Search of human proteins with 104876423

Search of human proteins with 104876423

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|104876423 heparan sulfate D-glucosaminyl
3-O-sulfotransferase 4 [Homo sapiens]
         (456 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|104876423 heparan sulfate D-glucosaminyl 3-O-sulfotransferase...   944   0.0  
gi|5174467 heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3...   446   e-125
gi|5174463 heparan sulfate D-glucosaminyl  3-O-sulfotransferase ...   446   e-125
gi|5174465 heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3...   440   e-123
gi|116089312 heparan sulfate (glucosamine) 3-O-sulfotransferase ...   402   e-112
gi|45267824 heparan sulfate (glucosamine) 3-O-sulfotransferase 5...   248   6e-66
gi|4826764 heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1...   232   6e-61
gi|4758766 N-deacetylase/N-sulfotransferase (heparan glucosaminy...   131   1e-30
gi|12007650 heparan sulfate N-deacetylase/N-sulfotransferase 4 [...   126   5e-29
gi|4505353 heparan glucosaminyl N-deacetylase/N-sulfotransferase...   123   3e-28
gi|4505351 N-deacetylase/N-sulfotransferase (heparan glucosaminy...   118   1e-26
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]                     72   1e-12
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]                     72   1e-12
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...    70   5e-12
gi|47132519 Ras association and pleckstrin homology domains 1 is...    69   1e-11
gi|11386183 WAS protein family, member 2 [Homo sapiens]                67   3e-11
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap...    65   1e-10
gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]                 64   4e-10
gi|39812378 RAN binding protein 9 [Homo sapiens]                       62   1e-09
gi|7706501 WW domain binding protein 11 [Homo sapiens]                 62   1e-09
gi|42544125 splicing factor 1 isoform 2 [Homo sapiens]                 61   2e-09
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]             60   3e-09
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ...    59   9e-09
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...    58   2e-08
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...    58   2e-08
gi|33356148 formin-like 1 [Homo sapiens]                               58   2e-08
gi|222418647 mucin 7, secreted precursor [Homo sapiens]                58   2e-08
gi|222418649 mucin 7, secreted precursor [Homo sapiens]                58   2e-08
gi|222418645 mucin 7, secreted precursor [Homo sapiens]                58   2e-08
gi|42544123 splicing factor 1 isoform 3 [Homo sapiens]                 58   2e-08

>gi|104876423 heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4
           [Homo sapiens]
          Length = 456

 Score =  944 bits (2440), Expect = 0.0
 Identities = 456/456 (100%), Positives = 456/456 (100%)

Query: 1   MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQ 60
           MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQ
Sbjct: 1   MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQ 60

Query: 61  FPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAA 120
           FPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAA
Sbjct: 61  FPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAA 120

Query: 121 PGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGS 180
           PGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGS
Sbjct: 121 PGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGS 180

Query: 181 SERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKG 240
           SERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKG
Sbjct: 181 SERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKG 240

Query: 241 LEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQ 300
           LEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQ
Sbjct: 241 LEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQ 300

Query: 301 TLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERL 360
           TLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERL
Sbjct: 301 TLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERL 360

Query: 361 IVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRI 420
           IVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRI
Sbjct: 361 IVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRI 420

Query: 421 DPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK 456
           DPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK
Sbjct: 421 DPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK 456


>gi|5174467 heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1
           [Homo sapiens]
          Length = 390

 Score =  446 bits (1147), Expect = e-125
 Identities = 240/443 (54%), Positives = 287/443 (64%), Gaps = 72/443 (16%)

Query: 8   PPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLALQE 67
           P PPPPPPP+               RKL  +  +     Y+      GS +    L L  
Sbjct: 20  PQPPPPPPPVR--------------RKLALLFAMLCVWLYMFLYSCAGSCAAAPGLLLLG 65

Query: 68  SPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAPGTDGWG 127
           S   AA  PP+                        L  A  G PP  P + A P T    
Sbjct: 66  SGSRAAHDPPA------------------------LATAPDGTPPRLPFR-APPAT---- 96

Query: 128 LPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGSSERGGAV 187
                          PLA  + +   +A PE ++ E   +   ++   + +GS       
Sbjct: 97  ---------------PLASGKEMAEGAASPEEQSPEVPDSPSPISSFFSGSGS------- 134

Query: 188 STPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKGLEWYRNV 247
                  K+LPQA+IIGVKKGGTRALLE +RVHPDVRAVG EPHFFDR+Y+KGL WYR++
Sbjct: 135 -------KQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKGLAWYRDL 187

Query: 248 MPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQTLSKKPE 307
           MP+TLDGQITMEKTPSYFVT EAP RI +M+KD KLIVVVR+PVTRAISDYTQTLSK+P+
Sbjct: 188 MPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPD 247

Query: 308 IPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERLIVDPAGE 367
           IPTFE L FKNRT GLID SWSAI+IGIYA HLE+WL++FP+ Q+LFVSGERLI DPAGE
Sbjct: 248 IPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLRHFPIRQMLFVSGERLISDPAGE 307

Query: 368 MAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRIDPDVIHR 427
           + +VQDFLGLKR++T+KHFYFNKTKGFPCLKK E SS P CLGK+KGRTHP ID +V+ R
Sbjct: 308 LGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSRPHCLGKTKGRTHPEIDREVVRR 367

Query: 428 LRKFYKPFNLMFYQMTGQDFQWE 450
           LR+FY+PFNL FYQMTG DF W+
Sbjct: 368 LREFYRPFNLKFYQMTGHDFGWD 390


>gi|5174463 heparan sulfate D-glucosaminyl  3-O-sulfotransferase 2
           [Homo sapiens]
          Length = 367

 Score =  446 bits (1146), Expect = e-125
 Identities = 241/432 (55%), Positives = 288/432 (66%), Gaps = 84/432 (19%)

Query: 29  GPP----ARKLLFMCTLSLSVTYLCYSLL------GGSGSLQFPLALQESPGAAAEPPPS 78
           GPP    AR+LLF  TLSLS TYLCYS L      G S  L  P  L+  P A  +    
Sbjct: 10  GPPQPRRARRLLFAFTLSLSCTYLCYSFLCCCDDLGRSRLLGAPRCLR-GPSAGGQ---- 64

Query: 79  PPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAPGTDGWGLPSGGGGAQDA 138
                      +L   S+P  P        G  P  P  P+AP                 
Sbjct: 65  -----------KLLQKSRPCDPS-------GPTPSEPSAPSAPA---------------- 90

Query: 139 WLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGSSERGGAVSTPDYGEKKLP 198
                          +A+P                    +GS+  G    +P  G K+LP
Sbjct: 91  ---------------AAVPAPRL----------------SGSNHSG----SPKLGTKRLP 115

Query: 199 QALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKGLEWYRNVMPKTLDGQITM 258
           QALI+GVKKGGTRA+LE IRVHPDVRA+G EPHFFDRNY +GL+WYR++MP+TL+ QIT+
Sbjct: 116 QALIVGVKKGGTRAVLEFIRVHPDVRALGTEPHFFDRNYGRGLDWYRSLMPRTLESQITL 175

Query: 259 EKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQTLSKKPEIPTFEVLAFKN 318
           EKTPSYFVT EAP+RI +M++D KLIVVVRNPVTRAISDYTQTLSKKP+IPTFE L+F+N
Sbjct: 176 EKTPSYFVTQEAPRRIFNMSRDTKLIVVVRNPVTRAISDYTQTLSKKPDIPTFEGLSFRN 235

Query: 319 RTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLK 378
           RTLGL+D SW+AIRIG+Y LHLE+WLQYFPL+QI FVSGERLI DPAGEM +VQDFLG+K
Sbjct: 236 RTLGLVDVSWNAIRIGMYVLHLESWLQYFPLAQIHFVSGERLITDPAGEMGRVQDFLGIK 295

Query: 379 RVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNLM 438
           R +T+KHFYFNKTKGFPCLKK E S  PRCLGKSKGRTH +IDP+VI +LR+FY+P+N+ 
Sbjct: 296 RFITDKHFYFNKTKGFPCLKKTESSLLPRCLGKSKGRTHVQIDPEVIDQLREFYRPYNIK 355

Query: 439 FYQMTGQDFQWE 450
           FY+  GQDF+WE
Sbjct: 356 FYETVGQDFRWE 367


>gi|5174465 heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1
           [Homo sapiens]
          Length = 406

 Score =  440 bits (1131), Expect = e-123
 Identities = 222/347 (63%), Positives = 260/347 (74%), Gaps = 23/347 (6%)

Query: 122 GTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPE---------REAQESSTTDEDLA 172
           G  G G+ +GG      W   P A       Q  LP+         R+  E +  +E+  
Sbjct: 64  GAPGGGVLAGGPRELAVW---PAAAQRKRLLQ--LPQWRRRRPPAPRDDGEEAAWEEESP 118

Query: 173 GRRAANGSSERGGAVSTP---------DYGEKKLPQALIIGVKKGGTRALLEAIRVHPDV 223
           G     G S  G  V+           D G K+LPQA+IIGVKKGGTRALLE +RVHPDV
Sbjct: 119 GLSGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDV 178

Query: 224 RAVGVEPHFFDRNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKL 283
           RAVG EPHFFDR+Y+KGL WYR++MP+TLDGQITMEKTPSYFVT EAP RI +M+KD KL
Sbjct: 179 RAVGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKL 238

Query: 284 IVVVRNPVTRAISDYTQTLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENW 343
           IVVVR+PVTRAISDYTQTLSK+P+IPTFE L FKNRT GLID SWSAI+IGIYA HLE+W
Sbjct: 239 IVVVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHW 298

