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Search of human proteins with 187608615
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187608615 tyrosine kinase 2 [Homo sapiens]
(1187 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187608615 tyrosine kinase 2 [Homo sapiens] 2458 0.0
gi|102469034 janus kinase 1 [Homo sapiens] 990 0.0
gi|4826776 Janus kinase 2 [Homo sapiens] 756 0.0
gi|47157315 Janus kinase 3 [Homo sapiens] 713 0.0
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 174 6e-43
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 174 6e-43
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 169 1e-41
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 169 1e-41
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 169 1e-41
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 166 1e-40
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 166 1e-40
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 165 3e-40
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 165 3e-40
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 165 3e-40
gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 165 3e-40
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 163 8e-40
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 163 8e-40
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 163 8e-40
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 162 2e-39
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 162 2e-39
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 162 2e-39
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 162 2e-39
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 161 3e-39
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 161 3e-39
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 161 3e-39
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 161 3e-39
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 160 7e-39
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 160 7e-39
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 159 1e-38
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 159 1e-38
>gi|187608615 tyrosine kinase 2 [Homo sapiens]
Length = 1187
Score = 2458 bits (6370), Expect = 0.0
Identities = 1187/1187 (100%), Positives = 1187/1187 (100%)
Query: 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI 60
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
Sbjct: 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI 60
Query: 61 AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP 120
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
Sbjct: 61 AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP 120
Query: 121 AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK 180
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
Sbjct: 121 AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK 180
Query: 181 NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR 240
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
Sbjct: 181 NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR 240
Query: 241 FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP 300
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
Sbjct: 241 FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP 300
Query: 301 TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK 360
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
Sbjct: 301 TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK 360
Query: 361 AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV 420
AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
Sbjct: 361 AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV 420
Query: 421 DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP 480
DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
Sbjct: 421 DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP 480
Query: 481 YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA 540
YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
Sbjct: 481 YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA 540
Query: 541 GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR 600
GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
Sbjct: 541 GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR 600
Query: 601 TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS 660
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
Sbjct: 601 TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS 660
Query: 661 LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS 720
LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
Sbjct: 661 LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS 720
Query: 721 ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA 780
ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
Sbjct: 721 ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA 780
Query: 781 PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ 840
PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
Sbjct: 781 PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ 840
Query: 841 LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI 900
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
Sbjct: 841 LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI 900
Query: 901 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII 960
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
Sbjct: 901 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII 960
Query: 961 KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI 1020
KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
Sbjct: 961 KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI 1020
Query: 1021 HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY 1080
HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
Sbjct: 1021 HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY 1080
Query: 1081 ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC 1140
ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
Sbjct: 1081 ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC 1140
Query: 1141 PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 1187
PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
Sbjct: 1141 PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 1187
>gi|102469034 janus kinase 1 [Homo sapiens]
Length = 1154
Score = 990 bits (2560), Expect = 0.0
Identities = 530/1130 (46%), Positives = 725/1130 (64%), Gaps = 54/1130 (4%)
Query: 52 TAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRN 111
TAEE+CI A I+P C NLFAL+D ++W PN + + SL L++R+RFYF N
Sbjct: 56 TAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTN 115
Query: 112 WHGMNPREPAVYRCGPPGTEASSDQTA--QGMQLLDPASFEYLFEQGKHEFVNDVASLWE 169
WHG N E +V+R P + ++ LLD +S EYLF QG+++ V +A + +
Sbjct: 116 WHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRD 175
Query: 170 LSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSAL 229
TE++ H +NE LGMA L + H A+ + L E+ K S+K IP + + IRQ + L
Sbjct: 176 PKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLL 235
Query: 230 TRLRLRNVFRRFLRDFQ-----PGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLA 284
TR+R+ NVF+ FL++F +S + VKYLATLE L +G E L + +
Sbjct: 236 TRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISS 295
Query: 285 QAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSG 344
+ E + D G +EV+VTG GIQW V+ E+ +
Sbjct: 296 ENEMNWFHSNDGG------------NVLYYEVMVTGNLGIQWRHKPNVVSVEKEKN---- 339
Query: 345 RNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLE 404
L KK + + ++ RE W F F +ITH+V+KE VSI++QDNK +E
Sbjct: 340 -----KLKRKKLENKHKKDEEKNKIREE-WNNFSYFPEITHIVIKESVVSINKQDNKKME 393
Query: 405 LSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKL 464
L L S ALSFVSLVDGYFRLTAD+ HYLC +VAPP +V +I++G HGP+ + KL
Sbjct: 394 LKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKL 453
Query: 465 RPE---DGLYLIHWSTSHPYRLILTVA--QRSQAPDGMQSLRLRKFPIEQQDGAFVLEGW 519
R E +G+Y++ WS + +++TV ++S+ G Q + + F IE Q G + L G
Sbjct: 454 RQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQK-QFKNFQIEVQKGRYSLHGS 512
Query: 520 GRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIM-RGARASPRTLNLSQ 578
RSFPS+ +L + L+ +LR + F L+RCC P+P E SNL++ + A+ +SQ
Sbjct: 513 DRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQ 572
Query: 579 LSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELR 638
LSF R+ +K++ Q HLG+GTRT++Y G L MD +D G ++++
Sbjct: 573 LSFDRILKKDLVQGEHLGRGTRTHIYSGTL------------MDYKDD--EGTSEEKKIK 618
Query: 639 VVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVW 698
V+LKVLDPSH DI+LAF+E AS+M QVSH H+ +++GVCVR ENIMV E+VE GPLD++
Sbjct: 619 VILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLF 678
Query: 699 LRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLS 758
+ R+ + WK VA+QLASALSYLE+K+LVHGNVC +N+LLAR G+ PFIKLS
Sbjct: 679 MHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLS 738
Query: 759 DPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSR 818
DPG+ + LSR+E +ERIPW+APEC+ N LS A DKW FG TL EIC++GE PL+ +
Sbjct: 739 DPGIPITVLSRQECIERIPWIAPECVEDSKN-LSVAADKWSFGTTLWEICYNGEIPLKDK 797
Query: 819 SPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVL 878
+ EKE FY+ + R PSC +LA L ++C+ Y+P QRP FR I+RD+ +L+ N D++
Sbjct: 798 TLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQN-PDIV 856
Query: 879 TVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGP 938
+ + DPT F KR+LK+IRDLGEGHFGKV L YDP D TGE VAVK+LK + G
Sbjct: 857 SEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGG 916
Query: 939 QHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--IG 996
H + K+EI+ILR LYHE+I+KYKG C + G ++L+ME++P GSL++YLP++ I
Sbjct: 917 NHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKIN 976
Query: 997 LAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYR 1056
L Q L +A QIC+GM YL ++ Y+HRDLAARNVL++++ VKIGDFGL KA+ EYY
Sbjct: 977 LKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYT 1036
Query: 1057 VREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQ 1116
