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Search of human proteins with 10518503
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10518503 coagulation factor VII isoform b precursor [Homo
sapiens]
(444 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10518503 coagulation factor VII isoform b precursor [Homo sap... 935 0.0
gi|4503645 coagulation factor VII isoform a precursor [Homo sapi... 922 0.0
gi|4503625 coagulation factor X preproprotein [Homo sapiens] 358 7e-99
gi|4503649 coagulation factor IX preproprotein [Homo sapiens] 356 3e-98
gi|4506115 protein C [Homo sapiens] 312 3e-85
gi|4506121 protein Z, vitamin K-dependent plasma glycoprotein [H... 176 3e-44
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens] 173 3e-43
gi|4506153 prostasin preproprotein [Homo sapiens] 169 4e-42
gi|4503627 coagulation factor XI precursor [Homo sapiens] 167 1e-41
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 167 2e-41
gi|223942069 enterokinase precursor [Homo sapiens] 159 4e-39
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa... 159 5e-39
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa... 159 5e-39
gi|33667063 transmembrane protease, serine 9 [Homo sapiens] 158 8e-39
gi|4506147 protease, serine, 2 preproprotein [Homo sapiens] 154 2e-37
gi|116256363 transmembrane protease, serine 13 [Homo sapiens] 152 6e-37
gi|4504383 HGF activator preproprotein [Homo sapiens] 152 8e-37
gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens] 149 5e-36
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens] 149 5e-36
gi|110578663 hypothetical protein LOC203074 [Homo sapiens] 149 5e-36
gi|4505881 plasminogen [Homo sapiens] 149 7e-36
gi|4503635 coagulation factor II preproprotein [Homo sapiens] 149 7e-36
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ... 148 9e-36
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ... 148 9e-36
gi|13994276 marapsin [Homo sapiens] 148 1e-35
gi|11545839 protease, serine, 22 [Homo sapiens] 147 2e-35
gi|4758508 transmembrane protease, serine 11D [Homo sapiens] 147 2e-35
gi|33695155 hepsin [Homo sapiens] 146 3e-35
gi|4504481 hepsin [Homo sapiens] 146 3e-35
gi|58218970 protease, serine, 36 [Homo sapiens] 146 3e-35
>gi|10518503 coagulation factor VII isoform b precursor [Homo
sapiens]
Length = 444
Score = 935 bits (2417), Expect = 0.0
Identities = 444/444 (100%), Positives = 444/444 (100%)
Query: 1 MVSQALRLLCLLLGLQGCLAAVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQC 60
MVSQALRLLCLLLGLQGCLAAVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQC
Sbjct: 1 MVSQALRLLCLLLGLQGCLAAVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQC 60
Query: 61 SFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCE 120
SFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCE
Sbjct: 61 SFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCE 120
Query: 121 THKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 180
THKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE
Sbjct: 121 THKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 180
Query: 181 KRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR 240
KRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
Sbjct: 181 KRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR 240
Query: 241 NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLC 300
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLC
Sbjct: 241 NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLC 300
Query: 301 LPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPN 360
LPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPN
Sbjct: 301 LPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPN 360
Query: 361 ITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQ 420
ITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQ
Sbjct: 361 ITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQ 420
Query: 421 YIEWLQKLMRSEPRPGVLLRAPFP 444
YIEWLQKLMRSEPRPGVLLRAPFP
Sbjct: 421 YIEWLQKLMRSEPRPGVLLRAPFP 444
>gi|4503645 coagulation factor VII isoform a precursor [Homo
sapiens]
Length = 466
Score = 922 bits (2384), Expect = 0.0
Identities = 444/466 (95%), Positives = 444/466 (95%), Gaps = 22/466 (4%)
Query: 1 MVSQALRLLCLLLGLQGCLAA----------------------VFVTQEEAHGVLHRRRR 38
MVSQALRLLCLLLGLQGCLAA VFVTQEEAHGVLHRRRR
Sbjct: 1 MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR 60
Query: 39 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS 98
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
Sbjct: 61 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS 120
Query: 99 CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL 158
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
Sbjct: 121 CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL 180
Query: 159 LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG 218
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
Sbjct: 181 LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG 240
Query: 219 TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN 278
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
Sbjct: 241 TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN 300
Query: 279 HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL 338
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
Sbjct: 301 HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL 360
Query: 339 NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG 398
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
Sbjct: 361 NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG 420
Query: 399 IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 444
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