Query: 344 LQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDS 403
           L++FP+ Q+LFVSGERLI DPAGE+ +VQDFLGLKR++T+KHFYFNKTKGFPCLKK E S
Sbjct: 299 LRHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGS 358

Query: 404 SAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQWE 450
           S P CLGK+KGRTHP ID +V+ RLR+FY+PFNL FYQMTG DF W+
Sbjct: 359 SRPHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWD 405


>gi|116089312 heparan sulfate (glucosamine) 3-O-sulfotransferase 6
           [Homo sapiens]
          Length = 311

 Score =  402 bits (1033), Expect = e-112
 Identities = 191/275 (69%), Positives = 227/275 (82%), Gaps = 4/275 (1%)

Query: 178 NGSSERGGAVSTP---DYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFD 234
           + S  R GA   P     G ++ PQALI+GVKKGGTRALLE +R+HPDVRA+G EPHFFD
Sbjct: 37  SSSVHRPGAPGLPLASGPGRRRFPQALIVGVKKGGTRALLEFLRLHPDVRALGSEPHFFD 96

Query: 235 RNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRA 294
           R YE+GL WYR++MP+TLDGQITMEKTPSYFVT EAP+RIH+M+ D KLIVVVRNPVTRA
Sbjct: 97  RCYERGLAWYRSLMPRTLDGQITMEKTPSYFVTREAPRRIHAMSPDTKLIVVVRNPVTRA 156

Query: 295 ISDYTQTLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILF 354
           ISDY QTLSK P +P+F  LAF++  LG +D +WSA+RIG+YA HL++WL+YFPLS  LF
Sbjct: 157 ISDYAQTLSKTPGLPSFRALAFRHG-LGPVDTAWSAVRIGLYAQHLDHWLRYFPLSHFLF 215

Query: 355 VSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKG 414
           VSGERL+ DPAGE+ +VQDFLGLKRVVT+KHFYFN TKGFPCLKK +  S PRCLGKSKG
Sbjct: 216 VSGERLVSDPAGEVGRVQDFLGLKRVVTDKHFYFNATKGFPCLKKAQGGSRPRCLGKSKG 275

Query: 415 RTHPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQW 449
           R HPR+   ++ RL++FY+PFN  FYQMTGQDF W
Sbjct: 276 RPHPRVPQALVRRLQEFYRPFNRRFYQMTGQDFGW 310


>gi|45267824 heparan sulfate (glucosamine) 3-O-sulfotransferase 5
           [Homo sapiens]
          Length = 346

 Score =  248 bits (634), Expect = 6e-66
 Identities = 127/261 (48%), Positives = 168/261 (64%), Gaps = 9/261 (3%)

Query: 195 KKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDR--NYEKGLEWYRNVMPKTL 252
           ++LP+A+IIGV+KGGTRALLE + +HP V     E HFFD   NY KG+EWYR  MP + 
Sbjct: 88  QQLPKAIIIGVRKGGTRALLEMLNLHPAVVKASQEIHFFDNDENYGKGIEWYRKKMPFSY 147

Query: 253 DGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQTLS----KKPEI 308
             QIT+EK+P+YF+T E P+RI+ M   IKL+++VR P TRAISDYTQ L     K    
Sbjct: 148 PQQITIEKSPAYFITEEVPERIYKMNSSIKLLIIVREPTTRAISDYTQVLEGKERKNKTY 207

Query: 309 PTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERLIVDPAGEM 368
             FE LA    T   ++  + A+R  IY  HLE WL+YFP+ Q   V G+RLI +P  E+
Sbjct: 208 YKFEKLAIDPNTCE-VNTKYKAVRTSIYTKHLERWLKYFPIEQFHVVDGDRLITEPLPEL 266

Query: 369 AKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRIDPDVIHRL 428
             V+ FL L   +++ + YFN T+GF CL+   +    +CL  SKGR HP +DP VI +L
Sbjct: 267 QLVEKFLNLPPRISQYNLYFNATRGFYCLR--FNIIFNKCLAGSKGRIHPEVDPSVITKL 324

Query: 429 RKFYKPFNLMFYQMTGQDFQW 449
           RKF+ PFN  FYQ+TG+   W
Sbjct: 325 RKFFHPFNQKFYQITGRTLNW 345


>gi|4826764 heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1
           precursor [Homo sapiens]
          Length = 307

 Score =  232 bits (591), Expect = 6e-61
 Identities = 118/294 (40%), Positives = 182/294 (61%), Gaps = 25/294 (8%)

Query: 162 QESSTTDEDLAGRRAANGSSERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHP 221
           +++ T  +D+    A NGS+++             LPQ +IIGV+KGGTRALLE + +HP
Sbjct: 32  RKAGTLQDDVRDGVAPNGSAQQ-------------LPQTIIIGVRKGGTRALLEMLSLHP 78

Query: 222 DVRAVGVEPHFFD--RNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAK 279
           DV A   E HFFD   +Y  GL WY + MP +   Q+T+EKTP+YF + + P+R++SM  
Sbjct: 79  DVAAAENEVHFFDWEEHYSHGLGWYLSQMPFSWPHQLTVEKTPAYFTSPKVPERVYSMNP 138

Query: 280 DIKLIVVVRNPVTRAISDYTQT----LSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGI 335
            I+L++++R+P  R +SDYTQ     + K    P+ E    ++   G ++  + A+   +
Sbjct: 139 SIRLLLILRDPSERVLSDYTQVFYNHMQKHKPYPSIEEFLVRD---GRLNVDYKALNRSL 195

Query: 336 YALHLENWLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFP 395
           Y +H++NWL++FPL  I  V G+RLI DP  E+ KV+ FL L   +   +FYFNKTKGF 
Sbjct: 196 YHVHMQNWLRFFPLRHIHIVDGDRLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFY 255

Query: 396 CLKKPEDSSAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQW 449
           CL+   DS   RCL +SKGR HP++DP ++++L +++   N  F+++ G+ F W
Sbjct: 256 CLR---DSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELVGRTFDW 306


>gi|4758766 N-deacetylase/N-sulfotransferase (heparan glucosaminyl)
           3 [Homo sapiens]
          Length = 873

 Score =  131 bits (330), Expect = 1e-30
 Identities = 88/257 (34%), Positives = 133/257 (51%), Gaps = 17/257 (6%)

Query: 196 KLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEP------HFFDRN-YEKGLEWYRNV- 247
           +LP+ L+IG +K GT AL   + +HP + +    P       FF+RN Y +G++WY +  
Sbjct: 594 RLPKFLVIGPQKTGTTALYLFLVMHPSILSNSPSPKTFEEVQFFNRNNYHRGIDWYMDFF 653

Query: 248 -MPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQTLSKKP 306
            +P  +      EK+ +YF + EAPKR  S+    K+I ++ +P  RA S Y    S + 
Sbjct: 654 PVPSNVTTDFLFEKSANYFHSEEAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHED 713

Query: 307 ----EIPTFEVLAFKNRTLGLIDASWSAIRI-GIYALHLENWLQYFPLSQILFVSGERLI 361
               +   +EV++   R    + A      + G YA H+E WL YFP  Q+L + G++L 
Sbjct: 714 PAALKFSFYEVISAGPRAPSELRALQKRCLVPGWYASHIERWLVYFPPFQLLIIDGQQLR 773

Query: 362 VDPAGEMAKVQDFLG-LKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRI 420
            DPA  M +VQ FLG L      +   F+  KGF C    E  +  +CLGKSKGR +P +
Sbjct: 774 TDPATVMDEVQKFLGVLPHYNYSEALTFDSHKGFWCQLLEEGKT--KCLGKSKGRKYPPM 831

Query: 421 DPDVIHRLRKFYKPFNL 437
           D D    L  +Y+  N+
Sbjct: 832 DSDSRTFLSSYYRDHNV 848


>gi|12007650 heparan sulfate N-deacetylase/N-sulfotransferase 4
           [Homo sapiens]
          Length = 872

 Score =  126 bits (316), Expect = 5e-29
 Identities = 86/260 (33%), Positives = 131/260 (50%), Gaps = 25/260 (9%)

Query: 197 LPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDR-------NYEKGLEWYRNVMP 249
           LP+ L+IG +K GT AL   + +HP + +    P  F+        NY KG++WY +  P
Sbjct: 594 LPKFLVIGPQKTGTTALYLFLLMHPSIISNLPSPKTFEEVQFFNGNNYHKGIDWYMDFFP 653

Query: 250 --KTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQTLSKKPE 307
                      EK+ +YF + EAP+R  S+    K+I ++ +P  RA S Y    S +  
Sbjct: 654 TPSNTTSDFLFEKSANYFHSEEAPRRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDP 713

Query: 308 IPT----FEVLAFKN-RTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERLIV 362
                  +EV++  +     L       +  G YA+H+E WL YF  SQ+L + G++L  
Sbjct: 714 AALRFNFYEVISTGHWAPSDLKTLQRRCLVPGWYAVHIERWLTYFATSQLLIIDGQQLRS 773

Query: 363 DPAGEMAKVQDFLGLKRVVTEKHFY-----FNKTKGFPCLKKPEDSSAPRCLGKSKGRTH 417
           DPA  M +VQ FLG    VT ++ Y     F+  KGF C  +  +    +CLGKSKGR +
Sbjct: 774 DPATVMDEVQKFLG----VTPRYNYSEALTFDPQKGFWC--QLLEGGKTKCLGKSKGRKY 827

Query: 418 PRIDPDVIHRLRKFYKPFNL 437
           P +DP+    L  +Y+  N+
Sbjct: 828 PPMDPESRTFLSNYYRDHNV 847


>gi|4505353 heparan glucosaminyl N-deacetylase/N-sulfotransferase 2
           [Homo sapiens]
          Length = 883