V++D DSPVFWYAPECL + KFY ASDVWSFGVTL+ELLT+CDS SP FL++IG
Sbjct: 1037 VKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTH 1096
Query: 1117 GQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLI 1166
GQMTV RL L+ G+RLP P CP EVY LM+ CWE + S R +F+NLI
Sbjct: 1097 GQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLI 1146
Score = 66.2 bits (160), Expect = 2e-10
Identities = 66/289 (22%), Positives = 126/289 (43%), Gaps = 41/289 (14%)
Query: 609 RVEGSGDPEEGKMD--DEDPLVPGRDRGQELRVVLKVLDPSHHDIALA-FYETASLMSQV 665
R+ G+ GK++ DP G + G++ V +K L P +A + ++ +
Sbjct: 877 RIRDLGEGHFGKVELCRYDP--EGDNTGEQ--VAVKSLKPESGGNHIADLKKEIEILRNL 932
Query: 666 SHTHLAFVHGVCVRGPEN--IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALS 723
H ++ G+C N ++ E++ G L +L + + + + ++ A Q+ +
Sbjct: 933 YHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMD 992
Query: 724 YLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALS-------REERVERI 776
YL ++ VH ++ RN+L+ + +K+ D G+ + +++R +
Sbjct: 993 YLGSRQYVHRDLAARNVLVE-------SEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV 1045
Query: 777 PWLAPECLPGGANSLSTAMDKWGFGATLLEI---CFDGEAP----LQSRSPSEKEHFYQR 829
W APECL + A D W FG TL E+ C +P L+ P+ + R
Sbjct: 1046 FWYAPECLM--QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTR 1103
Query: 830 Q-------HRLP-EPSCP-QLATLTSQCLTYEPTQRPSFRTILRDLTRL 869
RLP P+CP ++ L +C ++P+ R SF+ ++ L
Sbjct: 1104 LVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL 1152
>gi|4826776 Janus kinase 2 [Homo sapiens]
Length = 1132
Score = 756 bits (1952), Expect = 0.0
Identities = 451/1192 (37%), Positives = 647/1192 (54%), Gaps = 139/1192 (11%)
Query: 28 LKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPP 87
L+V L+ + ++TF AEE+CI + GITP N+FAL ++W PP
Sbjct: 39 LQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPP 98
Query: 88 NHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCG-PPGTEASSDQTAQGMQLLDP 146
NH+ I + +RIRFYF W+ YR G G EA LLD
Sbjct: 99 NHVFHIDESTRHNVLYRIRFYFPRWYCSGSNR--AYRHGISRGAEAP---------LLDD 147
Query: 147 ASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVA 206
YLF Q +H+FV+ + H + E LGMA L + +A + +
Sbjct: 148 FVMSYLFAQWRHDFVHGWIKV------PVTHETQEECLGMAVLDMMRIAKENDQTPLAIY 201
Query: 207 KKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERL 266
S+K +P+ R I+ + LTR R+R FRRF++ F + + + + +KYL LE L
Sbjct: 202 NSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETL 261
Query: 267 APRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQW 326
F TE+ V ++ G P+ G E A +++TG GGIQW
Sbjct: 262 QSAFYTEKFEV----------------KEPGSGPS--GEEIFA-----TIIITGNGGIQW 298
Query: 327 WPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHV 386
S G++ ++ E +CDF +I V
Sbjct: 299 ---------------SRGKHKESETL-----------------TEQDLQLYCDFPNIIDV 326
Query: 387 VLKE---------HCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHE 437
+K+ V+IH+QD K LE+ L S ALSFVSL+DGY+RLTAD+ HYLC E
Sbjct: 327 SIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKE 386
Query: 438 VAPPRLVMSIRDGIHGPLLEPFVQAKLRP---EDGLYLIHWSTSHPYRLILTVAQRSQAP 494
VAPP ++ +I+ HGP+ F +KL+ + GLY++ S + LT A +
Sbjct: 387 VAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENV 446
Query: 495 DGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQ 554
+ + K E+ + L G ++F S+++L Q +R+ + F +CC P+
Sbjct: 447 IEYKHCLITKNENEEYN----LSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPK 502
Query: 555 PGETSNLIIMRGARASP--------RTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEG 606
P + SNL++ R S R +++Q+ FH++ +++ LGQGT T +++G
Sbjct: 503 PKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG 562
Query: 607 RLRVEGSGDPEEGKMDDEDPLVPGRDRGQ--ELRVVLKVLDPSHHDIALAFYETASLMSQ 664
R G D GQ E V+LKVLD +H + + +F+E AS+MS+
Sbjct: 563 VRREVG-------------------DYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSK 603
Query: 665 VSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSY 724
+SH HL +GVCV G ENI+V E+V+ G LD +L++ + + + WK+ VA+QLA A+ +
Sbjct: 604 LSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHF 663
Query: 725 LENKNLVHGNVCGRNILLARL-GLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPEC 783
LE L+HGNVC +NILL R G PFIKLSDPG+ + L ++ ERIPW+ PEC
Sbjct: 664 LEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPEC 723
Query: 784 LPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLAT 843
+ N L+ A DKW FG TL EIC G+ PL + K FY+ +H+LP P +LA
Sbjct: 724 IENPKN-LNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELAN 782
Query: 844 LTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPAS--------------DP 889
L + C+ YEP RPSFR I+RDL L + ++LT N P DP
Sbjct: 783 LINNCMDYEPDFRPSFRAIIRDLNSLFTPDY-ELLTENDMLPNMRIGALGFSGAFEDRDP 841
Query: 890 TVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEID 949
T F +R+LK ++ LG+G+FG V + YDP D TGE+VAVK L+ +H +++EI+
Sbjct: 842 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST-EEHLRDFEREIE 900
Query: 950 ILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--IGLAQLLLFAQQI 1007
IL++L H++I+KYKG C G ++L+L+MEY+P GSLRDYL +H I +LL + QI
Sbjct: 901 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI 960
Query: 1008 CEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFW 1067
C+GM YL + YIHRDLA RN+L++N+ VKIGDFGL K +P+ EYY+V+E G+SP+FW
Sbjct: 961 CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW 1020
Query: 1068 YAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIG-IAQGQMTVLRLTE 1126
YAPE L E KF ASDVWSFGV LYEL T+ + S+SPP +F+ +IG QGQM V L E
Sbjct: 1021 YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE 1080
Query: 1127 LLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQG 1178
LL+ RLPRPD CP E+Y +M CW + RP+F +L + + + G
Sbjct: 1081 LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 1132
>gi|47157315 Janus kinase 3 [Homo sapiens]
Length = 1124
Score = 713 bits (1841), Expect = 0.0
Identities = 459/1198 (38%), Positives = 629/1198 (52%), Gaps = 148/1198 (12%)
Query: 26 GGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWL 85
G L VLL GPG + ++FS AE++C+ A GI P +LFAL W
Sbjct: 24 GALHVLLPARGPGPPQR-LSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWF 82
Query: 86 PPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLD 145
PP+HI + ++ +L +RIRFYF NW G+ +R G AS+ +LD
Sbjct: 83 PPSHIFSVEDASTQVLLYRIRFYFPNWFGLEK----CHRFGLRKDLASA--------ILD 130
Query: 146 PASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEV 205
E+LF Q + + V+ + LS +E+ E L +A L L +A E+
Sbjct: 131 LPVLEHLFAQHRSDLVSGRLPVG-LSLKEQ-----GECLSLAVLDLARMAREQAQRPGEL 184
Query: 206 AKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLER 265
K S+K C+P S R I+ S +TR R+R RR LR + + +M KY+ LER
Sbjct: 185 LKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLER 244
Query: 266 LAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQ 325
L P E H+ L P G G + V G GGI
Sbjct: 245 LDPAGAAETF---HVGL-----------------PGALGGHDGLGL----LRVAGDGGIA 280
Query: 326 WWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITH 385
W E+EV QP FCDF +I
Sbjct: 281 WTQGEQEVL-----------------------------QP-----------FCDFPEIVD 300
Query: 386 VVLKE----------HCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLC 435
+ +K+ V++ R DN+ LE P ALSFV+LVDGYFRLT DS H+ C
Sbjct: 301 ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFC 360
Query: 436 HEVAPPRLVMSIRDGIHGPLLEPFVQAKLRP---EDGLYLIHWSTSHPYRLILTVAQRSQ 492
EVAPPRL+ + + HGP+ F KL+ G Y++ S +LTV ++
Sbjct: 361 KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNP 420
Query: 493 APDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCL 552
+ +R+ P G F+L G R S+REL A L +L CC+
Sbjct: 421 LGPDYKGCLIRRSPT----GTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCI 476
Query: 553 PQPGETSNLIIMRGARASPRT--------LNLSQLSFHRVDQKEITQLSHLGQGTRTNVY 604
P+P E SNLI+++ + P + LSQ++FH++ + +LG G+ T +Y
Sbjct: 477 PRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIY 536
Query: 605 EGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQ 664
G +V G R E V+LKV+D H + +F E ASLMSQ
Sbjct: 537 RGC----------------RHEVVDGEARKTE--VLLKVMDAKHKNCMESFLEAASLMSQ 578
Query: 665 VSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGH-VPMAWKMVVAQQLASALS 723
VS+ HL +HGVC+ G ++ MV E+V G +D++LR+ RGH VP +WK+ V +QLA AL+
Sbjct: 579 VSYRHLVLLHGVCMAG-DSTMVQEFVHLGAIDMYLRK-RGHLVPASWKLQVVKQLAYALN 636
Query: 724 YLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPEC 783
YLE+K L HGNV R +LLAR G A+G+ PFIKLSDPGV LS E +RIPW+APEC
Sbjct: 637 YLEDKGLPHGNVSARKVLLAREG-ADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPEC 695
Query: 784 LPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLAT 843
L A +LS DKWGFGAT+ E+ P+ + P++K FY+ + +LP P +LA
Sbjct: 696 LRE-AQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELAL 754
Query: 844 LTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPA--------------SDP 889
L QC+ YEP QRPSFR ++RDL L + + P + A DP
Sbjct: 755 LIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDP 814
Query: 890 TVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEID 949
T+F +R+LK I LG+G+FG V L YDP D TG +VAVK L+ GP + +++EI
Sbjct: 815 TIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS-GPDQQRDFQREIQ 873
Query: 950 ILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGL--AQLLLFAQQI 1007
IL+ L+ + I+KY+G G +SL+LVMEY+P G LRD+L RH L ++LLL++ QI
Sbjct: 874 ILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQI 933
Query: 1008 CEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFW 1067
C+GM YL ++ +HRDLAARN+L++++ VKI DFGLAK +P +YY VRE G SP+FW
Sbjct: 934 CKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFW 993
Query: 1068 YAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTEL 1127
YAPE L + F SDVWSFGV LYEL T+CD S SP +FL ++G + + RL EL
Sbjct: 994 YAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLEL 1053
Query: 1128 LERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFS 1185
LE G+RLP P CP EV+ LMK CW RP+F L P L + +G F+
Sbjct: 1054 LEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFT 1111
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sapiens]
