELQEDLE--SERASRNKAEKQKRDLGEELEA 1143
Query: 150 TVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYEN 209
L+D + + +E S E+E+ L + E E +A+ +R +
Sbjct: 1144 LKTELEDT----LDSTAAQQELRSKREQEVNILKKTL---EEEAKTHEAQIQEMRQKHSQ 1196
Query: 210 TEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKE 269
++L++ + K L+ ++ + R +A ++ + G ++ ++
Sbjct: 1197 AVEELAEQLEQTKRVKANLEKAKQTL--------ENERGELANEVKVLLQGKGDSEHKRK 1248
Query: 270 K-----ECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQ 324
K + LQ ++ L + + + + + ++++ + S + T+ E
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 325 DVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELND 384
+ + L E N + ++ + + + ++ +EQ + ++ L K++ H ++ D
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 385 IKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLE 444
+K+K++D+ L++ E R++ + L ++ E E A + + +L+
Sbjct: 1369 MKKKMEDS-------VGCLETAEEVKRKLQKDLEGLSQRHE--EKVAAYDKLEKTKTRLQ 1419
Query: 445 LITAEAEGNRLKEKVDSLNREVEQHLNAERSYK--SQISTLHKSV-VKMEEELQKVQF-- 499
L + + L+ + + N E+ K Q+ K++ K EE + +
Sbjct: 1420 --------QELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEA 1471
Query: 500 -EKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIE----LLR 554
EK + L+ E ++ + E LN+Q + +++ ++++ + E+E L
Sbjct: 1472 REKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531
Query: 555 SQMANERISMQNLEALLVANRDKEYQSQIALQE-----------KESEIQLLKEHLCLAE 603
Q+ + ++ LE L A D + + ++ LQ ++ + + K+ L
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQV 1591
Query: 604 NKMAIQSRDVAQFRNVVT----QLEADLDITKRQLGTERFERERAVQELRR 650
+M + D + R++ +LE DL + + + R+ A+++LR+
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK 1642
Score = 81.3 bits (199), Expect = 3e-15
Identities = 118/569 (20%), Positives = 235/569 (41%), Gaps = 110/569 (19%)
Query: 24 ELLKTTTRDREELKCMLEKYER------HLAEIQGNVKVLKSERDKIFLLYEQAQEEITR 77
+L KT TR ++EL +L + +L + Q L +E I Y + ++
Sbjct: 1410 KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEA 1469
Query: 78 LRREMMKSCKSPKSTTAHAILRRVETER-DVAF-TDLRRMTTERDSLRERLKIAQETAFN 135
RE S A+ ++ E ER + F T++ + + +D + + + +++
Sbjct: 1470 EAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKS--- 1526
Query: 136 EKAHLEQRIEELECTVHNLDDE-------RMEQMSNMTLMKETISTVEKEMKSLARKAMD 188
K LEQ++EE++ + L+DE ++ N+ MK + E++++ ++ +
Sbjct: 1527 -KRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK---AQFERDLQGRDEQSEE 1582
Query: 189 TESELGRQKAENNSLRLLYENTEKDLSDTQRH-----LAKKKYELQLTQEKIMCLDEKID 243
+ +L RQ E E +L D ++ A+KK E+ L L+ ID
Sbjct: 1583 KKKQLVRQVRE----------MEAELEDERKQRSMAVAARKKLEMDLKD-----LEAHID 1627
Query: 244 NFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKN 303
+ + R+E + L K + ++ C+ + + AS E LA ++ +K+
Sbjct: 1628 SANKN----RDE------AIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS 1677
Query: 304 IIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAK 363
+ AEM Q E L E+ + +++ DE DE+A + + + + L+ + A+
Sbjct: 1678 MEAEMIQLQ----EELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQ 1733
Query: 364 AKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANED 423
++E L + I +++ NL+++++ L E S
Sbjct: 1734 LEEE-------LEEEQGNTELINDRLKKANLQIDQINTDLNLERSH-------------- 1772
Query: 424 AENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTL 483
A+ EN +Q E N LK++L E EG + YK+ I+ L
Sbjct: 1773 AQKNENARQQLERQNKELKVKL--QEMEGT------------------VKSKYKASITAL 1812
Query: 484 HKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQE---IEMRE 540
+ ++EE+L E+ +A C ++ +++ L L+ D E E +
Sbjct: 1813 EAKIAQLEEQLDNETKERQAA----------CKQVRRTEKKLKDVLLQVDDERRNAEQYK 1862
Query: 541 NELDSAHSEIELLRSQMANERISMQNLEA 569
++ D A + ++ L+ Q+ Q A
Sbjct: 1863 DQADKASTRLKQLKRQLEEAEEEAQRANA 1891
Score = 70.1 bits (170), Expect = 7e-12
Identities = 96/488 (19%), Positives = 202/488 (41%), Gaps = 43/488 (8%)
Query: 182 LARKAMDTESELGRQKAENNSLRLLYENTEKDLS----DTQRHLAKKKYELQLT--QEKI 235
LARKA +++ + ++++L N L R K K LQ++ +E++
Sbjct: 794 LARKAF------AKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEM 847
Query: 236 MCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGES----L 291
M +E++ + +A ++ + + L EK LQ L ++E A E
Sbjct: 848 MAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLT 907
Query: 292 AMKEKTISGMKNIIAEMEQASRQCTEALIV---CEQDVSRMRRQLDETNDELAQIARERD 348
A K++ ++ A +E+ +C +Q++ + QL+E ++ E+
Sbjct: 908 AKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKV 967
Query: 349 ILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEES 408
L+E+ + +N L+K+ + + + + + + L + E+
Sbjct: 968 TTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEA 1027
Query: 409 ENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQ 468
+ E+LR+ + + E R+ E D+ L ++ +A+ LK ++ E++
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQA 1087
Query: 469 HLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQ 528
L +Q + K + ++E ++ ++Q DL S R K + K L +
Sbjct: 1088 ALARVEEEAAQKNMALKKIRELESQISELQ-------EDLESERASRNKAEKQKRDLGEE 1140
Query: 529 LVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNL-------EALLVANRDKEYQS 581
L A E+ E+ LDS ++ EL + I + L EA + R K Q+
Sbjct: 1141 LEALKTEL---EDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQA 1197
Query: 582 QIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFER 641
L E+ + + +K +L A+ + + ++A V+ Q + D + ++++
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKV------- 1250
Query: 642 ERAVQELR 649
E +QEL+
Sbjct: 1251 EAQLQELQ 1258
Score = 50.1 bits (118), Expect = 7e-06
Identities = 69/359 (19%), Positives = 140/359 (38%), Gaps = 72/359 (20%)
Query: 26 LKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKS 85
+ + ++R+E L K + + + + ++ R++I ++ ++++ + EM++
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ- 1684
Query: 86 CKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQ---ETAFNEKAHLEQ 142
++ E A R+ ERD L + + + A EK LE
Sbjct: 1685 ---------------LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729
Query: 143 RIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENN- 201
RI +LE +E E+ N L+ + + ++ + +T+ L R A+ N
Sbjct: 1730 RIAQLE-------EELEEEQGNTELINDRLKKANLQIDQI-----NTDLNLERSHAQKNE 1777
Query: 202 SLRLLYENTEKDLSDTQRHL---AKKKYELQLT--QEKIMCLDEKIDNFTRQNIAQREEI 256
+ R E K+L + + K KY+ +T + KI L+E++DN T++ A +++
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1837
Query: 257 SILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCT 316
EK+ L E +N +QA + T
Sbjct: 1838 R---------RTEKKLKDVLLQVDDER------------------RNAEQYKDQADKAST 1870
Query: 317 EALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKL 375
+ +++RQL+E +E + R L + ++ E +E +L KL
Sbjct: 1871 R--------LKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 100 bits (249), Expect = 5e-21
Identities = 115/575 (20%), Positives = 245/575 (42%), Gaps = 55/575 (9%)
Query: 111 DLRRMTTERDSLRERLKIAQETAFN---EKAHLEQRIEELECTVHNLDDERMEQMSNMTL 167
DL + RD LR++++ +E + EK+ + +++L+ + +E+ +
Sbjct: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNS 1310
Query: 168 MKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYE 227
++ + + + M SL + +EL R +A+ R L + +++L+ HL E
Sbjct: 1311 LESELMELHETMASLQSRLR--RAELQRMEAQGE--RELLQAAKENLTAQVEHLQAAVVE 1366
Query: 228 LQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASL 287
+ L+E + + EE+ L ++ E A EN+A L
Sbjct: 1367 ARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALL 1426
Query: 288 GESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARER 347
++LA +E+ + ++ I E+E+ AL + D+ + +++D +++ ++ + R
Sbjct: 1427 TQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCR 1486
Query: 348 DILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEE 407
+L H +QE+ K + + + + D + N ++ ++ LE+ K +++S+
Sbjct: 1487 SVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQL----LELEKKDQMIESQR 1542
Query: 408 SENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKV--DSLNRE 465
+ + + +QL A E + E +K E EG R ++V L +
Sbjct: 1543 GQVQDLKKQLVTLECLALELEENHHKMECQQKLIK------ELEGQRETQRVALTHLTLD 1596
Query: 466 VEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELL 525
+E+ ++ SQI L + ELQ+ E + S RE +L KE L
Sbjct: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQERDQE-------VKSQREQIEELQRQKEHL 1649
Query: 526 NRQLVAKDQEIEMRENEL----DSAHSEIELLRSQMANERISMQNLEALLV--------- 572
+ L +DQE+ +++ + D + ++L + ++S++ L
Sbjct: 1650 TQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQER 1709
Query: 573 ---------ANRDKEYQSQIALQEKESEIQLLKEHLC-LAENKMAIQS------RDVAQF 616
A R ++ L++KE E++ +EH+ L E K ++ R V +
Sbjct: 1710 AEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGET 1769
Query: 617 RNVVTQLEADLDITKRQLGTERFERERAVQELRRQ 651
+++Q E ++ + ++QL R + E Q L+ Q
Sbjct: 1770 SLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQ 1804
Score = 94.0 bits (232), Expect = 4e-19
Identities = 138/659 (20%), Positives = 269/659 (40%), Gaps = 71/659 (10%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM 83
E ++ +DRE + +LE L E++ ++++S+R ++ L +Q + L E+
Sbjct: 1508 EQIRELEKDRETQRNVLE---HQLLELEKKDQMIESQRGQVQDLKKQLVT-LECLALELE 1563
Query: 84 KSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQR 143
++ K +++ +E +R+ L +T + + + L+ + ++H
Sbjct: 1564 EN--HHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVL 1621
Query: 144 IEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSL 203
EL+ + +R EQ+ + KE ++ + L R+ + + R + +
Sbjct: 1622 ARELQERDQEVKSQR-EQIEELQRQKEHLT------QDLERRDQELMLQKERIQVLEDQR 1674
Query: 204 RLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTL 263
+ E+DL + L ++ EL TQ ++M E+ + + AQR + + L
Sbjct: 1675 TRQTKILEEDLEQIKLSLRERGRELT-TQRQLM--QERAEEGKGPSKAQRGSLEHMKLIL 1731
Query: 264 NDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCE 323
D KE EC Q E+I L E E+ + G+ + E Q + ++V +