 Score =  123 bits (309), Expect = 3e-28
 Identities = 83/277 (29%), Positives = 136/277 (49%), Gaps = 21/277 (7%)

Query: 196 KLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDR-------NYEKGLEWYRNV- 247
           +LP+ LI+G +K GT A+   + +HP V +    P  F+        NY KG++WY +  
Sbjct: 602 RLPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQFFNSPNYHKGIDWYMDFF 661

Query: 248 -MPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQTLSKKP 306
            +P         EK+ +YF +   P+R  ++    K+I V+ NP  RA S Y    +   
Sbjct: 662 PVPSNASTDFLFEKSATYFDSEVVPRRGAALLPRAKIITVLTNPADRAYSWYQHQRAHGD 721

Query: 307 EIPT----FEVLAFKNRT-LGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERLI 361
            +      ++V++  ++T L L       +  G Y+ HL+ WL Y+P  Q+L V G+ L 
Sbjct: 722 PVALNYTFYQVISASSQTPLALRSLQNRCLVPGYYSTHLQRWLTYYPSGQLLIVDGQELR 781

Query: 362 VDPAGEMAKVQDFLGLKRVVT-EKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRI 420
            +PA  M  +Q FLG+   +   +   F+  KGF C  +  +    RCLG+SKGR +P +
Sbjct: 782 TNPAASMESIQKFLGITPFLNYTRTLRFDDDKGFWC--QGLEGGKTRCLGRSKGRRYPDM 839

Query: 421 DPDVIHRLRKFYKPFNLMFYQMTGQDFQ----WEQEE 453
           D +    L  F++  NL   ++  +  Q    W +EE
Sbjct: 840 DTESRLFLTDFFRNHNLELSKLLSRLGQPVPSWLREE 876


>gi|4505351 N-deacetylase/N-sulfotransferase (heparan glucosaminyl)
           1 [Homo sapiens]
          Length = 882

 Score =  118 bits (295), Expect = 1e-26
 Identities = 86/277 (31%), Positives = 136/277 (49%), Gaps = 21/277 (7%)

Query: 196 KLPQALIIGVKKGGTRALLEAIRVHPDVRA------VGVEPHFFD-RNYEKGLEWYRNV- 247
           + P+ LIIG +K GT AL   + +HPD+ +         E  FF+  NY KG++WY    
Sbjct: 603 RFPKLLIIGPQKTGTTALYLFLGMHPDLSSNYPSSETFEEIQFFNGHNYHKGIDWYMEFF 662

Query: 248 -MPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQTLSKKP 306
            +P         EK+ +YF +  AP+R  ++    K++ ++ NP  RA S Y    +   
Sbjct: 663 PIPSNTTSDFYFEKSANYFDSEVAPRRAAALLPKAKVLTILINPADRAYSWYQHQRAHDD 722

Query: 307 EIP---TF-EVLAFKNRTLGLIDASWSAIRI-GIYALHLENWLQYFPLSQILFVSGERLI 361
            +    TF EV+   +     + A  +   + G YA H+E WL  +  +QIL + G+ L 
Sbjct: 723 PVALKYTFHEVITAGSDASSKLRALQNRCLVPGWYATHIERWLSAYHANQILVLDGKLLR 782

Query: 362 VDPAGEMAKVQDFLGLKRVVT-EKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRI 420
            +PA  M  VQ FLG+   +   K   F+  KGF C  +  +    +CLGKSKGR +P +
Sbjct: 783 TEPAKVMDMVQKFLGVTNTIDYHKTLAFDPKKGFWC--QLLEGGKTKCLGKSKGRKYPEM 840

Query: 421 DPDVIHRLRKFYKPFNL----MFYQMTGQDFQWEQEE 453
           D D    L+ +Y+  N+    + Y+M      W +E+
Sbjct: 841 DLDSRAFLKDYYRDHNIELSKLLYKMGQTLPTWLRED 877


>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
          Length = 1263

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 51/128 (39%), Positives = 58/128 (45%), Gaps = 21/128 (16%)

Query: 5   PAPPPPPPPPPPL------AAPPP-PGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSG 57
           P PPPPPPPPPPL      ++PP  PG +A  PP         LS   T      L    
Sbjct: 600 PPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPP-------PLSGDATIPPPPPLPEGV 652

Query: 58  SLQFPLALQESPGAAAEPPPSPPPPSLL---PTPVRLGAPSQPPAPPPLDNASHGEPPEP 114
            +  P +L   PG  A PPP P P S     P P   G+   PP PPPL   + G PP P
Sbjct: 653 GIPSPSSL---PGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEA-GMPPPP 708

Query: 115 PEQPAAPG 122
           P  P  PG
Sbjct: 709 PPLPGGPG 716



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 42/138 (30%), Positives = 47/138 (34%), Gaps = 34/138 (24%)

Query: 1   MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQ 60
           MA   A     PP  P  AP PP      PP                    L G SG++ 
Sbjct: 553 MASLSAAAITVPPSVPSRAPVPPA-----PP--------------------LPGDSGTII 587

Query: 61  FPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPA------PPPLDNASHGEPPEP 114
            P            PPP PPPP  LP  V + +P   P       PPPL   +   PP P
Sbjct: 588 PPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPP 647

Query: 115 -PEQPAAPGTDGWGLPSG 131
            PE    P      LP G
Sbjct: 648 LPEGVGIPSPS--SLPGG 663



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 37/110 (33%), Positives = 38/110 (34%), Gaps = 41/110 (37%)

Query: 2   ARWPAPPPP-------PPPPPPLAA----PPPPGASAKGPPARKLLFMCTLSLSVTYLCY 50
           AR P PPPP       PPPPPPL      PPPP      PP                   
Sbjct: 676 ARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPP------PP------------------- 710

Query: 51  SLLGGSGSLQFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAP 100
            L GG G    P      PG    PPP P      P P   G P+ P  P
Sbjct: 711 -LPGGPGIPPPP----PFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLP 755



 Score = 33.5 bits (75), Expect = 0.41
 Identities = 18/41 (43%), Positives = 19/41 (46%), Gaps = 7/41 (17%)

Query: 7   PPPP-------PPPPPPLAAPPPPGASAKGPPARKLLFMCT 40
           PPPP       PPPPP +  PPPP      P A  L F  T
Sbjct: 719 PPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLT 759



 Score = 33.1 bits (74), Expect = 0.54
 Identities = 26/94 (27%), Positives = 33/94 (35%), Gaps = 11/94 (11%)

Query: 68  SPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAPGTDGW- 126
           S  A   PP  P    + P P   G       PPP    S   PP PP  P  P   G  
Sbjct: 557 SAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGV 616

Query: 127 ---GLPSGGGGAQDAWLRTPLAPSEMITAQSALP 157
                PS  GG       T ++P   ++  + +P
Sbjct: 617 CISSPPSLPGG-------TAISPPPPLSGDATIP 643


>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
          Length = 1272

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 51/128 (39%), Positives = 58/128 (45%), Gaps = 21/128 (16%)

Query: 5   PAPPPPPPPPPPL------AAPPP-PGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSG 57
           P PPPPPPPPPPL      ++PP  PG +A  PP         LS   T      L    
Sbjct: 609 PPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPP-------PLSGDATIPPPPPLPEGV 661

Query: 58  SLQFPLALQESPGAAAEPPPSPPPPSLL---PTPVRLGAPSQPPAPPPLDNASHGEPPEP 114
            +  P +L   PG  A PPP P P S     P P   G+   PP PPPL   + G PP P
Sbjct: 662 GIPSPSSL---PGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEA-GMPPPP 717

Query: 115 PEQPAAPG 122
           P  P  PG
Sbjct: 718 PPLPGGPG 725



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 42/138 (30%), Positives = 47/138 (34%), Gaps = 34/138 (24%)

Query: 1   MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQ 60
           MA   A     PP  P  AP PP      PP                    L G SG++ 
Sbjct: 562 MASLSAAAITVPPSVPSRAPVPPA-----PP--------------------LPGDSGTII 596

Query: 61  FPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPA------PPPLDNASHGEPPEP 114
            P            PPP PPPP  LP  V + +P   P       PPPL   +   PP P
Sbjct: 597 PPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPP 656

Query: 115 -PEQPAAPGTDGWGLPSG 131
            PE    P      LP G
Sbjct: 657 LPEGVGIPSPS--SLPGG 672



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 37/110 (33%), Positives = 38/110 (34%), Gaps = 41/110 (37%)

Query: 2   ARWPAPPPP-------PPPPPPLAA----PPPPGASAKGPPARKLLFMCTLSLSVTYLCY 50
           AR P PPPP       PPPPPPL      PPPP      PP                   
Sbjct: 685 ARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPP------PP------------------- 719

Query: 51  SLLGGSGSLQFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAP 100
            L GG G    P      PG    PPP P      P P   G P+ P  P
Sbjct: 720 -LPGGPGIPPPP----PFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLP 764



 Score = 33.5 bits (75), Expect = 0.41
 Identities = 18/41 (43%), Positives = 19/41 (46%), Gaps = 7/41 (17%)

Query: 7   PPPP-------PPPPPPLAAPPPPGASAKGPPARKLLFMCT 40
           PPPP       PPPPP +  PPPP      P A  L F  T
Sbjct: 728 PPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLT 768



 Score = 33.1 bits (74), Expect = 0.54
 Identities = 26/94 (27%), Positives = 33/94 (35%), Gaps = 11/94 (11%)

Query: 68  SPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAPGTDGW- 126
           S  A   PP  P    + P P   G       PPP    S   PP PP  P  P   G  
Sbjct: 566 SAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGV 625

Query: 127 ---GLPSGGGGAQDAWLRTPLAPSEMITAQSALP 157
                PS  GG       T ++P   ++  + +P
Sbjct: 626 CISSPPSLPGG-------TAISPPPPLSGDATIP 652