Length = 1038
Score = 174 bits (440), Expect = 6e-43
Identities = 107/270 (39%), Positives = 154/270 (57%), Gaps = 21/270 (7%)
Query: 897 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADC--GPQHRSGWKQEIDILRTL 954
L+ + LG+G FG V +D + G VAVK LK D P+ + +E++ + +L
Sbjct: 126 LRLLEKLGDGSFGVVRRGEWDAPS-GKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 184
Query: 955 YHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--IGLAQLLLFAQQICEGMA 1012
H ++I+ G +++V E PLGSL D L +H L L +A Q+ EGM
Sbjct: 185 DHRNLIRLYGVVLTP---PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMG 241
Query: 1013 YLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPEC 1072
YL ++ +IHRDLAARN+LL LVKIGDFGL +A+P+ ++Y ++E P W APE
Sbjct: 242 YLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 301
Query: 1073 LKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGE 1132
LK F +ASD W FGVTL+E+ T+ Q P IG+ Q+ L ++ + GE
Sbjct: 302 LKTRTFSHASDTWMFGVTLWEMFTY---GQEP------WIGLNGSQI----LHKIDKEGE 348
Query: 1133 RLPRPDKCPCEVYHLMKNCWETEASFRPTF 1162
RLPRP+ CP ++Y++M CW + RPTF
Sbjct: 349 RLPRPEDCPQDIYNVMVQCWAHKPEDRPTF 378
Score = 93.2 bits (230), Expect = 1e-18
Identities = 76/254 (29%), Positives = 116/254 (45%), Gaps = 23/254 (9%)
Query: 634 GQELRVVLKVLDP---SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYV 690
G+ + V +K L P S + F + M + H +L ++GV + P MVTE
Sbjct: 150 GKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMK-MVTELA 208
Query: 691 EHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEG 750
G L LR+ +GH + A Q+A + YLE+K +H ++ RN+LLA
Sbjct: 209 PLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLA------- 261
Query: 751 TSPFIKLSDPGVGLGA-------LSREERVERIPWLAPECLPGGANSLSTAMDKWGFGAT 803
T +K+ D G+ + +E R W APE L + S A D W FG T
Sbjct: 262 TRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLK--TRTFSHASDTWMFGVT 319
Query: 804 LLEICFDGEAPLQSRSPSEKEHFYQRQ-HRLPEP-SCPQ-LATLTSQCLTYEPTQRPSFR 860
L E+ G+ P + S+ H ++ RLP P CPQ + + QC ++P RP+F
Sbjct: 320 LWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFV 379
Query: 861 TILRDLTRLQPHNL 874
+ L QP ++
Sbjct: 380 ALRDFLLEAQPTDM 393
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sapiens]
Length = 1086
Score = 174 bits (440), Expect = 6e-43
Identities = 107/270 (39%), Positives = 154/270 (57%), Gaps = 21/270 (7%)
Query: 897 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADC--GPQHRSGWKQEIDILRTL 954
L+ + LG+G FG V +D + G VAVK LK D P+ + +E++ + +L
Sbjct: 189 LRLLEKLGDGSFGVVRRGEWDAPS-GKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 247
Query: 955 YHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--IGLAQLLLFAQQICEGMA 1012
H ++I+ G +++V E PLGSL D L +H L L +A Q+ EGM
Sbjct: 248 DHRNLIRLYGVVLTP---PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMG 304
Query: 1013 YLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPEC 1072
YL ++ +IHRDLAARN+LL LVKIGDFGL +A+P+ ++Y ++E P W APE
Sbjct: 305 YLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 364
Query: 1073 LKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGE 1132
LK F +ASD W FGVTL+E+ T+ Q P IG+ Q+ L ++ + GE
Sbjct: 365 LKTRTFSHASDTWMFGVTLWEMFTY---GQEP------WIGLNGSQI----LHKIDKEGE 411
Query: 1133 RLPRPDKCPCEVYHLMKNCWETEASFRPTF 1162
RLPRP+ CP ++Y++M CW + RPTF
Sbjct: 412 RLPRPEDCPQDIYNVMVQCWAHKPEDRPTF 441
Score = 93.2 bits (230), Expect = 1e-18
Identities = 76/254 (29%), Positives = 116/254 (45%), Gaps = 23/254 (9%)
Query: 634 GQELRVVLKVLDP---SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYV 690
G+ + V +K L P S + F + M + H +L ++GV + P MVTE
Sbjct: 213 GKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMK-MVTELA 271
Query: 691 EHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEG 750
G L LR+ +GH + A Q+A + YLE+K +H ++ RN+LLA
Sbjct: 272 PLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLA------- 324
Query: 751 TSPFIKLSDPGVGLGA-------LSREERVERIPWLAPECLPGGANSLSTAMDKWGFGAT 803
T +K+ D G+ + +E R W APE L + S A D W FG T
Sbjct: 325 TRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLK--TRTFSHASDTWMFGVT 382
Query: 804 LLEICFDGEAPLQSRSPSEKEHFYQRQ-HRLPEP-SCPQ-LATLTSQCLTYEPTQRPSFR 860
L E+ G+ P + S+ H ++ RLP P CPQ + + QC ++P RP+F
Sbjct: 383 LWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFV 442
Query: 861 TILRDLTRLQPHNL 874
+ L QP ++
Sbjct: 443 ALRDFLLEAQPTDM 456
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform b
precursor [Homo sapiens]
Length = 825
Score = 169 bits (428), Expect = 1e-41
Identities = 113/289 (39%), Positives = 153/289 (52%), Gaps = 40/289 (13%)
Query: 901 RDLGEGHFGKVSLY-CYD--PTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHE 957
R+LGEG FGKV L CY+ PT D +VAVKALK D R +++E ++L L HE
Sbjct: 542 RELGEGAFGKVFLAECYNLSPTKDKM--LVAVKALK-DPTLAARKDFQREAELLTNLQHE 598
Query: 958 HIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS-----------------IGLAQL 1000
HI+K+ G C D L +V EY+ G L +L H +GL+Q+
Sbjct: 599 HIVKFYGVCGDGDP--LIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQM 656
Query: 1001 LLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVRED 1060
L A QI GM YL +QH++HRDLA RN L+ + LVKIGDFG+++ V +YYRV
Sbjct: 657 LHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV-YSTDYYRVGGH 715
Query: 1061 GDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMT 1120
P+ W PE + KF SDVWSFGV L+E+ T+ + P Q++
Sbjct: 716 TMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTY---GKQP-----------WFQLS 761
Query: 1121 VLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPIL 1169
+ E + +G L RP CP EVY +M CW+ E R + + IL
Sbjct: 762 NTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL 810
Score = 79.7 bits (195), Expect = 2e-14
Identities = 70/266 (26%), Positives = 116/266 (43%), Gaps = 35/266 (13%)
Query: 627 LVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 686
L P +D+ + V +K L F A L++ + H H+ +GVC G IMV
Sbjct: 560 LSPTKDK---MLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMV 616
Query: 687 TEYVEHGPLDVWL---------------RRERGHVPMAWKMVVAQQLASALSYLENKNLV 731
EY++HG L+ +L R+ +G + ++ + +A Q+AS + YL +++ V
Sbjct: 617 FEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFV 676
Query: 732 HGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSRE------ERVERIPWLAPECLP 785
H ++ RN L+ G + +K+ D G+ S + + I W+ PE +
Sbjct: 677 HRDLATRNCLV-------GANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIM 729
Query: 786 GGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CP-QLAT 843
+T D W FG L EI G+ P S +E + L P CP ++
Sbjct: 730 --YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYD 787
Query: 844 LTSQCLTYEPTQRPSFRTILRDLTRL 869
+ C EP QR + + I + L L
Sbjct: 788 VMLGCWQREPQQRLNIKEIYKILHAL 813
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 169 bits (428), Expect = 1e-41
Identities = 107/305 (35%), Positives = 159/305 (52%), Gaps = 21/305 (6%)
Query: 864 RDLTRLQPHNLADVLTVNPDSP-ASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDG 922
R L R L + LT + +P + + + LK+++ LG G FG V + P +
Sbjct: 684 RALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGET 743
Query: 923 TGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVP 982
VA+K L GP+ + E I+ ++ H H+++ G C ++QLV + +P
Sbjct: 744 VKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSP---TIQLVTQLMP 800
Query: 983 LGSLRDYLPRH--SIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIG 1040
G L +Y+ H +IG LL + QI +GM YL + +HRDLAARNVL+ + VKI
Sbjct: 801 HGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKIT 860
Query: 1041 DFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDS 1100
DFGLA+ + EG E + G P+ W A EC+ KF + SDVWS+GVT++EL+T
Sbjct: 861 DFGLARLL-EGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMT---- 915
Query: 1101 SQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRP 1160
G + + +LLE+GERLP+P C +VY +M CW +A RP
Sbjct: 916 ----------FGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRP 965
Query: 1161 TFENL 1165
F+ L
Sbjct: 966 KFKEL 970
Score = 77.0 bits (188), Expect = 1e-13
Identities = 71/304 (23%), Positives = 129/304 (42%), Gaps = 43/304 (14%)
Query: 577 SQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQE 636
+Q + + E+ ++ LG G VY+G EG E +P
Sbjct: 706 NQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG-----------ETVKIP------- 747
Query: 637 LRVVLKVLDPSHHDIA-LAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPL 695
V +K+L+ + A + F + A +M+ + H HL + GVC+ P +VT+ + HG L
Sbjct: 748 --VAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCL-SPTIQLVTQLMPHGCL 804
Query: 696 DVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFI 755
++ + ++ + Q+A + YLE + LVH ++ RN+L+ + +
Sbjct: 805 LEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVK-------SPNHV 857
Query: 756 KLSDPGVGLGALSREERVE--------RIPWLAPECLPGGANSLSTAMDKWGFGATLLEI 807
K++D GL L + E I W+A EC+ + D W +G T+ E+
Sbjct: 858 KITD--FGLARLLEGDEKEYNADGGKMPIKWMALECI--HYRKFTHQSDVWSYGVTIWEL 913
Query: 808 CFDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CP-QLATLTSQCLTYEPTQRPSFRTILRD 865
G P E ++ RLP+P C + + +C + RP F+ + +
Sbjct: 914 MTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAE 973
Query: 866 LTRL 869
+R+
Sbjct: 974 FSRM 977
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 169 bits (428), Expect = 1e-41
Identities = 107/305 (35%), Positives = 159/305 (52%), Gaps = 21/305 (6%)
Query: 864 RDLTRLQPHNLADVLTVNPDSP-ASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDG 922
R L R L + LT + +P + + + LK+++ LG G FG V + P +
Sbjct: 684 RALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGET 743
Query: 923 TGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVP 982
VA+K L GP+ + E I+ ++ H H+++ G C ++QLV + +P
Sbjct: 744 VKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSP---TIQLVTQLMP 800
Query: 983 LGSLRDYLPRH--SIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIG 1040
G L +Y+ H +IG LL + QI +GM YL + +HRDLAARNVL+ + VKI
Sbjct: 801 HGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKIT 860
Query: 1041 DFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDS 1100