Sbjct: 1732 RDKEKEVECQQ-------EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQ 1784
Query: 324 QDVSRMRRQ-----------LDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALS 372
Q + R Q LDE LAQ +E + L + Q Q + K++ AL
Sbjct: 1785 QQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQ 1844
Query: 373 KKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWE---- 428
L H L + ++QD + +L+ L E + + E L ++ E
Sbjct: 1845 GALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALL 1904
Query: 429 -------NKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQIS 481
+A++ E + L+ + A+A +++++L E + + E + +++
Sbjct: 1905 ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAE 1964
Query: 482 TLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMREN 541
L +++ K LQ + L EL L++S L L A E
Sbjct: 1965 ALQEALGKAHAALQGKE-------QHLLEQAELSRSLEASTATLQASLDACQAHSRQLEE 2017
Query: 542 ELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCL 601
L EI+ Q + +Q L+ L A RD+E + Q QE+E QLL++ L
Sbjct: 2018 ALRIQEGEIQ---DQDLRYQEDVQQLQQAL-AQRDEELRHQ---QERE---QLLEKSLA- 2066
Query: 602 AENKMAIQSRDVAQFRNVVTQLEAD----LDITKRQLGTERFERERAVQELRRQNYSSN 656
+Q + + +N+ + E + L + R+L ++E+ + ELR +N
Sbjct: 2067 ----QRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNN 2121
Score = 89.4 bits (220), Expect = 1e-17
Identities = 149/754 (19%), Positives = 295/754 (39%), Gaps = 97/754 (12%)
Query: 1 MMRSRSKSPRRPSPTARGANCDVELLKTTTRDRE--------------ELKCMLEKYERH 46
+M+ R++ + PS RG+ +E +K RD+E ELK LE+ +
Sbjct: 1705 LMQERAEEGKGPSKAQRGS---LEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQG 1761
Query: 47 LAEIQGNVKVLKSERD-KIFLLYEQAQE--EITRLRREMMKSCKSPKSTTAHAILRRVET 103
L G +L S+R+ +I +L +Q QE E L+ + ++S
Sbjct: 1762 LHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQS------------------ 1803
Query: 104 ERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMS 163
+ +R +RD E L+ Q+ A ++ ++++ + L+ + E+
Sbjct: 1804 ----QLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHG 1859
Query: 164 NMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAK 223
+ KE +E+E+ R+ E LG +AE+ EK L Q+ A+
Sbjct: 1860 ELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAES-------REQEKALLALQQQCAE 1912
Query: 224 KKYELQL-----------TQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKEC 272
+ E ++ Q + D++++ ++ + R + L +
Sbjct: 1913 QAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGK 1972
Query: 273 LQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQ 332
A L K +++ E E + + ++ + + SRQ EAL + E ++ +
Sbjct: 1973 AHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLR 2032
Query: 333 LDETNDELAQIARERD-ILAHDNDN---LQEQFAKAKQENQALSKK---LNDTHNELNDI 385
E +L Q +RD L H + L++ A+ QEN K+ E+ +
Sbjct: 2033 YQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGL 2092
Query: 386 KQKVQDTNLEV-NKLKNILKSEESENRQMMEQLRKANEDAENWENKAR------QSEADN 438
Q V++ L + K + IL+ E++ R +E L +++ + E + + + +
Sbjct: 2093 HQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQREL 2152
Query: 439 NTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQ 498
L+ L EA +EK L + Q + S + L SV++ + E Q++Q
Sbjct: 2153 ERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQ 2212
Query: 499 FE----------------KVSALADLSSTRELCIKLD--SSKELLNRQLVAKDQEIEMRE 540
E ++ A+L S E ++L S E + Q R
Sbjct: 2213 DELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRL 2272
Query: 541 NELDSAHSEIELLRSQMANERISMQN-LEALLVANRDKEYQSQIALQEKESEIQLLKEHL 599
L A + +E+ RS++ + +++ LE + R + ++ A Q EI
Sbjct: 2273 EHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASS 2332
Query: 600 CLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYH 659
++ ++ D V +L+ ++ + + QL ER +++ + + + H
Sbjct: 2333 PTQQDGRGQKNSDA----KCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLH 2388
Query: 660 MSSTMKPNTKCHSPERAHHRSPDRGLDRSLEENL 693
S + +PE + R LD SL ++L
Sbjct: 2389 HSLSHSLLAVAQAPEATVLEAETRRLDESLTQSL 2422
Score = 86.7 bits (213), Expect = 7e-17
Identities = 135/678 (19%), Positives = 274/678 (40%), Gaps = 86/678 (12%)
Query: 23 VELLKTTTRDREELK-------------CMLEKYERHLAEIQGNVKVLKSERDKIFLLYE 69
+E+ T RD ELK C+ E G+ ++ E ++ LL
Sbjct: 192 LEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLA 251
Query: 70 QAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIA 129
+ QE L +E + + L +++++ D+ +L+ TE +L +
Sbjct: 252 KTQE----LEKEAHERSQE---------LIQLKSQGDLEKAELQDRVTELSAL-----LT 293
Query: 130 QETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLM----KETISTVEKEMKSLARK 185
Q NE E+ I+ L TV L+ E M + + +E ++++ +K + +
Sbjct: 294 QSQKQNED--YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV 351
Query: 186 AMDTESELGRQKAENNSLRLL--------YENTEKDLSDTQRHLAKKKYELQLTQEKIMC 237
++ + + NSL L Y++ +K L+ + L +++ +Q ++++
Sbjct: 352 MVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAG 411
Query: 238 LDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKT 297
E ++ +Q+ EE L L L E++ L + SL + + +K
Sbjct: 412 CQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKA 471
Query: 298 ISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNL 357
++ + +EQ + + + + + Q +E +EL RER+ L L
Sbjct: 472 REELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGL 531
Query: 358 QEQFAKAKQENQALSKKLNDTHNELNDIKQ----------KVQDTNLEVNKLKNILKSEE 407
+ + +++ E L + L +H E ++Q + + + E++ +N LK+E
Sbjct: 532 EAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEV 591
Query: 408 SENRQMMEQLRKANE----DAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLN 463
++ R +L NE D + Q E +N ++ + AE N L+ +
Sbjct: 592 ADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAE 651
Query: 464 REVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKE 523
+ E ++Q+ ++ +++ +L+ +Q EK LS +R +E
Sbjct: 652 KRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH-------QQE 704
Query: 524 LLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQI 583
QL QE + +E L A E E L + A + +Q +E RD++ ++
Sbjct: 705 AATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVE------RDRQDLAE- 757
Query: 584 ALQEKESEIQLLKEHLCLAE----------NKMAIQSRDVAQFRNVVTQLEADLDITKRQ 633
LQ S +LL+ L A+ ++ +Q + V Q + V+ + ++ K +
Sbjct: 758 QLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI---QGEVRCLKLE 814
Query: 634 LGTERFERERAVQELRRQ 651
L TER + E+ RQ
Sbjct: 815 LDTERSQAEQERDAAARQ 832
Score = 86.3 bits (212), Expect = 9e-17
Identities = 132/688 (19%), Positives = 282/688 (40%), Gaps = 85/688 (12%)
Query: 33 REELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKST 92
++EL LE ER E++ +K ++E + I Q +EE T+ + + +
Sbjct: 870 QQELAKALESLEREKMELEMRLKEQQTEMEAI---QAQREEERTQAESALCQMQLETEKE 926
Query: 93 TAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVH 152
+ ++T++++A + +D ++LK + T L+ +++E +
Sbjct: 927 RVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI-----LQTQLQEAQ---R 978
Query: 153 NLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEK 212
L + + ++ ++E S++ ++ L ++ D +S+L A+++S RL+ + ++
Sbjct: 979 ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQL---VAQDDSQRLVEQEVQE 1035
Query: 213 DLSDTQRH------LAKKKYELQLT----QEKIMCLDEKIDNFTRQNI-AQREEISILGG 261
L +TQ + L ++K L L+ +++++ L E D+ +Q + A R+++ G
Sbjct: 1036 KLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEA-DSIRQQELSALRQDMQEAQG 1094
Query: 262 TLNDLAKEKECLQACLDKKSENI----ASLGESLAMKEKTISGMKNIIAEMEQASRQCTE 317
+L+ + E L+ + +K + A L E L T ++ + E + Q
Sbjct: 1095 EQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQL 1154
Query: 318 ALIVCEQDVSRMRRQLDETNDELAQ----------------IARERDILAHDNDNLQEQF 361
L E + + + N AQ + R L+ D+ +
Sbjct: 1155 RLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVW 1214
Query: 362 AKAKQEN-----------------QALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILK 404
+N +A++ L+ H +L +Q +V KL+ L
Sbjct: 1215 GLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLT 1274
Query: 405 SEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELI-----TAEAEGNRLKEKV 459
E+E Q+ +L+ + + + E N+L+ EL+ A + + ++
Sbjct: 1275 DTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAEL 1334
Query: 460 DSLNREVEQHL--NAERSYKSQISTLHKSVVK----------MEEELQKVQFEKVSALAD 507
+ + E+ L A+ + +Q+ L +VV+ +EE+L+ + +
Sbjct: 1335 QRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEE 1394
Query: 508 LSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQM--ANERISMQ 565
+ S RE L EL Q A + + + L E+E LR Q+ ++ MQ
Sbjct: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454
Query: 566 NLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRD--VAQFRNVVTQL 623
L++ K+ ++ LQ+++ + +L K L MA+Q R+ + R + +L
Sbjct: 1455 KAALELLSLDLKKRNQEVDLQQEQIQ-ELEKCRSVLEHLPMAVQEREQKLTVQREQIREL 1513
Query: 624 EADLDITKRQLGTERFERERAVQELRRQ 651
E D + + L + E E+ Q + Q
Sbjct: 1514 EKDRETQRNVLEHQLLELEKKDQMIESQ 1541
Score = 84.7 bits (208), Expect = 3e-16
Identities = 141/667 (21%), Positives = 284/667 (42%), Gaps = 64/667 (9%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM 83
E L R+RE L+ ML E +E + L+ + L E ++E T + +
Sbjct: 512 EELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571
Query: 84 KSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQR 143
++ +S A L E DLR + +L E L + +K L Q+
Sbjct: 572 RAEQSI------AELSSSENTLKTEVADLRAAAVKLSALNEALAL-------DKVGLNQQ 618
Query: 144 IEELECTVHNLDD--ERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENN 201
+ +LE ++ E EQ N ++ ++ EK ++L K E++L + +
Sbjct: 619 LLQLEEENQSVCSRMEAAEQARNA--LQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGA 676
Query: 202 SLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCL-------DEKIDNFTRQNIAQRE 254
L+ + +++ + Q+ L++ +++ + ++ L +E + ++ A
Sbjct: 677 ELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVR 736
Query: 255 EISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQ 314
E + L L + ++++ L L S L SL ++ S ++ ++E +