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 66/202 (32%), Positives = 81/202 (40%), Gaps = 35/202 (17%)

Query: 5   PAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFP-- 62
           P  PPPPPPPPP   PP P AS     A K   +  L L        LL   G   +P  
Sbjct: 220 PCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQ-LAPLHLPPIPPPLPLLPPCG---YPGL 275

Query: 63  LALQESPGAAAEPPPSPPPP----------SLLPTPVRLGAPSQPPAPPPL--DNASHGE 110
            A   SP   A+ PP+PPPP          + LP P   G  S    PPPL   + S   
Sbjct: 276 KAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQA 335

Query: 111 PPEP------PEQPAAPGTDGW------GLPSGGGGAQDAWLRTPLAPSEMITAQSALPE 158
           PP+       P  PA PG+  +      G P  GGG     L  P AP    +  + L  
Sbjct: 336 PPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGK----LNPPPAPPAR-SPTTELSS 390

Query: 159 REAQESSTTDEDLAGRRAANGS 180
           +  Q ++ T     G +  NGS
Sbjct: 391 KSQQATAWTPTQQPGGQLRNGS 412



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 56/166 (33%), Positives = 66/166 (39%), Gaps = 41/166 (24%)

Query: 5   PAPPPPPPPPPPLAAPPP-PGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSL-QFP 62
           PAPPPP PPPPP   PPP P +S    P                    L+   G L +  
Sbjct: 172 PAPPPPTPPPPPPPLPPPLPSSSPIKTP--------------------LVSPPGPLTKGN 211

Query: 63  LALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGE------PPEPPE 116
           L +   P   A PPP PPPP   PTP     P  PPA    D A   +      PP PP 
Sbjct: 212 LPVVAPPVPCAPPPPPPPPP---PTP-----PPLPPASVLSDKAVKPQLAPLHLPPIPPP 263

Query: 117 QPAAPGTDGWGLPS-GGGGAQDAW----LRTPLAPSEMITAQSALP 157
            P  P     GL +     AQDA        PL P    + +++LP
Sbjct: 264 LPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLP 309



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 20/27 (74%), Positives = 20/27 (74%), Gaps = 2/27 (7%)

Query: 5  PAPPPPPPPPPPLAAPPPPGASAKGPP 31
          P PPP PPPPPPL APPPP  SA  PP
Sbjct: 6  PPPPPLPPPPPPLGAPPPPPPSA--PP 30



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 20/37 (54%), Positives = 22/37 (59%), Gaps = 1/37 (2%)

Query: 8  PPPPPPPPPLAAPPPP-GASAKGPPARKLLFMCTLSL 43
          P PPPPPPPL  PPPP GA    PP+   +   T SL
Sbjct: 2  PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSL 38



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 21/47 (44%), Positives = 24/47 (51%), Gaps = 2/47 (4%)

Query: 75  PPPSPPPPSLLPTPVRLGAPSQPP--APPPLDNASHGEPPEPPEQPA 119
           P P PPPP L P P  LGAP  PP  APP   + S     +P  + A
Sbjct: 2   PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSA 48



 Score = 35.8 bits (81), Expect = 0.083
 Identities = 40/133 (30%), Positives = 51/133 (38%), Gaps = 37/133 (27%)

Query: 67  ESPGAA----------AEPPPS-PPPPSLLPTPVRLGAPSQ-----PPAP---------- 100
           E+ GAA          A PPP+ PPPP  LP P+   +P +     PP P          
Sbjct: 157 EAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVA 216

Query: 101 PPLDNASHGEPPEPPEQPAAPGTDGWGLPSGGGGAQDAWLRTPLAPSEM----------I 150
           PP+  A    PP PP  P  P      L       Q A L  P  P  +          +
Sbjct: 217 PPVPCAPPPPPPPPPPTP-PPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGL 275

Query: 151 TAQSALPEREAQE 163
            A+ A P ++AQE
Sbjct: 276 KAEPASPAQDAQE 288


>gi|47132519 Ras association and pleckstrin homology domains 1
           isoform 1 [Homo sapiens]
          Length = 1250

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 48/142 (33%), Positives = 55/142 (38%), Gaps = 26/142 (18%)

Query: 5   PAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSL---QF 61
           P PPPPPPPPPP   PPPP  S   P A     M     ++T L  +    SG+L     
Sbjct: 630 PPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRL-QNASQHSGALFKPPT 688

Query: 62  PLALQES---------PGAAAEPPPSPPPP--------SLLPTPVRLGAPSQPPAPPPL- 103
           P  +Q           P     PPP PPPP         L P P     P     PPPL 
Sbjct: 689 PPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLK 748

Query: 104 ----DNASHGEPPEPPEQPAAP 121
                + +   PP PP  P  P
Sbjct: 749 IHQVQHITQVAPPTPPPPPPIP 770



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 43/131 (32%), Positives = 55/131 (41%), Gaps = 33/131 (25%)

Query: 8   PPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLALQE 67
           PPPPPPPPP   P P  A A+  PA                C   L    +   PL + +
Sbjct: 710 PPPPPPPPP---PTPGSAMAQLKPAP---------------CAPSLPQFSAPPPPLKIHQ 751

Query: 68  SPGAAAEPPPSPPPPSLLPTPVRLGAPSQP----PAP-------PPLDNAS--HGEPPEP 114
                   PP+PPPP  +P P+   AP +P    PAP       P +  A+     PP P
Sbjct: 752 VQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVP 811

Query: 115 P--EQPAAPGT 123
           P  +QPA P +
Sbjct: 812 PAKKQPAFPAS 822



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 43/162 (26%), Positives = 61/162 (37%), Gaps = 21/162 (12%)

Query: 2    ARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLL-FMCTLSLSVTYLCYSLLGGSGSLQ 60
            +++P PP PP        P P   + + PPA K        S+ V    +       SL 
Sbjct: 867  SQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLV 926

Query: 61   FPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPA---------PPP-------LD 104
            FP      P +    PP PPPP+  PTP + G+P +  +         PPP       + 
Sbjct: 927  FP----PPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIK 982

Query: 105  NASHGEPPEPPEQPAAPGTDGWGLPSGGGGAQDAWLRTPLAP 146
            ++S  E PEP           +  P+  G      L  P AP
Sbjct: 983  SSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAP 1024



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 36/112 (32%), Positives = 48/112 (42%), Gaps = 15/112 (13%)

Query: 8   PPPPPPPPPLAAPPPPGASAKGPPARKLLFMC-TLSLSVTYLCYSLLGGSGSLQFPLALQ 66
           PP PPPPPP+ AP PP A    PP   +     T + +V  +       + +   P A +
Sbjct: 760 PPTPPPPPPIPAPLPPQA----PPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKK 815

Query: 67  ESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQP 118
           +    A+  PPSPP P   P PV       PP   P   +   +PP  P  P
Sbjct: 816 QPAFPASYIPPSPPTP---PVPV-------PPPTLPKQQSFCAKPPPSPLSP 857



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 46/165 (27%), Positives = 63/165 (38%), Gaps = 41/165 (24%)

Query: 4    WPAPPP-----PPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGS 58
            +P PPP     PPPPPPP A+P P  + + G    K                S  GG   
Sbjct: 927  FPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKT---------------SSPGGKKP 971

Query: 59   LQFP---LALQESPGAAAEPPPSPPPPSLL---PTPVRLGAPSQPPAPPPLDNASHGEPP 112
               P    +++ S GA    P  P   SL+     P   G+PS+   PPP        PP
Sbjct: 972  PPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPP------AAPP 1025

Query: 113  EPPEQPAA----PGTDGWGLPSG-----GGGAQDAWLRTPLAPSE 148
            +P +   +    PG    G  S       G  +D+ +  P  PS+
Sbjct: 1026 KPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSD 1070



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 41/155 (26%), Positives = 54/155 (34%), Gaps = 50/155 (32%)

Query: 5   PAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFP-- 62
           P+PP PP P PP   P      AK PP+          LS        +      QFP  
Sbjct: 826 PSPPTPPVPVPPPTLPKQQSFCAKPPPS---------PLSPVPSVVKQIAS----QFPPP 872

Query: 63  -----------------LALQESPGAAAEP--------------PPSPPPPSLL-PTPVR 90
                            +A Q  P   A+P              PP PP  SL+ P P  
Sbjct: 873 PTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPP 932

Query: 91  LGAPSQPPAPPPLDNAS---HGEPPEPPEQPAAPG 122
              P+ PP PPP  + +    G P +   + ++PG
Sbjct: 933 SPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPG 967



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 23/67 (34%), Positives = 26/67 (38%), Gaps = 6/67 (8%)

Query: 69  PGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAPGTDGWGL 128
           P  +  PP SP P  + P      +P  PP PPP        PP PP  P  P       
Sbjct: 601 PYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPP------PPPPPPPPPPPPPPLPSQSA 654

Query: 129 PSGGGGA 135
           PS G  A
Sbjct: 655 PSAGSAA 661



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 40/146 (27%), Positives = 52/146 (35%), Gaps = 28/146 (19%)

Query: 4   WPAPPPPPPPPPPLAAPPPP------GASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSG 57
           +PA   PP PP P    PPP         AK PP+        LS  V  +   +     
Sbjct: 819 FPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPS-------PLS-PVPSVVKQIASQFP 870

Query: 58  SLQFPLALQESP-------GAAAEPPPSPPPPSLLPTPVRLGAPSQPPAP-------PPL 103
               P A++  P        A   PP     P   P+ + + +P  PP P       PP 
Sbjct: 871 PPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPP 930

Query: 104 DNASHGEPPEPPEQPAAPGTDGWGLP 129
             +    PP PP   A+P  D  G P
Sbjct: 931 PPSPVPAPPPPPPPTASPTPDKSGSP 956