DFGLA+ + EG E + G P+ W A EC+ KF + SDVWS+GVT++EL+T
Sbjct: 861 DFGLARLL-EGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMT---- 915
Query: 1101 SQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRP 1160
G + + +LLE+GERLP+P C +VY +M CW +A RP
Sbjct: 916 ----------FGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRP 965
Query: 1161 TFENL 1165
F+ L
Sbjct: 966 KFKEL 970
Score = 77.0 bits (188), Expect = 1e-13
Identities = 71/304 (23%), Positives = 129/304 (42%), Gaps = 43/304 (14%)
Query: 577 SQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQE 636
+Q + + E+ ++ LG G VY+G EG E +P
Sbjct: 706 NQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG-----------ETVKIP------- 747
Query: 637 LRVVLKVLDPSHHDIA-LAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPL 695
V +K+L+ + A + F + A +M+ + H HL + GVC+ P +VT+ + HG L
Sbjct: 748 --VAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCL-SPTIQLVTQLMPHGCL 804
Query: 696 DVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFI 755
++ + ++ + Q+A + YLE + LVH ++ RN+L+ + +
Sbjct: 805 LEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVK-------SPNHV 857
Query: 756 KLSDPGVGLGALSREERVE--------RIPWLAPECLPGGANSLSTAMDKWGFGATLLEI 807
K++D GL L + E I W+A EC+ + D W +G T+ E+
Sbjct: 858 KITD--FGLARLLEGDEKEYNADGGKMPIKWMALECI--HYRKFTHQSDVWSYGVTIWEL 913
Query: 808 CFDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CP-QLATLTSQCLTYEPTQRPSFRTILRD 865
G P E ++ RLP+P C + + +C + RP F+ + +
Sbjct: 914 MTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAE 973
Query: 866 LTRL 869
+R+
Sbjct: 974 FSRM 977
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform c
precursor [Homo sapiens]
Length = 822
Score = 166 bits (420), Expect = 1e-40
Identities = 106/287 (36%), Positives = 149/287 (51%), Gaps = 33/287 (11%)
Query: 901 RDLGEGHFGKVSLY-CYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHI 959
R+LGEG FGKV L CY+ + +VAVK LK D R + +E ++L L HEHI
Sbjct: 542 RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKDFHREAELLTNLQHEHI 600
Query: 960 IKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--------------IGLAQLLLFAQ 1005
+K+ G C + L +V EY+ G L +L H + +Q+L AQ
Sbjct: 601 VKFYGVCVEGDP--LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQ 658
Query: 1006 QICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPV 1065
QI GM YL +QH++HRDLA RN L+ + LVKIGDFG+++ V +YYRV P+
Sbjct: 659 QIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDV-YSTDYYRVGGHTMLPI 717
Query: 1066 FWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLT 1125
W PE + KF SDVWS GV L+E+ T+ + P Q++ +
Sbjct: 718 RWMPPESIMYRKFTTESDVWSLGVVLWEIFTY---GKQP-----------WYQLSNNEVI 763
Query: 1126 ELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTV 1172
E + +G L RP CP EVY LM CW+ E R + + +L+ +
Sbjct: 764 ECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL 810
Score = 87.8 bits (216), Expect = 6e-17
Identities = 73/268 (27%), Positives = 122/268 (45%), Gaps = 35/268 (13%)
Query: 627 LVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 686
L P +D+ + V +K L + + F+ A L++ + H H+ +GVCV G IMV
Sbjct: 560 LCPEQDK---ILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMV 616
Query: 687 TEYVEHGPLDVWLRRE--------RGHVP----MAWKMVVAQQLASALSYLENKNLVHGN 734
EY++HG L+ +LR G+ P + + +AQQ+A+ + YL +++ VH +
Sbjct: 617 FEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRD 676
Query: 735 VCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSRE------ERVERIPWLAPECLPGGA 788
+ RN L+ G + +K+ D G+ S + + I W+ PE +
Sbjct: 677 LATRNCLV-------GENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIM--Y 727
Query: 789 NSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEP-SCPQ-LATLTS 846
+T D W G L EI G+ P S +E + L P +CPQ + L
Sbjct: 728 RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELML 787
Query: 847 QCLTYEPTQRPSFR---TILRDLTRLQP 871
C EP R + + T+L++L + P
Sbjct: 788 GCWQREPHMRKNIKGIHTLLQNLAKASP 815
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform a
precursor [Homo sapiens]
Length = 838
Score = 166 bits (420), Expect = 1e-40
Identities = 106/287 (36%), Positives = 149/287 (51%), Gaps = 33/287 (11%)
Query: 901 RDLGEGHFGKVSLY-CYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHI 959
R+LGEG FGKV L CY+ + +VAVK LK D R + +E ++L L HEHI
Sbjct: 558 RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKDFHREAELLTNLQHEHI 616
Query: 960 IKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--------------IGLAQLLLFAQ 1005
+K+ G C + L +V EY+ G L +L H + +Q+L AQ
Sbjct: 617 VKFYGVCVEGDP--LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQ 674
Query: 1006 QICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPV 1065
QI GM YL +QH++HRDLA RN L+ + LVKIGDFG+++ V +YYRV P+
Sbjct: 675 QIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDV-YSTDYYRVGGHTMLPI 733
Query: 1066 FWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLT 1125
W PE + KF SDVWS GV L+E+ T+ + P Q++ +
Sbjct: 734 RWMPPESIMYRKFTTESDVWSLGVVLWEIFTY---GKQP-----------WYQLSNNEVI 779
Query: 1126 ELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTV 1172
E + +G L RP CP EVY LM CW+ E R + + +L+ +
Sbjct: 780 ECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL 826
Score = 87.8 bits (216), Expect = 6e-17
Identities = 73/268 (27%), Positives = 122/268 (45%), Gaps = 35/268 (13%)
Query: 627 LVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 686
L P +D+ + V +K L + + F+ A L++ + H H+ +GVCV G IMV
Sbjct: 576 LCPEQDK---ILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMV 632
Query: 687 TEYVEHGPLDVWLRRE--------RGHVP----MAWKMVVAQQLASALSYLENKNLVHGN 734
EY++HG L+ +LR G+ P + + +AQQ+A+ + YL +++ VH +
Sbjct: 633 FEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRD 692
Query: 735 VCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSRE------ERVERIPWLAPECLPGGA 788
+ RN L+ G + +K+ D G+ S + + I W+ PE +
Sbjct: 693 LATRNCLV-------GENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIM--Y 743
Query: 789 NSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEP-SCPQ-LATLTS 846
+T D W G L EI G+ P S +E + L P +CPQ + L
Sbjct: 744 RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELML 803
Query: 847 QCLTYEPTQRPSFR---TILRDLTRLQP 871
C EP R + + T+L++L + P
Sbjct: 804 GCWQREPHMRKNIKGIHTLLQNLAKASP 831
>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 165 bits (417), Expect = 3e-40
Identities = 104/279 (37%), Positives = 154/279 (55%), Gaps = 28/279 (10%)
Query: 901 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII 960
R LGEG FG+V Y + G VAVK K DC ++ + E I++ L H HI+
Sbjct: 429 RILGEGFFGEVYEGVYT-NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIV 487
Query: 961 KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH--SIGLAQLLLFAQQICEGMAYLHAQH 1018
K G E E+ ++ME P G L YL R+ S+ + L+L++ QIC+ MAYL + +
Sbjct: 488 KLIGIIE---EEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESIN 544
Query: 1019 YIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKF 1078
+HRD+A RN+L+ + VK+GDFGL++ + E +YY+ P+ W +PE + +F
Sbjct: 545 CVHRDIAVRNILVASPECVKLGDFGLSRYI-EDEDYYKASVT-RLPIKWMSPESINFRRF 602
Query: 1079 YYASDVWSFGVTLYELLTHCDSSQSPPTKFLE---LIGIAQGQMTVLRLTELLERGERLP 1135
ASDVW F V ++E+L S P +LE +IG+ LE+G+RLP
Sbjct: 603 TTASDVWMFAVCMWEIL----SFGKQPFFWLENKDVIGV-------------LEKGDRLP 645
Query: 1136 RPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHE 1174
+PD CP +Y LM CW+ + S RP F L+ L V++
Sbjct: 646 KPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQ 684
Score = 82.4 bits (202), Expect = 2e-15
Identities = 66/245 (26%), Positives = 114/245 (46%), Gaps = 22/245 (8%)
Query: 633 RGQELRVVLKVLDPSHH-DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVE 691
+G+++ V +K D F A +M + H H+ + G+ P I++ Y
Sbjct: 448 KGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELY-P 506
Query: 692 HGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGT 751
+G L +L R + + + ++ + Q+ A++YLE+ N VH ++ RNIL+A +
Sbjct: 507 YGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVA-------S 559
Query: 752 SPFIKLSDPGVGLGALSREE-----RVERIP--WLAPECLPGGANSLSTAMDKWGFGATL 804
+KL D GL +E V R+P W++PE + +TA D W F +
Sbjct: 560 PECVKLGD--FGLSRYIEDEDYYKASVTRLPIKWMSPESI--NFRRFTTASDVWMFAVCM 615
Query: 805 LEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSC--PQLATLTSQCLTYEPTQRPSFRTI 862
EI G+ P + ++ RLP+P P L TL ++C Y+P+ RP F +
Sbjct: 616 WEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
Query: 863 LRDLT 867
+ L+
Sbjct: 676 VCSLS 680
>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
sapiens]
Length = 967
Score = 165 bits (417), Expect = 3e-40
Identities = 104/279 (37%), Positives = 154/279 (55%), Gaps = 28/279 (10%)
Query: 901 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII 960
R LGEG FG+V Y + G VAVK K DC ++ + E I++ L H HI+
Sbjct: 429 RILGEGFFGEVYEGVYT-NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIV 487
Query: 961 KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH--SIGLAQLLLFAQQICEGMAYLHAQH 1018
K G E E+ ++ME P G L YL R+ S+ + L+L++ QIC+ MAYL + +
Sbjct: 488 KLIGIIE---EEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESIN 544
Query: 1019 YIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKF 1078
+HRD+A RN+L+ + VK+GDFGL++ + E +YY+ P+ W +PE + +F
Sbjct: 545 CVHRDIAVRNILVASPECVKLGDFGLSRYI-EDEDYYKASVT-RLPIKWMSPESINFRRF 602
Query: 1079 YYASDVWSFGVTLYELLTHCDSSQSPPTKFLE---LIGIAQGQMTVLRLTELLERGERLP 1135
ASDVW F V ++E+L S P +LE +IG+ LE+G+RLP
Sbjct: 603 TTASDVWMFAVCMWEIL----SFGKQPFFWLENKDVIGV-------------LEKGDRLP 645
Query: 1136 RPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHE 1174
+PD CP +Y LM CW+ + S RP F L+ L V++
Sbjct: 646 KPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQ 684
Score = 82.4 bits (202), Expect = 2e-15
Identities = 66/245 (26%), Positives = 114/245 (46%), Gaps = 22/245 (8%)
Query: 633 RGQELRVVLKVLDPSHH-DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVE 691
+G+++ V +K D F A +M + H H+ + G+ P I++ Y
Sbjct: 448 KGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELY-P 506
Query: 692 HGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGT 751