Sbjct: 737 EKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT 796
Query: 315 CTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKK 374
T+A V + +V ++ +LD E +Q +ERD A Q A+A+QE + ++
Sbjct: 797 VTQAKEVIQGEVRCLKLELDT---ERSQAEQERDAAAR-------QLAQAEQEGKTALEQ 846
Query: 375 LNDTHN-ELNDIKQKVQ-DTNLEVNKLKNILKSEESENRQMMEQLRKANEDAE--NWENK 430
H E+N +++K + + + +L L+S E E ++ +L++ + E + +
Sbjct: 847 QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQRE 906
Query: 431 ARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAER---SYKSQISTLHKSV 487
+++A++ +++L T + + L+ + + + ER K Q ++
Sbjct: 907 EERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETT 966
Query: 488 VKMEEELQKVQFEKVSALA----DLSSTRE-----LCIKLDSSKEL--LNRQLVAKDQEI 536
++ +LQ+ Q E A DL++ +E L K+D K++ L QLVA+D
Sbjct: 967 GILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQ 1026
Query: 537 EMRENELDSAHSEIELLRSQMANERIS--MQNLEALLVANRDKEYQSQIALQEKES---- 590
+ E E+ E LR RI ++ +A L + ++ Q + LQE +S
Sbjct: 1027 RLVEQEVQ------EKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQ 1080
Query: 591 EIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRR 650
E+ L++ + A+ + S + R V + EAD + QL E Q+LR
Sbjct: 1081 ELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRA 1140
Query: 651 QNYSSNA 657
++ A
Sbjct: 1141 SLWAQEA 1147
Score = 82.0 bits (201), Expect = 2e-15
Identities = 136/634 (21%), Positives = 264/634 (41%), Gaps = 92/634 (14%)
Query: 40 LEKYERHLA-EIQGNVKVLKSERDKIFLLYEQAQ---EEITRLRREMMKSCKSPKSTTAH 95
LE + LA E+Q + +KS+R++I L Q + +++ R +E+M + +
Sbjct: 1614 LESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQ 1673
Query: 96 AILRRVETERDVAFTDL------RRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELEC 149
+ E D+ L R +TT+R ++ER A+E KA +E ++
Sbjct: 1674 RTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQER---AEEGKGPSKAQ-RGSLEHMKL 1729
Query: 150 TVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLR----- 204
+ + + E Q ++ ++E +E++++ L RK +T L +++ E L+
Sbjct: 1730 ILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE 1789
Query: 205 ------LLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISI 258
L ++ + L + QR LA++ EL+ L ++ Q +E+
Sbjct: 1790 AREQGELKEQSLQSQLDEAQRALAQRDQELE-------ALQQEQQQAQGQEERVKEKADA 1842
Query: 259 LGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEA 318
L G L + L E L E LA++ + + ++ ++ ++ SR+ +A
Sbjct: 1843 LQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKA 1902
Query: 319 LIVCEQDVSRMR-------RQLDETNDELAQIARERD----ILAHDNDNLQEQFAKAKQE 367
L+ +Q + R L ++ + + +ERD L ++ + + Q A+
Sbjct: 1903 LLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARAR 1962
Query: 368 NQALSKKLNDTHNELNDIKQKVQDT-----NLEVNK--LKNILKSEESENRQMMEQLRKA 420
+AL + L H L +Q + + +LE + L+ L + ++ +RQ+ E LR
Sbjct: 1963 AEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI- 2021
Query: 421 NEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREV-----------EQH 469
++ E + R E D L+ L + E +E+ L + + +Q+
Sbjct: 2022 -QEGEIQDQDLRYQE-DVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQN 2079
Query: 470 LNAERSYKSQISTLHKSV--------------VKMEEELQKVQFEKVSALADLSSTRELC 515
L ER + +I LH+SV +++ E Q+ E + S E
Sbjct: 2080 LGQERE-EEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQS 2138
Query: 516 IKLDSSKELLNRQ---LVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLV 572
+KLDS + L R+ L A ++ E RE E ++ L +Q S+Q + L
Sbjct: 2139 LKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFL- 2197
Query: 573 ANRDKEYQSQIALQEKESEIQLLKEHLCLAENKM 606
Q ++ E++SE Q L++ L L +
Sbjct: 2198 ---------QASVLERDSEQQRLQDELELTRRAL 2222
Score = 78.6 bits (192), Expect = 2e-14
Identities = 112/645 (17%), Positives = 268/645 (41%), Gaps = 64/645 (9%)
Query: 23 VELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLK-SERDKIFLLYEQAQE---EITRL 78
V LL+T + ++EL ++ ER ++ ++KV K E++ +L Q QE E+
Sbjct: 928 VSLLETLLQTQKELADASQQLER----LRQDMKVQKLKEQETTGILQTQLQEAQRELKEA 983
Query: 79 RREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKA 138
R+ + + ++ + +++ ++ V DL+ +D + ++ + E
Sbjct: 984 ARQHRDDLAALQEESSSLLQDKMDLQKQVE--DLKSQLVAQDDSQRLVEQEVQEKLRETQ 1041
Query: 139 HLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKA 198
+ +ELE +L ME+ + +++E S ++E+ +L + + + E A
Sbjct: 1042 EYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSA 1101
Query: 199 ENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKI-------------MCLDEKIDNF 245
+ LR + E D + L ++ +T++++ + L +
Sbjct: 1102 QMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTES 1161
Query: 246 TRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASL---GESL----------- 291
+ +A ++ LA LQ L E+ L G+S
Sbjct: 1162 QLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQN 1221
Query: 292 ----------AMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELA 341
+ + + + + ++ Q + + V V ++ +L +T E +
Sbjct: 1222 GARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKS 1281
Query: 342 QIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNL---EVNK 398
Q+ E L QE+ +K + + +L +L + H + ++ +++ L E
Sbjct: 1282 QVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG 1341
Query: 399 LKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEK 458
+ +L++ + +E L+ A +A + A E D T + L E +E+
Sbjct: 1342 ERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERER 1401
Query: 459 VDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKL 518
+L + E + ++ + ++ L +++ + EEE++ ++ + +L RE+
Sbjct: 1402 AQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR----GQIQELEKQREM---Q 1454
Query: 519 DSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKE 578
++ ELL+ L ++QE+++++ ++ E+E RS + + +++Q E L R++
Sbjct: 1455 KAALELLSLDLKKRNQEVDLQQEQI----QELEKCRSVLEHLPMAVQEREQKLTVQREQI 1510
Query: 579 YQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQL 623
+ + +++E++ +L+ L E K + Q +++ QL
Sbjct: 1511 RELE---KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL 1552
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 100 bits (249), Expect = 5e-21
Identities = 130/693 (18%), Positives = 284/693 (40%), Gaps = 118/693 (17%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDK-IFLLYEQAQEEITRLRREM 82
ELL+ ++ ++ L ER L ++G +K + RD+ + + +Q Q + +LRR M
Sbjct: 474 ELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSM 533
Query: 83 MKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQ 142
+ T HA+L E ER ++M+ L+ L+ E + ++ ++
Sbjct: 534 QDA------TQDHAVL---EAER-------QKMSALVRGLQRELEETSEETGHWQSMFQK 577
Query: 143 RIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKS-------------LARKAMDT 189
E+L T L RME+ + E I +++E++ L ++ + T
Sbjct: 578 NKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRT 637
Query: 190 ESELGRQKAENNSLRLLYENTEKDL----------SDTQRHLAKKKYELQLTQEKIMCLD 239
+ EL +AE S + + +++L +D R L ++ +LQ T ++ L
Sbjct: 638 QEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQ---LR 694
Query: 240 EKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTIS 299
+ + ++ + E ++LG + + ++ L + E + E+ +
Sbjct: 695 QDCEEASKAKMVAEAEATVLG-------QRRAAVETTLRETQEENDEFRRRILGLEQQLK 747
Query: 300 GMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQE 359
+ ++ E + + L E + ++ L+ + +E +A + L + Q
Sbjct: 748 ETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQR 807
Query: 360 QFAKAKQENQALSKKLNDTHNELN-------DIKQKVQDTNLEVNKLKNILKSEESENRQ 412
A+ QE Q L++ L + + +++++ + + V++L L+ +++Q
Sbjct: 808 GLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQ 867
Query: 413 MMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNA 472
++QL+ ED ++ KAR+ AD R+ + +
Sbjct: 868 ALQQLQAQLED---YKEKARREVAD------------------------AQRQAKDWASE 900
Query: 473 ERSYKSQISTLHKSVVKMEEELQKVQFEKVSALAD-------LSSTRELCIKLDSSKELL 525
+S L + ++ + LQ Q E+ +A D L + S++
Sbjct: 901 AEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDR 960
Query: 526 NRQLVAKDQEIEMRENELDSAHSEIEL--------------LRSQMANERISMQNLEA-- 569
RQL ++++ E ELD + +EL LR+++ ER + Q+LE
Sbjct: 961 ARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDK 1020
Query: 570 LLVANRDKEYQSQIA-----------LQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRN 618
+ + ++K+ ++++A L + ES+ QLL+E L E + + +
Sbjct: 1021 ISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLER 1080
Query: 619 VVTQLEADLDITKRQLGTERFERERAVQELRRQ 651
V +L ++ ++ + ++ + V+ L+RQ
Sbjct: 1081 KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQ 1113
Score = 81.6 bits (200), Expect = 2e-15
Identities = 124/593 (20%), Positives = 243/593 (40%), Gaps = 78/593 (13%)
Query: 18 GANCDVELLKTTT-RDREELK-CMLEKYERHLA------EIQGNVKVLKSERDKIFLLYE 69
G VE+LK R +EELK E+ + +A E++ + VL+ E D+ L E
Sbjct: 622 GDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEE 681
Query: 70 Q---AQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERL 126
Q Q+ + +LR++ ++ K+ A A + + R T LR E D R R+
Sbjct: 682 QNLQLQKTLQQLRQDCEEASKAKMVAEAEATV--LGQRRAAVETTLRETQEENDEFRRRI 739
Query: 127 KIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKA 186
LEQ+++E V E +E +++ + +E E + L
Sbjct: 740 -----------LGLEQQLKETRGLVDG--GEAVEAR-----LRDKLQRLEAEKQQL---- 777
Query: 187 MDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFT 246
E L + E SL E L + QR LA+ E Q + ++ +
Sbjct: 778 ---EEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLR 834
Query: 247 RQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIA 306
R E+ +L T++ L KE E + D K +L + A E + +A
Sbjct: 835 RGKAELEEQKRLLDRTVDRLNKELEKIGE--DSKQ----ALQQLQAQLEDYKEKARREVA 888
Query: 307 EMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQ 366
+ ++ ++ +SR++ ++ L ERD D + L ++ +Q
Sbjct: 889 DAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQ 948
Query: 367 ENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKN---ILKSEESENRQMMEQLR----K 419
E + + +D +L +++KV E+++ KN +L + R ++QLR +