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 22/53 (41%), Positives = 27/53 (50%), Gaps = 6/53 (11%)

Query: 58  SLQFPLALQE---SPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNAS 107
           SL  PL+ Q    +P  A++P P  PPP   P P     P  PP PPPL + S
Sbjct: 604 SLVPPLSPQPKIVTPYTASQPSPPLPPP---PPPPPPPPPPPPPPPPPLPSQS 653



 Score = 29.3 bits (64), Expect = 7.7
 Identities = 26/75 (34%), Positives = 35/75 (46%), Gaps = 9/75 (12%)

Query: 15   PPLAAPPPPGA-SAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLALQESPGAAA 73
            PP AAPP PG  +  G     +L    +S     L  S  G    ++FP     SP + +
Sbjct: 1019 PPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVL--SGRGKDSVVEFP-----SPPSDS 1071

Query: 74   EPPPSPPPPSLLPTP 88
            + PP PPP + LP P
Sbjct: 1072 DFPP-PPPETELPLP 1085


>gi|11386183 WAS protein family, member 2 [Homo sapiens]
          Length = 498

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 42/125 (33%), Positives = 47/125 (37%), Gaps = 34/125 (27%)

Query: 5   PAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLA 64
           P P PPPPPPP +  PPPP     G P                       G+     P +
Sbjct: 318 PPPAPPPPPPPMIGIPPPPPPVGFGSP-----------------------GTPPPPSPPS 354

Query: 65  LQESPGAAAEPPPSPPP----PSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAA 120
               P  AA PPP PPP    P+L P P+       PP PPP        PP  P  P  
Sbjct: 355 FPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPP-------PPPPGPPPPPF 407

Query: 121 PGTDG 125
            G DG
Sbjct: 408 TGADG 412



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 36/121 (29%), Positives = 41/121 (33%), Gaps = 52/121 (42%)

Query: 8   PPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLALQE 67
           P  PPP PPL +PP P                                            
Sbjct: 297 PSHPPPAPPLGSPPGP-------------------------------------------- 312

Query: 68  SPGAAAEPPPSPPPPSLL-----PTPVRLGAPSQPPAPPPLDNASHGE---PPEPPEQPA 119
            PG A  P P PPPP ++     P PV  G+P  PP P P     H +   PP PP  PA
Sbjct: 313 KPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPA 372

Query: 120 A 120
           A
Sbjct: 373 A 373



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 17/25 (68%), Positives = 17/25 (68%)

Query: 8   PPPPPPPPPLAAPPPPGASAKGPPA 32
           PPPPPPPPP   PPPP   A G PA
Sbjct: 391 PPPPPPPPPPGPPPPPFTGADGQPA 415



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 39/115 (33%), Positives = 45/115 (39%), Gaps = 16/115 (13%)

Query: 10  PPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLALQESP 69
           PPPP    A+ P P  S    P     F   +             GSG      +   SP
Sbjct: 247 PPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQ---------RGSGLAGPKRSSVVSP 297

Query: 70  GAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQP-AAPGT 123
              + PPP+PP  S  P P    AP  PPAPPP      G PP PP     +PGT
Sbjct: 298 ---SHPPPAPPLGSP-PGPKPGFAP--PPAPPPPPPPMIGIPPPPPPVGFGSPGT 346


>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
           sapiens]
          Length = 505

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 48/134 (35%), Positives = 53/134 (39%), Gaps = 33/134 (24%)

Query: 7   PPPPPPPPPPLAAPPPP--GASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLA 64
           PPPPPPPP     PPPP  G  A  PP  +                     + +   P  
Sbjct: 287 PPPPPPPPHNSGPPPPPARGRGAPPPPPSR---------------------APTAAPPPP 325

Query: 65  LQESPGAAAEPPPS----PPPPSLLPTPVRLGAPSQPPAPPP-LDNASHGEPPEPPEQPA 119
               P  A  PPP     PPPP  LP+     APS PP PPP +       PP PP  P 
Sbjct: 326 PPSRPSVAVPPPPPNRMYPPPPPALPS----SAPSGPPPPPPSVLGVGPVAPPPPPPPPP 381

Query: 120 APG-TDGWGLPSGG 132
            PG     GLPS G
Sbjct: 382 PPGPPPPPGLPSDG 395



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 43/128 (33%), Positives = 47/128 (36%), Gaps = 44/128 (34%)

Query: 6   APPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLAL 65
           APPPPPP  P +A PPPP      PP                              P AL
Sbjct: 321 APPPPPPSRPSVAVPPPPPNRMYPPP------------------------------PPAL 350

Query: 66  QESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAPGTDG 125
              P +A   PP PPP  L   PV   AP  PP PPP        PP PP  P  P    
Sbjct: 351 ---PSSAPSGPPPPPPSVLGVGPV---APPPPPPPPP--------PPGPPPPPGLPSDGD 396

Query: 126 WGLPSGGG 133
             +P+  G
Sbjct: 397 HQVPTTAG 404



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 14/19 (73%), Positives = 14/19 (73%)

Query: 5   PAPPPPPPPPPPLAAPPPP 23
           P  PPPPPPPPP   PPPP
Sbjct: 370 PVAPPPPPPPPPPPGPPPP 388



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 19/51 (37%), Positives = 23/51 (45%), Gaps = 1/51 (1%)

Query: 69  PGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPA 119
           P     PPP PPP +  P P        PP PPP    +   PP PP +P+
Sbjct: 282 PSRGGPPPPPPPPHNSGPPPPPARGRGAPP-PPPSRAPTAAPPPPPPSRPS 331


>gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]
          Length = 639

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 46/136 (33%), Positives = 55/136 (40%), Gaps = 16/136 (11%)

Query: 1   MARWPAPPPPPP--PPPPLAAPPPPGASAKG------PPARKLLFMCTLSLSVTYLCYSL 52
           M   P PPPPP   PPPP + P PP    +       PP+  +     L         + 
Sbjct: 475 MGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTT 534

Query: 53  LGGSGSL----QFPLALQESPGAA---AEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDN 105
             G+GS+    Q   A   SPGA      P   P PP + P P+  GAP  PP PPP   
Sbjct: 535 SAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQP-PLPPGAPPPPPPPPPGSA 593

Query: 106 ASHGEPPEPPEQPAAP 121
                PP PP  P  P
Sbjct: 594 GMMYAPPPPPPPPMDP 609



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 47/139 (33%), Positives = 56/139 (40%), Gaps = 20/139 (14%)

Query: 7   PPPP---PPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFP- 62
           PPPP   PPPPP    P PPG     PP  + L    +   V    Y L  G G +  P 
Sbjct: 420 PPPPWMQPPPPPMNQGPHPPGHHGP-PPMDQYLGSTPVGSGV----YRLHQGKGMMPPPP 474

Query: 63  LALQESPGAAAEPPPS--PPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAA 120
           + +   P     PPPS  PPPP   P P       QPP PPP  ++     P P +Q   
Sbjct: 475 MGMMPPP----PPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTT 530

Query: 121 PGTDGWGLPSGGGGAQDAW 139
             T      S G G+   W
Sbjct: 531 TTT-----TSAGTGSIPPW 544



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 48/200 (24%), Positives = 65/200 (32%), Gaps = 44/200 (22%)

Query: 12  PPPPPLAAPPPPGASAKGPPARKLLF-------MCTLSLSVTYLCYSLLG------GSGS 58
           P   PLA+ P P A A  PP   L+              S +   + + G      G G 
Sbjct: 335 PATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGP 394

Query: 59  LQFPLALQESPGA-----AAEPPPSPPPPSLLPTPVRLGAPSQPP---APPPLD------ 104
             FP  L    G          P  PPPP + P P  +     PP    PPP+D      
Sbjct: 395 HSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGST 454

Query: 105 ---------NASHGEPPEPP--EQPAAPGTDGWGLPSGGGGAQDAWLR------TPLAPS 147
                    +   G  P PP    P  P       P    G    W +       P  PS
Sbjct: 455 PVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPS 514

Query: 148 EMITAQSALPEREAQESSTT 167
             + + + LP ++   ++TT
Sbjct: 515 SSMASSTPLPWQQNTTTTTT 534



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 33/114 (28%), Positives = 37/114 (32%), Gaps = 45/114 (39%)

Query: 5   PAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLA 64
           P PP   PP PP A PPPP      PP                       GS  + +   
Sbjct: 568 PLPPGVQPPLPPGAPPPPPPP----PP-----------------------GSAGMMY--- 597

Query: 65  LQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQP 118
                 A   PPP P  PS   T + +G    PP          G PP PP  P
Sbjct: 598 ------APPPPPPPPMDPSNFVTMMGMGVAGMPP---------FGMPPAPPPPP 636



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 27/88 (30%), Positives = 35/88 (39%), Gaps = 14/88 (15%)

Query: 51  SLLGGSGSLQFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGE 110
           SL+   G    P ++  + G A  P  S P P+         AP+  P PP L + +   
Sbjct: 315 SLMAELGEAPVPASVGSTSGPATTPLASAPRPA---------APANNPPPPSLMSTTQSR 365

Query: 111 PP----EPPEQPAAPGTDGWGLPSGGGG 134
           PP     P E     G  G G P G GG
Sbjct: 366 PPWMNSGPSESRPYHGMHGGG-PGGPGG 392



 Score = 30.0 bits (66), Expect = 4.5
 Identities = 15/40 (37%), Positives = 15/40 (37%), Gaps = 22/40 (55%)

Query: 6   APPPPPPPP----------------------PPLAAPPPP 23
           APPPPPPPP                      PP   PPPP
Sbjct: 598 APPPPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPPPP 637