+G L +L R + + + ++ + Q+ A++YLE+ N VH ++ RNIL+A +
Sbjct: 507 YGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVA-------S 559
Query: 752 SPFIKLSDPGVGLGALSREE-----RVERIP--WLAPECLPGGANSLSTAMDKWGFGATL 804
+KL D GL +E V R+P W++PE + +TA D W F +
Sbjct: 560 PECVKLGD--FGLSRYIEDEDYYKASVTRLPIKWMSPESI--NFRRFTTASDVWMFAVCM 615
Query: 805 LEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSC--PQLATLTSQCLTYEPTQRPSFRTI 862
EI G+ P + ++ RLP+P P L TL ++C Y+P+ RP F +
Sbjct: 616 WEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
Query: 863 LRDLT 867
+ L+
Sbjct: 676 VCSLS 680
>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 165 bits (417), Expect = 3e-40
Identities = 104/279 (37%), Positives = 154/279 (55%), Gaps = 28/279 (10%)
Query: 901 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII 960
R LGEG FG+V Y + G VAVK K DC ++ + E I++ L H HI+
Sbjct: 429 RILGEGFFGEVYEGVYT-NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIV 487
Query: 961 KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH--SIGLAQLLLFAQQICEGMAYLHAQH 1018
K G E E+ ++ME P G L YL R+ S+ + L+L++ QIC+ MAYL + +
Sbjct: 488 KLIGIIE---EEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESIN 544
Query: 1019 YIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKF 1078
+HRD+A RN+L+ + VK+GDFGL++ + E +YY+ P+ W +PE + +F
Sbjct: 545 CVHRDIAVRNILVASPECVKLGDFGLSRYI-EDEDYYKASVT-RLPIKWMSPESINFRRF 602
Query: 1079 YYASDVWSFGVTLYELLTHCDSSQSPPTKFLE---LIGIAQGQMTVLRLTELLERGERLP 1135
ASDVW F V ++E+L S P +LE +IG+ LE+G+RLP
Sbjct: 603 TTASDVWMFAVCMWEIL----SFGKQPFFWLENKDVIGV-------------LEKGDRLP 645
Query: 1136 RPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHE 1174
+PD CP +Y LM CW+ + S RP F L+ L V++
Sbjct: 646 KPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQ 684
Score = 82.4 bits (202), Expect = 2e-15
Identities = 66/245 (26%), Positives = 114/245 (46%), Gaps = 22/245 (8%)
Query: 633 RGQELRVVLKVLDPSHH-DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVE 691
+G+++ V +K D F A +M + H H+ + G+ P I++ Y
Sbjct: 448 KGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELY-P 506
Query: 692 HGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGT 751
+G L +L R + + + ++ + Q+ A++YLE+ N VH ++ RNIL+A +
Sbjct: 507 YGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVA-------S 559
Query: 752 SPFIKLSDPGVGLGALSREE-----RVERIP--WLAPECLPGGANSLSTAMDKWGFGATL 804
+KL D GL +E V R+P W++PE + +TA D W F +
Sbjct: 560 PECVKLGD--FGLSRYIEDEDYYKASVTRLPIKWMSPESI--NFRRFTTASDVWMFAVCM 615
Query: 805 LEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSC--PQLATLTSQCLTYEPTQRPSFRTI 862
EI G+ P + ++ RLP+P P L TL ++C Y+P+ RP F +
Sbjct: 616 WEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
Query: 863 LRDLT 867
+ L+
Sbjct: 676 VCSLS 680
>gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 165 bits (417), Expect = 3e-40
Identities = 104/279 (37%), Positives = 154/279 (55%), Gaps = 28/279 (10%)
Query: 901 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII 960
R LGEG FG+V Y + G VAVK K DC ++ + E I++ L H HI+
Sbjct: 429 RILGEGFFGEVYEGVYT-NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIV 487
Query: 961 KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH--SIGLAQLLLFAQQICEGMAYLHAQH 1018
K G E E+ ++ME P G L YL R+ S+ + L+L++ QIC+ MAYL + +
Sbjct: 488 KLIGIIE---EEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESIN 544
Query: 1019 YIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKF 1078
+HRD+A RN+L+ + VK+GDFGL++ + E +YY+ P+ W +PE + +F
Sbjct: 545 CVHRDIAVRNILVASPECVKLGDFGLSRYI-EDEDYYKASVT-RLPIKWMSPESINFRRF 602
Query: 1079 YYASDVWSFGVTLYELLTHCDSSQSPPTKFLE---LIGIAQGQMTVLRLTELLERGERLP 1135
ASDVW F V ++E+L S P +LE +IG+ LE+G+RLP
Sbjct: 603 TTASDVWMFAVCMWEIL----SFGKQPFFWLENKDVIGV-------------LEKGDRLP 645
Query: 1136 RPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHE 1174
+PD CP +Y LM CW+ + S RP F L+ L V++
Sbjct: 646 KPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQ 684
Score = 82.4 bits (202), Expect = 2e-15
Identities = 66/245 (26%), Positives = 114/245 (46%), Gaps = 22/245 (8%)
Query: 633 RGQELRVVLKVLDPSHH-DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVE 691
+G+++ V +K D F A +M + H H+ + G+ P I++ Y
Sbjct: 448 KGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELY-P 506
Query: 692 HGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGT 751
+G L +L R + + + ++ + Q+ A++YLE+ N VH ++ RNIL+A +
Sbjct: 507 YGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVA-------S 559
Query: 752 SPFIKLSDPGVGLGALSREE-----RVERIP--WLAPECLPGGANSLSTAMDKWGFGATL 804
+KL D GL +E V R+P W++PE + +TA D W F +
Sbjct: 560 PECVKLGD--FGLSRYIEDEDYYKASVTRLPIKWMSPESI--NFRRFTTASDVWMFAVCM 615
Query: 805 LEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSC--PQLATLTSQCLTYEPTQRPSFRTI 862
EI G+ P + ++ RLP+P P L TL ++C Y+P+ RP F +
Sbjct: 616 WEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
Query: 863 LRDLT 867
+ L+
Sbjct: 676 VCSLS 680
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform 1
[Homo sapiens]
Length = 790
Score = 163 bits (413), Expect = 8e-40
Identities = 111/319 (34%), Positives = 162/319 (50%), Gaps = 46/319 (14%)
Query: 887 SDPTVFH--KRYLKKIRDLGEGHFGKVSLY-CYDPTNDGTGEMVAVKALKADCGPQHRSG 943
SD V H +R + +LGEG FGKV L C++ + +VAVKALK + R
Sbjct: 492 SDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQD 550
Query: 944 WKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--------- 994
+++E ++L L H+HI+++ G C + + L +V EY+ G L +L H
Sbjct: 551 FQREAELLTMLQHQHIVRFFGVCTEG--RPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 608
Query: 995 -------IGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKA 1047
+GL QLL A Q+ GM YL H++HRDLA RN L+ +VKIGDFG+++
Sbjct: 609 EDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRD 668
Query: 1048 VPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTK 1107
+ +YYRV P+ W PE + KF SDVWSFGV L+E+ T+ + P
Sbjct: 669 I-YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY---GKQP--- 721
Query: 1108 FLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIP 1167
Q++ + + +G L RP CP EVY +M+ CW+ E R +
Sbjct: 722 --------WYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHS------ 767
Query: 1168 ILKTVHEKYQ--GQAPSVF 1184
+K VH + Q QAP V+
Sbjct: 768 -IKDVHARLQALAQAPPVY 785
Score = 80.5 bits (197), Expect = 9e-15
Identities = 73/308 (23%), Positives = 121/308 (39%), Gaps = 50/308 (16%)
Query: 577 SQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQE 636
S H + +++I LG+G V+ + + L+P +D+
Sbjct: 492 SDACVHHIKRRDIVLKWELGEGAFGKVF----------------LAECHNLLPEQDK--- 532
Query: 637 LRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLD 696
+ V +K L + F A L++ + H H+ GVC G +MV EY+ HG L+
Sbjct: 533 MLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLN 592
Query: 697 VWLRRE--------------RGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILL 742
+LR G + + + VA Q+A+ + YL + VH ++ RN L+
Sbjct: 593 RFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV 652
Query: 743 ARLGLAEGTSPFIKLSDPGVGLGALSRE------ERVERIPWLAPECLPGGANSLSTAMD 796
G +K+ D G+ S + + I W+ PE + +T D
Sbjct: 653 -------GQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESIL--YRKFTTESD 703
Query: 797 KWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSC--PQLATLTSQCLTYEPT 854
W FG L EI G+ P S +E + L P P++ + C EP
Sbjct: 704 VWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQ 763
Query: 855 QRPSFRTI 862
QR S + +
Sbjct: 764 QRHSIKDV 771
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 163 bits (413), Expect = 8e-40
Identities = 111/319 (34%), Positives = 162/319 (50%), Gaps = 46/319 (14%)
Query: 887 SDPTVFH--KRYLKKIRDLGEGHFGKVSLY-CYDPTNDGTGEMVAVKALKADCGPQHRSG 943
SD V H +R + +LGEG FGKV L C++ + +VAVKALK + R
Sbjct: 498 SDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQD 556
Query: 944 WKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--------- 994
+++E ++L L H+HI+++ G C + + L +V EY+ G L +L H
Sbjct: 557 FQREAELLTMLQHQHIVRFFGVCTEG--RPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 614
Query: 995 -------IGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKA 1047
+GL QLL A Q+ GM YL H++HRDLA RN L+ +VKIGDFG+++
Sbjct: 615 EDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRD 674
Query: 1048 VPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTK 1107
+ +YYRV P+ W PE + KF SDVWSFGV L+E+ T+ + P
Sbjct: 675 I-YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY---GKQP--- 727
Query: 1108 FLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIP 1167
Q++ + + +G L RP CP EVY +M+ CW+ E R +
Sbjct: 728 --------WYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHS------ 773
Query: 1168 ILKTVHEKYQ--GQAPSVF 1184
+K VH + Q QAP V+
Sbjct: 774 -IKDVHARLQALAQAPPVY 791
Score = 80.5 bits (197), Expect = 9e-15
Identities = 73/308 (23%), Positives = 121/308 (39%), Gaps = 50/308 (16%)
Query: 577 SQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQE 636
S H + +++I LG+G V+ + + L+P +D+
Sbjct: 498 SDACVHHIKRRDIVLKWELGEGAFGKVF----------------LAECHNLLPEQDK--- 538
Query: 637 LRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLD 696
+ V +K L + F A L++ + H H+ GVC G +MV EY+ HG L+
Sbjct: 539 MLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLN 598
Query: 697 VWLRRE--------------RGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILL 742
+LR G + + + VA Q+A+ + YL + VH ++ RN L+
Sbjct: 599 RFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV 658
Query: 743 ARLGLAEGTSPFIKLSDPGVGLGALSRE------ERVERIPWLAPECLPGGANSLSTAMD 796
G +K+ D G+ S + + I W+ PE + +T D
Sbjct: 659 -------GQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESIL--YRKFTTESD 709
Query: 797 KWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSC--PQLATLTSQCLTYEPT 854
W FG L EI G+ P S +E + L P P++ + C EP
Sbjct: 710 VWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQ 769
Query: 855 QRPSFRTI 862
QR S + +
Sbjct: 770 QRHSIKDV 777
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform 3
[Homo sapiens]
Length = 760