Sbjct: 421 IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 466
>gi|4503625 coagulation factor X preproprotein [Homo sapiens]
Length = 488
Score = 358 bits (918), Expect = 7e-99
Identities = 187/491 (38%), Positives = 276/491 (56%), Gaps = 62/491 (12%)
Query: 2 VSQALRLLCLLLGLQGCLA---AVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEE 58
+ + L L+ L L G L ++F+ +E+A+ +L R RAN+FLEE++ G LEREC EE
Sbjct: 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE 60
Query: 59 QCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRN 118
CS+EEARE+F+D+++T FW Y DGDQC +SPCQN G CKD L Y C CL FEG+N
Sbjct: 61 TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN 120
Query: 119 CETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPI 178
CE + +C +NG C+Q+C + + C C GY+L +G +C PT YPCGK
Sbjct: 121 CELFT--RKLCSLDNGDCDQFCHEEQNSV-VCSCARGYTLADNGKACIPTGPYPCGK-QT 176
Query: 179 LEKRNASKPQG----------------------------------------------RIV 192
LE+R S Q RIV
Sbjct: 177 LERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIV 236
Query: 193 GGKVCPKGECPWQVLLLVNGAQ-LCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDL 251
GG+ C GECPWQ LL+ + CGGT+++ ++++AAHC + K ++ + G+ +
Sbjct: 237 GGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRV---GDRNT 293
Query: 252 SEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTL 311
+ +G E V VI + + T + DIA+LRL P+ +V P CLPER ++E TL
Sbjct: 294 EQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTL 353
Query: 312 AFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYS 371
+ +VSG+G+ ++G + L +L VP + C K+ S IT+ MFCAGY
Sbjct: 354 MTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSC-----KLSSSFIITQNMFCAGYD 408
Query: 372 DGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRS 431
+D+C+GDSGGPH T ++ T+++TGIVSWG+GCA G +G+YT+V+ +++W+ + M++
Sbjct: 409 TKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKT 468
Query: 432 EPRPGVLLRAP 442
P AP
Sbjct: 469 RGLPKAKSHAP 479
>gi|4503649 coagulation factor IX preproprotein [Homo sapiens]
Length = 461
Score = 356 bits (913), Expect = 3e-98
Identities = 186/461 (40%), Positives = 264/461 (57%), Gaps = 51/461 (11%)
Query: 3 SQALRLLCLLLGLQGCLAAVFVTQEEAHGVLHRRRRANAF-LEELRPGSLERECKEEQCS 61
S L +CLL L VF+ E A+ +L+R +R N+ LEE G+LEREC EE+CS
Sbjct: 11 SPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCS 70
Query: 62 FEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCET 121
FEEARE+F++ ERT FW Y DGDQC S+PC NGGSCKD + SY C+C FEG+NCE
Sbjct: 71 FEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCEL 130
Query: 122 HKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEK 181
+ C +NG CEQ+C + K C C EGY L + SC P V +PCG++ + +
Sbjct: 131 ----DVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQT 186
Query: 182 RNASKPQG-------------------------------RIVGGKVCPKGECPWQVLLLV 210
++ + R+VGG+ G+ PWQV+L
Sbjct: 187 SKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNG 246
Query: 211 NGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPS 270
CGG+++N W+V+AAHC ++ + V GEH++ E + EQ R V ++I
Sbjct: 247 KVDAFCGGSIVNEKWIVTAAHC---VETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHH 303
Query: 271 TYVPGTT--NHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFS--LVSGWGQLL 326
Y NHDIALL L +P+VL +V P+C+ ++ E T F++F VSGWG++
Sbjct: 304 NYNAAINKYNHDIALLELDEPLVLNSYVTPICIADK---EYTNIFLKFGSGYVSGWGRVF 360
Query: 327 DRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPH 386
+G +AL L L VP + CL+ ++ I MFCAG+ +G +DSC+GDSGGPH
Sbjct: 361 HKGRSALVLQYLRVPLVDRATCLRSTKFT-----IYNNMFCAGFHEGGRDSCQGDSGGPH 415
Query: 387 ATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQK 427
T GT +LTGI+SWG+ CA G +G+YT+VS+Y+ W+++
Sbjct: 416 VTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKE 456
>gi|4506115 protein C [Homo sapiens]
Length = 461
Score = 312 bits (800), Expect = 3e-85
Identities = 174/448 (38%), Positives = 253/448 (56%), Gaps = 36/448 (8%)
Query: 14 GLQGCLAAVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAE 73
G L +VF + E AH VL R+RAN+FLEELR SLEREC EE C FEEA+EIF++ +
Sbjct: 18 GTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVD 77
Query: 74 RTKLFWISYSDGDQCASSP--------CQNGGSCKDQLQSYICFCLPAFEGRNCETHKDD 125
T FW + DGDQC P C G+C D + S+ C C +EGR C+ +
Sbjct: 78 DTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQ-REVS 136
Query: 126 QLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKI-PILEKRNA 184
L C +NGGC YC + G +R C C GY L D + C P V++PCG+ +EK+ +
Sbjct: 137 FLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRS 195
Query: 185 ----------SKPQGRIVGGKVCPKGECPWQVLLLVNGAQL-CGGTLINTIWVVSAAHCF 233
+ R++ GK+ +G+ PWQV+LL + +L CG LI+ WV++AAHC
Sbjct: 196 HLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCM 255
Query: 234 DKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLT 293
D+ K L+ LGE+DL + E + +V + Y TT++DIALL L QP L+
Sbjct: 256 DESKK---LLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLS 312
Query: 294 DHVVPLCLPERTFSERTLAFV-RFSLVSGWGQLLDRGATALE-----LMVLNVPRLMTQD 347
+VP+CLP+ +ER L + +LV+GWG R A L + +P + +
Sbjct: 313 QTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNE 372
Query: 348 CLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCA 407
C + + ++E M CAG +D+C+GDSGGP + GTW+L G+VSWG+GC
Sbjct: 373 CSEVMSNM-----VSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCG 427
Query: 408 TVGHFGVYTRVSQYIEWLQKLMRSEPRP 435
+ ++GVYT+VS+Y++W+ +R + P
Sbjct: 428 LLHNYGVYTKVSRYLDWIHGHIRDKEAP 455
>gi|4506121 protein Z, vitamin K-dependent plasma glycoprotein [Homo
sapiens]
Length = 400
Score = 176 bits (447), Expect = 3e-44
Identities = 131/428 (30%), Positives = 197/428 (46%), Gaps = 40/428 (9%)