>gi|39812378 RAN binding protein 9 [Homo sapiens]
          Length = 729

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 55/171 (32%), Positives = 63/171 (36%), Gaps = 44/171 (25%)

Query: 7   PPPPPP----------PPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGS 56
           PPPPPP          PPPP A  P  G     PPA           + +    S  GG+
Sbjct: 5   PPPPPPQQQQQQQQLSPPPPAALAPVSGVVLPAPPAVS---------AGSSPAGSPGGGA 55

Query: 57  GSLQFPLALQESPGAAA-----EPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEP 111
           G         E  GAAA      PPP PPP +  P P     P  PP PP    A    P
Sbjct: 56  GG--------EGLGAAAAALLLHPPPPPPPATAAPPP-----PPPPPPPPASAAAPASGP 102

Query: 112 PEPPEQPAAPGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQ 162
           P PP   A PG         GG    A +    A +      SAL E+E +
Sbjct: 103 PAPPGLAAGPG-------PAGGAPTPALVAGSSAAAPFPHGDSALNEQEKE 146



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 20/34 (58%), Positives = 21/34 (61%), Gaps = 6/34 (17%)

Query: 5   PAPPPPP----PPPPPLAAPPPPGAS--AKGPPA 32
           P PPPPP    PPPPP   PPP  A+  A GPPA
Sbjct: 71  PPPPPPPATAAPPPPPPPPPPPASAAAPASGPPA 104



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 17/31 (54%), Positives = 18/31 (58%), Gaps = 5/31 (16%)

Query: 5   PAPPPPPPPPP-----PLAAPPPPGASAKGP 30
           P PPPPPPPPP     P + PP P   A GP
Sbjct: 82  PPPPPPPPPPPASAAAPASGPPAPPGLAAGP 112


>gi|7706501 WW domain binding protein 11 [Homo sapiens]
          Length = 641

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 47/124 (37%), Positives = 51/124 (41%), Gaps = 16/124 (12%)

Query: 5   PAPPP-PPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPL 63
           P PPP  PPP PPL  P PP     GPP     F+    +          G  G L   L
Sbjct: 408 PGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMP---------GLRGPLPRLL 458

Query: 64  ALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQ--PPAPPPLDNASHG---EPPEPPEQP 118
                PG    PPP  PPP L P P   G P +  PPAPP +     G    P  PP  P
Sbjct: 459 PPGPPPGRPPGPPPG-PPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGP 517

Query: 119 AAPG 122
           A PG
Sbjct: 518 APPG 521



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 29/79 (36%), Positives = 35/79 (44%), Gaps = 10/79 (12%)

Query: 68  SPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAPGTDGWG 127
           S G +        PP  +P P ++ AP  P  PPPL     G PP PP +P  P T   G
Sbjct: 380 SDGTSTASSQQQAPPQSVP-PSQIQAPPMP-GPPPL-----GPPPAPPLRPPGPPT---G 429

Query: 128 LPSGGGGAQDAWLRTPLAP 146
           LP G       +LR P  P
Sbjct: 430 LPPGPPPGAPPFLRPPGMP 448



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 36/112 (32%), Positives = 40/112 (35%), Gaps = 34/112 (30%)

Query: 3   RWPAPPPPPPP-----PPPLAAPP--PPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGG 55
           R P PPP PPP     PPP   PP  PP A    PP R                      
Sbjct: 466 RPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPR---------------------- 503

Query: 56  SGSLQFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNAS 107
            G ++ PL     P      PP   PP+ LP P  L AP      P  D+ S
Sbjct: 504 PGMMRPPLVPPLGPA-----PPGLFPPAPLPNPGVLSAPPNLIQRPKADDTS 550



 Score = 38.1 bits (87), Expect = 0.017
 Identities = 23/56 (41%), Positives = 26/56 (46%), Gaps = 11/56 (19%)

Query: 66  QESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAP 121
           Q  P +  + PP P PP L P P     P +PP PP       G PP PP  P AP
Sbjct: 395 QSVPPSQIQAPPMPGPPPLGPPP---APPLRPPGPPT------GLPPGPP--PGAP 439



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 27/80 (33%), Positives = 29/80 (36%), Gaps = 16/80 (20%)

Query: 67  ESPGAAAEPPPSPPP-PSLLPTPVRLGAPSQPP--APP------------PLDNASHGEP 111
           ++P     PP  PPP P L P     G P  PP  APP            PL       P
Sbjct: 403 QAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMPGLRGPLPRLLPPGP 462

Query: 112 PEPPEQPAAPGTDGWGLPSG 131
           P P   P  P     GLP G
Sbjct: 463 P-PGRPPGPPPGPPPGLPPG 481



 Score = 29.6 bits (65), Expect = 5.9
 Identities = 28/91 (30%), Positives = 35/91 (38%), Gaps = 28/91 (30%)

Query: 5   PAPPPPPPP--------PPPLAAPPP--PGASAKGPPARKLLFMCTLSLSVTYLCYSLLG 54
           P P  P  P        P P A PP      SA GPP R +  +  L             
Sbjct: 140 PLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAVSILPLL------------- 186

Query: 55  GSGSLQFPLALQESPGAAAEPPPSPPPPSLL 85
           G G  + P   ++ PG    PPP PPPP ++
Sbjct: 187 GHGVPRLPPG-RKPPG----PPPGPPPPQVV 212


>gi|42544125 splicing factor 1 isoform 2 [Homo sapiens]
          Length = 638

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 47/143 (32%), Positives = 61/143 (42%), Gaps = 25/143 (17%)

Query: 1   MARWPAPPPPP--PPPPPLAAPPPPGASAK------GPPARKLLFMCTLSLSVTYLCYSL 52
           M   P PPPPP   PPPP + P PP    +       PP+  +     L         + 
Sbjct: 475 MGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTT 534

Query: 53  LGGSGSLQFPLALQESPGAAAEP--PPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGE 110
             G+GS+  P   Q+   AAA P  P     P+++P P  +    QPP PP       G 
Sbjct: 535 SAGTGSI--PPWQQQQAAAAASPGAPQMQGNPTMVPLPPGV----QPPLPP-------GA 581

Query: 111 PPEPPEQPAAPGTDGWGLPSGGG 133
           PP PP  P  PG+ G  +P  GG
Sbjct: 582 PPPPP--PPPPGSAGMMIPPRGG 602



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 46/141 (32%), Positives = 56/141 (39%), Gaps = 19/141 (13%)

Query: 5   PAPPPPP---PPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSL-Q 60
           P  PPPP   PPPPP+   P P      PP  + L    +   V    Y L  G G +  
Sbjct: 417 PNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGV----YRLHQGKGMMPP 472

Query: 61  FPLALQESPGAAAEPPPS--PPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQP 118
            P+ +   P     PPPS  PPPP   P P       QPP PPP  ++     P P +Q 
Sbjct: 473 PPMGMMPPP----PPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQN 528

Query: 119 AAPGTDGWGLPSGGGGAQDAW 139
               T      S G G+   W
Sbjct: 529 TTTTT-----TSAGTGSIPPW 544



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 48/200 (24%), Positives = 65/200 (32%), Gaps = 44/200 (22%)

Query: 12  PPPPPLAAPPPPGASAKGPPARKLLF-------MCTLSLSVTYLCYSLLG------GSGS 58
           P   PLA+ P P A A  PP   L+              S +   + + G      G G 
Sbjct: 335 PATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGP 394

Query: 59  LQFPLALQESPGA-----AAEPPPSPPPPSLLPTPVRLGAPSQPP---APPPLD------ 104
             FP  L    G          P  PPPP + P P  +     PP    PPP+D      
Sbjct: 395 HSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGST 454

Query: 105 ---------NASHGEPPEPP--EQPAAPGTDGWGLPSGGGGAQDAWLR------TPLAPS 147
                    +   G  P PP    P  P       P    G    W +       P  PS
Sbjct: 455 PVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPS 514

Query: 148 EMITAQSALPEREAQESSTT 167
             + + + LP ++   ++TT
Sbjct: 515 SSMASSTPLPWQQNTTTTTT 534



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 27/88 (30%), Positives = 35/88 (39%), Gaps = 14/88 (15%)

Query: 51  SLLGGSGSLQFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGE 110
           SL+   G    P ++  + G A  P  S P P+         AP+  P PP L + +   
Sbjct: 315 SLMAELGEAPVPASVGSTSGPATTPLASAPRPA---------APANNPPPPSLMSTTQSR 365

Query: 111 PP----EPPEQPAAPGTDGWGLPSGGGG 134
           PP     P E     G  G G P G GG
Sbjct: 366 PPWMNSGPSESRPYHGMHGGG-PGGPGG 392



 Score = 33.9 bits (76), Expect = 0.31
 Identities = 14/25 (56%), Positives = 14/25 (56%)

Query: 6   APPPPPPPPPPLAAPPPPGASAKGP 30
           APPPPPPPPP  A    P     GP
Sbjct: 581 APPPPPPPPPGSAGMMIPPRGGDGP 605


>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
          Length = 502

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 56/194 (28%), Positives = 63/194 (32%), Gaps = 50/194 (25%)

Query: 5   PAPPPP---PPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQF 61
           P PP P    PPPP    PPPPG     PP                              
Sbjct: 341 PLPPVPLGIAPPPPTPRGPPPPGRGGPPPP------------------------------ 370

Query: 62  PLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAP 121
                  P A     P PPPP     P   G P  PP PPP    S G  P PP  P A 
Sbjct: 371 ------PPPATGRSGPLPPPP-----PGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPAL 419

Query: 122 GTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREA-QESSTTDEDLAGRRAANGS 180
              G   P GG GA    L   +     +      PE  A Q    + E L G    +  
Sbjct: 420 VPAGGLAPGGGRGA----LLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVG-ALMHVM 474