Score = 163 bits (413), Expect = 8e-40
Identities = 111/319 (34%), Positives = 162/319 (50%), Gaps = 46/319 (14%)
Query: 887 SDPTVFH--KRYLKKIRDLGEGHFGKVSLY-CYDPTNDGTGEMVAVKALKADCGPQHRSG 943
SD V H +R + +LGEG FGKV L C++ + +VAVKALK + R
Sbjct: 462 SDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQD 520
Query: 944 WKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--------- 994
+++E ++L L H+HI+++ G C + + L +V EY+ G L +L H
Sbjct: 521 FQREAELLTMLQHQHIVRFFGVCTEG--RPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 578
Query: 995 -------IGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKA 1047
+GL QLL A Q+ GM YL H++HRDLA RN L+ +VKIGDFG+++
Sbjct: 579 EDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRD 638
Query: 1048 VPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTK 1107
+ +YYRV P+ W PE + KF SDVWSFGV L+E+ T+ + P
Sbjct: 639 I-YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY---GKQP--- 691
Query: 1108 FLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIP 1167
Q++ + + +G L RP CP EVY +M+ CW+ E R +
Sbjct: 692 --------WYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHS------ 737
Query: 1168 ILKTVHEKYQ--GQAPSVF 1184
+K VH + Q QAP V+
Sbjct: 738 -IKDVHARLQALAQAPPVY 755
Score = 80.5 bits (197), Expect = 9e-15
Identities = 73/308 (23%), Positives = 121/308 (39%), Gaps = 50/308 (16%)
Query: 577 SQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQE 636
S H + +++I LG+G V+ + + L+P +D+
Sbjct: 462 SDACVHHIKRRDIVLKWELGEGAFGKVF----------------LAECHNLLPEQDK--- 502
Query: 637 LRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLD 696
+ V +K L + F A L++ + H H+ GVC G +MV EY+ HG L+
Sbjct: 503 MLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLN 562
Query: 697 VWLRRE--------------RGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILL 742
+LR G + + + VA Q+A+ + YL + VH ++ RN L+
Sbjct: 563 RFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV 622
Query: 743 ARLGLAEGTSPFIKLSDPGVGLGALSRE------ERVERIPWLAPECLPGGANSLSTAMD 796
G +K+ D G+ S + + I W+ PE + +T D
Sbjct: 623 -------GQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESIL--YRKFTTESD 673
Query: 797 KWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSC--PQLATLTSQCLTYEPT 854
W FG L EI G+ P S +E + L P P++ + C EP
Sbjct: 674 VWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQ 733
Query: 855 QRPSFRTI 862
QR S + +
Sbjct: 734 QRHSIKDV 741
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform a
precursor [Homo sapiens]
Length = 839
Score = 162 bits (410), Expect = 2e-39
Identities = 113/302 (37%), Positives = 155/302 (51%), Gaps = 52/302 (17%)
Query: 901 RDLGEGHFGKVSLY-CYD--PTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHE 957
R+LGEG FGKV L CY+ PT D +VAVKALK D R +++E ++L L HE
Sbjct: 542 RELGEGAFGKVFLAECYNLSPTKDKM--LVAVKALK-DPTLAARKDFQREAELLTNLQHE 598
Query: 958 HIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS-----------------IGLAQL 1000
HI+K+ G C D L +V EY+ G L +L H +GL+Q+
Sbjct: 599 HIVKFYGVCGDGDP--LIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQM 656
Query: 1001 LLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAV----------PE 1050
L A QI GM YL +QH++HRDLA RN L+ + LVKIGDFG+++ V P
Sbjct: 657 LHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPS 716
Query: 1051 GHEYYRVREDGDS---PVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTK 1107
G+++ E G P+ W PE + KF SDVWSFGV L+E+ T+ + P
Sbjct: 717 GNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTY---GKQP--- 770
Query: 1108 FLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIP 1167
Q++ + E + +G L RP CP EVY +M CW+ E R + +
Sbjct: 771 --------WFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK 822
Query: 1168 IL 1169
IL
Sbjct: 823 IL 824
Score = 74.3 bits (181), Expect = 6e-13
Identities = 70/280 (25%), Positives = 116/280 (41%), Gaps = 49/280 (17%)
Query: 627 LVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 686
L P +D+ + V +K L F A L++ + H H+ +GVC G IMV
Sbjct: 560 LSPTKDK---MLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMV 616
Query: 687 TEYVEHGPLDVWL---------------RRERGHVPMAWKMVVAQQLASALSYLENKNLV 731
EY++HG L+ +L R+ +G + ++ + +A Q+AS + YL +++ V
Sbjct: 617 FEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFV 676
Query: 732 HGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSRE--------------------E 771
H ++ RN L+ G + +K+ D G+ S +
Sbjct: 677 HRDLATRNCLV-------GANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGH 729
Query: 772 RVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQH 831
+ I W+ PE + +T D W FG L EI G+ P S +E +
Sbjct: 730 TMLPIRWMPPESIM--YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGR 787
Query: 832 RLPEPS-CP-QLATLTSQCLTYEPTQRPSFRTILRDLTRL 869
L P CP ++ + C EP QR + + I + L L
Sbjct: 788 VLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHAL 827
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 162 bits (409), Expect = 2e-39
Identities = 112/322 (34%), Positives = 160/322 (49%), Gaps = 42/322 (13%)
Query: 880 VNPDSPASDPTVFHKRYLKKIRDLGEGHFGKV---SLYCYDPTNDGTGEMVAVKALKADC 936
V+ D P F + L + LGEG FG+V + DP VAVK LK +
Sbjct: 410 VSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA 469
Query: 937 GPQHRSGWKQEIDILRTL-YHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL----- 990
+ + E+++++ + H++II G C +G L +++E G+LR++L
Sbjct: 470 SDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGP--LYVIVECAAKGNLREFLRARRP 527
Query: 991 ---------PRHSIG---LAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVK 1038
PR S G L+ A Q+ GM YL ++ IHRDLAARNVL+ D ++K
Sbjct: 528 PGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMK 587
Query: 1039 IGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHC 1098
I DFGLA+ V +YY+ +G PV W APE L + + + SDVWSFG+ L+E+ T
Sbjct: 588 IADFGLARGV-HHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT-- 644
Query: 1099 DSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASF 1158
L G + V L LL G R+ RP CP E+Y LM+ CW S
Sbjct: 645 ------------LGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQ 692
Query: 1159 RPTFENLI----PILKTVHEKY 1176
RPTF+ L+ +L V E+Y
Sbjct: 693 RPTFKQLVEALDKVLLAVSEEY 714
Score = 66.2 bits (160), Expect = 2e-10
Identities = 72/289 (24%), Positives = 122/289 (42%), Gaps = 38/289 (13%)
Query: 625 DPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENI 684
DP P D+ + V + + S D+A E + H ++ + GVC +
Sbjct: 450 DPARP--DQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLY 507
Query: 685 MVTEYVEHGPLDVWLRRER-------------GHVPMAWKMVV--AQQLASALSYLENKN 729
++ E G L +LR R P+++ ++V A Q+A + YLE++
Sbjct: 508 VIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRK 567
Query: 730 LVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGA----LSREERVERIP--WLAPEC 783
+H ++ RN+L+ +K++D G+ G ++ R+P W+APE
Sbjct: 568 CIHRDLAARNVLVTE-------DNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 620
Query: 784 LPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPE-PSC-PQL 841
L + + D W FG L EI G +P E + HR+ P C P+L
Sbjct: 621 LFDRVYTHQS--DVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPEL 678
Query: 842 ATLTSQCLTYEPTQRPSFRTILRDLTR----LQPHNLADVLTVNPDSPA 886
L +C P+QRP+F+ ++ L + + L LT P SP+
Sbjct: 679 YGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPS 727
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 162 bits (409), Expect = 2e-39
Identities = 112/322 (34%), Positives = 160/322 (49%), Gaps = 42/322 (13%)
Query: 880 VNPDSPASDPTVFHKRYLKKIRDLGEGHFGKV---SLYCYDPTNDGTGEMVAVKALKADC 936
V+ D P F + L + LGEG FG+V + DP VAVK LK +
Sbjct: 450 VSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA 509
Query: 937 GPQHRSGWKQEIDILRTL-YHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL----- 990
+ + E+++++ + H++II G C +G L +++E G+LR++L
Sbjct: 510 SDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGP--LYVIVECAAKGNLREFLRARRP 567
Query: 991 ---------PRHSIG---LAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVK 1038
PR S G L+ A Q+ GM YL ++ IHRDLAARNVL+ D ++K
Sbjct: 568 PGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMK 627
Query: 1039 IGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHC 1098
I DFGLA+ V +YY+ +G PV W APE L + + + SDVWSFG+ L+E+ T
Sbjct: 628 IADFGLARGV-HHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT-- 684
Query: 1099 DSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASF 1158
L G + V L LL G R+ RP CP E+Y LM+ CW S
Sbjct: 685 ------------LGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQ 732
Query: 1159 RPTFENLI----PILKTVHEKY 1176
RPTF+ L+ +L V E+Y
Sbjct: 733 RPTFKQLVEALDKVLLAVSEEY 754
Score = 66.2 bits (160), Expect = 2e-10
Identities = 72/289 (24%), Positives = 122/289 (42%), Gaps = 38/289 (13%)
Query: 625 DPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENI 684
DP P D+ + V + + S D+A E + H ++ + GVC +
Sbjct: 490 DPARP--DQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLY 547
Query: 685 MVTEYVEHGPLDVWLRRER-------------GHVPMAWKMVV--AQQLASALSYLENKN 729
++ E G L +LR R P+++ ++V A Q+A + YLE++
Sbjct: 548 VIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRK 607
Query: 730 LVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGA----LSREERVERIP--WLAPEC 783
+H ++ RN+L+ +K++D G+ G ++ R+P W+APE
Sbjct: 608 CIHRDLAARNVLVTE-------DNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 660
Query: 784 LPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPE-PSC-PQL 841
L + + D W FG L EI G +P E + HR+ P C P+L
Sbjct: 661 LFDRVYTHQS--DVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPEL 718
Query: 842 ATLTSQCLTYEPTQRPSFRTILRDLTR----LQPHNLADVLTVNPDSPA 886
L +C P+QRP+F+ ++ L + + L LT P SP+
Sbjct: 719 YGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPS 767
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 162 bits (409), Expect = 2e-39
Identities = 112/322 (34%), Positives = 160/322 (49%), Gaps = 42/322 (13%)
Query: 880 VNPDSPASDPTVFHKRYLKKIRDLGEGHFGKV---SLYCYDPTNDGTGEMVAVKALKADC 936
V+ D P F + L + LGEG FG+V + DP VAVK LK +
Sbjct: 450 VSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA 509