Query: 6 LRLLCLLLGLQGCLAAVFVTQEEAHGVLHRRRRANAFL-EELRPGSLERECKEEQCSFEE 64
L+ L L+L L +VF+ +A+ VL R +RA ++L EEL G+LE+EC EE C +EE
Sbjct: 8 LQGLVLVLALHRVEPSVFLPASKANDVLVRWKRAGSYLLEELFEGNLEKECYEEICVYEE 67
Query: 65 AREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKD 124
ARE+F++ T FW Y G C S PC + GSC+D + Y C C P +EG NCE K+
Sbjct: 68 AREVFENEVVTDEFWRRYKGGSPCISQPCLHNGSCQDSIWGYTCTCSPGYEGSNCELAKN 127
Query: 125 DQLICVNE-NGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRN 183
+ C E GC+ +C +C C +GY L D C P + CG + EKR
Sbjct: 128 E---CHPERTDGCQHFCLPGQ-ESYTCSCAQGYRLGEDHKQCVPHDQCACG-VLTSEKRA 182
Query: 184 ASKPQGRIVGGKVCPKGECPWQVLLL-VNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNL 242
+ PWQV L G CGG +I +V++ A C +N
Sbjct: 183 PDLQ-------------DLPWQVKLTNSEGKDFCGGVIIRENFVLTTAKCSLLHRN---- 225
Query: 243 IAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLP 302
+ + + D ++ V + Y +D++LL L P+ +P+C P
Sbjct: 226 --ITVKTYFNRTSQDPLMIKITHVHVHMRYDADAGENDLSLLELEWPIQCPGAGLPVCTP 283
Query: 303 ERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNIT 362
E+ F+E L L+SGW R T L + P L + + G N+T
Sbjct: 284 EKDFAEHLLIPRTRGLLSGWA----RNGTDLGNSLTTRP-----VTLVEGEECGQVLNVT 334
Query: 363 EYMFCAGYSDGSKDSCKGDSGGPHAT-HYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQY 421
+ Y + S + G T +RG+W+LTG++ Q H + T+VS+Y
Sbjct: 335 --VTTRTYCERSSVAAMHWMDGSVVTREHRGSWFLTGVLG-SQPVGGQAHMVLVTKVSRY 391
Query: 422 IEWLQKLM 429
W +++M
Sbjct: 392 SLWFKQIM 399
>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
Length = 638
Score = 173 bits (438), Expect = 3e-43
Identities = 96/253 (37%), Positives = 139/253 (54%), Gaps = 16/253 (6%)
Query: 185 SKPQGRIVGGKVCPKGECPWQVLLLVN---GAQLCGGTLINTIWVVSAAHCFDKIKN--- 238
+K RIVGG GE PWQV L V LCGG+LI WV++AAHCFD +
Sbjct: 385 TKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDV 444
Query: 239 WRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVP 298
WR +L D+++ D ++ ++II Y NHDIAL++L P+ T+ P
Sbjct: 445 WRIYSGILNLSDITK---DTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKP 501
Query: 299 LCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDS 358
+CLP + T V+GWG ++G L +N+P + ++C ++ +
Sbjct: 502 ICLPSKG---DTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDY--- 555
Query: 359 PNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRV 418
IT+ M CAGY +G KD+CKGDSGGP + G W L GI SWG+GCA GVYT+V
Sbjct: 556 -KITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKV 614
Query: 419 SQYIEWLQKLMRS 431
++Y++W+ + +S
Sbjct: 615 AEYMDWILEKTQS 627
>gi|4506153 prostasin preproprotein [Homo sapiens]
Length = 343
Score = 169 bits (429), Expect = 4e-42
Identities = 98/271 (36%), Positives = 137/271 (50%), Gaps = 19/271 (7%)
Query: 170 EYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSA 229
E PCG P Q RI GG G+ PWQV + G +CGG+L++ WV+SA
Sbjct: 34 EAPCGVAP----------QARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSA 83
Query: 230 AHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQP 289
AHCF + LG H L + D + + +I +Y+ + DIALL+L +P
Sbjct: 84 AHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRP 143
Query: 290 VVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGA--TALELMVLNVPRLM--T 345
+ + ++ P+CLP + + V+GWG + + T L L VP + T
Sbjct: 144 ITFSRYIRPICLPA---ANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRET 200
Query: 346 QDCLQQSRKVGDSPN-ITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQ 404
+CL + P+ + E M CAGY +G KD+C+GDSGGP + G WYLTGIVSWG
Sbjct: 201 CNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGD 260
Query: 405 GCATVGHFGVYTRVSQYIEWLQ-KLMRSEPR 434
C GVYT S Y W+Q K+ +PR
Sbjct: 261 ACGARNRPGVYTLASSYASWIQSKVTELQPR 291
>gi|4503627 coagulation factor XI precursor [Homo sapiens]
Length = 625
Score = 167 bits (424), Expect = 1e-41
Identities = 110/354 (31%), Positives = 169/354 (47%), Gaps = 26/354 (7%)
Query: 91 SPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSD------HT 144
S +G S + S FC +F ++ ++ + C++ C++ T
Sbjct: 272 SKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFT 331
Query: 145 GTKRSCRCHEG----YSLLADGVSCTPTVEYPCG------KIPILEKRNASKPQGRIVGG 194
T C+EG Y L+ S T + G ++ ++ +K + RIVGG
Sbjct: 332 YTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGG 391
Query: 195 KVCPKGECPWQVLLLVNGA---QLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDL 251
+GE PWQV L LCGG++I W+++AAHCF +++ + L G +
Sbjct: 392 TASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQ 451
Query: 252 SEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTL 311
SE D V ++II Y + +DIALL+L V TD P+CLP + +R +
Sbjct: 452 SEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSK--GDRNV 509
Query: 312 AFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYS 371
+ V+GWG R L +P + ++C ++ R IT M CAGY
Sbjct: 510 IYTD-CWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYR----GHKITHKMICAGYR 564
Query: 372 DGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWL 425
+G KD+CKGDSGGP + + W+L GI SWG+GCA GVYT V +Y++W+
Sbjct: 565 EGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWI 618
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 167 bits (422), Expect = 2e-41
Identities = 112/347 (32%), Positives = 169/347 (48%), Gaps = 20/347 (5%)
Query: 93 CQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNE----NGGCEQYCSDHT--GT 146
C C + L C C F+ + T +C + NG E+ C + GT
Sbjct: 474 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 533
Query: 147 KRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQV 206
+ +C + + C + G P RIVGG V +GE PWQ
Sbjct: 534 F-TFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQA 592
Query: 207 LLLVNGAQLCGGTLINTIWVVSAAHCF--DKIKNWRNLIAVLGEHDLSEHDGDEQSRRVA 264
L V G +CGG LI WV++AAHCF D + + LG+ + E S +V+