Query: 181 SERGGAVSTPDYGE 194
            +R  A+ + D GE
Sbjct: 475 QKRSRAIHSSDEGE 488



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 21/56 (37%), Positives = 22/56 (39%), Gaps = 4/56 (7%)

Query: 74  EPPPSPPPPS----LLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAPGTDG 125
           EP P PPPPS     LP P  +G       P P        PP  P  P  PG  G
Sbjct: 311 EPLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPPPPGRGG 366


>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
           subunit [Homo sapiens]
          Length = 551

 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 56/192 (29%), Positives = 67/192 (34%), Gaps = 60/192 (31%)

Query: 8   PPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLALQE 67
           PPP PPPP    PPPPG     PP                         G L  PL L  
Sbjct: 305 PPPGPPPPQQGPPPPPGPFPPRPP-------------------------GPLGPPLTLAP 339

Query: 68  SPGAAAEPPPSPPP-----PSLLPTPVRLGAP-SQPPAPPPLDNASHGEPPEPPEQPAAP 121
            P     PP +PPP     P+  P P   G P S    PPP D   +G PP     P   
Sbjct: 340 PPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTD--PYGRPP-----PYDR 392

Query: 122 GTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGSS 181
           G  G   P G                EM TA++ L E E +E    +  ++    +   S
Sbjct: 393 GDYG---PPG---------------REMDTARTPLSEAEFEEIMNRNRAISSSAISRAVS 434

Query: 182 ERGGAVSTPDYG 193
           +     S  DYG
Sbjct: 435 D----ASAGDYG 442



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 45/129 (34%), Positives = 47/129 (36%), Gaps = 27/129 (20%)

Query: 5   PAPPPPP------PPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGS 58
           P  PPPP      PP PPL  P PPG     PP +              L   L G    
Sbjct: 223 PGGPPPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQ-------------VLPPPLAGPPNR 269

Query: 59  LQFPLALQESPGAA-AEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEP-PE 116
              P      PG    +PP  P PP   P PV    P  PP PPP      G PP P P 
Sbjct: 270 GDRPPPPVLFPGQPFGQPPLGPLPPG-PPPPVPGYGP--PPGPPP---PQQGPPPPPGPF 323

Query: 117 QPAAPGTDG 125
            P  PG  G
Sbjct: 324 PPRPPGPLG 332



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 31/112 (27%), Positives = 38/112 (33%), Gaps = 37/112 (33%)

Query: 54  GGSGSLQFPLALQESPGAAAEP------------------------------PPSPPPPS 83
           GG G  +FP A+   PG    P                              PP PPPP 
Sbjct: 200 GGRGRGRFPGAV---PGGDRFPGPAGPGGPPPPFPAGQTPPRPPLGPPGPPGPPGPPPPG 256

Query: 84  LLPTPVRLGAPSQPPAPPP---LDNASHGEPPEPPEQPA-APGTDGWGLPSG 131
            +  P   G P++   PPP         G+PP  P  P   P   G+G P G
Sbjct: 257 QVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPG 308


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 44/127 (34%), Positives = 52/127 (40%), Gaps = 21/127 (16%)

Query: 9   PPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLALQES 68
           PPPPPPP    PPP   S+ G      L    LSLS +       G SG L  P   +  
Sbjct: 307 PPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLP-PPPSERP 365

Query: 69  PGAAAEPP----PSPPPPSL---------------LPTPVRLGAPSQPPAPP-PLDNASH 108
           P    +PP    P PPPP +               LP+   + +P   P PP P D  S 
Sbjct: 366 PPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSA 425

Query: 109 GEPPEPP 115
           G PP PP
Sbjct: 426 GAPPPPP 432



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 44/172 (25%), Positives = 61/172 (35%), Gaps = 30/172 (17%)

Query: 7   PPPPPPPPPPL-------AAPPPPGASAK---GPPARKLLFMCTLSLSVTYLCYSLLGGS 56
           PPP P  P P+        +PP PG   +   GP           +L    +  S L  S
Sbjct: 184 PPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSS 243

Query: 57  GSLQFPLALQESPGAAAEPPPSPPPP-----------SLLPTPVRLGAPSQPPAPPPLDN 105
                   L  +P  A +  P PPPP           ++ P P +   P  P  P P  +
Sbjct: 244 SPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSAS 303

Query: 106 ASHGEPPEPPEQPAAPGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALP 157
           +    PP PP +P  P      LP    G  +    TP  P   ++  S+ P
Sbjct: 304 SQAPPPPPPPSRPGPP-----PLPPSSSGNDE----TPRLPQRNLSLSSSTP 346



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 33/109 (30%), Positives = 37/109 (33%), Gaps = 17/109 (15%)

Query: 5   PAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLA 64
           P PPPP   PPP     PPG S   PP   +                   GS S   P  
Sbjct: 356 PLPPPPSERPPP-PVRDPPGRSGPLPPPPPVS----------------RNGSTSRALPAT 398

Query: 65  LQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPE 113
            Q    +  + P S P P L P     GAP  PP    + N     P E
Sbjct: 399 PQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCE 447



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 24/89 (26%), Positives = 37/89 (41%), Gaps = 9/89 (10%)

Query: 69  PGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAPGTDGWGL 128
           P   ++P   PPP    P P++    ++   P P       +P   P  P  PG  G  L
Sbjct: 174 PDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVP---GGPRQPSPGPTPPPFPGNRGTAL 230

Query: 129 PSGGGGAQDAWLRTPLAPSEMITAQSALP 157
             GGG  +    ++PL+ S   + +  LP
Sbjct: 231 --GGGSIR----QSPLSSSSPFSNRPPLP 253



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 11/15 (73%), Positives = 11/15 (73%)

Query: 5  PAPPPPPPPPPPLAA 19
          P PPPP PPPPP  A
Sbjct: 2  PVPPPPAPPPPPTFA 16


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 44/127 (34%), Positives = 52/127 (40%), Gaps = 21/127 (16%)

Query: 9   PPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLALQES 68
           PPPPPPP    PPP   S+ G      L    LSLS +       G SG L  P   +  
Sbjct: 307 PPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLP-PPPSERP 365

Query: 69  PGAAAEPP----PSPPPPSL---------------LPTPVRLGAPSQPPAPP-PLDNASH 108
           P    +PP    P PPPP +               LP+   + +P   P PP P D  S 
Sbjct: 366 PPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSA 425

Query: 109 GEPPEPP 115
           G PP PP
Sbjct: 426 GAPPPPP 432



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 44/172 (25%), Positives = 61/172 (35%), Gaps = 30/172 (17%)

Query: 7   PPPPPPPPPPL-------AAPPPPGASAK---GPPARKLLFMCTLSLSVTYLCYSLLGGS 56
           PPP P  P P+        +PP PG   +   GP           +L    +  S L  S
Sbjct: 184 PPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSS 243

Query: 57  GSLQFPLALQESPGAAAEPPPSPPPP-----------SLLPTPVRLGAPSQPPAPPPLDN 105
                   L  +P  A +  P PPPP           ++ P P +   P  P  P P  +
Sbjct: 244 SPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSAS 303

Query: 106 ASHGEPPEPPEQPAAPGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALP 157
           +    PP PP +P  P      LP    G  +    TP  P   ++  S+ P
Sbjct: 304 SQAPPPPPPPSRPGPP-----PLPPSSSGNDE----TPRLPQRNLSLSSSTP 346



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 33/109 (30%), Positives = 37/109 (33%), Gaps = 17/109 (15%)

Query: 5   PAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLA 64
           P PPPP   PPP     PPG S   PP   +                   GS S   P  
Sbjct: 356 PLPPPPSERPPP-PVRDPPGRSGPLPPPPPVS----------------RNGSTSRALPAT 398

Query: 65  LQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPE 113
            Q    +  + P S P P L P     GAP  PP    + N     P E
Sbjct: 399 PQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCE 447



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 24/89 (26%), Positives = 37/89 (41%), Gaps = 9/89 (10%)

Query: 69  PGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAPGTDGWGL 128
           P   ++P   PPP    P P++    ++   P P       +P   P  P  PG  G  L
Sbjct: 174 PDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVP---GGPRQPSPGPTPPPFPGNRGTAL 230

Query: 129 PSGGGGAQDAWLRTPLAPSEMITAQSALP 157
             GGG  +    ++PL+ S   + +  LP
Sbjct: 231 --GGGSIR----QSPLSSSSPFSNRPPLP 253



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 11/15 (73%), Positives = 11/15 (73%)

Query: 5  PAPPPPPPPPPPLAA 19
          P PPPP PPPPP  A
Sbjct: 2  PVPPPPAPPPPPTFA 16


>gi|33356148 formin-like 1 [Homo sapiens]
          Length = 1100

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 40/122 (32%), Positives = 43/122 (35%), Gaps = 47/122 (38%)

Query: 5   PAPPPPPPPPPPLAAPP-----PPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSL 59
           PAP   PPPPPPL   P     PP A  + PP                            
Sbjct: 536 PAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPL--------------------------- 568

Query: 60  QFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPA 119
                    PG + EPPP+PP P  LP P     P  PP PP  D      PP PP  P 
Sbjct: 569 ---------PG-SPEPPPAPPLPGDLPPP-----PPPPPPPPGTDGPVPPPPPPPPPPPG 613

Query: 120 AP 121
            P
Sbjct: 614 GP 615



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 34/80 (42%), Positives = 39/80 (48%), Gaps = 13/80 (16%)

Query: 55  GSGSLQFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGE---- 110
           GS S     A + +PGAA  PPP PP P  LP+P +   PS PP  PPL  +        
Sbjct: 524 GSPSPDLAPAAEPAPGAA--PPPPPPLPG-LPSP-QEAPPSAPPQAPPLPGSPEPPPAPP 579