Sbjct: 949 EAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQ 1008
Query: 420 ANEDAENWENKARQSEADNNTLKLELITAEA--EGNRLKEKVDSLNREVEQHLNAERSYK 477
++ E E N LK L ++E + + +++S N+ +++ L AE K
Sbjct: 1009 ERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREK 1068
Query: 478 SQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIE 537
+ + + ++ K+E ++ +EL I+++ ++ +N Q ++
Sbjct: 1069 TVLQSTNR---KLERKV-----------------KELSIQIEDERQHVNDQKDQLSLRVK 1108
Query: 538 MRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKES 590
+ ++D A EIE L + ++ + +++ Q++I EK+S
Sbjct: 1109 ALKRQVDEAEEEIERLDGLRKKAQREVEEQHEV-----NEQLQARIKSLEKDS 1156
Score = 59.7 bits (143), Expect = 9e-09
Identities = 90/414 (21%), Positives = 180/414 (43%), Gaps = 82/414 (19%)
Query: 296 KTISGMKNIIAEMEQASRQCTEALIV---CEQDVSRMRRQLDETNDELAQIARERDILAH 352
K ++G + ++E+ R+ E + E + RQL+E +E ++
Sbjct: 356 KAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSR---------- 405
Query: 353 DNDNLQEQFAKAKQENQALSKKLNDTHNELN---DIKQKVQDTNLEV-NKLKNILKSEES 408
LQE + K E Q +K+L + L+ D++ ++ +E+ NKLK++ E +
Sbjct: 406 ----LQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPA 461
Query: 409 ENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQ 468
+ + + L E E K R E L+L A LKE+V S ++EVE
Sbjct: 462 KEVLLKDLLETRELLEEVLEGKQRVEEQ----LRLRERELTALKGALKEEVASRDQEVE- 516
Query: 469 HLNAERSYKSQISTLHKSV--VKMEEELQKVQFEKVSALA-------------------- 506
+ + Y+ L +S+ + + + + +K+SAL
Sbjct: 517 --HVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSM 574
Query: 507 ------DLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHS------EIELLR 554
DL +T++ ++L KE + +L ++IE+ + EL+ A + ++E+L+
Sbjct: 575 FQKNKEDLRATKQELLQLRMEKEEMEEEL---GEKIEVLQRELEQARASAGDTRQVEVLK 631
Query: 555 SQMANERISMQNLEA------LLVANRDKEYQSQIAL---------QEKESEIQLLKEHL 599
++ + ++ L+A + +RD+E + Q+A+ + +E +QL K
Sbjct: 632 KELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQ 691
Query: 600 CLAEN-KMAIQSRDVAQFR-NVVTQLEADLDITKRQLGTERFERERAVQELRRQ 651
L ++ + A +++ VA+ V+ Q A ++ T R+ E E R + L +Q
Sbjct: 692 QLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQ 745
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 99.0 bits (245), Expect = 1e-20
Identities = 132/666 (19%), Positives = 296/666 (44%), Gaps = 87/666 (13%)
Query: 17 RGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERD--KIFLLYEQAQEE 74
+ C+VE L T + R++ K ++ GNV+ L +E + K +E +E
Sbjct: 1371 KSLECEVEELHRTVQKRQQQKDFID----------GNVESLMTELEIEKSLKHHEDIVDE 1420
Query: 75 ITRLRREMMKSCKSPKSTTAHAILRRVETERDVA----------FTDLRRMTTERDSLRE 124
I + + ++K + + A +L E+E FTD +R + +S E
Sbjct: 1421 IECIEKTLLK--RRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAE 1478
Query: 125 RL-KIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLA 183
L + AQETA N +Q++ L+ +L+ +++Q + + + ++ + + + L+
Sbjct: 1479 ELERRAQETAVN-LVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLS 1537
Query: 184 RKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEK-- 241
+K EL + +KD+ +R+ + + LQ+ +E + L K
Sbjct: 1538 KKKEKLTEEL--------------QKLQKDIEMAERN---EDHHLQVLKESEVLLQAKRA 1580
Query: 242 -IDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISG 300
++ Q +Q++E+++L L +E LQ + + A L E+L + E ++
Sbjct: 1581 ELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAK---ADLQEALRLGETEVTE 1637
Query: 301 MKNIIAE----MEQASRQCTEALIVCEQ---DVSRMRRQLDETNDELAQIARERDILAHD 353
N I E +E+ S Q E + + ++ +++++++ + L + R+ +
Sbjct: 1638 KCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTE 1697
Query: 354 NDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQM 413
N+ + E Q L + + +EL + V + LE+ L+ I + ++ E
Sbjct: 1698 LKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQ 1757
Query: 414 MEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLN-- 471
+ L + + E ++R ++ +E ++ E E L+EK D +++ Q
Sbjct: 1758 KQLLERDKREIERMTAESRALQSC-----VECLSKEKED--LQEKCDIWEKKLAQTKRVL 1810
Query: 472 --AERSYKSQISTLHK---SVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLN 526
AE + K + S L K +V K+++EL ++ +K+S D+S+ ++ + + L
Sbjct: 1811 AAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQ 1870
Query: 527 RQLVAKDQEIEMRENEL--DSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIA 584
+L + + + +L + H ++ L + IS ANR ++ Q +
Sbjct: 1871 EELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEW-------ANRFEDCQKE-- 1921
Query: 585 LQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEAD---LDITKRQLGTERFER 641
+ K+ ++Q+L+ + ENK+ + +++ F+ + + E++ L+ +K L ++ +
Sbjct: 1922 EETKQQQLQVLQNE--IEENKLKLVQQEM-MFQRLQKERESEESKLETSKVTLKEQQHQL 1978
Query: 642 ERAVQE 647
E+ + +
Sbjct: 1979 EKELTD 1984
Score = 94.0 bits (232), Expect = 4e-19
Identities = 132/677 (19%), Positives = 284/677 (41%), Gaps = 96/677 (14%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLK-SERDKIFLLYEQAQEEIT----RL 78
E+ K + +C+ +K E+ E+Q K ++ +ER++ L + E+ R
Sbjct: 1521 EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRA 1580
Query: 79 RREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKA 138
E +KS + + + R++ +++ M + L+E L++ ET EK
Sbjct: 1581 ELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLG-ETEVTEKC 1639
Query: 139 H----LEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELG 194
+ ++ +EEL L+ + E+ + +TL+K+ I E+ ++ + R+ ++EL
Sbjct: 1640 NHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELK 1699
Query: 195 R-------QKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQE-------KIMCLDE 240
+ E L+L ++ +L TQ + ++K EL+ Q+ +I +
Sbjct: 1700 NILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQ 1759
Query: 241 KIDNFTRQNIAQREEISILGGTLNDLAKEKECLQ-------------------------- 274
++ R+ E L + L+KEKE LQ
Sbjct: 1760 LLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKM 1819
Query: 275 --ACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQ 332
+ L+K N+ L + L + + N I+ M+Q ++ EA+ +++++ ++
Sbjct: 1820 EQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDH 1879
Query: 333 LDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDT 392
L+ +L + +D+L + LQ+ ++ + K+ +L +V
Sbjct: 1880 LNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQL-----QVLQN 1934
Query: 393 NLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEG 452
+E NKLK + + M ++L+K + E++ + L+ +T + +
Sbjct: 1935 EIEENKLKLV------QQEMMFQRLQK-------------ERESEESKLETSKVTLKEQQ 1975
Query: 453 NRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTR 512
++L++++ +++Q L+ + + ++ TL EEE EK LS T+
Sbjct: 1976 HQLEKELTDQKSKLDQVLSKVLAAEERVRTL------QEEERWCESLEKT-----LSQTK 2024
Query: 513 ELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQ-NLEALL 571
S +E +QLV K E+ + E DS ++ LLR+Q ER + + +L
Sbjct: 2025 RQL----SERE---QQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK 2077
Query: 572 VANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITK 631
A + + Q + L E++ E +++ + E + + Q++ + K
Sbjct: 2078 EALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELK 2137
Query: 632 RQLGTERFERERAVQEL 648
+Q+ ++ + ER E+
Sbjct: 2138 KQMANQK-DLERRQMEI 2153
Score = 74.7 bits (182), Expect = 3e-13
Identities = 113/570 (19%), Positives = 237/570 (41%), Gaps = 60/570 (10%)
Query: 111 DLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKE 170
+L + + + + LK + +A Q +E+E HN+DD E+ S ++E
Sbjct: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
Query: 171 TISTVEKEMKSL-----ARKAMDTESELGRQKAENNSLRLLYENTEK-------DLSDTQ 218
TV+K + +++ TE E+ + + + E EK +L +
Sbjct: 1380 LHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREAD 1439
Query: 219 RHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLA-------KEKE 271
R LA+ + EL T+EK EK + R + + L + A ++
Sbjct: 1440 RLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLR 1499
Query: 272 CLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRR 331
LQA ++ E L K ++ + + + + TE L ++D+ R
Sbjct: 1500 SLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAER 1559
Query: 332 QLDETNDELAQIARERDILAH----DNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQ 387
D Q+ +E ++L + + L+ Q +QE L ++L EL+ ++
Sbjct: 1560 ----NEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG 1615
Query: 388 KVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELIT 447
+ ++ + + ++E +E + +++ E+ + + ++ T +L LI
Sbjct: 1616 SMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKT-QLTLIK 1674
Query: 448 AEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALAD 507
E E + +E + + R++ +H K+++ + + ELQ ++ + +++
Sbjct: 1675 QEIE--KEEENLQVVLRQMSKH-------KTELKNILDMLQLENHELQGLKLQHDQRVSE 1725
Query: 508 LSSTRELCIKLDSSKELLNRQLVAKDQ--EIEMRENELDSAHSEIELLRSQMANERISMQ 565
L T+ L+ EL N Q +++ Q EIE ++ L+ EIE +M E ++Q
Sbjct: 1726 LEKTQ--VAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE----RMTAESRALQ 1779
Query: 566 NLEALLVANRDKEYQSQIALQEK----ESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVT 621
+ L +++KE LQEK E ++ K L AE ++ ++ + V
Sbjct: 1780 SCVECL--SKEKE-----DLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR 1832
Query: 622 QLEADLDITKRQLGTERFERERAVQELRRQ 651
+L+ +LD QL ++ + +++Q
Sbjct: 1833 KLQQELD----QLNRDKLSLHNDISAMQQQ 1858
Score = 64.7 bits (156), Expect = 3e-10
Identities = 130/616 (21%), Positives = 261/616 (42%), Gaps = 106/616 (17%)
Query: 70 QAQEEITRLRREMMKSCKSPKSTTAHAILRRV-ETERDVAFTDLRRMTTERDSLRER--- 125
+ +EI + ++++++ + K L+++ E +D+ + L + LR+
Sbjct: 455 ELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALD 514
Query: 126 LKIAQETAFNEKAHLEQRIEELECTVHNLDD----------ERMEQMSNMTLMKETISTV 175
L++ E E A ++ I++L+ + +LD ++ + + +M + +
Sbjct: 515 LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL 574
Query: 176 EKEMKS-LARKAMDTES--ELGRQKAENN--SLRLLYENTEKDLSDTQRHLAKKKYELQL 230
E + L+R A +TE +L Q E + L ++ E +S Q +L K +
Sbjct: 575 ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQ 634