Sbjct: 593 SLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVS 652
Query: 265 QVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERT-FSERTLAFVRFSLVSGWG 323
++++ + + ++D+ALL+L PVV + V P+CLP R+ F E L ++GWG
Sbjct: 653 RLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGL----HCWITGWG 708
Query: 324 QLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSG 383
L + G + L ++V +L+ QD + + +T M CAGY G KD+C+GDSG
Sbjct: 709 ALREGGPISNALQKVDV-QLIPQDLCSEVYRY----QVTPRMLCAGYRKGKKDACQGDSG 763
Query: 384 GPHATH-YRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLM 429
GP G W+L G+VSWG GC +FGVYTR++ I W+Q+++
Sbjct: 764 GPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVV 810
>gi|223942069 enterokinase precursor [Homo sapiens]
Length = 1019
Score = 159 bits (403), Expect = 4e-39
Identities = 96/280 (34%), Positives = 141/280 (50%), Gaps = 11/280 (3%)
Query: 154 EGYSLLADGVSCTPT--VEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVN 211
+G+ +L C + C +K A +IVGG +G PW V L
Sbjct: 746 DGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYG 805
Query: 212 GAQLCGGTLINTIWVVSAAHC-FDKIKNWRNLIAVLGEHDLSEHDGDEQ-SRRVAQVIIP 269
G LCG +L+++ W+VSAAHC + + A+LG H S + R + +++I
Sbjct: 806 GRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVIN 865
Query: 270 STYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRG 329
Y ++DIA++ L V TD++ P+CLPE + R ++GWG ++ +G
Sbjct: 866 PHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEEN---QVFPPGRNCSIAGWGTVVYQG 922
Query: 330 ATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATH 389
TA L +VP L + C QQ + NITE M CAGY +G DSC+GDSGGP
Sbjct: 923 TTANILQEADVPLLSNERCQQQMPEY----NITENMICAGYEEGGIDSCQGDSGGPLMCQ 978
Query: 390 YRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLM 429
W+L G+ S+G CA GVY RVS++ EW+Q +
Sbjct: 979 ENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFL 1018
>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
sapiens]
Length = 529
Score = 159 bits (402), Expect = 5e-39
Identities = 96/252 (38%), Positives = 131/252 (51%), Gaps = 14/252 (5%)
Query: 185 SKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKN----WR 240
S Q RIVGG+ G PWQV L V +CGG++I W+V+AAHC +K N W
Sbjct: 287 SSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWT 346
Query: 241 NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLC 300
+L + + G + V +VI Y T N+DIAL++L +P+ D V P+C
Sbjct: 347 AFAGILRQSFMFYGAGYQ----VEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVC 402
Query: 301 LPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPN 360
LP L + +SGWG ++G T+ L V + TQ C SR V D+
Sbjct: 403 LPNPGMM---LQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRC--NSRYVYDNL- 456
Query: 361 ITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQ 420
IT M CAG+ G+ DSC+GDSGGP T W+L G SWG GCA GVY V
Sbjct: 457 ITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMV 516
Query: 421 YIEWLQKLMRSE 432
+ +W+ + MR++
Sbjct: 517 FTDWIYRQMRAD 528
>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
sapiens]
Length = 492
Score = 159 bits (402), Expect = 5e-39
Identities = 96/252 (38%), Positives = 131/252 (51%), Gaps = 14/252 (5%)
Query: 185 SKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKN----WR 240
S Q RIVGG+ G PWQV L V +CGG++I W+V+AAHC +K N W
Sbjct: 250 SSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWT 309
Query: 241 NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLC 300
+L + + G + V +VI Y T N+DIAL++L +P+ D V P+C
Sbjct: 310 AFAGILRQSFMFYGAGYQ----VEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVC 365
Query: 301 LPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPN 360
LP L + +SGWG ++G T+ L V + TQ C SR V D+
Sbjct: 366 LPNPGMM---LQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRC--NSRYVYDNL- 419
Query: 361 ITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQ 420
IT M CAG+ G+ DSC+GDSGGP T W+L G SWG GCA GVY V
Sbjct: 420 ITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMV 479
Query: 421 YIEWLQKLMRSE 432
+ +W+ + MR++
Sbjct: 480 FTDWIYRQMRAD 491
>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
Length = 1059
Score = 158 bits (400), Expect = 8e-39
Identities = 95/264 (35%), Positives = 139/264 (52%), Gaps = 15/264 (5%)
Query: 173 CGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHC 232
CG P +EK R+VGG GE PWQV L CG T++ W++SAAHC
Sbjct: 492 CGARPAMEKPT------RVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHC 545
Query: 233 FDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVL 292
F+ K + A LG L G + +V++ Y PG + D+A+L L P+
Sbjct: 546 FNHTKV-EQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAF 604
Query: 293 TDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQS 352
++ P+CLP + + R ++SGWG + AT EL+ ++ Q ++
Sbjct: 605 NKYIQPVCLP---LAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQ----KT 657
Query: 353 RKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYR-GTWYLTGIVSWGQGCATVGH 411
V + ++T+ M CAG+ +G DSC+GDSGGP A G +YL GIVSWG GCA V
Sbjct: 658 CSVLYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKK 717
Query: 412 FGVYTRVSQYIEWLQKLMRSEPRP 435
GVYTR+++ W+ ++M S+P P
Sbjct: 718 PGVYTRITRLKGWILEIMSSQPLP 741
Score = 155 bits (391), Expect = 9e-38
Identities = 93/257 (36%), Positives = 128/257 (49%), Gaps = 8/257 (3%)
Query: 189 GRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGE 248
GRIVGG GE PWQ L N CG +IN W+VSAAHCF++ ++ +A +G
Sbjct: 201 GRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVGA 260
Query: 249 HDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSE 308
LS + +V Q++ Y T + D+A+L L P+ H+ P+CLP T
Sbjct: 261 TYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAAT--- 317