Query: 111 -----PPEPPEQPAAPGTDG 125
                PP PP  P  PGTDG
Sbjct: 580 LPGDLPPPPPPPPPPPGTDG 599



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 18/36 (50%), Positives = 18/36 (50%), Gaps = 10/36 (27%)

Query: 5   PAPPPPPPPPPPLAAPPP----------PGASAKGP 30
           P PPPPPPPPPP   PP           PG  AK P
Sbjct: 600 PVPPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKP 635



 Score = 38.1 bits (87), Expect = 0.017
 Identities = 38/129 (29%), Positives = 45/129 (34%), Gaps = 30/129 (23%)

Query: 9   PPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYL----CYSLLGGSGSLQ---- 60
           PP P   P AAP  P A               L L V  L       +L G G       
Sbjct: 459 PPEPEKAPPAAPTRPSA---------------LELKVEELEEKGLIRILRGPGDAVSIEI 503

Query: 61  FPLALQESPGAAAEPPPSP---PPPSLLPTPVRLGAPSQPPAPPP---LDNASHGEPPEP 114
            P+A+    G  A  P  P   P P L P        + PP PPP   L +     P  P
Sbjct: 504 LPVAVATPSGGDAPTPGVPTGSPSPDLAPA-AEPAPGAAPPPPPPLPGLPSPQEAPPSAP 562

Query: 115 PEQPAAPGT 123
           P+ P  PG+
Sbjct: 563 PQAPPLPGS 571



 Score = 37.7 bits (86), Expect = 0.022
 Identities = 18/31 (58%), Positives = 18/31 (58%), Gaps = 8/31 (25%)

Query: 5   PAPPPP----PPPPPPLAAPPPPGASAKGPP 31
           P PPPP    P PPPP   PPPPG    GPP
Sbjct: 590 PPPPPPGTDGPVPPPPPPPPPPPG----GPP 616


>gi|222418647 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 50/173 (28%), Positives = 71/173 (41%), Gaps = 28/173 (16%)

Query: 2   ARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQF 61
           A  PAPP    PP   AAPP P A+ + PP+       T +                   
Sbjct: 174 ATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPT---------------- 217

Query: 62  PLALQESPGAAAEPPPS----PPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPE---P 114
           P A   +P +++ PP +    P P +  P P+   AP +  A PP  +A+  +P     P
Sbjct: 218 PPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSSASAP 277

Query: 115 PEQPAAPGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQESSTT 167
           PE  AAP T     P+    +  A   T  AP   IT  ++ P   A ++S T
Sbjct: 278 PETTAAPPTPSATTPA--PPSSPAPQETTAAP---ITTPNSSPTTLAPDTSET 325



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 41/148 (27%), Positives = 53/148 (35%), Gaps = 11/148 (7%)

Query: 63  LALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPE---PPEQPA 119
           LA   SP         P P +  P P    AP +  A PP  +A+   PP    PPE  A
Sbjct: 154 LAPVNSPAPQDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTA 213

Query: 120 APGTDGWGLP----SGGGGAQDAWLRTPLAPSEMITAQSALPEREA----QESSTTDEDL 171
           AP T     P    S       A   TP A +    + SA PE  A      ++T D   
Sbjct: 214 APPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSS 273

Query: 172 AGRRAANGSSERGGAVSTPDYGEKKLPQ 199
           A       ++    + +TP       PQ
Sbjct: 274 ASAPPETTAAPPTPSATTPAPPSSPAPQ 301


>gi|222418649 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 50/173 (28%), Positives = 71/173 (41%), Gaps = 28/173 (16%)

Query: 2   ARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQF 61
           A  PAPP    PP   AAPP P A+ + PP+       T +                   
Sbjct: 174 ATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPT---------------- 217

Query: 62  PLALQESPGAAAEPPPS----PPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPE---P 114
           P A   +P +++ PP +    P P +  P P+   AP +  A PP  +A+  +P     P
Sbjct: 218 PPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSSASAP 277

Query: 115 PEQPAAPGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQESSTT 167
           PE  AAP T     P+    +  A   T  AP   IT  ++ P   A ++S T
Sbjct: 278 PETTAAPPTPSATTPA--PPSSPAPQETTAAP---ITTPNSSPTTLAPDTSET 325



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 41/148 (27%), Positives = 53/148 (35%), Gaps = 11/148 (7%)

Query: 63  LALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPE---PPEQPA 119
           LA   SP         P P +  P P    AP +  A PP  +A+   PP    PPE  A
Sbjct: 154 LAPVNSPAPQDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTA 213

Query: 120 APGTDGWGLP----SGGGGAQDAWLRTPLAPSEMITAQSALPEREA----QESSTTDEDL 171
           AP T     P    S       A   TP A +    + SA PE  A      ++T D   
Sbjct: 214 APPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSS 273

Query: 172 AGRRAANGSSERGGAVSTPDYGEKKLPQ 199
           A       ++    + +TP       PQ
Sbjct: 274 ASAPPETTAAPPTPSATTPAPPSSPAPQ 301


>gi|222418645 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 50/173 (28%), Positives = 71/173 (41%), Gaps = 28/173 (16%)

Query: 2   ARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQF 61
           A  PAPP    PP   AAPP P A+ + PP+       T +                   
Sbjct: 174 ATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPT---------------- 217

Query: 62  PLALQESPGAAAEPPPS----PPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPE---P 114
           P A   +P +++ PP +    P P +  P P+   AP +  A PP  +A+  +P     P
Sbjct: 218 PPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSSASAP 277

Query: 115 PEQPAAPGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQESSTT 167
           PE  AAP T     P+    +  A   T  AP   IT  ++ P   A ++S T
Sbjct: 278 PETTAAPPTPSATTPA--PPSSPAPQETTAAP---ITTPNSSPTTLAPDTSET 325



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 41/148 (27%), Positives = 53/148 (35%), Gaps = 11/148 (7%)

Query: 63  LALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPE---PPEQPA 119
           LA   SP         P P +  P P    AP +  A PP  +A+   PP    PPE  A
Sbjct: 154 LAPVNSPAPQDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTA 213

Query: 120 APGTDGWGLP----SGGGGAQDAWLRTPLAPSEMITAQSALPEREA----QESSTTDEDL 171
           AP T     P    S       A   TP A +    + SA PE  A      ++T D   
Sbjct: 214 APPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSS 273

Query: 172 AGRRAANGSSERGGAVSTPDYGEKKLPQ 199
           A       ++    + +TP       PQ
Sbjct: 274 ASAPPETTAAPPTPSATTPAPPSSPAPQ 301


>gi|42544123 splicing factor 1 isoform 3 [Homo sapiens]
          Length = 548

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 42/123 (34%), Positives = 52/123 (42%), Gaps = 14/123 (11%)

Query: 5   PAPPPPP---PPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSL-Q 60
           P  PPPP   PPPPP+   P P      PP  + L    +   V    Y L  G G +  
Sbjct: 417 PNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGV----YRLHQGKGMMPP 472

Query: 61  FPLALQESPGAAAEPPPS--PPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQP 118
            P+ +   P     PPPS  PPPP   P P       QPP PPP  ++     P P +Q 
Sbjct: 473 PPMGMMPPP----PPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQR 528

Query: 119 AAP 121
           + P
Sbjct: 529 SLP 531



 Score = 37.4 bits (85), Expect = 0.028
 Identities = 46/190 (24%), Positives = 59/190 (31%), Gaps = 44/190 (23%)

Query: 12  PPPPPLAAPPPPGASAKGPPARKLLF-------MCTLSLSVTYLCYSLLG------GSGS 58
           P   PLA+ P P A A  PP   L+              S +   + + G      G G 
Sbjct: 335 PATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGP 394

Query: 59  LQFPLALQESPGA-----AAEPPPSPPPPSLLPTPVRLGAPSQPP---APPPLD------ 104
             FP  L    G          P  PPPP + P P  +     PP    PPP+D      
Sbjct: 395 HSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGST 454

Query: 105 ---------NASHGEPPEPP--EQPAAPGTDGWGLPSGGGGAQDAWLR------TPLAPS 147
                    +   G  P PP    P  P       P    G    W +       P  PS
Sbjct: 455 PVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPS 514

Query: 148 EMITAQSALP 157
             + + + LP
Sbjct: 515 SSMASSTPLP 524



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 27/88 (30%), Positives = 35/88 (39%), Gaps = 14/88 (15%)

Query: 51  SLLGGSGSLQFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGE 110
           SL+   G    P ++  + G A  P  S P P+         AP+  P PP L + +   
Sbjct: 315 SLMAELGEAPVPASVGSTSGPATTPLASAPRPA---------APANNPPPPSLMSTTQSR 365

Query: 111 PP----EPPEQPAAPGTDGWGLPSGGGG 134
           PP     P E     G  G G P G GG
Sbjct: 366 PPWMNSGPSESRPYHGMHGGG-PGGPGG 392



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 15/34 (44%), Positives = 16/34 (47%), Gaps = 3/34 (8%)

Query: 1   MARWPAPPPP---PPPPPPLAAPPPPGASAKGPP 31
           M   P PPPP    PPPPP    PP     + PP
Sbjct: 475 MGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPP 508


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.136    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,781,390
Number of Sequences: 37866
Number of extensions: 1784955
Number of successful extensions: 68130
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 930
Number of HSP's successfully gapped in prelim test: 1331
Number of HSP's that attempted gapping in prelim test: 20081
Number of HSP's gapped (non-prelim): 22619
length of query: 456
length of database: 18,247,518
effective HSP length: 106
effective length of query: 350
effective length of database: 14,233,722
effective search space: 4981802700
effective search space used: 4981802700
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.