Query: 937 GPQHRSGWKQEIDILRTL-YHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL----- 990
+ + E+++++ + H++II G C +G L +++E G+LR++L
Sbjct: 510 SDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGP--LYVIVECAAKGNLREFLRARRP 567
Query: 991 ---------PRHSIG---LAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVK 1038
PR S G L+ A Q+ GM YL ++ IHRDLAARNVL+ D ++K
Sbjct: 568 PGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMK 627
Query: 1039 IGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHC 1098
I DFGLA+ V +YY+ +G PV W APE L + + + SDVWSFG+ L+E+ T
Sbjct: 628 IADFGLARGV-HHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT-- 684
Query: 1099 DSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASF 1158
L G + V L LL G R+ RP CP E+Y LM+ CW S
Sbjct: 685 ------------LGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQ 732
Query: 1159 RPTFENLI----PILKTVHEKY 1176
RPTF+ L+ +L V E+Y
Sbjct: 733 RPTFKQLVEALDKVLLAVSEEY 754
Score = 66.2 bits (160), Expect = 2e-10
Identities = 72/289 (24%), Positives = 122/289 (42%), Gaps = 38/289 (13%)
Query: 625 DPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENI 684
DP P D+ + V + + S D+A E + H ++ + GVC +
Sbjct: 490 DPARP--DQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLY 547
Query: 685 MVTEYVEHGPLDVWLRRER-------------GHVPMAWKMVV--AQQLASALSYLENKN 729
++ E G L +LR R P+++ ++V A Q+A + YLE++
Sbjct: 548 VIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRK 607
Query: 730 LVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGA----LSREERVERIP--WLAPEC 783
+H ++ RN+L+ +K++D G+ G ++ R+P W+APE
Sbjct: 608 CIHRDLAARNVLVTE-------DNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA 660
Query: 784 LPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPE-PSC-PQL 841
L + + D W FG L EI G +P E + HR+ P C P+L
Sbjct: 661 LFDRVYTHQS--DVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPEL 718
Query: 842 ATLTSQCLTYEPTQRPSFRTILRDLTR----LQPHNLADVLTVNPDSPA 886
L +C P+QRP+F+ ++ L + + L LT P SP+
Sbjct: 719 YGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPS 767
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 161 bits (408), Expect = 3e-39
Identities = 104/282 (36%), Positives = 148/282 (52%), Gaps = 24/282 (8%)
Query: 901 RDLGEGHFGKVSLYCY-DPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHI 959
R +GEG FG V Y P N VA+K K R + QE +R H HI
Sbjct: 448 RCIGEGQFGDVHQGIYMSPENPALA--VAIKTCKNCTSDSVREKFLQEALTMRQFDHPHI 505
Query: 960 IKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLP--RHSIGLAQLLLFAQQICEGMAYLHAQ 1017
+K G E + ++ME LG LR +L ++S+ LA L+L+A Q+ +AYL ++
Sbjct: 506 VKLIGVIT---ENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK 562
Query: 1018 HYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYK 1077
++HRD+AARNVL+ ++ VK+GDFGL++ + E YY+ + G P+ W APE + +
Sbjct: 563 RFVHRDIAARNVLVSSNDCVKLGDFGLSRYM-EDSTYYKASK-GKLPIKWMAPESINFRR 620
Query: 1078 FYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRP 1137
F ASDVW FGV ++E+L H K ++IG +E GERLP P
Sbjct: 621 FTSASDVWMFGVCMWEILMH-GVKPFQGVKNNDVIG-------------RIENGERLPMP 666
Query: 1138 DKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQ 1179
CP +Y LM CW + S RP F L L T+ E+ + Q
Sbjct: 667 PNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQ 708
Score = 87.4 bits (215), Expect = 7e-17
Identities = 79/282 (28%), Positives = 128/282 (45%), Gaps = 33/282 (11%)
Query: 600 RTNVYEGRLRVEGS-GDPEEG-KMDDEDPLVPGRDRGQELRVVLKVLDPSHHD-IALAFY 656
R + GR EG GD +G M E+P L V +K D + F
Sbjct: 441 RERIELGRCIGEGQFGDVHQGIYMSPENPA---------LAVAIKTCKNCTSDSVREKFL 491
Query: 657 ETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQ 716
+ A M Q H H+ + GV P I++ E G L +L+ + + +A ++ A
Sbjct: 492 QEALTMRQFDHPHIVKLIGVITENPVWIIM-ELCTLGELRSFLQVRKYSLDLASLILYAY 550
Query: 717 QLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVER- 775
QL++AL+YLE+K VH ++ RN+L++ ++ +KL D GL + +
Sbjct: 551 QLSTALAYLESKRFVHRDIAARNVLVS-------SNDCVKLGD--FGLSRYMEDSTYYKA 601
Query: 776 ------IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQR 829
I W+APE + ++A D W FG + EI G P Q ++ +
Sbjct: 602 SKGKLPIKWMAPESI--NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIEN 659
Query: 830 QHRLP-EPSC-PQLATLTSQCLTYEPTQRPSFRTILRDLTRL 869
RLP P+C P L +L ++C Y+P++RP F + L+ +
Sbjct: 660 GERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTI 701
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 161 bits (408), Expect = 3e-39
Identities = 104/282 (36%), Positives = 148/282 (52%), Gaps = 24/282 (8%)
Query: 901 RDLGEGHFGKVSLYCY-DPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHI 959
R +GEG FG V Y P N VA+K K R + QE +R H HI
Sbjct: 426 RCIGEGQFGDVHQGIYMSPENPALA--VAIKTCKNCTSDSVREKFLQEALTMRQFDHPHI 483
Query: 960 IKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLP--RHSIGLAQLLLFAQQICEGMAYLHAQ 1017
+K G E + ++ME LG LR +L ++S+ LA L+L+A Q+ +AYL ++
Sbjct: 484 VKLIGVIT---ENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK 540
Query: 1018 HYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYK 1077
++HRD+AARNVL+ ++ VK+GDFGL++ + E YY+ + G P+ W APE + +
Sbjct: 541 RFVHRDIAARNVLVSSNDCVKLGDFGLSRYM-EDSTYYKASK-GKLPIKWMAPESINFRR 598
Query: 1078 FYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRP 1137
F ASDVW FGV ++E+L H K ++IG +E GERLP P
Sbjct: 599 FTSASDVWMFGVCMWEILMH-GVKPFQGVKNNDVIG-------------RIENGERLPMP 644
Query: 1138 DKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQ 1179
CP +Y LM CW + S RP F L L T+ E+ + Q
Sbjct: 645 PNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQ 686
Score = 87.4 bits (215), Expect = 7e-17
Identities = 79/282 (28%), Positives = 128/282 (45%), Gaps = 33/282 (11%)
Query: 600 RTNVYEGRLRVEGS-GDPEEG-KMDDEDPLVPGRDRGQELRVVLKVLDPSHHD-IALAFY 656
R + GR EG GD +G M E+P L V +K D + F
Sbjct: 419 RERIELGRCIGEGQFGDVHQGIYMSPENPA---------LAVAIKTCKNCTSDSVREKFL 469
Query: 657 ETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQ 716
+ A M Q H H+ + GV P I++ E G L +L+ + + +A ++ A
Sbjct: 470 QEALTMRQFDHPHIVKLIGVITENPVWIIM-ELCTLGELRSFLQVRKYSLDLASLILYAY 528
Query: 717 QLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVER- 775
QL++AL+YLE+K VH ++ RN+L++ ++ +KL D GL + +
Sbjct: 529 QLSTALAYLESKRFVHRDIAARNVLVS-------SNDCVKLGD--FGLSRYMEDSTYYKA 579
Query: 776 ------IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQR 829
I W+APE + ++A D W FG + EI G P Q ++ +
Sbjct: 580 SKGKLPIKWMAPESI--NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIEN 637
Query: 830 QHRLP-EPSC-PQLATLTSQCLTYEPTQRPSFRTILRDLTRL 869
RLP P+C P L +L ++C Y+P++RP F + L+ +
Sbjct: 638 GERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTI 679
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 161 bits (408), Expect = 3e-39
Identities = 101/286 (35%), Positives = 152/286 (53%), Gaps = 28/286 (9%)
Query: 897 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYH 956
+K ++ LG G FG+V + Y N+ T VAVK LK G + +E ++++TL H
Sbjct: 226 IKLVKRLGAGQFGEVWMGYY---NNST--KVAVKTLKP--GTMSVQAFLEEANLMKTLQH 278
Query: 957 EHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIG---LAQLLLFAQQICEGMAY 1013
+ +++ E+ + ++ EY+ GSL D+L G L +L+ F+ QI EGMAY
Sbjct: 279 DKLVRLYAVVTR--EEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAY 336
Query: 1014 LHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECL 1073
+ ++YIHRDL A NVL+ + KI DFGLA+ + + Y RE P+ W APE +
Sbjct: 337 IERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNE--YTAREGAKFPIKWTAPEAI 394
Query: 1074 KEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGER 1133
F SDVWSFG+ LYE++T+ I T + L +G R
Sbjct: 395 NFGCFTIKSDVWSFGILLYEIVTYGK--------------IPYPGRTNADVMTALSQGYR 440
Query: 1134 LPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQ 1179
+PR + CP E+Y +MK CW+ +A RPTF+ L +L + +GQ
Sbjct: 441 MPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQ 486
Score = 82.0 bits (201), Expect = 3e-15
Identities = 62/230 (26%), Positives = 110/230 (47%), Gaps = 18/230 (7%)
Query: 638 RVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDV 697
+V +K L P + AF E A+LM + H L ++ V R ++TEY+ G L
Sbjct: 250 KVAVKTLKPGTMSVQ-AFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLD 308
Query: 698 WLRRERGHVPMAWKMV-VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIK 756
+L+ + G + K++ + Q+A ++Y+E KN +H ++ N+L++ S K
Sbjct: 309 FLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE-------SLMCK 361
Query: 757 LSDPGVGL-----GALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDG 811
++D G+ +RE I W APE + G ++ + D W FG L EI G
Sbjct: 362 IADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS--DVWSFGILLYEIVTYG 419
Query: 812 EAPLQSRSPSEKEHFYQRQHRLPE-PSCP-QLATLTSQCLTYEPTQRPSF 859
+ P R+ ++ + +R+P +CP +L + C + +RP+F
Sbjct: 420 KIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 469
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog isoform
A [Homo sapiens]
Length = 512
Score = 161 bits (408), Expect = 3e-39
Identities = 101/286 (35%), Positives = 152/286 (53%), Gaps = 28/286 (9%)
Query: 897 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYH 956
+K ++ LG G FG+V + Y N+ T VAVK LK G + +E ++++TL H
Sbjct: 247 IKLVKRLGAGQFGEVWMGYY---NNST--KVAVKTLKP--GTMSVQAFLEEANLMKTLQH 299
Query: 957 EHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIG---LAQLLLFAQQICEGMAY 1013
+ +++ E+ + ++ EY+ GSL D+L G L +L+ F+ QI EGMAY
Sbjct: 300 DKLVRLYAVVTR--EEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAY 357
Query: 1014 LHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECL 1073
+ ++YIHRDL A NVL+ + KI DFGLA+ + + Y RE P+ W APE +
Sbjct: 358 IERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNE--YTAREGAKFPIKWTAPEAI 415
Query: 1074 KEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGER 1133
F SDVWSFG+ LYE++T+ I T + L +G R
Sbjct: 416 NFGCFTIKSDVWSFGILLYEIVTYGK--------------IPYPGRTNADVMTALSQGYR 461
Query: 1134 LPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQ 1179
+PR + CP E+Y +MK CW+ +A RPTF+ L +L + +GQ
Sbjct: 462 MPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQ 507