Query: 231 TQEKIMCL-DEKIDNFTRQNIAQ--REEISILGGTLNDLAKEKECLQACLDKKSENIASL 287
Q + L DEK R + R+++ I+ ++ KE L++ L ++ E ASL
Sbjct: 635 AQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASL 694
Query: 288 GES---LAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIA 344
++ L+ E + N+ + + Q E L + V+R+ QL+++ + A++
Sbjct: 695 QQTQGDLSAYEAELEARLNL---RDAEANQLKEEL----EKVTRLT-QLEQSALQ-AELE 745
Query: 345 RERDILAHDNDNLQEQFAKAK-QENQALSKKLNDTHNELNDIKQKVQDTNLEVN------ 397
+ER L N + QF++ K QEN L KL ++ N +KQ+++D +N
Sbjct: 746 KERQALK--NALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGL 803
Query: 398 ---------------KLK------------NIL-KSEESENRQMMEQLRKANEDAENWEN 429
KLK ++L KS +Q E L ++ + + +
Sbjct: 804 VRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQV 863
Query: 430 KARQSEADNNTLKLELITAEAEGNRLKEKV--DSLNREVEQHLNAERSYKSQISTLHKSV 487
+ R+ + + + +L T + E + E+ +N + QH + +++I L +++
Sbjct: 864 RERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENL 923
Query: 488 VKMEE-------ELQKVQFEKVSALADL-----------SSTRELCIKLDSSKELLNRQL 529
MEE +LQ+ EK LA L + ++E LD + L + +
Sbjct: 924 KSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAV 983
Query: 530 VAKDQ----EIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIA- 584
D+ E+ + +++L S H + +I+ + E L A R +Q A
Sbjct: 984 ATSDKLATAELTIAKDQLKSLHGTV---------MKINQERAEELQEAERFSRKAAQAAR 1034
Query: 585 -LQEKESEIQLLKEHL 599
L E+EI+LL+ L
Sbjct: 1035 DLTRAEAEIELLQNLL 1050
Score = 46.6 bits (109), Expect = 8e-05
Identities = 84/463 (18%), Positives = 189/463 (40%), Gaps = 58/463 (12%)
Query: 26 LKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRR----- 80
L++ +++ E+ L++ + L+ + ++ + RD ++ E++TRL +
Sbjct: 680 LESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSA 739
Query: 81 ---EMMKSCKSPKSTTAHA-ILRRVETERDVAFTDLRRMTTERDSLRERLKIAQE----- 131
E+ K ++ K+ A E E L+ + + + L+++LK Q
Sbjct: 740 LQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHV 799
Query: 132 -TAFNEKAHLEQRIEEL---------ECTVHNLDDERMEQMSNMTLMKETI---STVEKE 178
+ R++EL E +H+ D + ++++ I S E++
Sbjct: 800 VDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERD 859
Query: 179 MKSLARKAMDTESEL-------GRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLT 231
+ + + E L G+++ R L D + + + + E+
Sbjct: 860 EAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
Query: 232 QEKIMCLDEKIDNFTRQNIAQR-EEISILGGTLNDLAKEKECLQAC-------LDK---K 280
QE + ++E I T + + EE + L +L K+K+ A LDK K
Sbjct: 920 QENLKSMEE-IQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKK 978
Query: 281 SENIASLGESLAMKEKTISG--MKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETND 338
+ + + LA E TI+ +K++ + + +++ E L Q+ R R+ +
Sbjct: 979 LKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEEL----QEAERFSRKAAQAAR 1034
Query: 339 ELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNK 398
+L + E ++L + EQF + + E + N E+ + + ++ E+ +
Sbjct: 1035 DLTRAEAEIELLQNLLRQKGEQF-RLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIAR 1093
Query: 399 LKNILKSEESENR----QMMEQLRKANEDAENWENKARQSEAD 437
L+N+L S+N+ ++E++ + + +++N S AD
Sbjct: 1094 LQNVLDLTGSDNKGGFENVLEEIAELRREV-SYQNDYISSMAD 1135
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 98.6 bits (244), Expect = 2e-20
Identities = 131/549 (23%), Positives = 241/549 (43%), Gaps = 68/549 (12%)
Query: 58 KSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTT 117
KSE K+ E A+++I L E K+ +S+ A +I R ++ R++ T+L+ +
Sbjct: 776 KSEMKKLRQQLEAAEKQIKHLEIE-----KNAESSKASSITRELQG-RELKLTNLQENLS 829
Query: 118 E----RDSLRERLKIAQET---AFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKE 170
E +++L + L+I +E A E +++ ++E +H +++ S++ ++E
Sbjct: 830 EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE 889
Query: 171 TISTVEKEMKSLARKAMDTESEL--GRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYEL 228
++ +E + R+ + E +L ++K EN+ ++ K D L K EL
Sbjct: 890 NLADMEAKF----REKDEREEQLIKAKEKLENDIAEIM-----KMSGDNSSQLTKMNDEL 940
Query: 229 QLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLA-KEKECLQACLDKKSENIASL 287
+L + + L K+ T+ N E S L ++ D+ K ++ Q K E L
Sbjct: 941 RLKERDVEELQLKL---TKAN----ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL 993
Query: 288 GESLAMKEKTISGMKNIIAEME-QASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARE 346
L+ EK + N E++ + R +E E+ + +++ L +T D+L E
Sbjct: 994 ERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREE 1053
Query: 347 RDILAHDNDNLQEQFAKAKQENQA---------LSKKLNDTHNELNDIKQ---KVQDT-- 392
L + + L++Q KAK A ++K+ +T L D KQ K+Q+
Sbjct: 1054 NSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELD 1113
Query: 393 NLEVNKLKNILKSEESEN-----RQMMEQLRKANEDAENWENKARQSEADNNTLKLELIT 447
L+ N LKN+ + +S+ Q ME+ RK + E + A Q + L+ E +
Sbjct: 1114 TLKENNLKNVEELNKSKELLTVENQKMEEFRK---EIETLKQAAAQKSQQLSALQEENVK 1170
Query: 448 AEAEGNRLKEKVDSLNREVEQHLNAERSY-KSQISTLHKSVVKMEEELQKVQFEKVSALA 506
E R +++V S Q L ERS +Q+ + K K ++ + EK S
Sbjct: 1171 LAEELGRSRDEVTS-----HQKLEEERSVLNNQLLEMKKRESKFIKDADE---EKASLQK 1222
Query: 507 DLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQN 566
+S T L + D+ E L ++ E S HS ++ L S + ++N
Sbjct: 1223 SISITSALLTEKDAELEKLRNEVTVLRGE----NASAKSLHSVVQTLESDKVKLELKVKN 1278
Query: 567 LEALLVANR 575
LE L N+
Sbjct: 1279 LELQLKENK 1287
Score = 97.4 bits (241), Expect = 4e-20
Identities = 146/711 (20%), Positives = 304/711 (42%), Gaps = 112/711 (15%)
Query: 37 KCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHA 96
K E + +A + ++++ E+D + +E+ LRR + + + + +
Sbjct: 482 KLQRELEDTRVATVSEKSRIMELEKDLALRV-----QEVAELRRRLESNKPAGDVDMSLS 536
Query: 97 ILRRVET---ERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEEL----EC 149
+L+ + + + +V TD +R T SL+E +ET E L E+L E
Sbjct: 537 LLQEISSLQEKLEVTRTDHQREIT---SLKEHFGAREETHQKEIKALYTATEKLSKENES 593
Query: 150 TVHNLDDERMEQMSNMTLMKETISTV-------EKEMKSLARKAMDTES-ELGRQKAENN 201
L+ E + L K + T +E+K K + TE+ E K +
Sbjct: 594 LKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIE 653
Query: 202 SLRLLYENTEKDLS---DTQRHLAKKKYE------LQLTQEKIMCLD---EKIDNFTRQN 249
+RL Y++ ++L D++R K+ E +++ +EK L+ K+D Q+
Sbjct: 654 KMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH 713
Query: 250 IAQREEISILGGTLNDL------AKEKECLQACLDKKSENIASLGESLAMKEKTI----- 298
+ + E+ TLN L KE E LQA +++++ I + L E+ +
Sbjct: 714 LVEMED------TLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA 767
Query: 299 ---------SGMKNIIAEMEQASRQCTEALIVCEQDVSRMR--------RQLDETN--DE 339
S MK + ++E A +Q I + S+ R+L TN +
Sbjct: 768 LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQEN 827
Query: 340 LAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKL 399
L+++++ ++ L + L+E+FA+A +E ++ + + +T N+L+ +++ + ++ KL
Sbjct: 828 LSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 887
Query: 400 KNILKSEES---ENRQMMEQLRKANEDAEN------------------WENKARQSEADN 438
+ L E+ E + EQL KA E EN ++ R E D
Sbjct: 888 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 947
Query: 439 NTLKLELITAEAEGNRLKEKVDSLNREVEQ-HLNAERSYKSQISTLHKSVVKMEEELQKV 497
L+L+L A + L++ ++ + + EQ A + ++ + L + + +E++++
Sbjct: 948 EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETS 1007
Query: 498 --QFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRS 555
Q +++ A + +T E K + + L + L+ + +++ E E+E LR
Sbjct: 1008 HNQCQELKARYE-RATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK 1066
Query: 556 QMANERISMQNLEAL-LVANRDKEYQSQIALQEK--------ESEIQLLKEH-------L 599
Q + + +A+ ++ KE +A E ++E+ LKE+ L
Sbjct: 1067 QADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEEL 1126
Query: 600 CLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRR 650
++ + ++++ + +FR + L+ +QL + E + +EL R
Sbjct: 1127 NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1177
Score = 79.3 bits (194), Expect = 1e-14
Identities = 103/538 (19%), Positives = 225/538 (41%), Gaps = 66/538 (12%)
Query: 20 NCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLR 79
N + + TR+ + + L + +L+E+ + L+ E + + +A EE ++
Sbjct: 801 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 860
Query: 80 REMMKSCKS--PKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEK 137
R M ++ K + + +E R+ D+ E+D E+L A+E N+
Sbjct: 861 RSMQETVNKLHQKEEQFNMLSSDLEKLRE-NLADMEAKFREKDEREEQLIKAKEKLENDI 919
Query: 138 AHLEQRIEELECTVHNLDDERM-------EQMSNMTLMKETISTVEKEMKSLARKAMDTE 190
A + + + + ++DE E +T E S ++K ++ + KA ++
Sbjct: 920 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 979
Query: 191 SELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNI 250
E ++ E + E+ LSD ++ +++ + + L + + T +
Sbjct: 980 QEAAKKHEEEK------KELERKLSDLEK-------KMETSHNQCQELKARYERATSETK 1026
Query: 251 AQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGE--SLAMKEKTISGMKNIIAEM 308
+ EEI L L ++ L+ ++ S + L E A K K ++ + M
Sbjct: 1027 TKHEEI--LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM 1084
Query: 309 EQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQEN 368
EQ +++ TE L L++T A++ E D L +N E+ K+K+
Sbjct: 1085 EQMTKEKTETLA-----------SLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELL 1133
Query: 369 QALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWE 428
++K+ + E+ +KQ + +++ L + EN ++ E+L ++ ++ + +
Sbjct: 1134 TVENQKMEEFRKEIETLKQAAAQKSQQLSAL-------QEENVKLAEELGRSRDEVTSHQ 1186
Query: 429 NKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVV 488
+ NN L +K++ ++ ++ + S + IS +
Sbjct: 1187 KLEEERSVLNNQLL-----------EMKKRESKFIKDADEE---KASLQKSISITSALLT 1232
Query: 489 KMEEELQKVQFEKVSAL----ADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENE 542
+ + EL+K++ E V+ L A S + L+S K L +L K+ E++++EN+
Sbjct: 1233 EKDAELEKLRNE-VTVLRGENASAKSLHSVVQTLESDKVKL--ELKVKNLELQLKENK 1287
Score = 38.5 bits (88), Expect = 0.021
Identities = 72/374 (19%), Positives = 140/374 (37%), Gaps = 92/374 (24%)