Query: 309 RTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCA 368
+ L+SGWG L + E++ L+ Q + G S +T+ M CA
Sbjct: 318 HIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC--ASLYGHS--LTDRMVCA 373
Query: 369 GYSDGSKDSCKGDSGGPHATHY-RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQK 427
GY DG DSC+GDSGGP G ++L GIVSWG GCA GVY RV++ +W+ +
Sbjct: 374 GYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWILE 433
Query: 428 LMRSEPRPGVLLRAPFP 444
P AP P
Sbjct: 434 ATTKASMPLAPTMAPAP 450
Score = 140 bits (352), Expect = 3e-33
Identities = 92/238 (38%), Positives = 123/238 (51%), Gaps = 12/238 (5%)
Query: 190 RIVGGKVCPKGECPWQVLLLVNGAQ-LCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGE 248
RIVGG +GE PWQV L + + CG L+ W++SAAHCFD + + A LG
Sbjct: 826 RIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGT 885
Query: 249 HDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSE 308
LS +G Q RVA++ Y T ++D+ALL L PV + V P+CLPE +
Sbjct: 886 PFLSGAEG--QLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEP--AP 941
Query: 309 RTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCA 368
R R +++GWG + + G+ A +L V L Q C + I+ M CA
Sbjct: 942 RPPDGTR-CVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFY-----PVQISSRMLCA 995
Query: 369 GYSDGSKDSCKGDSGGPHATHY-RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWL 425
G+ G DSC GD+GGP A G W LTG+ SWG GC GVYTRV+ W+
Sbjct: 996 GFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053
>gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]
Length = 247
Score = 154 bits (388), Expect = 2e-37
Identities = 93/238 (39%), Positives = 128/238 (53%), Gaps = 21/238 (8%)
Query: 190 RIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEH 249
+IVGG +C + P+QV L +G CGG+LI+ WVVSA HC+ R LGEH
Sbjct: 23 KIVGGYICEENSVPYQVSLN-SGYHFCGGSLISEQWVVSAGHCYKSRIQVR-----LGEH 76
Query: 250 DLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSER 309
++ +G+EQ A++I Y T ++DI L++L P V+ V + LP +
Sbjct: 77 NIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINSRVSAISLPTAPPAAG 136
Query: 310 TLAFVRFSLVSGWGQLLDRGATAL-ELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCA 368
T SL+SGWG L GA EL L+ P L +C + IT MFC
Sbjct: 137 TE-----SLISGWGNTLSSGADYPDELQCLDAPVLSQAEC-----EASYPGKITNNMFCV 186
Query: 369 GYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQ 426
G+ +G KDSC+GDSGGP ++ L GIVSWG GCA GVYT+V Y++W++
Sbjct: 187 GFLEGGKDSCQGDSGGPVVSNGE----LQGIVSWGYGCAQKNRPGVYTKVYNYVDWIK 240
>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
Length = 567
Score = 152 bits (384), Expect = 6e-37
Identities = 90/252 (35%), Positives = 130/252 (51%), Gaps = 18/252 (7%)
Query: 189 GRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCF-----DKIKNWRNLI 243
GRIVGG + + PWQV L +CGGTLI+ WV++AAHCF ++ W+
Sbjct: 324 GRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYA 383
Query: 244 AVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPE 303
H L E + +A++II S Y ++DIAL+RL +P+ L+ H+ P CLP
Sbjct: 384 GTSNLHQLPE------AASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLP- 436
Query: 304 RTFSERTLAFVRFSLVSGWGQLLDRG-ATALELMVLNVPRLMTQDCLQQSRKVGDSPNIT 362
+T + ++G+G+ + T+ L + V + + C V DS +T
Sbjct: 437 --MHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC--NDYLVYDS-YLT 491
Query: 363 EYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYI 422
M CAG G +DSC+GDSGGP WYL G+ SWG GC GVYT+V++ +
Sbjct: 492 PRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVL 551
Query: 423 EWLQKLMRSEPR 434
W+ M SE R
Sbjct: 552 PWIYSKMESEVR 563
>gi|4504383 HGF activator preproprotein [Homo sapiens]
Length = 655
Score = 152 bits (383), Expect = 8e-37
Identities = 130/469 (27%), Positives = 188/469 (40%), Gaps = 100/469 (21%)
Query: 53 RECKEEQCSFEEAREIFKDA------------ERTKLF----WISYSDGDQCASSPCQNG 96
++C E+C F+E R + + E+ + F W + C SSPC NG
Sbjct: 195 KDCGTEKC-FDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNG 253
Query: 97 GSCKDQLQS--YICFCLPAFEGRNCETHKDDQLICVNENG-------------------- 134
G+C + + +C C P F GR C D++ N G
Sbjct: 254 GTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSD 313
Query: 135 -------------------GCEQYCSDHTGTKR-------------------SCRCHEGY 156
G YC + +R +C
Sbjct: 314 LLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACESLTRV 373
Query: 157 SLLADGVSCTPTVEYP----CGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNG 212
L D ++ P P CG+ +KR +P RI+GG G PW + + G
Sbjct: 374 QLSPDLLATLPEPASPGRQACGRRH--KKRTFLRP--RIIGGSSSLPGSHPWLAAIYI-G 428
Query: 213 AQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTY 272
C G+L++T WVVSAAHCF ++ VLG+H + Q+ + + I + Y
Sbjct: 429 DSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLY 488
Query: 273 -VPGTTNHDIALLRLHQP----VVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLD 327
V ++HD+ L+RL + + V P+CLPE T ++GWG L +
Sbjct: 489 SVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPE---PGSTFPAGHKCQIAGWGHLDE 545
Query: 328 R-GATALELMVLNVPRLMTQDCLQQSRKVGD-SPNITEYMFCAGYSDGSKDSCKGDSGGP 385
+ L VP + C D SPN M CAGY D D+C+GDSGGP
Sbjct: 546 NVSGYSSSLREALVPLVADHKCSSPEVYGADISPN----MLCAGYFDCKSDACQGDSGGP 601
Query: 386 HATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPR 434
A G YL GI+SWG GC + GVYTRV+ Y++W+ +R R
Sbjct: 602 LACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRR 650
Score = 52.4 bits (124), Expect = 8e-07
Identities = 33/95 (34%), Positives = 43/95 (45%), Gaps = 13/95 (13%)
Query: 86 DQCASSPCQNGGSCKD--QLQSYICFCLPAFEGRNCETHKDDQLICVNEN-----GGCEQ 138
D CAS PC NGGSC + QSY C C AF G++C T K C +E G ++
Sbjct: 162 DPCASGPCLNGGSCSNTQDPQSYHCSCPRAFTGKDCGTEK-----CFDETRYEYLEGGDR 216
Query: 139 YCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPC 173
+ G C C G + +G T + PC