Score = 82.0 bits (201), Expect = 3e-15
Identities = 62/230 (26%), Positives = 110/230 (47%), Gaps = 18/230 (7%)
Query: 638 RVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDV 697
+V +K L P + AF E A+LM + H L ++ V R ++TEY+ G L
Sbjct: 271 KVAVKTLKPGTMSVQ-AFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLD 329
Query: 698 WLRRERGHVPMAWKMV-VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIK 756
+L+ + G + K++ + Q+A ++Y+E KN +H ++ N+L++ S K
Sbjct: 330 FLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE-------SLMCK 382
Query: 757 LSDPGVGL-----GALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDG 811
++D G+ +RE I W APE + G ++ + D W FG L EI G
Sbjct: 383 IADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS--DVWSFGILLYEIVTYG 440
Query: 812 EAPLQSRSPSEKEHFYQRQHRLPE-PSCP-QLATLTSQCLTYEPTQRPSF 859
+ P R+ ++ + +R+P +CP +L + C + +RP+F
Sbjct: 441 KIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 490
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 160 bits (405), Expect = 7e-39
Identities = 106/290 (36%), Positives = 147/290 (50%), Gaps = 29/290 (10%)
Query: 883 DSPASDPT------VFHKRYLKKIRD--LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKA 934
+SP +DP V+ R L + D LG G+FG V Y + VAVK LK
Sbjct: 326 ESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKK--VVKTVAVKILKN 383
Query: 935 DCG-PQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH 993
+ P + E ++++ L + +I++ G CE + S LVME LG L YL ++
Sbjct: 384 EANDPALKDELLAEANVMQQLDNPYIVRMIGICEAE---SWMLVMEMAELGPLNKYLQQN 440
Query: 994 S-IGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGH 1052
+ ++ Q+ GM YL +++HRDLAARNVLL KI DFGL+KA+
Sbjct: 441 RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE 500
Query: 1053 EYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELI 1112
YY+ + G PV WYAPEC+ YKF SDVWSFGV ++E ++ Q P
Sbjct: 501 NYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSY---GQKP-------- 549
Query: 1113 GIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTF 1162
M +T +LE+GER+ P CP E+Y LM CW + RP F
Sbjct: 550 ---YRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 596
Score = 85.1 bits (209), Expect = 4e-16
Identities = 66/236 (27%), Positives = 111/236 (47%), Gaps = 24/236 (10%)
Query: 639 VVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLD 696
V +K+L +D AL A++M Q+ + ++ + G+C ++V E E GPL+
Sbjct: 376 VAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLN 434
Query: 697 VWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIK 756
+L++ R HV + + Q++ + YLE N VH ++ RN+LL T + K
Sbjct: 435 KYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV-------TQHYAK 486
Query: 757 LSDPGVGLGALSREERVER--------IPWLAPECLPGGANSLSTAMDKWGFGATLLEIC 808
+SD G+ AL +E + + W APEC+ S+ D W FG + E
Sbjct: 487 ISDFGLS-KALRADENYYKAQTHGKWPVKWYAPECI--NYYKFSSKSDVWSFGVLMWEAF 543
Query: 809 FDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CP-QLATLTSQCLTYEPTQRPSFRTI 862
G+ P + SE ++ R+ P+ CP ++ L + C TY+ RP F +
Sbjct: 544 SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 599
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 160 bits (405), Expect = 7e-39
Identities = 106/290 (36%), Positives = 147/290 (50%), Gaps = 29/290 (10%)
Query: 883 DSPASDPT------VFHKRYLKKIRD--LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKA 934
+SP +DP V+ R L + D LG G+FG V Y + VAVK LK
Sbjct: 349 ESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKK--VVKTVAVKILKN 406
Query: 935 DCG-PQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH 993
+ P + E ++++ L + +I++ G CE + S LVME LG L YL ++
Sbjct: 407 EANDPALKDELLAEANVMQQLDNPYIVRMIGICEAE---SWMLVMEMAELGPLNKYLQQN 463
Query: 994 S-IGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGH 1052
+ ++ Q+ GM YL +++HRDLAARNVLL KI DFGL+KA+
Sbjct: 464 RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE 523
Query: 1053 EYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELI 1112
YY+ + G PV WYAPEC+ YKF SDVWSFGV ++E ++ Q P
Sbjct: 524 NYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSY---GQKP-------- 572
Query: 1113 GIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTF 1162
M +T +LE+GER+ P CP E+Y LM CW + RP F
Sbjct: 573 ---YRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619
Score = 85.1 bits (209), Expect = 4e-16
Identities = 66/236 (27%), Positives = 111/236 (47%), Gaps = 24/236 (10%)
Query: 639 VVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLD 696
V +K+L +D AL A++M Q+ + ++ + G+C ++V E E GPL+
Sbjct: 399 VAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLN 457
Query: 697 VWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIK 756
+L++ R HV + + Q++ + YLE N VH ++ RN+LL T + K
Sbjct: 458 KYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV-------TQHYAK 509
Query: 757 LSDPGVGLGALSREERVER--------IPWLAPECLPGGANSLSTAMDKWGFGATLLEIC 808
+SD G+ AL +E + + W APEC+ S+ D W FG + E
Sbjct: 510 ISDFGLS-KALRADENYYKAQTHGKWPVKWYAPECI--NYYKFSSKSDVWSFGVLMWEAF 566
Query: 809 FDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CP-QLATLTSQCLTYEPTQRPSFRTI 862
G+ P + SE ++ R+ P+ CP ++ L + C TY+ RP F +
Sbjct: 567 SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [Homo
sapiens]
Length = 466
Score = 159 bits (402), Expect = 1e-38
Identities = 106/286 (37%), Positives = 153/286 (53%), Gaps = 37/286 (12%)
Query: 903 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKY 962
+GEG FG V Y G+ VAVK +K D Q + E ++ + HE++++
Sbjct: 200 IGEGEFGAVLQGEY------LGQKVAVKNIKCDVTAQ---AFLDETAVMTKMQHENLVRL 250
Query: 963 KGCCEDQGEKSLQLVMEYVPLGSLRDYLP---RHSIGLAQLLLFAQQICEGMAYLHAQHY 1019
G QG L +VME+V G+L ++L R + AQLL F+ + EGM YL ++
Sbjct: 251 LGVILHQG---LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKL 307
Query: 1020 IHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFY 1079
+HRDLAARN+L+ D + K+ DFGLAKA +G + R+ PV W APE LK KF
Sbjct: 308 VHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRL------PVKWTAPEALKHGKFT 361
Query: 1080 YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDK 1139
SDVWSFGV L+E+ ++ ++P K M++ ++E +E+G R+ P+
Sbjct: 362 SKSDVWSFGVLLWEVFSY---GRAPYPK-----------MSLKEVSEAVEKGYRMEPPEG 407
Query: 1140 CPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFS 1185
CP V+ LM +CWE E + RP F L K E AP+ S
Sbjct: 408 CPGPVHVLMSSCWEAEPARRPPFRKLAE--KLARELRSAGAPASVS 451
Score = 85.5 bits (210), Expect = 3e-16
Identities = 74/226 (32%), Positives = 109/226 (48%), Gaps = 24/226 (10%)
Query: 652 ALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLR-RERGHVPMAW 710
A AF + ++M+++ H +L + GV + I V E+V G L +LR R R V A
Sbjct: 229 AQAFLDETAVMTKMQHENLVRLLGVILHQGLYI-VMEHVSKGNLVNFLRTRGRALVNTAQ 287
Query: 711 KMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSRE 770
+ + +A + YLE+K LVH ++ RNIL++ +A K+SD G L++
Sbjct: 288 LLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVA-------KVSDFG-----LAKA 335
Query: 771 ER----VERIP--WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKE 824
ER R+P W APE L G ++ D W FG L E+ G AP S E
Sbjct: 336 ERKGLDSSRLPVKWTAPEALKHG--KFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVS 393
Query: 825 HFYQRQHRL-PEPSCP-QLATLTSQCLTYEPTQRPSFRTILRDLTR 868
++ +R+ P CP + L S C EP +RP FR + L R
Sbjct: 394 EAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLAR 439
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [Homo
sapiens]
Length = 508
Score = 159 bits (402), Expect = 1e-38
Identities = 106/286 (37%), Positives = 153/286 (53%), Gaps = 37/286 (12%)
Query: 903 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKY 962
+GEG FG V Y G+ VAVK +K D Q + E ++ + HE++++
Sbjct: 242 IGEGEFGAVLQGEY------LGQKVAVKNIKCDVTAQ---AFLDETAVMTKMQHENLVRL 292
Query: 963 KGCCEDQGEKSLQLVMEYVPLGSLRDYLP---RHSIGLAQLLLFAQQICEGMAYLHAQHY 1019
G QG L +VME+V G+L ++L R + AQLL F+ + EGM YL ++
Sbjct: 293 LGVILHQG---LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKL 349
Query: 1020 IHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFY 1079
+HRDLAARN+L+ D + K+ DFGLAKA +G + R+ PV W APE LK KF
Sbjct: 350 VHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRL------PVKWTAPEALKHGKFT 403
Query: 1080 YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDK 1139
SDVWSFGV L+E+ ++ ++P K M++ ++E +E+G R+ P+
Sbjct: 404 SKSDVWSFGVLLWEVFSY---GRAPYPK-----------MSLKEVSEAVEKGYRMEPPEG 449
Query: 1140 CPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFS 1185
CP V+ LM +CWE E + RP F L K E AP+ S
Sbjct: 450 CPGPVHVLMSSCWEAEPARRPPFRKLAE--KLARELRSAGAPASVS 493
Score = 85.5 bits (210), Expect = 3e-16
Identities = 74/226 (32%), Positives = 109/226 (48%), Gaps = 24/226 (10%)
Query: 652 ALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLR-RERGHVPMAW 710
A AF + ++M+++ H +L + GV + I V E+V G L +LR R R V A
Sbjct: 271 AQAFLDETAVMTKMQHENLVRLLGVILHQGLYI-VMEHVSKGNLVNFLRTRGRALVNTAQ 329
Query: 711 KMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSRE 770
+ + +A + YLE+K LVH ++ RNIL++ +A K+SD G L++
Sbjct: 330 LLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVA-------KVSDFG-----LAKA 377
Query: 771 ER----VERIP--WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKE 824
ER R+P W APE L G ++ D W FG L E+ G AP S E
Sbjct: 378 ERKGLDSSRLPVKWTAPEALKHG--KFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVS 435
Query: 825 HFYQRQHRL-PEPSCP-QLATLTSQCLTYEPTQRPSFRTILRDLTR 868
++ +R+ P CP + L S C EP +RP FR + L R
Sbjct: 436 EAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLAR 481
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,372,198
Number of Sequences: 37866
Number of extensions: 2559814
Number of successful extensions: 9013
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 617
Number of HSP's successfully gapped in prelim test: 175
Number of HSP's that attempted gapping in prelim test: 5948
Number of HSP's gapped (non-prelim): 1649
length of query: 1187
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1074
effective length of database: 13,968,660
effective search space: 15002340840
effective search space used: 15002340840
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.