Query: 329 MRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQK 388
++ L E + Q+ ERD+ + + +QE AL++ +D H
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQE-LALARDGHDQH--------- 402
Query: 389 VQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITA 448
V + ++++L+ ++++ + E +++ QL +
Sbjct: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEE---------------------------- 434
Query: 449 EAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSA---L 505
K KV+ L VE+ + ++Q H + ++E Q + FEK A
Sbjct: 435 -------KRKVEDLQFRVEEESITKGDLETQTKLEHARIKELE---QSLLFEKTKADKLQ 484
Query: 506 ADLSSTRELCIKLDSSKELLNRQLVAKDQEI-EMRE------------------NELDSA 546
+L TR + S L + L + QE+ E+R E+ S
Sbjct: 485 RELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSL 544
Query: 547 HSEIELLRSQM------------ANERISMQNLEALLVANR--DKEYQS-----QIALQE 587
++E+ R+ A E + ++AL A KE +S + A +E
Sbjct: 545 QEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKE 604
Query: 588 KESEIQLLKEHL--CLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAV 645
I L K L +A ++ A++ V+ + + T+ A+ K Q+ R + + +
Sbjct: 605 NSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTE-TAEFAELKTQIEKMRLDYQHEI 663
Query: 646 QELRRQNYSSNAYH 659
+ L+ Q S A H
Sbjct: 664 ENLQNQQDSERAAH 677
>gi|110815815 centlein isoform 1 [Homo sapiens]
Length = 1406
Score = 97.4 bits (241), Expect = 4e-20
Identities = 142/664 (21%), Positives = 284/664 (42%), Gaps = 75/664 (11%)
Query: 10 RRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYE 69
+R +P G E+L+ T + EL+ L+ +E+ +++ K L E D + L +
Sbjct: 675 KRSTPEKNGK----EMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLK 730
Query: 70 QAQEEITRLRREMMKSCKSPKSTTAHAILRRVE-TERDVAFTDLRRMTTERDSLRERLKI 128
Q QE+ +E+ + K K +V+ +E + T LRR E ++LR
Sbjct: 731 QQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALR----- 785
Query: 129 AQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMD 188
NE L +E+ H D +M+ M + + M + KA
Sbjct: 786 ------NENEELINPMEKS----HQSADRAKSEMATMKVRSGRYDC-KTTMTKVKFKAAK 834
Query: 189 TESELGRQKAE-NNSLRLL---YENTEKD--------LSDTQRHLAKKKYELQL-TQEKI 235
+GR N+S++++ +EN KD SD++ ++ + + T +KI
Sbjct: 835 KNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKI 894
Query: 236 MCL----DEKIDNFTRQNIAQREEI-----SILGGTLNDLAKEKECLQACLDKKSENIAS 286
D+K + T + Q +EI +I G T D +K + KK+ +
Sbjct: 895 SPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQK 954
Query: 287 LGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARE 346
+ KNI A+ ++ I+ Q + + + +T + + +E
Sbjct: 955 SSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKE 1014
Query: 347 -RDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKN---- 401
+ L H ++F ++Q + L+ L E D+ +K++ ++ E+ L
Sbjct: 1015 VNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSS-EITSLAEENSQ 1073
Query: 402 -----ILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLK 456
I + S +R M ++++ +N N+ + ++ TLK EL+ E +
Sbjct: 1074 VTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMH 1133
Query: 457 EKVDSLNREV--EQHLNAERSYKSQIS-TLHKSVVKMEEELQKVQFEKVSALADLSSTRE 513
EK+ + R++ ++HL + ++ +++ +KS +M + L K KV L + S ++
Sbjct: 1134 EKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDK----KVKTLTEECSNKK 1189
Query: 514 LCIKLDSSKELLNRQLVAKDQEIEM---RENELDSAHSEIELLRSQMANERISMQNLEAL 570
+ +DS K+ LN + K Q +M + EL+ ++ LL S+++ +M +E
Sbjct: 1190 --VSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETA 1247
Query: 571 LVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDIT 630
K+ Q ++ALQ E ++ ++ L LA K+ + V + + +L+ D+ +
Sbjct: 1248 ----ASKQLQ-ELALQ-SEQVLEGAQKTLLLANEKVEEFTTFV---KALAKELQNDVHVV 1298
Query: 631 KRQL 634
+RQ+
Sbjct: 1299 RRQI 1302
Score = 72.0 bits (175), Expect = 2e-12
Identities = 132/615 (21%), Positives = 244/615 (39%), Gaps = 101/615 (16%)
Query: 72 QEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQ- 130
+EE++ L+ E+ C++ K R T D+ T + + ER+ + K +
Sbjct: 106 EEELSSLKEELAL-CQADKEFVWSLWKRLQVTNPDL--TQVVSLVVEREKQKSEAKDRKV 162
Query: 131 ----ETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKA 186
+ + EQR L+ +++L ++ +++ S +EK+ K +++
Sbjct: 163 LEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEI 222
Query: 187 MDTESELGRQKAENNSLRLLYENTEKD-------LSDTQRHLAK-KKYELQLTQEKIMCL 238
DT+ E + K E N RL+ +N E++ +D L K +K E L +EK
Sbjct: 223 KDTK-ECVQNKEEQN--RLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEK-YST 278
Query: 239 DEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLG------ESLA 292
D KI F I R+E+ + N L+ + Q L +K +I + ++L
Sbjct: 279 DAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLY 338
Query: 293 MKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVS-----RMRRQLDETNDELAQIARER 347
+ T + + + + Q T+ ++ ++DV ++ +E +
Sbjct: 339 KQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNE 398
Query: 348 DILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQ-DTNLEV------NKLK 400
+L NLQ+Q + +QEN L +KL ++ + Q+ D + +V + L+
Sbjct: 399 AMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLE 458
Query: 401 NILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVD 460
++ S++SE + E+L+ ANE K ++ + N + I AEG
Sbjct: 459 TLMVSQKSEIEYLQEKLKIANE-------KLSENISANKGFSRKSIMTSAEGK------- 504
Query: 461 SLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDS 520
+ E K S KS EELQK++ K +
Sbjct: 505 ----------HKEPPVKRSRSLSPKSSFTDSEELQKLR------------------KAER 536
Query: 521 SKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQ 580
E L + L K QE +EL AH + ER+ M V + K+++
Sbjct: 537 KIENLEKALQLKSQE----NDELRDAH--------EKRKERLQMLQTNYRAVKEQLKQWE 584
Query: 581 -----SQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLG 635
++I ++ QL +E N++A R+ + LE +LD K +
Sbjct: 585 EGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHIS 644
Query: 636 TERFERERAVQELRR 650
++ A+QEL R
Sbjct: 645 IDK----AAIQELNR 655
Score = 64.3 bits (155), Expect = 4e-10
Identities = 96/546 (17%), Positives = 222/546 (40%), Gaps = 63/546 (11%)
Query: 31 RDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEE-------ITRLRREMM 83
+++ ++ +E +L E + V+V +S+ + + L Q E IT +R+E+
Sbjct: 273 KEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQ 332
Query: 84 KSCKSPKSTTAHAILR-RVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQ 142
+ K + H + + + V D +++ ++ + I+ + +NE H+
Sbjct: 333 ELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNE-LHI-- 389
Query: 143 RIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNS 202
C +E M + S +T +++ + E+E L K +++ E++
Sbjct: 390 ------CFETTKSNEAMLRQS-VTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDP 442
Query: 203 LRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGT 262
LS + + +K E++ QEK+ +EK+ +NI+ + S
Sbjct: 443 DYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLS----ENISANKGFSRKSIM 498
Query: 263 LNDLAKEKEC----LQACLDKKSENIASLGESLAMKEKTISGMKNIIA-------EMEQA 311
+ K KE ++ K S + + L E+ I ++ + E+ A
Sbjct: 499 TSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDA 558
Query: 312 SRQCTEALIVCEQDVSRMRRQLDETND-----ELAQIARE--RDILAHDNDNLQEQFAKA 364
+ E L + + + ++ QL + + E+ +I R + + D+D + + A
Sbjct: 559 HEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYF 618
Query: 365 KQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNIL-------------------KS 405
K+ENQ L + + EL+++K + + +L + +
Sbjct: 619 KRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRST 678
Query: 406 EESENRQMMEQLRKANEDAEN----WENKARQSEADNNTLKLELITAEAEGNRLKEKVDS 461
E ++M+EQ + + EN +E ++R+ + N L E ++ + +E ++
Sbjct: 679 PEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTET 738
Query: 462 LNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSS 521
+E+EQ + + + + + L + ++E E+ ++ + A A + EL ++ S
Sbjct: 739 REKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKS 798
Query: 522 KELLNR 527
+ +R
Sbjct: 799 HQSADR 804
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 97.1 bits (240), Expect = 5e-20
Identities = 133/689 (19%), Positives = 291/689 (42%), Gaps = 85/689 (12%)
Query: 24 ELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM 83
EL K +R EEL + E E L + Q NV+ + ++ + A+ E + RRE+
Sbjct: 1149 ELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIR-------AESEAKQYRRELE 1201
Query: 84 KSCKSPKSTTAHAILRRVETERDVAF-TDLRRMTTERDSLRERLKIAQETAFNEKAHLEQ 142
+ ++ R +E R + + +R E + L R ++ +E F + LE
Sbjct: 1202 TIVREKEAAE-----RELERVRQLTIEAEAKRAAVEENLLNFRNQL-EENTFTRRT-LED 1254
Query: 143 RIEELECTVHNLDDERMEQMSNMTLMK----ETISTVEKEMKSLARKAMDTESELG-RQK 197
++ + ++++L+ ++ + M + + E + +++ K LA + E +L +QK
Sbjct: 1255 HLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQK 1314
Query: 198 AENNSLRLLYE-------NTEKDLSDTQRHLAKKKYELQLTQEKIMC--LDEKIDNFTRQ 248
E + R + E N TQ + LQ +K L +++D T
Sbjct: 1315 IELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAA 1374
Query: 249 NIAQREEISILGGTLNDLAKEK-------ECLQACLDKKSENIASLGESLAMKEKTISGM 301
N +++ L LN L EK L+ LD+ + + L L K++ G
Sbjct: 1375 NRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGY 1434
Query: 302 KNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQF 361
+ E+ + Q T Q+ S +++ EL + E+ L + D +
Sbjct: 1435 SQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAH 1494
Query: 362 AKAKQENQALSKKLNDTHNEL------------NDIKQKVQDTNLEVNKLKNILKSEESE 409
A A++ Q L+ +++ +E + +K++ + ++ ++ L+NI +E+
Sbjct: 1495 AVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQL--LQNIKAEKENN 1552
Query: 410 NR--QMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRL------------ 455
++ ++ E+L K+NE AE + K + NN KL + +AE +
Sbjct: 1553 DKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCE 1612
Query: 456 ---------KEKVDSLNREVEQHLNAERSYKSQISTLHKSVVK----MEEELQKVQFEKV 502
K+++ S N + + E+ ++ +I L + + K + E QK + +
Sbjct: 1613 ALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNI 1672