Sbjct: 217 WARVRQGHVEQCECFGGRT-WCEGTRHTACLSSPC 250
>gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]
Length = 304
Score = 149 bits (376), Expect = 5e-36
Identities = 92/238 (38%), Positives = 127/238 (53%), Gaps = 21/238 (8%)
Query: 190 RIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEH 249
+IVGG C + P+QV L +G+ CGG+LI+ WVVSAAHC+ R LGEH
Sbjct: 80 KIVGGYTCEENSLPYQVSLN-SGSHFCGGSLISEQWVVSAAHCYKTRIQVR-----LGEH 133
Query: 250 DLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSER 309
++ +G+EQ A++I Y T ++DI L++L P V+ V + LP +
Sbjct: 134 NIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPPAAG 193
Query: 310 TLAFVRFSLVSGWGQLLDRGATAL-ELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCA 368
T L+SGWG L GA EL L+ P L +C K IT MFC
Sbjct: 194 TEC-----LISGWGNTLSFGADYPDELKCLDAPVLTQAEC-----KASYPGKITNSMFCV 243
Query: 369 GYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQ 426
G+ +G KDSC+ DSGGP + + L G+VSWG GCA GVYT+V Y++W++
Sbjct: 244 GFLEGGKDSCQRDSGGPVVCNGQ----LQGVVSWGHGCAWKNRPGVYTKVYNYVDWIK 297
>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
Length = 247
Score = 149 bits (376), Expect = 5e-36
Identities = 92/238 (38%), Positives = 127/238 (53%), Gaps = 21/238 (8%)
Query: 190 RIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEH 249
+IVGG C + P+QV L +G+ CGG+LI+ WVVSAAHC+ R LGEH
Sbjct: 23 KIVGGYTCEENSLPYQVSLN-SGSHFCGGSLISEQWVVSAAHCYKTRIQVR-----LGEH 76
Query: 250 DLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSER 309
++ +G+EQ A++I Y T ++DI L++L P V+ V + LP +
Sbjct: 77 NIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPPAAG 136
Query: 310 TLAFVRFSLVSGWGQLLDRGATAL-ELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCA 368
T L+SGWG L GA EL L+ P L +C K IT MFC
Sbjct: 137 TEC-----LISGWGNTLSFGADYPDELKCLDAPVLTQAEC-----KASYPGKITNSMFCV 186
Query: 369 GYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQ 426
G+ +G KDSC+ DSGGP + + L G+VSWG GCA GVYT+V Y++W++
Sbjct: 187 GFLEGGKDSCQRDSGGPVVCNGQ----LQGVVSWGHGCAWKNRPGVYTKVYNYVDWIK 240
>gi|110578663 hypothetical protein LOC203074 [Homo sapiens]
Length = 352
Score = 149 bits (376), Expect = 5e-36
Identities = 95/274 (34%), Positives = 139/274 (50%), Gaps = 20/274 (7%)
Query: 167 PTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWV 226
P+ CG I E R RI GG GE PWQV + CGG+++N W+
Sbjct: 47 PSPVSECGDRSIFEGRTR---YSRITGGMEAEVGEFPWQVSIQARSEPFCGGSILNKWWI 103
Query: 227 VSAAHCFDKIKNW-RNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLR 285
++AAHC + + L VLG +DL+ + + VA +I+ + ++DIALL
Sbjct: 104 LTAAHCLYSEELFPEELSVVLGTNDLT--SPSMEIKEVASIILHKDFKRANMDNDIALLL 161
Query: 286 LHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQ--LLDRGATALELMVLNVPRL 343
L P+ L D VP+CLP ++ A R V+GWGQ D+ + +LM + +
Sbjct: 162 LASPIKLDDLKVPICLP----TQPGPATWRECWVAGWGQTNAADKNSVKTDLMKAPMVIM 217
Query: 344 MTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGP-HATHYRG-TWYLTGIVS 401
++C + P +T+ M CAGY + S D+CKGDSGGP T G WY GI+S
Sbjct: 218 DWEECSKM------FPKLTKNMLCAGYKNESYDACKGDSGGPLVCTPEPGEKWYQVGIIS 271
Query: 402 WGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRP 435
WG+ C G+YT + Y W++K+ + E RP
Sbjct: 272 WGKSCGEKNTPGIYTSLVNYNLWIEKVTQLEGRP 305
>gi|4505881 plasminogen [Homo sapiens]
Length = 810
Score = 149 bits (375), Expect = 7e-36
Identities = 92/264 (34%), Positives = 132/264 (50%), Gaps = 22/264 (8%)
Query: 171 YPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVN-GAQLCGGTLINTIWVVSA 229
+ CGK + K K GR+VGG V PWQV L G CGGTLI+ WV++A
Sbjct: 565 FDCGKPQVEPK----KCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTA 620
Query: 230 AHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQP 289
AHC +K + +LG H + Q V+++ + T DIALL+L P
Sbjct: 621 AHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPT------RKDIALLKLSSP 674
Query: 290 VVLTDHVVPLCLPERTF--SERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQD 347
V+TD V+P CLP + ++RT F+ +GWG+ L L +P + +
Sbjct: 675 AVITDKVIPACLPSPNYVVADRTECFI-----TGWGETQGTFGAGL-LKEAQLPVIENKV 728
Query: 348 CLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCA 407
C + G + CAG+ G DSC+GDSGGP + + L G+ SWG GCA
Sbjct: 729 CNRYEFLNG---RVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCA 785
Query: 408 TVGHFGVYTRVSQYIEWLQKLMRS 431
GVY RVS+++ W++ +MR+
Sbjct: 786 RPNKPGVYVRVSRFVTWIEGVMRN 809
>gi|4503635 coagulation factor II preproprotein [Homo sapiens]
Length = 622
Score = 149 bits (375), Expect = 7e-36
Identities = 99/291 (34%), Positives = 153/291 (52%), Gaps = 37/291 (12%)
Query: 170 EYPCGKIPILEKRNA----------SKPQGRIVGGKVCPKGECPWQVLLLVNGAQ--LCG 217
E CG P+ EK++ S GRIV G G PWQV+L Q LCG
Sbjct: 333 EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCG 392
Query: 218 GTLINTIWVVSAAHC-----FDKIKNWRNLIAVLGEHDLSEHDGD-EQSRRVAQVIIPST 271
+LI+ WV++AAHC +DK +L+ +G+H + ++ + E+ + ++ I
Sbjct: 393 ASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPR 452
Query: 272 YV-PGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLD--- 327
Y + DIAL++L +PV +D++ P+CLP+R + L V+GWG L +
Sbjct: 453 YNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWT 512
Query: 328 ----RGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYS--DGSK-DSCKG 380
+G ++ L V+N+P + C +R IT+ MFCAGY +G + D+C+G
Sbjct: 513 ANVGKGQPSV-LQVVNLPIVERPVCKDSTRI-----RITDNMFCAGYKPDEGKRGDACEG 566
Query: 381 DSGGPHA--THYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLM 429
DSGGP + + WY GIVSWG+GC G +G YT V + +W+QK++
Sbjct: 567 DSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI 617
Score = 73.2 bits (178), Expect = 5e-13
Identities = 38/79 (48%), Positives = 50/79 (63%), Gaps = 4/79 (5%)
Query: 5 ALRLLCLLLGLQGCLAAVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEE 64