Query: 503 SALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERI 562
R L +L++SKE R +Q++++++ ++ ++ ++ ++ ++ + I
Sbjct: 1673 IIQNTKKEVRNLNAELNASKEEKRR----GEQKVQLQQAQVQELNNRLKKVQDELHLKTI 1728
Query: 563 SMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQ 622
Q +V +++ + + + +E +++ L E + EN ++ D + ++
Sbjct: 1729 EEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSR 1788
Query: 623 LEADLDITKRQLGTERFERERAVQELRRQ 651
+ + + + T E ER +Q+ R Q
Sbjct: 1789 AQENAKLCE----TNIKELERQLQQYREQ 1813
Score = 86.3 bits (212), Expect = 9e-17
Identities = 115/615 (18%), Positives = 262/615 (42%), Gaps = 70/615 (11%)
Query: 23 VELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRL---- 78
+E L+ + EEL ++++ E+ LA + + E+ KI L +A+ +IT +
Sbjct: 1274 MEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIEL---EARRKITEIQYTC 1330
Query: 79 RREMMKSCKSPKSTTAHAIL---------RRVETERDV---------AFTDLRRMTTERD 120
R + C ++T+ A+ + E ++ V A D+R +T E +
Sbjct: 1331 RENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELN 1390
Query: 121 SLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDD-------------ERMEQMSNMTL 167
+L+ ++E A K L++ L C L+ E Q++ T
Sbjct: 1391 ALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTG 1450
Query: 168 MKETISTVEKEMKSLARK-AMDTES---ELGRQKAENNSLRLLYENTEKDLS--DTQRHL 221
E ++K + R ++ ES E G+ + E + + + EK++ ++Q H
Sbjct: 1451 KAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHS 1510
Query: 222 AKKKYEL---QLTQEKIMCLDEKIDNFTRQNI----AQREEISILGGTLNDLAKEKECLQ 274
+ + EL Q+ Q K L E+ + Q + A++E + +L K EC +
Sbjct: 1511 FRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAE 1570
Query: 275 ACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLD 334
K E E+ M ++ + +NI+ E + ++C EAL + + QL
Sbjct: 1571 MLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRC-EALKI---QADGFKDQLR 1626
Query: 335 ETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNL 394
TN+ L + + L+E AK++ +K + + + + K++V++ N
Sbjct: 1627 STNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNA 1686
Query: 395 EVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNR 454
E+N K + E + + Q+++ N + +++ + +++ + E +
Sbjct: 1687 ELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGK 1746
Query: 455 LKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTREL 514
K+ + +++E+ + ++ ++ IS + V +++E + Q +L
Sbjct: 1747 FKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQ-----------ENAKL 1795
Query: 515 CIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVAN 574
C +++ + L RQL ++++ ++ + + + + L ++ ++ ++NL+ +
Sbjct: 1796 C---ETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM-DQ 1851
Query: 575 RDKEYQSQIALQEKE 589
+ KE++ Q+ L + E
Sbjct: 1852 QIKEHEHQLVLLQCE 1866
Score = 58.9 bits (141), Expect = 2e-08
Identities = 134/709 (18%), Positives = 293/709 (41%), Gaps = 104/709 (14%)
Query: 24 ELLKTTTRDREE-------------LKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQ 70
ELLK+ R+ +E ++ LE E L + +F + EQ
Sbjct: 724 ELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQ 783
Query: 71 AQ--EEITRLRREM---MKSCKSPKS-TTAHAILRRVETERDVAFTDLRRMTTERDSLRE 124
+ +E+ RL+ ++ C+ S A + + + +E +V ++ ++ + + +
Sbjct: 784 EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 843
Query: 125 RLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLAR 184
+LK N +A + + +L T ++ + +N+ + T+ E+ +
Sbjct: 844 KLKTVNLVLKNTQA--AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 901
Query: 185 KAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDN 244
E EL + KA ++ + Y+ E+DL D H K ++ Q + +IDN
Sbjct: 902 VFHALEDELQKAKAISDEMFKTYK--ERDL-DFDWHKEKADQLVERWQN----VHVQIDN 954
Query: 245 FTRQNIAQREEISILGGT---LNDLAKEKECLQACL-DKKSENIASLGESLAMKEKTISG 300
R + + T L+D ++ E Q + + + EN +L L ++ +S
Sbjct: 955 RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1014
Query: 301 MKNIIAEMEQASRQCTE-ALIVCEQDVSRMRRQLDETNDELAQIARER-----DILAHDN 354
++ ++M++ + + + V + ++ M + + + + + R R D++ +
Sbjct: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
Query: 355 DNLQEQFA-----------------KAKQENQALSKKLNDTHNELNDIKQKVQDTNLE-- 395
+L+ ++ K +E + K H +D+ Q+ + T LE
Sbjct: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENS 1134
Query: 396 -----VNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEA 450
+++L+ ++ + + ++ E+L K E A EN+ R+ + + + L+ I AE+
Sbjct: 1135 KLTGKISELERMVAELKKQKSRVEEELPKVREAA---ENELRKQQRNVEDISLQKIRAES 1191
Query: 451 EGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSS 510
E + + +++++ RE E AER ++ + + ++ E + V+ +L +
Sbjct: 1192 EAKQYRRELETIVREKEA---AER----ELERVRQLTIEAEAKRAAVE-------ENLLN 1237
Query: 511 TRELCIKLDSSKELLNRQLVAKD---QEIEMRENELDSAHSEIELLRSQMANERISMQNL 567
R + ++ L L KD ++E ++N+L +E LR + NE + L
Sbjct: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKL------MEELRRKRDNEE---ELL 1288
Query: 568 EALLVANRDKEYQSQIA---LQEK-----ESEIQLLKEHLCLAENKMAIQSRDVAQFRNV 619
+ + +D +Q Q+A L+EK E+ ++ + EN + + A
Sbjct: 1289 KLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRA 1348
Query: 620 VTQLEADLD-----ITKRQLGTERFERERAVQELRRQNYSSNAYHMSST 663
VT L+ + D K+Q+ +A Q++R Y NA + T
Sbjct: 1349 VTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397
Score = 30.8 bits (68), Expect = 4.4
Identities = 53/225 (23%), Positives = 90/225 (40%), Gaps = 19/225 (8%)
Query: 357 LQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNL---EVNK--LKNILK-----SE 406
L F+ + N + KL L +K + D NL E+N ++++L
Sbjct: 237 LVPNFSSGVEPNSLQTLKLMQIRKPL--LKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294
Query: 407 ESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLK----EKVDSL 462
+ + + L EN +N R E ++LK I+ LK EK+ L
Sbjct: 295 QLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRL 354
Query: 463 NREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCI--KLDS 520
+ + LN R+ + + TLH V + EL + ++ +A S R I K D
Sbjct: 355 ESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDY 414
Query: 521 SKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQ 565
EL+ R+L K++ I+ + + E R + R +MQ
Sbjct: 415 HAELM-RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQ 458
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 97.1 bits (240), Expect = 5e-20
Identities = 107/503 (21%), Positives = 224/503 (44%), Gaps = 49/503 (9%)
Query: 26 LKTTTRDREELKCMLEKYERHLA-----EIQGNVKVLKSERDKIFLLYEQAQEEITRLRR 80
L+++ +R++L+ L+ L EI N L + + YE+A +E+ +++
Sbjct: 448 LESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQK 507
Query: 81 EMMKSCKSPKSTTAHAI---LRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEK 137
+M SP+S ++ LR E E +V DL+ E + +E+++ +E +
Sbjct: 508 QMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVERE 567
Query: 138 AH--LEQRIEELE------CTV-HNLDDER-------MEQMSNMTLMKETI--------S 173
++ +EE E C+V N++ E+ E + +K+T+ S
Sbjct: 568 KGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS 627
Query: 174 TVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQE 233
++MK + +D EL +Q +E L LY+ + +L D + K+K +T E
Sbjct: 628 DEAEDMKEAMNRMID---ELNKQVSE---LSQLYKEAQAELEDYR----KRKSLEDVTAE 677
Query: 234 KIMCLD-EKIDNFTRQNIAQREE-ISILGGTLNDLAKEKECLQACLDKKSENIASLGESL 291
I + EK+ T + A+ E+ +S + + + E L+ +D + EN S+ E L
Sbjct: 678 YIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHL 737
Query: 292 AMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILA 351
+ I+ ++ EME+ E L E +V+++ +QL E + R
Sbjct: 738 ----QVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYE 793
Query: 352 HDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENR 411
+L+ + + + + K+ H+E+ I+ +V E ++ +LKS+E E
Sbjct: 794 KLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 853
Query: 412 QMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLN 471
+++++ ++A E+ + A S ++ E +LKE ++SL+ ++ +
Sbjct: 854 ELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS-QLSYSTS 912
Query: 472 AERSYKSQISTLHKSVVKMEEEL 494
+ + Q+ L + V +++ +L
Sbjct: 913 SSKRQSQQLEALQQQVKQLQNQL 935
Score = 89.7 bits (221), Expect = 8e-18
Identities = 132/666 (19%), Positives = 289/666 (43%), Gaps = 99/666 (14%)
Query: 11 RPSPTARGANCDVELLKTTTRDREELKCMLE----KYERHLAEIQGNVKVLKSERDKIFL 66
R S + GA+ +++ ++ D+++L +L+ H E+Q ++ + + L
Sbjct: 328 RLSDSTTGADSLLDI--SSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADL 385
Query: 67 LYEQAQEEITRLRREMMK-------SCKSPKSTTAHAILRRVETERDVAFTDLRRMTTER 119
++ T L + K KS S H+ L + T+ DV L+ + +
Sbjct: 386 SFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHS-LGKSTTDNDVRIQQLQEILQD- 443
Query: 120 DSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEM 179
L++RL+ ++ + L+ R EL C + E +S +KET S E+ M
Sbjct: 444 --LQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQK--LKETQSKYEEAM 499
Query: 180 KSLARKAMDTESELGRQKAEN-------NSLRLLYENTEKDLSDTQRHLAKKKYELQLTQ 232
K + ++ + +LG E+ + LR+ TE++++ ++ L E + +
Sbjct: 500 KEVL--SVQKQMKLGLVSPESMDNYSHFHELRV----TEEEINVLKQDLQNALEESERNK 553
Query: 233 EKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLA 292
EK+ L+EK+ +RE+ +++ + + + K + ++ ++ A L E
Sbjct: 554 EKVRELEEKL--------VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQ 605
Query: 293 MKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAH 352
++ I +K+ + S+ EA E M R +DE N +++++++ L
Sbjct: 606 EAQEEIMKLKDTLK-----SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQ----LYK 656
Query: 353 DNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQ 412
+ E + K K ++ ++ +E + +Q TN+ K ++ L +S+ +
Sbjct: 657 EAQAELEDYRKRKSLEDVTAEYIHKAEHE-----KLMQLTNVSRAKAEDALSEMKSQYSK 711
Query: 413 MMEQLRKANEDAENWENKARQSEADNNTLKLELITA-EAEGNRLKEKVDSLNREVEQHLN 471
++ +L + + + A++ + + T L++IT ++EK+ +L
Sbjct: 712 VLNELTQLKQLVD-----AQKENSVSITEHLQVITTLRTAAKEMEEKISNL--------- 757
Query: 472 AERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVA 531