AL LC L+ Q VF+ ++A +L R RRAN FLEE+R G+LEREC EE CS+EE
Sbjct: 14 ALAALCSLVHSQH----VFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEE 69
Query: 65 AREIFKDAERTKLFWISYS 83
A E + + T +FW Y+
Sbjct: 70 AFEALESSTATDVFWAKYT 88
>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
sapiens]
Length = 418
Score = 148 bits (374), Expect = 9e-36
Identities = 91/259 (35%), Positives = 132/259 (50%), Gaps = 17/259 (6%)
Query: 168 TVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVV 227
TV+ CGK + N RI G + PK PWQ L + CG TLI+ W+V
Sbjct: 170 TVQASCGKRVVPLNVN------RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLV 223
Query: 228 SAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLH 287
+AAHCF K KN G ++ + R V + II Y +DIA++++
Sbjct: 224 TAAHCFQKYKNPHQWTVSFG----TKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVS 279
Query: 288 QPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQD 347
V +D + +CLPE + S + V ++G+G L G + +L V ++++ D
Sbjct: 280 SRVTFSDDIRQICLPEASASFQPNLTVH---ITGFGALYYGGESQNDLREARV-KIISDD 335
Query: 348 CLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATH-YRGTWYLTGIVSWGQGC 406
+Q + G+ +I MFCAGY +G D+C+GDSGGP T + TWYL GIVSWG C
Sbjct: 336 VCKQPQVYGN--DIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNC 393
Query: 407 ATVGHFGVYTRVSQYIEWL 425
GVYT+V+ Y W+
Sbjct: 394 GQKDKPGVYTQVTYYRNWI 412
>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
sapiens]
Length = 421
Score = 148 bits (374), Expect = 9e-36
Identities = 91/259 (35%), Positives = 132/259 (50%), Gaps = 17/259 (6%)
Query: 168 TVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVV 227
TV+ CGK + N RI G + PK PWQ L + CG TLI+ W+V
Sbjct: 173 TVQASCGKRVVPLNVN------RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLV 226
Query: 228 SAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLH 287
+AAHCF K KN G ++ + R V + II Y +DIA++++
Sbjct: 227 TAAHCFQKYKNPHQWTVSFG----TKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVS 282
Query: 288 QPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQD 347
V +D + +CLPE + S + V ++G+G L G + +L V ++++ D
Sbjct: 283 SRVTFSDDIRQICLPEASASFQPNLTVH---ITGFGALYYGGESQNDLREARV-KIISDD 338
Query: 348 CLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATH-YRGTWYLTGIVSWGQGC 406
+Q + G+ +I MFCAGY +G D+C+GDSGGP T + TWYL GIVSWG C
Sbjct: 339 VCKQPQVYGN--DIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNC 396
Query: 407 ATVGHFGVYTRVSQYIEWL 425
GVYT+V+ Y W+
Sbjct: 397 GQKDKPGVYTQVTYYRNWI 415
>gi|13994276 marapsin [Homo sapiens]
Length = 290
Score = 148 bits (373), Expect = 1e-35
Identities = 86/246 (34%), Positives = 125/246 (50%), Gaps = 9/246 (3%)
Query: 190 RIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEH 249
R+VGG+ +GE PWQV + NG+ CGG+LI WV++AAHCF +LG
Sbjct: 34 RMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSETSLYQVLLGAR 93
Query: 250 DLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSER 309
L + RV QV Y ++ D+AL+ L PV T++++P+CLP+ +
Sbjct: 94 QLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPVCLPDPSVIFE 153
Query: 310 TLAFVRFSLVSGWGQLLDRGATALE--LMVLNVPRLMTQDC---LQQSRKVGDSP-NITE 363
T V+GWG + L L VP + T C + + G P I
Sbjct: 154 T---GMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIKN 210
Query: 364 YMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIE 423
M CAG+ +G KD+CKGDSGGP +W G++SWG+GCA GVY RV+ +
Sbjct: 211 DMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQNRPGVYIRVTAHHN 270
Query: 424 WLQKLM 429
W+ +++
Sbjct: 271 WIHRII 276
>gi|11545839 protease, serine, 22 [Homo sapiens]
Length = 317
Score = 147 bits (371), Expect = 2e-35
Identities = 99/269 (36%), Positives = 134/269 (49%), Gaps = 16/269 (5%)
Query: 186 KPQ--GRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLI 243
KPQ R+VGG+ E PW V + NG C G+L+ + WV++AAHCF N L
Sbjct: 43 KPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLF 102
Query: 244 AVL-GEHDLSEHDGDEQSRRVAQVIIPSTYV-PGTTNHDIALLRLHQPVVLTDHVVPLCL 301
+VL G L Q VA V Y DIAL+RL + + ++ V+P+CL
Sbjct: 103 SVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICL 162
Query: 302 PERTFSERTLAFVRFSLVSGWGQLLDRGATA--LELMVLNVPRLMTQDCLQQS-RKVGDS 358
P+ + L +SGWG + D L L VP + ++ C R G
Sbjct: 163 PDASIH---LPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQG 219
Query: 359 PNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRV 418
P ITE M CAGY +G +D+C GDSGGP G W L GI+SWG+GCA GVY +
Sbjct: 220 P-ITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISL 278
Query: 419 SQYIEWLQKL-----MRSEPRPGVLLRAP 442
S + W++K+ +R + G LRAP
Sbjct: 279 SAHRSWVEKIVQGVQLRGRAQGGGALRAP 307
>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
Length = 418
Score = 147 bits (370), Expect = 2e-35
Identities = 88/239 (36%), Positives = 123/239 (51%), Gaps = 11/239 (4%)
Query: 190 RIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEH 249
RI+GG +G PWQV L +N A CGG+LIN +W+++AAHCF N R+ IA G
Sbjct: 186 RILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSG-- 243
Query: 250 DLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSER 309
+ RV ++I + Y T +DIAL+RL V T + +CLP T +
Sbjct: 244 --ISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAAT---Q 298
Query: 310 TLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAG 369
+ + V+GWG G T EL V R+++ D + I M CAG
Sbjct: 299 NIPPGSTAYVTGWGAQEYAGHTVPELRQGQV-RIISNDVCNAPHSYNGA--ILSGMLCAG 355
Query: 370 YSDGSKDSCKGDSGGPHATH-YRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQK 427
G D+C+GDSGGP R W++ GIVSWG C GVYTRV+ Y++W+++
Sbjct: 356 VPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQ 414
>gi|33695155 hepsin [Homo sapiens]
Length = 417
Score = 146 bits (369), Expect = 3e-35