K +++ V K+E++L E+ +A+ D R KL SS E L +
Sbjct: 758 -----KEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSSLESEVSVLAS 808
Query: 532 KDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESE 591
K +E E + HSE+ +RS+++ + +N++ L L+ KE E
Sbjct: 809 KLKE---SVKEKEKVHSEVVQIRSEVSQVKREKENIQTL--------------LKSKEQE 851
Query: 592 IQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQ 651
+ L + A+ ++A ++ ++ ++LE D D ++ E + + A+ L +
Sbjct: 852 VNELLQKFQQAQEELA----EMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 907
Query: 652 NYSSNA 657
+YS+++
Sbjct: 908 SYSTSS 913
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 97.1 bits (240), Expect = 5e-20
Identities = 107/503 (21%), Positives = 224/503 (44%), Gaps = 49/503 (9%)
Query: 26 LKTTTRDREELKCMLEKYERHLA-----EIQGNVKVLKSERDKIFLLYEQAQEEITRLRR 80
L+++ +R++L+ L+ L EI N L + + YE+A +E+ +++
Sbjct: 437 LESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQK 496
Query: 81 EMMKSCKSPKSTTAHAI---LRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEK 137
+M SP+S ++ LR E E +V DL+ E + +E+++ +E +
Sbjct: 497 QMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVERE 556
Query: 138 AH--LEQRIEELE------CTV-HNLDDER-------MEQMSNMTLMKETI--------S 173
++ +EE E C+V N++ E+ E + +K+T+ S
Sbjct: 557 KGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS 616
Query: 174 TVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQE 233
++MK + +D EL +Q +E L LY+ + +L D + K+K +T E
Sbjct: 617 DEAEDMKEAMNRMID---ELNKQVSE---LSQLYKEAQAELEDYR----KRKSLEDVTAE 666
Query: 234 KIMCLD-EKIDNFTRQNIAQREE-ISILGGTLNDLAKEKECLQACLDKKSENIASLGESL 291
I + EK+ T + A+ E+ +S + + + E L+ +D + EN S+ E L
Sbjct: 667 YIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHL 726
Query: 292 AMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILA 351
+ I+ ++ EME+ E L E +V+++ +QL E + R
Sbjct: 727 ----QVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYE 782
Query: 352 HDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENR 411
+L+ + + + + K+ H+E+ I+ +V E ++ +LKS+E E
Sbjct: 783 KLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 842
Query: 412 QMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLN 471
+++++ ++A E+ + A S ++ E +LKE ++SL+ ++ +
Sbjct: 843 ELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS-QLSYSTS 901
Query: 472 AERSYKSQISTLHKSVVKMEEEL 494
+ + Q+ L + V +++ +L
Sbjct: 902 SSKRQSQQLEALQQQVKQLQNQL 924
Score = 89.7 bits (221), Expect = 8e-18
Identities = 132/666 (19%), Positives = 289/666 (43%), Gaps = 99/666 (14%)
Query: 11 RPSPTARGANCDVELLKTTTRDREELKCMLE----KYERHLAEIQGNVKVLKSERDKIFL 66
R S + GA+ +++ ++ D+++L +L+ H E+Q ++ + + L
Sbjct: 317 RLSDSTTGADSLLDI--SSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADL 374
Query: 67 LYEQAQEEITRLRREMMK-------SCKSPKSTTAHAILRRVETERDVAFTDLRRMTTER 119
++ T L + K KS S H+ L + T+ DV L+ + +
Sbjct: 375 SFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHS-LGKSTTDNDVRIQQLQEILQD- 432
Query: 120 DSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEM 179
L++RL+ ++ + L+ R EL C + E +S +KET S E+ M
Sbjct: 433 --LQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQK--LKETQSKYEEAM 488
Query: 180 KSLARKAMDTESELGRQKAEN-------NSLRLLYENTEKDLSDTQRHLAKKKYELQLTQ 232
K + ++ + +LG E+ + LR+ TE++++ ++ L E + +
Sbjct: 489 KEVL--SVQKQMKLGLVSPESMDNYSHFHELRV----TEEEINVLKQDLQNALEESERNK 542
Query: 233 EKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLA 292
EK+ L+EK+ +RE+ +++ + + + K + ++ ++ A L E
Sbjct: 543 EKVRELEEKL--------VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQ 594
Query: 293 MKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAH 352
++ I +K+ + S+ EA E M R +DE N +++++++ L
Sbjct: 595 EAQEEIMKLKDTLK-----SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQ----LYK 645
Query: 353 DNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQ 412
+ E + K K ++ ++ +E + +Q TN+ K ++ L +S+ +
Sbjct: 646 EAQAELEDYRKRKSLEDVTAEYIHKAEHE-----KLMQLTNVSRAKAEDALSEMKSQYSK 700
Query: 413 MMEQLRKANEDAENWENKARQSEADNNTLKLELITA-EAEGNRLKEKVDSLNREVEQHLN 471
++ +L + + + A++ + + T L++IT ++EK+ +L
Sbjct: 701 VLNELTQLKQLVD-----AQKENSVSITEHLQVITTLRTAAKEMEEKISNL--------- 746
Query: 472 AERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVA 531
K +++ V K+E++L E+ +A+ D R KL SS E L +
Sbjct: 747 -----KEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSSLESEVSVLAS 797
Query: 532 KDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESE 591
K +E E + HSE+ +RS+++ + +N++ L L+ KE E
Sbjct: 798 KLKE---SVKEKEKVHSEVVQIRSEVSQVKREKENIQTL--------------LKSKEQE 840
Query: 592 IQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQ 651
+ L + A+ ++A ++ ++ ++LE D D ++ E + + A+ L +
Sbjct: 841 VNELLQKFQQAQEELA----EMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 896
Query: 652 NYSSNA 657
+YS+++
Sbjct: 897 SYSTSS 902
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 97.1 bits (240), Expect = 5e-20
Identities = 107/503 (21%), Positives = 224/503 (44%), Gaps = 49/503 (9%)
Query: 26 LKTTTRDREELKCMLEKYERHLA-----EIQGNVKVLKSERDKIFLLYEQAQEEITRLRR 80
L+++ +R++L+ L+ L EI N L + + YE+A +E+ +++
Sbjct: 416 LESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQK 475
Query: 81 EMMKSCKSPKSTTAHAI---LRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEK 137
+M SP+S ++ LR E E +V DL+ E + +E+++ +E +
Sbjct: 476 QMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVERE 535
Query: 138 AH--LEQRIEELE------CTV-HNLDDER-------MEQMSNMTLMKETI--------S 173
++ +EE E C+V N++ E+ E + +K+T+ S
Sbjct: 536 KGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS 595
Query: 174 TVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQE 233
++MK + +D EL +Q +E L LY+ + +L D + K+K +T E
Sbjct: 596 DEAEDMKEAMNRMID---ELNKQVSE---LSQLYKEAQAELEDYR----KRKSLEDVTAE 645
Query: 234 KIMCLD-EKIDNFTRQNIAQREE-ISILGGTLNDLAKEKECLQACLDKKSENIASLGESL 291
I + EK+ T + A+ E+ +S + + + E L+ +D + EN S+ E L
Sbjct: 646 YIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHL 705
Query: 292 AMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILA 351
+ I+ ++ EME+ E L E +V+++ +QL E + R
Sbjct: 706 ----QVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYE 761
Query: 352 HDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENR 411
+L+ + + + + K+ H+E+ I+ +V E ++ +LKS+E E
Sbjct: 762 KLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 821
Query: 412 QMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLN 471
+++++ ++A E+ + A S ++ E +LKE ++SL+ ++ +
Sbjct: 822 ELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS-QLSYSTS 880
Query: 472 AERSYKSQISTLHKSVVKMEEEL 494
+ + Q+ L + V +++ +L
Sbjct: 881 SSKRQSQQLEALQQQVKQLQNQL 903
Score = 89.7 bits (221), Expect = 8e-18
Identities = 132/666 (19%), Positives = 289/666 (43%), Gaps = 99/666 (14%)
Query: 11 RPSPTARGANCDVELLKTTTRDREELKCMLE----KYERHLAEIQGNVKVLKSERDKIFL 66
R S + GA+ +++ ++ D+++L +L+ H E+Q ++ + + L
Sbjct: 296 RLSDSTTGADSLLDI--SSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADL 353
Query: 67 LYEQAQEEITRLRREMMK-------SCKSPKSTTAHAILRRVETERDVAFTDLRRMTTER 119
++ T L + K KS S H+ L + T+ DV L+ + +
Sbjct: 354 SFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHS-LGKSTTDNDVRIQQLQEILQD- 411
Query: 120 DSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEM 179
L++RL+ ++ + L+ R EL C + E +S +KET S E+ M
Sbjct: 412 --LQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQK--LKETQSKYEEAM 467
Query: 180 KSLARKAMDTESELGRQKAEN-------NSLRLLYENTEKDLSDTQRHLAKKKYELQLTQ 232
K + ++ + +LG E+ + LR+ TE++++ ++ L E + +
Sbjct: 468 KEVL--SVQKQMKLGLVSPESMDNYSHFHELRV----TEEEINVLKQDLQNALEESERNK 521
Query: 233 EKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLA 292
EK+ L+EK+ +RE+ +++ + + + K + ++ ++ A L E
Sbjct: 522 EKVRELEEKL--------VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQ 573
Query: 293 MKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAH 352
++ I +K+ + S+ EA E M R +DE N +++++++ L
Sbjct: 574 EAQEEIMKLKDTLK-----SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQ----LYK 624
Query: 353 DNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQ 412
+ E + K K ++ ++ +E + +Q TN+ K ++ L +S+ +
Sbjct: 625 EAQAELEDYRKRKSLEDVTAEYIHKAEHE-----KLMQLTNVSRAKAEDALSEMKSQYSK 679
Query: 413 MMEQLRKANEDAENWENKARQSEADNNTLKLELITA-EAEGNRLKEKVDSLNREVEQHLN 471
++ +L + + + A++ + + T L++IT ++EK+ +L
Sbjct: 680 VLNELTQLKQLVD-----AQKENSVSITEHLQVITTLRTAAKEMEEKISNL--------- 725
Query: 472 AERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVA 531
K +++ V K+E++L E+ +A+ D R KL SS E L +
Sbjct: 726 -----KEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSSLESEVSVLAS 776
Query: 532 KDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESE 591
K +E E + HSE+ +RS+++ + +N++ L L+ KE E
Sbjct: 777 KLKE---SVKEKEKVHSEVVQIRSEVSQVKREKENIQTL--------------LKSKEQE 819
Query: 592 IQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQ 651
+ L + A+ ++A ++ ++ ++LE D D ++ E + + A+ L +
Sbjct: 820 VNELLQKFQQAQEELA----EMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 875
Query: 652 NYSSNA 657
+YS+++
Sbjct: 876 SYSTSS 881
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.125 0.326
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,163,662
Number of Sequences: 37866
Number of extensions: 941244
Number of successful extensions: 13992
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 441
Number of HSP's successfully gapped in prelim test: 960
Number of HSP's that attempted gapping in prelim test: 5097
Number of HSP's gapped (non-prelim): 4478
length of query: 698
length of database: 18,247,518
effective HSP length: 109
effective length of query: 589
effective length of database: 14,120,124
effective search space: 8316753036
effective search space used: 8316753036
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.