Identities = 94/262 (35%), Positives = 134/262 (51%), Gaps = 31/262 (11%)
Query: 187 PQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDK----IKNWR-- 240
P RIVGG+ G PWQV L +GA LCGG+L++ WV++AAHCF + + WR
Sbjct: 159 PVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVF 218
Query: 241 -NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVP------GTTNHDIALLRLHQPVVLT 293
+A H L V V+ Y+P ++DIAL+ L P+ LT
Sbjct: 219 AGAVAQASPHGL--------QLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270
Query: 294 DHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSR 353
+++ P+CLP + + L + V+GWG G A L VP +++ D +
Sbjct: 271 EYIQPVCLPA---AGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVP-IISNDVCNGAD 326
Query: 354 KVGDSPNITEYMFCAGYSDGSKDSCKGDSGGP----HATHYRGTWYLTGIVSWGQGCATV 409
G+ I MFCAGY +G D+C+GDSGGP + W L GIVSWG GCA
Sbjct: 327 FYGN--QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALA 384
Query: 410 GHFGVYTRVSQYIEWLQKLMRS 431
GVYT+VS + EW+ + +++
Sbjct: 385 QKPGVYTKVSDFREWIFQAIKT 406
>gi|4504481 hepsin [Homo sapiens]
Length = 417
Score = 146 bits (369), Expect = 3e-35
Identities = 94/262 (35%), Positives = 134/262 (51%), Gaps = 31/262 (11%)
Query: 187 PQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDK----IKNWR-- 240
P RIVGG+ G PWQV L +GA LCGG+L++ WV++AAHCF + + WR
Sbjct: 159 PVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVF 218
Query: 241 -NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVP------GTTNHDIALLRLHQPVVLT 293
+A H L V V+ Y+P ++DIAL+ L P+ LT
Sbjct: 219 AGAVAQASPHGL--------QLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270
Query: 294 DHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSR 353
+++ P+CLP + + L + V+GWG G A L VP +++ D +
Sbjct: 271 EYIQPVCLPA---AGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVP-IISNDVCNGAD 326
Query: 354 KVGDSPNITEYMFCAGYSDGSKDSCKGDSGGP----HATHYRGTWYLTGIVSWGQGCATV 409
G+ I MFCAGY +G D+C+GDSGGP + W L GIVSWG GCA
Sbjct: 327 FYGN--QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALA 384
Query: 410 GHFGVYTRVSQYIEWLQKLMRS 431
GVYT+VS + EW+ + +++
Sbjct: 385 QKPGVYTKVSDFREWIFQAIKT 406
>gi|58218970 protease, serine, 36 [Homo sapiens]
Length = 855
Score = 146 bits (369), Expect = 3e-35
Identities = 102/288 (35%), Positives = 137/288 (47%), Gaps = 35/288 (12%)
Query: 166 TPTVEYP----CGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLI 221
+PT E P CG+ +P RIVGG G PWQV L G +CGG+LI
Sbjct: 27 SPTQEEPEDLDCGR---------PEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLI 77
Query: 222 NTIWVVSAAHCF------DKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPG 275
WV+SAAHCF + W L LG H +R VA +++P+ Y
Sbjct: 78 APSWVLSAAHCFMTNGTLEPAAEWSVL---LGVHSQDGPLDGAHTRAVAAIVVPANYSQV 134
Query: 276 TTNHDIALLRLHQPVVLTDHVVPLCLPERT--FSERTLAFVRFSLVSGWGQLLDRGATAL 333
D+ALLRL P L V P+CLP + F T + +GWG + + L
Sbjct: 135 ELGADLALLRLASPASLGPAVWPVCLPRASHRFVHGTACWA-----TGWGDVQEADPLPL 189
Query: 334 ELMVLNVP-RLM---TQDCL-QQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHAT 388
++ V RL+ T CL Q + I M CAGY +G +D+C+GDSGGP
Sbjct: 190 PWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVC 249
Query: 389 HYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWL-QKLMRSEPRP 435
G W+ GI S+G GC GV+T V+ Y W+ +++M SEP P
Sbjct: 250 EEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIREQVMGSEPGP 297
Score = 57.4 bits (137), Expect = 3e-08
Identities = 63/232 (27%), Positives = 92/232 (39%), Gaps = 42/232 (18%)
Query: 194 GKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCF----------DKIKNWRNLI 243
GK G PW+ ++V G++ C G L++ WV++ A CF + WR L+
Sbjct: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385
Query: 244 AVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPE 303
++ RVA+ ++ D+ALL+L PV L+ P+CLP
Sbjct: 386 -----------PSRPRAERVAR-LVQHENASWDNASDLALLQLRTPVNLSAASRPVCLPH 433
Query: 304 RTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQ---DCL--QQSRKV--- 355
E ++ WG RG AL L L+ CL +Q V
Sbjct: 434 ---PEHYFLPGSRCRLARWG----RGEPALGPGALLEAELLGGWWCHCLYGRQGAAVPLP 486
Query: 356 GDSPNITEYMFCAGYSDGSK-DSCKGDSGGPHATHYRGTWYLTGIVSWGQGC 406
GD P + C Y + + SC DS GTW+L GI + GC
Sbjct: 487 GDPP----HALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGC 534
Score = 45.8 bits (107), Expect = 8e-05
Identities = 54/205 (26%), Positives = 82/205 (40%), Gaps = 22/205 (10%)
Query: 203 PWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR--NLIAVLGEHDLSE-HDGDEQ 259
PW + V G ++C G L+ WV++A HC + + + LG S G +
Sbjct: 602 PWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQV 661
Query: 260 SRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLV 319
SR V + +P +ALL L V + +P+CL + V
Sbjct: 662 SRLVISIRLPQHL---GLRPPLALLELSSRVEPSPSALPICLHPAGIPPGASCW-----V 713
Query: 320 SGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCK 379
GW + DR A + +L R+ DCL Q G P T C Y++G ++ C+
Sbjct: 714 LGWKEPQDRVPVAAAVSIL-TQRIC--DCLYQ----GILPPGT---LCVLYAEGQENRCE 763
Query: 380 GDSGGPHATHY-RGTWYLTGIVSWG 403
S P G+W L G+ G
Sbjct: 764 MTSAPPLLCQMTEGSWILVGMAVQG 788
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.446
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,336,614
Number of Sequences: 37866
Number of extensions: 941837
Number of successful extensions: 3956
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 282
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 2011
Number of HSP's gapped (non-prelim): 1299
length of query: 444
length of database: 18,247,518
effective HSP length: 105
effective length of query: 339
effective length of database: 14,271,588
effective search space: 4838068332
effective search space used: 4838068332
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.